Tracing regulatory element networks using epigenetic traits to identify key transcription factors: TENET R/Bioconductor package.

Summary: There is a lack of publicly available bioinformatic tools that can be widely used by researchers to identify transcription factors (TFs) that regulate cell type-specific regulatory elements (REs). To address this, we developed the Tracing regulatory Element Networks using Epigenetic Traits (TENET) R/Bioconductor package. By collecting hundreds of histone mark and open chromatin datasets from a variety of cell lines, primary cells, and tissues, and comparing these features along with matched DNA methylation and gene expression data, TENET identifies TFs and REs linked to a specific cell type.

FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury.

Age-related hearing loss (ARHL) is the most common sensorineural hearing loss, and the dysfunction of spiral ganglion neurons (SGNs) and ribbon synapses plays a crucial role in the pathogenesis. The fibroblast growth factor 13 (FGF13) is considered to be associated with neuronal survival and synaptic transmission. However, whether FGF13 is involved in degeneration of SGNs and ribbon synapses, the typical changes of ARHL, is still unknown.

A systematic review of biomechanics of clear aligners by finite element analysis.

Purpose: This review systematically collects the investigations on clear aligners (CA) by finite element analysis (FEA), and summarizes the biomechanical mechanism of CA including typical side effects and reformative designs of CA and auxiliary.

Methods: Literatures on FEA biomechanical analysis of CA are searched on Web of Science and PubMed. The information of FEA methods and results, FEA-simulated orthodontic clinical scenarios are collected and discussed in categories.

The Dual Role of TRADD in Liver Disease: From Cell Death Regulation to Inflammatory Microenvironment Remodeling.

The global burden of liver diseases continues to rise, encompassing diverse pathologies such as viral hepatitis, alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular carcinoma (HCC). In recent years, TNFR1-associated death domain protein (TRADD), a pivotal adaptor molecule in the TNF signaling pathway, has been found to play a dual regulatory role in the pathogenesis of liver diseases. Through its death domain, TRADD binds to TNFR1 and dynamically recruits downstream factors (e.

The effect of sustainability awareness on climate emotions of Chinese college students - moderated by future time perspective.

Chinese college students' emotional responses to climate change are shaped by awareness of sustainability, which can be shaped by future time perspective. This study investigates the effect of sustainability awareness on climate emotions of Chinese college students, moderated by future time perspective. Drawing on value-belief-norm theory, this research examines the influences of demographic factors such as gender, college location, and educational level on sustainability consciousness and climate emotions.

Methyl-Micro-C: simultaneous characterization of chromatin accessibility, interactions, and DNA methylation.

Epigenomes, characterized by patterns of different signatures such as chromatin accessibility, chromatin interactions, and DNA methylation, vary across cell types and play a pivotal role in regulating gene expression. By mapping these signatures, the underlying mechanisms of development and diseases can be uncovered. However, many canonical epigenetic methods focus on mapping only one signature.

Response mechanism of extracellular polymers in the remediation of chromium pollution by carbonate mineralizing bacteria.

This study examines the adaptability of carbonate mineralizing bacteria in Cr(iii)-contaminated environments with varying Cr(iii) concentrations and their response mechanism EPS. Cr(iii) removal efficiency declined with concentrations exceeding 1000 mg L, while the removal amount continued to rise, indicating strong Cr(iii) tolerance in the bacterium. Analysis of dynamic changes in EPS revealed a significant increase in production, with polysaccharides and proteins playing key roles in Cr(iii) binding.

Landscape structure evolution and ecological risk evaluation of oasis desert cities: A case study of Tiemenguan city.

The rapid development of oasis desert cities adversely affects fragile ecosystems, preventing regional sustainable development. This study investigates the spatiotemporal evolution characteristics and potential quantitative relationship between oasis landscape structure (OLS) and the ecological risk index (ERI) and the trend in different development scenarios in Tiemenguan City, a typical oasis city in an arid zone in northwestern China, from 1990 to 2020. We calculated the ERI thresholds for different landscape types, classified ecological risk levels, and examined the factors influencing ecological risk.

Multi-Index Quantitative Analysis of Pharyngiyan Tablet Characteristics by Screening Different Quality Control Components.

Pharyngiyan tablet is a traditional Chinese medicine (TCM) renowned for its efficacy in moisturizing the lungs, clearing the throat. However, it exhibits quality variations due to discrepancies in regulatory standards and challenges in comprehensive evaluation. In this study, ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) was used to qualitatively analyze the chemical composition of pharyngiyan tablets.

Advances in copper-containing biomaterials for managing bone-related diseases.

Bone-related diseases pose a major challenge in contemporary society, with significant implications for both health and economy. Copper, a vital trace metal in the human body, facilitates a wide range of physiological processes by being crucial for the function of proteins and enzymes. Numerous studies have validated copper's role in bone regeneration and protection, particularly in the development and expansion of bone collagen.

Hexosamine biosynthesis dysfunction-induced LIFR N-glycosylation deficiency exacerbates steatotic liver ischemia/reperfusion injury.

Background: More and more steatotic livers undergo resection or transplantation but they exhibit higher susceptibility to ischemia-reperfusion injury (IRI), which results in increased perioperative complication morbidity and mortality. IRI is driven by various cytokines and receptors, both of which are extensively modified by N-glycosylation. We aim to elucidate susceptibility of steatotic livers to IRI from the perspective of N-glycosylation.

Deep Reinforcement Learning-Based Routing Method for Low Earth Orbit Mega-Constellation Satellite Networks with Service Function Constraints.

Low-orbit satellite communication networks have gradually become the research focus of fifth-generation (5G) beyond and sixth generation (6G) networks due to their advantages of wide coverage, large communication capacity, and low terrain influence. However, the low earth orbit mega satellite network (LEO-MSN) also has difficulty in constructing stable traffic transmission paths, network load imbalance and congestion due to the large scale of network nodes, a highly complex topology, and uneven distribution of traffic flow in time and space. In the service-based architecture proposed by 3GPP, the introduction of service function chain (SFC) constraints exacerbates these challenges.

Thermo-responsive and phase-separated hydrogels for cardiac arrhythmia diagnosis with deep learning algorithms.

Adhesive epidermal hydrogel electrodes are essential for achieving robust signal transduction and cardiac arrhythmia diagnosis, but detachment of conventional adhesive dressings easily causes secondary damage to delicate wound tissues due to lack of programmable capability of changed adhesion. Herein, we developed hydrogel-based skin-interfacing electrodes capable of on-demand programmable adhesion and detachment to capture electrocardiogram signals for diagnosing cardiac arrhythmia. This was achieved by integrating dynamic multiscale contact and coordinated regulation through temperature-mediated switchable hydrogen bond interactions in phase-separated smart hydrogels.

alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway.

Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated in modulating IRI, and plays a pivotal role in regulating host inflammatory and immune responses, but its specific role in liver transplantation IRI remains unclear. This study explores whether can mitigate IRI and its underlying mechanisms.

Efficient removal of Cr(iii) by microbially induced calcium carbonate precipitation.

Microbially induced calcium carbonate precipitation (MICP) has emerged as a promising technique for environmental remediation, particularly for heavy metal removal. This study explores the potential of MICP for Cr(iii) removal, analyzing the effects of temperature, pH, calcium source addition, and initial Cr(iii) concentration on removal efficiency. The results show that Cr(iii) can be efficiently removed with a removal rate approaching 100% under optimal conditions (25 °C, pH 7.

Development of a novel test of splenic function for use in a clinical diagnostic laboratory.

The spleen is prone to both physical damage and functional impairment, which can be difficult to detect before catastrophic complications occur. Currently available tests of splenic function are laborious, user-dependent and unreliable, so there is an unmet need for a reliable test offered routinely in diagnostic laboratories. In this study, we have assessed a simple flow cytometry-based method measuring high mannose glycans (HMGs) on erythrocytes, which has previously been proposed as a potential test of splenic function.

Genuine Multipartite Entanglement Detection with Imperfect Measurements: Concept and Experiment.

Standard procedures for entanglement detection assume that experimenters can exactly implement specific quantum measurements. Here, we depart from such idealizations and investigate, in both theory and experiment, the detection of genuine multipartite entanglement when measurements are subject to small imperfections. For arbitrary qubits number n, we construct multipartite entanglement witnesses where the detrimental influence of the imperfection is independent of n.

Hsa_circ_0000825 promotes the progression of laryngeal squamous cell carcinoma by sponging miR-766 and interacting with ELAVL1.

Emerging evidence suggests that circular RNAs (circRNAs) are involved in the regulation of tumourigenesis and progression of a variety of malignant tumours. In this study, we aimed to identify laryngeal squamous cell carcinoma (LSCC)-specific circRNAs and explore their biological functions and underlying molecular mechanisms. Employing microarray and qRT-PCR, hsa_circ_0000825 was found to be significantly increased in LSCC tissues versus para-cancerous tissues.

Enhancing melanoma therapy by modulating the immunosuppressive microenvironment with an MMP-2 sensitive and nHA/GNE co-encapsulated hydrogel.

The immunosuppressive tumor microenvironment, such as lactic acid and matrix metalloproteinases (MMPs) overexpression, has been well confirmed to be adverse for tumor therapy. In current study, a tumor microenvironment modulatory hydrogel was successfully developed to treat melanoma by taking advantage of the synergistic effects of nano-hydroxyapatite (nHA) with well-documented selective anti-tumor action, lactate dehydrogenase A inhibitor (R)-GNE-140 (GNE), and matrix metalloproteinase-2 (MMP-2) sensitive peptide. The hydrogel was acquired by the reaction of 4-arm-polyethylene glycol-maleic anhydride (4-arm-PEG-MAL) and MMP-2 sensitive peptide (CC-14), in which nHA and GNE were co-encapsulated physically.

Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice.

Depression is a prominent contributor to global disability. A growing body of data suggests that depression is associated with the pathophysiology of the medial prefrontal cortex (mPFC), but the underlying mechanisms remain poorly understood. Mice were subjected to chronic restraint stress (CRS) for 3 weeks to create depression models during this investigation.

Purifying Photon Indistinguishability through Quantum Interference.

Indistinguishability between photons is a key requirement for scalable photonic quantum technologies. We experimentally demonstrate that partly distinguishable single photons can be purified to reach near-unity indistinguishability by the process of quantum interference with ancillary photons followed by heralded detection of a subset of them. We report on the indistinguishability of the purified photons by interfering two purified photons and show improvements in the photon indistinguishability of 2.

Effect of group online-based peer support intervention on psychological distress of adolescent and young adult cancer patients: a randomized controlled trial.

Purpose: Adolescent and young adult (AYA) cancer patients, aged between 15 to 39 years old, suffer from long-term psychological distress, confronting low self-efficacy and various psychological problems. This study constructs a group online-based peer support intervention combined with offline activities to explore its impact on the psychological distress of AYA cancer patients.

Methods: A randomized, two-arm clinical trial was conducted in which 90 AYA cancer patients were recruited.

Formation of Linear Plasmonic Heterotrimers Using Nanoparticle Docking to DNA Origami Cages.

The fabrication of complex assemblies with interesting collective properties from plasmonic nanoparticles (NPs) is often challenging. While DNA-directed self-assembly has emerged as one of the most promising approaches to forming such complex assemblies, the resulting structures tend to have large variability in gap sizes and shapes, as the DNA strands used to organize these particles are flexible, and the polydispersity of the NPs leads to variability in these critical structural features. Here, we use a new strategy termed docking to DNA origami cages (D-DOC) to organize spherical NPs into a linear heterotrimer with a precisely defined geometrical arrangement.

Comparison of clinical research trends and hotspots in allergic rhinitis and asthma from 2013 to 2023 based on bibliometric analysis.

Purpose: To analyze and compare clinical research trends and hot topics in allergic rhinitis (AR) and asthma and provide valuable theoretical data and references for future research.

Methods: Clinical studies focusing on AR or asthma published from 2013 to 2023 were retrieved from the Web of Science Core Collection. Eligible articles were screened and analyzed using bibliometrics from multiple indicators.