Clinical implementation and outcome evaluation of dihydropyrimidine dehydrogenase (DPYD) pharmacogenomic testing for fluoropyrimidine dosing in a Canadian Provincial Healthcare center.

Background: 5-Fluorouracil (5-FU) and its pro-drug, capecitabine, are widely used to treat solid tumors. Patients with dihydropyrimidine dehydrogenase (DPYD) deficiency are at increased risk for severe treatment-related toxicity. This study reported the implementation of DPYD genotyping in clinical practice and assessed the impact of genotype-guided dosing on clinical outcomes.

Hierarchical hollow nanospheres of imine-based covalent organic frameworks with built-in Ag sites for fast-charging lithium metal batteries.

Lithium metal is deemed to be the ultimate anode material for high-energy-density and fast-charging lithium batteries. However, issues of dendritic deposition and frangible solid electrolyte interphases must be resolved for lithium metal anodes. Herein, a hybrid interfacial layer, hierarchical hollow nanospheres assembled from lithiophilic imine-based covalent organic frameworks and built-in Ag sites (Ag@ICOFs), has been applied to regulate the interfacial lithium ion flux and enhance the anode stability for effectively inhibiting dendrite formation.

An Escherichia coli Nissle 1917-based live therapeutics platform with integrated phage resistance and programmable temperature sensitivity.

Live bacterial therapeutics (LBT) represent a transformative modality for managing refractory chronic diseases. However, the absence of optimized microbial chassis systems is a significant barrier to clinical translation. To bridge this gap, we engineered Escherichia coli Nissle 1917 (EcN) into a versatile platform that meets the requirements for strain development and clinical application.

Accelerated crystallization of all-silica TON-type zeolite: mechanistic insights into methanol as a dual-function agent.

Rapid and straightforward synthesis of all-silica zeolites is essential for scaling up their industrial applications in adsorption and separation. However, the synthesis typically necessitates the use of complex organic structure-directing agents (OSDAs) and/or fluoride, presenting challenges in the development of straightforward strategies. Herein, a siliceous TON zeolite, referred to as Si-TON, is successfully obtained without the need for any costly OSDAs, utilizing seeds and methanol as facilitating agents.

Promoting electrocatalytic CO reduction to -propanol over ethanol at Cu step sites.

Obtaining valuable C products directly from the electrocatalytic reduction of CO or CO is an attractive but challenging task, due to the much more complicated reaction pathways and sluggish kinetics of C products than their C and C counterparts. As different C products and competitive C side-products may share the common rate-determining step ( the carbon-carbon coupling), the regulation of subsequent selectivity-determining step(s) is critical for promoting the selectivity of C products. Herein, we focused on tuning the selectivity competition between -propanol (-CHOH, an important C alcohol) ethanol (CHOH, a major C side product), based on the constant potential computations on the Cu surface with different step sites.

Dynamic relationships of antibiotic resistomes and greenhouse gas-functioning microbes across diverse habitats.

Reservoir ecosystems with diverse habitats form critical interfaces where antibiotic resistance genes (ARGs) and greenhouse gas (GHG) emissions converge. Despite their distribution and ecological implications of ARGs across diverse habitats remain greatly unknown. There is a critical gap in dissecting the interlinkages between antibiotic resistomes and GHG-functioning microbes.

Mapping gender networks of smartphone addiction and academic procrastination: a network analysis study.

Background: Smartphone addiction (SA) and academic procrastination (AP) are two of the educational challenges encountered by many higher education students today that have led to a series of adverse effects on their well-being.

Aims Sample And Methods: Previous studies have reported inconsistent findings regarding gender differences in SA and AP, and limited attention has been paid to gender differences in the interaction between SA and AP. To address this gap, the present study employs network analysis to investigate gender differences in the SA, AP, and SA-AP interaction networks among higher education students.

Association between the American heart association's life's essential 8 score and cognitive function: a cross-sectional NHANES study.

Background: Dementia is difficult to early diagnosis while intervention in late stage has limited effectiveness. Our study aimed to explore the associations between a potential risk factor, Life's Essential 8 (LE8), and cognitive performance informs of cognitive test score and subjective cognitive performance.

Methods: Data were obtained from NHANES 2011-2012 and 2013-2014.

The complex diagnosis of post-dialysis fever: a case report and literature review of infective endocarditis in a dialysis patient.

Background: Post-dialysis fever is a common but diagnostically challenging issue in hemodialysis patients, with potential causes including dialysis-related infections, pulmonary infections, and cardiovascular complications.

Case Presentation: We report a 76-year-old male with end-stage renal disease (ESRD) on maintenance hemodialysis, coronary artery disease, and prior cardiac stent implantation, who presented with recurrent post-dialysis fever. Despite persistently negative conventional cultures, metagenomic next-generation sequencing (NGS) of pre-dialysis blood samples identified Pseudomonas aeruginosa (P.

[Effect of interleukin17 gene polymorphism on susceptibility to cow's milk protein allergy in infants and its association with gut microbiota].

Objectives: To investigate the effect of interleukin-17 () gene polymorphism on the susceptibility to cow's milk protein allergy (CMPA) in infants and its association with gut microbiota.

Methods: A prospective study was conducted involving 100 infants diagnosed with CMPA at the Women and Children's Hospital of Ningbo University from January 2022 to October 2024. A total of 100 healthy infants undergoing routine check-ups at the same hospital during the same period was enrolled as the control group.

[Anthropogenic Source Emission Inventory of VOCs Components in Cangzhou and Their Ozone Formation Potential].

Accurate emission inventories are essential for effective ozone pollution control in urban areas. Cangzhou has been frequently plagued by volatile organic compounds （VOCs） pollution along with its rapid economic development and urbanization in recent years. In this study， a high spatial resolution VOCs emission inventory for Cangzhou was established for the year 2021 using source-specific emission factors and the latest activity data from different sources.

Deciphering the transcriptomic characteristic of lactate metabolism and the immune infiltration landscape in abdominal aortic aneurysm.

Background: Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease characterized by progressive dilation of the abdominal aorta, which poses a life-threatening risk upon rupture. Lactate, a key metabolic byproduct and immunomodulatory molecule, plays a crucial role in regulating immune cell functions in various inflammatory diseases. However, the specific involvement of lactate metabolism in the pathogenesis of AAA remains poorly understood.

Framework Nucleic Acid-Programmed Sensing Interface with Densely Monodispersed Probes.

The uniform monodispersity of probes anchored on devices is of great value for molecular recognition and ligand binding. However, the uncontrollability of probe interfacial dispersity makes the probe orientations challenging to disperse on a densely monodispersed level. Herein, we report a framework nucleic acid (FNA)-programmed strategy to construct a densely monodispersed nucleic acid recognition interface.

CAR-T cells targeting CD155 reduce tumor burden in preclinical models of leukemia and solid tumors.

CAR-T cells are a powerful yet expensive tool in cancer immunotherapy. Although their use in targeting hematological malignancies is well established, using a single CAR-T cell therapy to treat both hematological and solid tumors, which can reduce cost, remains largely unexplored. In this study, we identified CD155, an adhesion molecule that is upregulated during tumor progression, as a target for CAR-T cell therapy in both leukemia and solid tumors.

Modeling the relationships between growth language mindset, L2 grit, and foreign language learning burnout.

While the existing literature acknowledges the existence of foreign language learning burnout (FLLB) and its deleterious effect on English as a foreign language (EFL) learners, the protective factors that may alleviate FLLB in EFL contexts remain largely unexplored. The current study addresses this gap by examining the impact of learners' growth language mindset (GLM) on FLLB by employing the structural equation modeling (SEM). Furthermore, the mediating role of L2 grit in the relationship between GLM and FLLB was scrutinized.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice.

Background: Understanding the evolutionary history of cultivated rice (Oryza sativa) and the genomic basis of heterosis is crucial for advancing rice productivity and ensuring global food security. The origins of the two main subspecies, indica and japonica, remain contentious, with debates over single versus multiple domestication events. Additionally, the genetic mechanisms underlying heterosis in elite super-hybrid rice varieties are not fully elucidated.

Comparative transcriptomic and proteomic analyses of hypoxia response in wild and cultivated tomato roots.

Background: Hypoxia significantly impairs tomato productivity and yield. Although cultivated tomato varieties (Solanum lycopersicum) are generally sensitive to low-oxygen conditions, their wild relatives (Solanum habrochaites) display substantially lower sensitivity. To elucidate the molecular mechanisms underlying these contrasting phenotypes, as well as the impact of positive selection and protein-protein interactions of differentially expressed genes (DEGs) and proteins (DEPs), we conducted transcriptomic and proteomic analyses of root samples from a wild tomato accession, T178 (S.

Therapeutic effects of mecobalamin combined with epalrestat on diabetic peripheral neuropathy: reduction of inflammatory factors and improvement in electromyogram indices.

Objective: To evaluate the clinical efficacy of mecobalamin combined with epalrestat in treating diabetic peripheral neuropathy (DPN) and its effects on inflammatory factors and electromyogram (EMG) indices.

Methods: Data from 100 DPN patients treated at Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital between June 2021 and December 2022 were retrospectively analyzed. Among them, the control group was 45 patients treated with mecobalamin alone.

Electrocatalytic conversion of 5-hydroxymethylfurfural to 5-methyl-2-furanmethanol by delocalization state-tuned bond cleavage.

The electrocatalytic conversion of 5-hydroxymethylfurfural (HMF) represents a green strategy for valorizing biomass-derived platform molecules into renewable fuels and value-added chemicals. However, most current electrocatalysts focus on reducing HMF to 2,5-furandimethanol (BHMF), while the selective reduction of HMF into 5-methyl-2-furanmethanol (MFA) in neutral electrolytes has received much less progress. In this work, we developed a CuGe intermetallic catalyst to modulate the electronic properties of Cu.

Submucosal Microbiome in Peri-Implantitis: A Comparative Metagenomic Analysis.

Through metagenomic sequencing, this study reveals significant microbial and functional differences between peri-implant health and peri-implantitis, identifying pathogenic species, virulence genes, and antibiotic resistance markers that may contribute to disease progression.

Metagenomic Insights Into the Subgingival Microbiome in Periodontal Health and Different Grades of Periodontitis.

Aim: This cross-sectional study compared the subgingival microbiome in periodontal health (PH) and periodontitis, focusing on distinguishing Stage III Grade B periodontitis (PD-S3gB) and Stage III Grade C periodontitis (PD-S3gC) as defined by the 2018 Classification of Periodontitis.

Methods: Subgingival samples from subjects with PH, PD-S3gB, and PD-S3gC were analyzed using metagenomic sequencing. Taxonomic and functional annotations were performed, followed by analyses of microbial diversity, differential abundance, interspecies networks, predictive modeling, and functional pathway enrichment.

8MW0511, a novel, long-acting granulocyte-colony stimulating factor fusion protein for the prevention of chemotherapy-induced neutropenia: final results from the phase III clinical trial.

Background: 8MW0511 is a novel, long-acting recombinant human granulocyte-colony stimulating factor (G-CSF) produced by the fusion of the N-terminus of highly active modified G-CSF with the C-terminus of human serum albumin (HSA). Current G-CSF treatments require frequent administration and have limitations in efficacy and convenience, highlighting the need for a longer-acting alternative with fewer injections and improved outcomes. Here, we report a phase III study comparing the efficacy and safety of 8MW0511 with those of the approved PEG-rhG-CSF.

Mating disruption of Chilo suppressalis (Lepidoptera: Crambidae) with novel aerosol dispensers in rice field.

Background: Chilo suppressalis is an important rice pest. Its control has relied heavily on synthetic insecticides. To reduce the application of insecticides, integrated pest management strategies such as incorporating mating disruption (MD) with insect pheromones are critically needed.

Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway.

Hydroxyapatite (HAp), traditionally recognized for its efficacy in bone regeneration, has rarely been explored for skin regeneration applications. This investigation explored HAp microspheres with distinct physicochemical properties tailored away from conventional bone regeneration parameters, and the capacity promoting skin regeneration and mitigating the aging process were investigated when encapsulated in hyaluronate hydrogels. By benchmarking against well-established dermal fillers like PMMA and PLLA, it was revealed the specific attributes of HAp that were conducive to skin regeneration, providing initial insights into the underlying mechanism.

Effect of Plasma Exchange on Hepatitis B-Related Acute-On-Chronic Liver Failure: A Cross-Sectional Study.

Background: To evaluate the effect of plasma exchange (PE) on the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).

Methods: The basic information (gender, age, blood type), the frequency and dosage of PE, the changes of indicators before and after PE, the adverse reactions related to PE and the prognosis of patients with HBV-ACLF who received PE in our hospital from April 2018 to December 2021 were retrospectively analyzed.

Results: 197 patients with HBV-ACLF who underwent PE were included in the analysis.