Diagnostic systematic review and meta-analysis of machine learning in predicting biochemical recurrence of prostate cancer.

Prostate cancer (PCa) is the most prevalent malignant tumor in males, and many patients remain at risk of biochemical recurrence (BCR) following initial treatment. Accurate prediction of BCR is vital for effective clinical management and treatment planning. This study evaluates the effectiveness of machine learning (ML) models in predicting BCR among prostate cancer patients, comparing their performance to traditional prognostic methods.

Study of the interaction between cardiometabolic index and inflammatory index on the risk of prostate cancer development.

Background: Prostate cancer (PCa) is an important cause of fatality in older men, with inflammation and metabolic disorders as risk factors for PCa. This study examined how systemic inflammation, measured by inflammatory indices, interacts with the cardiometabolic index (CMI), a marker of obesity and dyslipidemia, to influence the risk of developing PCa.

Methods: This study consisted of 1,591 male patients recruited from the Department of Urology at the First Affiliated Hospital of Xinjiang Medical University between 2022 and 2024.

Association of visceral obesity indicators with prostate cancer: a cross-sectional study from Xinjiang.

Background: Prostate cancer (PCa) is a common malignancy among men worldwide, and its risk is strongly associated with obesity, especially visceral obesity. Visceral obesity has been assessed by the visceral adiposity index (VAI), cardiometabolic index (CMI), and lipid accumulation product (LAP), but their associations with PCa remain underexplored. This study investigated the relationship between these visceral obesity indicators and PCa risk.

Intestinal microbiota changes in early life of very preterm infants with bronchopulmonary dysplasia: a nested case-control study.

Background And Aim: Bronchopulmonary dysplasia (BPD) is one of the most important complications of very preterm infants. This study was to investigate changes in the intestinal microbiota of very preterm infants with BPD.

Methods: We enrolled 50 very preterm infants at the gestational age of 24+-31+ weeks, categorizing them into the BPD group and control group, and fecal samples were collected on days 1, 7, 14, 21, and 28, respectively.

Diagnostic ultrasound characteristics of Morel-Lavallée lesions: Case and dataset analysis.

Morel-Lavallée lesions (MLLs) are uncommon closed soft tissue injuries often arising from blunt trauma, characterized by a separation between the subcutaneous tissue and the underlying fascia, leading to fluid accumulation. This case report aims to enhance the understanding of ultrasonographic features associated with MLLs, supported by data from a patient with a confirmed MLL verified through surgical intervention or magnetic resonance imaging (MRI). A 45-year-old male presented with a history of lower leg trauma, sustained approximately 18 days prior to the initial ultrasonographic assessment.

Structural characterization of a fucoidan from Sargassum fusiforme and its antagonistic effect on T cell proliferation-inhibition induced by CAFs.

A water-soluble sulfated polysaccharide, SFAP-4, was isolated from Sargassum fusiforme via ion-exchange and gel-filtration column chromatography. It comprised a large amount of fucose (Fuc), minor amount of galactose (Gal), and small amounts of glucose (Glc), mannose (Man), rhammnose (Rha), xylose (Xyl) and glucuronic acid (GlcA). Structural analysis showed that SFAP-4 has very complex structure.

Hepatocyte Growth Factor-Modified Dental Pulp Stem Cells Potentially Regulate Novel Renal Fibrosis-Associated Gene via PI3K/AKT/GSK3β Pathway to Alleviate Renal Fibrosis.

Chronic kidney disease (CKD) is a major global health problem characterized by renal fibrosis, for which effective therapeutic options are still lacking. Mesenchymal stem cells (MSCs) have emerged as potential candidates for treating fibrosis due to their paracrine effects. This study first compared the antifibrotic capacities of umbilical cord-derived MSCs (UCMSCs) and dental pulp stem cells (DPSCs).

GBD: incidence rates and prevalence of anxiety disorders, depression and schizophrenia in countries with different SDI levels, 1990-2021.

Background: Anxiety disorders, depression and schizophrenia are the focus of global mental health attention, resulting in a significant number of disability-adjusted life years and a considerable social and economic burden. It's can affect the socioeconomic landscape as a result of experiencing a global epidemic. And rarely, different Socio-demographic Index (SDI) levels and Age-Period-Cohort (APC) have been used to evaluate the prevalence of mental disorders worldwide.

Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies.

Diquat is a widely used bipyridyl herbicide that is extensively applied in agricultural production and water management due to its high efficacy in weed control. However, its environmental persistence and the toxic effects it induces have raised widespread concern. Studies show that Diquat primarily enters the body through the digestive tract, leading to poisoning.

High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer.

Introduction: Identifying predictive biomarkers for immune checkpoint inhibitor (ICI) treatment is critical for gastric cancer (GC) prognosis. C-X-C motif chemokine ligand 13(CXCL13) plays an important role in immune regulation by binding exclusively to its receptor CXCR5. However, its role, underlying mechanisms, and prognostic significance in ICI-treated GC patients remain controversial.

A clinical efficacy analysis of ankle arthrography-assisted modified ankle capsule repair in the treatment of recurrent bunion cysts.

Objective: This study aims to retrospectively analyze the clinical efficacy of ankle arthrography-assisted modified ankle capsular repair for treating recurrent bunion cysts.

Methods: Clinical data from 16 cases of recurrent bunion cysts, treated between December 2021 and June 2024, were collected. All patients underwent intraoperative ankle arthrography with cyst excision, followed by ankle capsule repair based on the arthrography results.

Constructing Built-In Electric Field in Hierarchical-Flower Heterostructure for High-Performance Serum Metabolic Assay.

Laser desorption ionization mass spectrometry (LDI-MS) is a critical platform for high-throughput nontargeted metabolomics analysis in clinical diagnosis. However, traditional organic matrices inherently suffer from background interference in the low-mass range and exhibit low sensitivity for small molecule detections. Heterostructure has been regarded as an effective structure for high charge carrier mobility and tunable band gaps, which can enhance ion transfer efficiency and photothermal conversion during the LDI-MS process.

Rapid Onset of Pain Relief with Crisugabalin in Patients with Diabetic Peripheral Neuropathic Pain: Findings from a Multicenter, Randomized, Double-Blind, Controlled Study.

Introduction: This study aims to evaluate the efficacy and safety of Crisugabalin in patients with diabetic peripheral neuropathic pain (DPNP), with a focus on its rapid onset of action.

Methods: All the analyses in this study were based on data from a phase 2/3 adaptive randomized clinical trial that enrolled 596 patients. Participants were categorized into four treatment groups according to the intervention received: Crisugabalin 40 mg/day, Crisugabalin 80 mg/day, placebo, and Pregabalin 300 mg/day.

Association of non-insulin-based insulin resistance indices, mean platelet volume and prostate cancer: a cross-sectional study.

Purpose: Insulin resistance and prostate cancer (PCa) association results remain controversial. However, few studies have compared the role of various non-insulin-based insulin resistance (NI-IR) indices and mean platelet volume (MPV) in PCa.

Methods: We conducted a cross-sectional study, the case group included 354 patients with PCa, and the control group included 1,498 non-PCa participants.

Sargassum henslowianum polysaccharides induce apoptosis of prostate cancer associated macrophages via the CD206-ERK-ROS pathway.

Tumor-associated macrophages (TAMs) are a predominant immunosuppressive cell type within the tumor microenvironment. Whether polysaccharides from Sargassum henslowianum C. Ag.

Amorphous Roxithromycin Loaded in-situ Gel for the Treatment of Induced Upper Respiratory Tract Infection.

Objective: Upper respiratory tract infections are among the most prevalent respiratory diseases, imposing both financial and physical burdens on affected individuals. Roxithromycin (ROX), a primary drug for treating bacterial-induced respiratory tract infections, is typically administered orally due to its hydrophobic nature. However, the non-specific distribution resulting from oral administration reduces bioavailability and can cause side effects such as diarrhea.

Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoE mice through the miR-34a/FGF-21 axis.

Introduction: Increasing evidence indicates that cellular senescence is a significant risk factor for atherosclerosis (AS).

Methods: In the present study, we used an apolipoprotein E knockout (ApoE) mouse model to address the effect of sodium nitrate on senescence accompanied by atherosclerosis. After sodium nitrate intervention, the degree of AS pathological and cellular senescence changes was evaluated in mouse aortic.

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and risk of prostate cancer: a retrospective study.

Background: Prostate cancer is one of the most frequent malignancies in the world, with significant morbidity and death rates. Identifying novel biomarkers is critical to reducing morbidity and mortality from the illness today. Although lipids have been linked to an increased risk of prostate cancer, it is unclear if the non-high-density lipoprotein cholesterol (NHDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) is related to prostate cancer.

A Facile Way to Enhance the Therapeutic Efficacy of Hydrophobic Drugs via Amorphous Solid Dispersions.

Approximately 40% of marketed drugs and 75% of invested drugs in the pharmaceutical field are poorly soluble hydrophobic drugs with minimal solubility in water which make them difficult to be absorbed by the body and significantly limiting their applications. Among chemotherapeutic agents, numerous antitumor drugs such as platinum compounds, camptothecin, paclitaxel and others are also restricted in processing and preparation due to solubility issues. Therefore, improving the solubility and enhancing the therapeutic efficacy of drugs have always been significant research topics in current pharmaceutics.

Regorafenib plus sintilimab as a salvage treatment for microsatellite stable metastatic colorectal cancer: a single-arm, open-label, phase II clinical trial.

Immune checkpoint inhibitors (ICIs) have limited efficacy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC), and combination therapy needs to be further explored. In this single-arm, open-label, phase II trial (NCT04745130), we evaluate the efficacy and safety of the combination therapy of antiangiogenesis (regorafenib) and ICI (sintilimab) in patients with MSS mCRC. The primary endpoint is overall survival (OS).

Innovative approaches to English pronunciation instruction in ESL contexts: integration of multi-sensor detection and advanced algorithmic feedback.

Introduction: Teaching English pronunciation in an English as a Second Language (ESL) context involves tailored strategies to help learners accurately produce sounds, intonation, and rhythm.

Methods: This study presents an innovative method utilizing advanced technology and algorithms to enhance pronunciation accuracy, fluency, and completeness. The approach employs multi-sensor detection methods for precise data collection, preprocessing techniques such as pre-emphasis, normalization, framing, windowing, and endpoint detection to ensure high-quality speech signals.

SlABCG9 Functioning as a Jasmonic Acid Transporter Influences Tomato Resistance to .

Jasmonic acid (JA) is crucial for plant stress responses, which rely on intercellular jasmonate transport. However, JA transporters have not been fully identified, especially in tomato ( L.).

Clinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis.

Objective: The purpose of this study was to investigate the clinical efficacy of antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in the treatment of multidrug-resistant diabetic foot ulcers (MDRO-DFUs).

Methods: A retrospective analysis of the clinical data of 80 patients with MDROs-DFU who were used Vacuum sealing drainage (VSD) as NPWT excipient and met the inclusion criteria from January 2019 to January 2024 at our hospital. Patients were divided into an experimental group and a control group, with 40 cases in each.

Efficacy and safety of multi-target tyrosine kinase inhibitor AL2846 combined with gemcitabine in pancreatic cancer.

Pancreatic cancer patients urgently need new treatments, and we explored the efficacy and safety of combination therapy with AL2846 and gemcitabine in pancreatic cancer patients. This was a single-arm, single-center, open-label phase I/IIa study (NCT06278493). The dose-escalation phase was designed to evaluate the maximum tolerated dose (MTD) of AL2846 combined with gemcitabine.