Clinical efficacy of a novel 3D-printed zirconia single crown: A randomized controlled trial.

Objectives: This randomized controlled trial (RCT) aims to evaluate the clinical efficacy of Nano Particle Jetting (NPJ)-printed zirconia single crowns compared to Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM)-milled crowns over a 12-month follow-up period.

Methods: A total of 43 participants with 48 posterior teeth (vital or endodontically treated) were included. Randomization and allocation concealment were conducted using a computer-generated list and sealed envelopes, assigning 24 teeth to each group.

Epigenetic factors associated with peri-implantitis: a review.

Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue. Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence, influencing diverse physiological activities, including immune response, inflammation, and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition.

Potential short-term shift in oral microbiota of patients with stage III-IV periodontitis and type 2 diabetes treated by non-surgical periodontal therapy.

Background/purpose: Adjunctive use of systemic antibiotics has more clinical improvement than scaling and root planing alone in stage III-IV periodontitis patients with type 2 diabetes mellitus (T2DM). There is still no study that concentrate on dynamic changes in oral microbiota by high throughput sequencing technique with the treatment regimen including adjunctive antibiotics.

Materials And Methods: Thirty-two periodontitis patients with T2DM who received non-surgical periodontal treatment (NSPT) in the previously published randomized trial were selected for microbiological analysis.

Stability of Augmented Bone and Its Influencing Factors After Simultaneous Guided Bone Regeneration With Implant Placement in the Posterior Mandible: A Retrospective Study.

Aim: To analyse the stability of augmented bone and its influencing factors after simultaneous guided bone regeneration (GBR) with implant placement in the posterior mandible.

Materials And Methods: A total of 165 implants in 102 patients were included. General information, peri-implant soft-tissue parameters and complications were recorded.

Submucosal Microbiome in Peri-Implantitis: A Comparative Metagenomic Analysis.

Through metagenomic sequencing, this study reveals significant microbial and functional differences between peri-implant health and peri-implantitis, identifying pathogenic species, virulence genes, and antibiotic resistance markers that may contribute to disease progression.

Prediction models for the complication incidence and survival rate of dental implants-a systematic review and critical appraisal.

Purpose: This systematic review aims to assess the performance, methodological quality and reporting transparency in prediction models for the dental implant's complications and survival rates.

Methods: A literature search was conducted in PubMed, Web of Science, and Embase databases. Peer-reviewed studies that developed prediction models for dental implant's complications and survival rate were included.

Role of immune dysregulation in peri-implantitis.

Peri-implantitis, a complex condition that can lead to dental implant failure, is characterized by inflammatory destruction resulting from immune dysregulation. Oral microbial dysbiosis and foreign body stimulation are the main factors contributing to such dysregulation, impairing immune cell function and triggering an inflammatory response. Immune dysregulation plays a critical role in the pathophysiology of peri-implantitis, impacting the balance of T cell subsets, the production of inflammatory factors, and immune-related molecular signaling pathways.

Microbiome of diseased and healthy implants-a comprehensive microbial data analysis.

Objective: The purpose of this systematic bioinformatics analysis was to describe the compositions and differences in submucosal microbial profiles of peri-implants' diseases and healthy implant.

Material And Methods: PubMed, Embase, ETH Z, Scopus, CNKI, and Wanfang databases were searched to screen relevant literature on the analysis of peri-implant microflora based on the sequencing analysis technique of 16S ribosomal RNA (16S rRNA) gene. High-throughput sequencing of the 16S rRNA gene of microorganisms from healthy implants, peri-implant mucositis, and peri-implantitis was downloaded from the screened articles.

Bone volume and height changes for lateral window sinus floor elevation using two types of deproteinized bovine bone mineral: A retrospective cohort study of 1-4 years.

Objective: To compare bone volume and height changes of two types of deproteinized bovine bone mineral (DBBM) for lateral window sinus floor elevation (LSFE) with simultaneous implant placement.

Materials And Methods: This retrospective cohort study involved 72 patients who underwent LSFE using low-temperature sintered cancellous bone-derived DBBM (C-DBBM) or high-temperature two-step sintered epiphyseal-derived DBBM (E-DBBM). Cone-beam computed tomography (CBCT) was acquired preoperatively, immediately postoperatively, 6 months and 1-4 years post-surgery.

Clinical efficacy of a two-piece abutment conforming to the concept of one abutment one time in the posterior region: A clinical pilot study.

Objectives: To assess the impact of a two-piece abutment workflow on enhancing the stability of the alveolar bone and gingiva surrounding the dental implant, and to determine the level of patient satisfaction.

Materials And Methods: A total of 48 patients with dentition defect in the posterior region were included and divided into two groups: the two-piece abutment workflow (TAW) and the sealing screw with submerged healing workflow (SHW). Marginal bone level (MBL), soft tissue indicators, oral hygiene indicators, and patient satisfaction were assessed and recorded partially at 0, 3, 6, and 12 months after surgery.

Metabolic profiling of peri-implant crevicular fluid in peri-implantitis.

Objects: This study aims to explore the etiology of peri-implantitis by comparing the metabolic profiles in peri-implant crevicular fluid (PICF) from patients with healthy implants (PH) and those with peri-implantitis (PI).

Materials And Methods: Fifty-six patients were enrolled in this cross-sectional study. PICF samples were collected and analyzed using both non-targeted and targeted metabolomics approaches.

Predictive factors for the treatment success of peri-implantitis: a protocol for a prospective cohort study.

Introduction: Peri-implantitis, a common biological complication of dental implant, has attracted considerable attention due to its increasing prevalence and limited treatment efficacy. Previous studies have reported several risk factors associated with the onset of peri-implantitis (eg, history of periodontitis, poor plaque control and smoking). However, inadequate data are available on the association between these risk factors and successful outcome after peri-implantitis therapy.

Influence of edentulism on the structure and function of temporomandibular joint.

Background: With the acceleration of the aging process of the population, the number of edentulous patients continuously increased. Edentulism induces the loss of occlusal relationship and cause adverse effects on the stomatognathic system. Temporomandibular joint (TMJ), as a significant component of this system, may also be affected by edentulism in the process of supporting mandibular movement.

Heavy metals in drinking water and periodontitis: evidence from the national oral health survey from China.

Background: Periodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace heavy metals has been associated with various diseases; however, the relationships between essential trace heavy metals and periodontitis remain inconclusive.

Objectives: To investigate the association between essential trace heavy metals in tap water and periodontitis in a nationally representative sample in China.

Comparison of the inflammatory states of serum and gingival crevicular fluid in periodontitis patients with or without type 2 diabetes mellitus.

Unlabelled: There is a two-way relationship between periodontitis and type 2 diabetes mellitus. This study aimed to compare the inflammatory states in serum and gingival crevicular fluid (GCF) in periodontitis patients with or without type 2 diabetes mellitus (T2DM) and healthy subjects.

Materials And Methods: 20 subjects were systematic and periodontal healthy (H group), 40 subjects were with periodontitis (CP group), and other 40 were with periodontitis and type 2 diabetes mellitus (DC group).

Digital workflow for proximal adjustment of teeth adjacent to implant-supported fixed restorations using a predesigned computer-aided grinding guide.

Clinically, the proximal surfaces of teeth adjacent to an implant restoration usually need to be adjusted to build a preferable adjacency relationship. However, it is difficult for freehand preparation to get a favorable proximal contour in some cases. In the workflow presented here, virtual grinding can be made to adjacent teeth, under the consideration of functional reconstruction and biological requirements, and then the grinding can be implemented using digital templates and a specialized bur.

Application of functionalized hyaluronic acid hydrogel with the activity of regulating the behaviors of stem cells in repairing rabbit knee articular cartilage.

Using injectable hydrogels loaded with mesenchymal stem cells (MSCs) to repair chondral defects is a new trend of cartilage tissue engineering in recent years. In this study, hyaluronic acid (HA) hydrogels containing the system of sustained-release Kartogenin (KGN) and modified by RGD and HAV peptides were used to facilitate repair of cartilage defect in the knee joint of rabbits. Different groups of implants were injected into osteochondral defects, and samples were taken 4 weeks after operation.

The Characteristics of Microbiome and Cytokines in Healthy Implants and Peri-Implantitis of the Same Individuals.

Aim: To characterize the profile of submucosal microbiome and cytokine levels in peri-implant crevicular fluid (PICF) from clinically healthy implants and peri-implantitis in the same individuals.

Material And Methods: A total of 170 patients were screened and, finally, 14 patients with at least one healthy implant and one peri-implantitis implant were included. Submucosal microbiota and cytokines from 28 implants were analyzed using 16S rRNA gene sequencing and multifactor assays, respectively.

Interactions of periodontal pathogens with platelets in the gingival crevicular fluid of patients with periodontitis.

Aim: To explore the immunological defensive effects of platelets on periodontal pathogens in the gingival crevicular fluid (GCF).

Materials And Methods: GCF samples were collected from 20 patients with periodontitis and 10 healthy controls. Platelets in the GCF were detected by immunocytochemistry and immunofluorescence.

The sampling strategy of oral microbiome.

There are multiple habitats in the oral cavity with bacteria, fungi, viruses, and protozoa residing in, which together constitute the oral micro-ecosystem. These microflorae in the oral cavity primarily include saliva, supragingival dental plaque, subgingival dental plaque, submucosal plaque around implants, plaque in root canals, and plaque on the mucosal surface. The interest and knowledge of the microbiome have dynamically increased with the advancement of technology.

Effect of adjunctive systemic antibiotics on microbial populations compared with scaling and root planing alone for the treatment of periodontitis: A pilot randomized clinical trial.

Background: To investigate the microbial shift after periodontitis being treated by scaling and root planing (SRP) with or without adjunctive antibiotics, and to assess the relationship between oral microbiota and systemic factors.

Methods: A 6-month pilot randomized controlled trial recruited 14 subjects with severe periodontitis, divided into test group and control group to receive full-mouth SRP with or without amoxicillin (500 mg) and metronidazole (200 mg) (three times a day for 7 days). Clinical examination, collection of subgingival plaque and saliva, and blood tests were performed at baseline pre-treatment, 3 months, and 6 months post-treatment.

The occurrence of peri-implant mucositis associated with the shift of submucosal microbiome in patients with a history of periodontitis during the first two years.

Aim: To investigate the dynamic changes of peri-implant microbiome in patients with a history of periodontitis and to construct a microbial prediction model.

Materials And Methods: The prospective study was performed at one month (T1), one year (T2) and two years (T3) after restoration. Clinical examinations [probing depth (PD), bleeding on probing (BOP), suppuration (SUP)], radiographic examinations and sample collection were conducted at three timepoints.

Functional characterization of a starch synthesis-related gene in .

has attracted tremendous interest because of its high contents of glucomannan and starch. Very few genes regulating glucomannan and starch were reported in . In this study, an ADP-glucose pyrophosphorylase () gene that plays a significant role in plant starch synthesis was cloned from .