The role of hope, academic thriving, and adaptive coping in fostering peace of mind among university students: a mixed-methods study.

Introduction: University students face significant academic stress, making psychological resources like hope, academic thriving, and adaptive coping essential for emotional well-being. Drawing on Snyder's Hope Theory and Schreiner's model of academic thriving, this study examines how these psychological constructs contribute to students' peace of mind.

Methods: This mixed-methods study collected quantitative data from 562 undergraduate students in mainland China using validated measures of hope, academic thriving, adaptive coping, and peace of mind.

An endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation.

Gastric perforation (GP) is characterized by full-thickness injury of the stomach wall, a severe and potentially life-threatening gastrointestinal disease. However, current treatment, including surgical sutures and endoscopic closure, faces limitations, achieving complete sealing of the perforation and favorable healing remains a great challenge and an acute clinical demand. Here, we report a hydrogel dry powder (PPCL@Mg) for the minimally invasive treatment of GP, which can be delivered to target perforation wounds by spraying via an endoscope, and rapidly absorbing interfacial water and spontaneously forming a hydrogel.

The value of contrast-enhanced harmonic endoscopic ultrasound in the diagnosis of periampullary mass.

Background: Periampullary masses encompass both benign and malignant lesions that are clinically challenging to differentiate. This study aimed to investigate the diagnostic value of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) for periampullary masses and compare its performance with computed tomography (CT) and magnetic resonance imaging (MRI).

Methods: We conducted a retrospective analysis of 54 patients with pathologically confirmed malignant periampullary masses or benign lesions validated by ≥1-year follow-up.

Multimodal artificial intelligence for subepithelial lesion classification and characterization: a multicenter comparative study (with video).

Background: Subepithelial lesions (SELs) present significant diagnostic challenges in gastrointestinal endoscopy, particularly in differentiating malignant types, such as gastrointestinal stromal tumors (GISTs) and neuroendocrine tumors, from benign types like leiomyomas. Misdiagnosis can lead to unnecessary interventions or delayed treatment. To address this challenge, we developed ECMAI-WME, a parallel fusion deep learning model integrating white light endoscopy (WLE) and microprobe endoscopic ultrasonography (EUS), to improve SEL classification and lesion characterization.

Equity-enhanced glaucoma progression prediction from OCT with knowledge distillation.

Glaucoma is a progressive disease that can lead to permanent vision loss, making progression prediction vital for guiding effective treatment. Deep learning aids progression prediction but may yield unequal outcomes across demographic groups. We proposed a model called FairDist, which utilized baseline optical coherence tomography scans to predict glaucoma progression.

A Novel Injectable Composite Hydrogel HAp-GelMA Co-Doped Magnesium/Zinc Promotes Bone Generation and Angiogenesis Synergistically.

Bone is a crucial organ in the human body; however, conventional bone repair materials, such as autologous and allogeneic bone, are associated with challenges like limited availability and infection risks. Therefore, the development of novel biomaterials for bone repair is essential. This study employed a hydrothermal method to synthesize hydroxyapatite (HAp) doped with various elements and characterized its physicochemical properties.

Pathogen identification and biological fungicides screening for blight in China.

is an important ornamental horticultural plant with high ornamental value. blight was first detected in 2023 in Wanzhou District, Chongqing City, China. This disease seriously reduces the ornamental value of .

[Quantitative Analysis of the Drivers of Spatial and Temporal Evolution of Vegetation Cover in the Beijing-Tianjin-Hebei Ecological Barrier Area].

The Taihangshan-Yanshan Region （TYR） is an important ecological barrier region for Beijing-Tianjin-Hebei. The effectiveness of its ecological protection is of great significance to the ecological security pattern of Northern China. In this study， based on the 22 a long time series of fractional vegetation cover （FVC） data from 2000-2021， we explored the spatial and temporal succession process of vegetation cover in the TYR by using methods such as spatio-temporal heterogeneity analysis and correlation analysis and quantitatively separated the contributions of climate change and human activities to the impact of the FVC.

ABA promotes fatty acid biosynthesis and transport to boost arbuscular mycorrhizal symbiosis in apple roots.

The roots of most land plants form symbioses with arbuscular mycorrhizal (AM) fungi. The fungus promotes nutrient uptake from the soil while receiving plant-derived photosynthates as lipids and sugars. Nutrient exchange must be regulated by both partners; however, the mechanisms underlying the regulation of lipid supply from the plant to the AM fungus remain unclear.

A novel therapeutic strategy for osteosarcoma using anti-GD2 ADC and EZH2 inhibitor.

Osteosarcoma is the commonest malignant bone tumour in children, with a poor prognosis due to limited treatment options. Antibody-drug conjugates (ADCs) offer targeted therapeutic potential but are limited by the low expression of specific antigens like disialoganglioside (GD2) on osteosarcoma cells. This study aimed to enhance the efficacy of an anti-GD2 ADC by combining it with the enhancer of zeste homolog 2 (EZH2) inhibitor tazemetostat to upregulate GD2 expression and improve treatment outcomes.

Simultaneous measurement of interaction force and liquid film thickness between two approaching droplets using integrated optical interferometry and interface probe method.

Comprehensive quantitative measurement of the variation in inter-droplet interaction forces is crucial for a deeper understanding of the fundamental nature of droplet-droplet interactions. Existing methods have not yet achieved the measurement of dynamic interaction processes between droplets, highlighting the necessity of developing a novel measurement approach. An apparatus was designed and custom-developed specifically for investigating the dynamic interaction between aqueous droplets in an organic medium, while also examining the effects of different operational conditions on the film drainage process.

Pharmacokinetics and Pharmacodynamics of Prusogliptin (DBPR108), a Once-Daily Dipeptidyl Peptidase-4 Inhibitor, in Patients with Type 2 Diabetes.

Background And Objective: DBPR108 (prusogliptin) is a novel, orally bioavailable dipeptidyl peptidase-4 (DPP-4) inhibitor. This study investigated the pharmacokinetics and pharmacodynamic characteristics of DBPR108 tablets in patients with type 2 diabetes.

Methods: In this randomized, parallel-group, open-label, phase I study, Chinese adults with type 2 diabetes, glycated hemoglobin of 7.

[Optimization of Carbon Balance Zoning and Pattern in Beijing-Tianjin-Hebei Counties].

As an important "capital city economic circle," the determination of county carbon balance zones in the Beijing-Tianjin-Hebei counties is of great significance to its regional low-carbon development and achievement of the "dual-carbon" strategy. This study explores the spatial and temporal distribution patterns of carbon emissions and sequestration in the Beijing-Tianjin-Hebei counties from 2002 to 2020 based on the China carbon accounting database （CAD） and net ecosystem productivity （NEP） data. It further introduces the economy contributive coefficient （ECC） and ecological support coefficient （ESC） to analyze the energy efficiency and carbon sequestration capacity of the Beijing-Tianjin-Hebei counties, followed by the integration of the main functional areas （MFAs） of the territorial spatial planning.

Utilization of Image-Based Deep Learning in Multimodal Glaucoma Detection Neural Network from a Primary Patient Cohort.

Purpose: To develop a clinically motivated multimodal neural network glaucoma detection model trained on minimally processed imaging data of time-matched multimodal testing including fundus photographs, OCT scans, and Humphrey visual field (HVF) analysis.

Design: Evaluation of a diagnostic technology.

Subjects: A total of 716 encounters with time-matched fundus photographs, OCT optic nerve imaging, and HVF testing from 706 eyes (557 nonglaucomatous, 149 glaucomatous) from 571 individual patients seen at a tertiary medical center and 4 external single-modality (fundus photograph and OCT) datasets.

[Quantitative Separation of Spatiotemporal Patterns and Driving Factors of Carbon Sequestration Benefits in the Beijing-Tianjin-Hebei Region].

Net ecosystem productivity （NEP） is an important indicator for evaluating carbon sources and sinks in regional ecosystems. Clarifying its spatiotemporal differentiation pattern and driving mechanisms is crucial for precise protection and restoration of the Beijing-Tianjin-Hebei ecosystem. We estimated the net ecosystem productivity （NEP） based on MODIS remote sensing data and explored the spatial and temporal patterns of carbon sequestration benefits and succession patterns in the Beijing-Tianjin-Hebei Region from 2002 to 2020 by using Sen's trend + MK test, Hurst index, and center of gravity shift and quantitatively separated the relative contributions of carbon sequestration benefits driven by human activities and climate change by using bias correlation, complex correlation, and residual analysis.

Comparing the bowel cleansing efficacy between sodium picosulfate vs. 2L polyethylene glycol electrolyte lavage solution for colonoscopy: a prospective observational study.

Background: This study aimed to compare the bowel cleansing efficacy, adverse reactions, and patient compliance of two low-volume bowel preparation regimens, sodium picosulfate (PICO) and 2 L polyethylene glycol electrolyte lavage solution (2 L PEG-ELS).

Methods: This single-center, prospective observational trial was conducted at the Gastrointestinal Endoscopy Center of The Third People's Hospital of Chengdu between May and October 2023. Patients undergoing colonoscopy were enrolled, with the primary outcome being the rate of adequate bowel cleansing, as assessed by the Boston Bowel Preparation Scale (BBPS) with three segments scoring ≥ 2.

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis.

Background: Uveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design a novel multi-epitope vaccine targeting HSV-1 glycoproteins B, C, D, H, and L using an immuno-informatics approach, which are essential for viral entry and pathogenesis.

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects.

Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long-term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situation. Considering the complex microenvironment and persistent mechanisms mediated by resistant bacteria, it is crucial to develop an implant with enhanced osseointegration and sustained and effective infection clearance effects.

The double-edged role of IL-18 in reproductive endocrine and reproductive immune related disorders.

Interleukin (IL)-18 is one of the members of IL-1 family cytokines, it was originally named as interferon gamma (IFN-γ) inducing factor. IL-18 is a pleiotropic immune regulator and has a bidirectional regulatory effect on immunity. It exerts a potent pro-inflammatory effect by inducing the expression of IFN-γ, also has an important anti-inflammatory role.

A ceramic microbridge microfluidic chip to study osteogenic differentiation of mesenchymal stem cells in bioactive ceramic immune microenvironment.

Bioactive ceramics have been used in bone tissue repair and regeneration. However, because of the complex in vivo osteogenesis process, long cycle, and difficulty of accurately tracking, the mechanism of interaction between materials and cells has yet to be fully understood, hindering its development. The ceramic microbridge microfluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo.

The role of FAM171A2-GRN-NF-κB pathway in TBBPA induced oxidative stress and inflammatory response in mouse-derived hippocampal neuronal HT22 cells.

Tetrabromobisphenol A (TBBPA) is one of the brominated flame retardants (BFRs) widely used in industry, which has a broad toxic effect on organisms. However, there is still limited research on the neurotoxic mechanism of TBBPA. Using mouse hippocampal neurons (HT22) cells, the toxicity of TBBPA was evaluated, especially focusing on its alteration on the key molecules in FAM171A2-GRN-NF-κB signaling pathway.