The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.

Cerebrovascular ageing is a complex process characterized with increased vessel stiffness, decreased sensitivity to vasodilators and vasoconstrictors, and reduced angiogenesis, which is mediated via time-dependent manner. The triglyceride-glucose (TyG) index, calculated by ln[fasting triglycerides (TG) (mg/dl) × fasting blood glucose (FBG) (mg/dl)/2], has recently been evidenced as a reliable surrogate of insulin resistance (IR). Currently extensive studies provide robust statistical evidence of the predictability of the TyG index in the development and prognosis of ageing-related cerebrovascular diseases.

MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6.

Tumor cells typically exhibit dysregulation of mitochondrial energy metabolism and cell death. The role of mitochondrial function in ovarian cancer (OC) progression has garnered substantial attention, yet its precise molecular mechanisms remain elusive. Mitochondrial ribosomal protein L13 (MRPL13), involved in the translation of oxidative phosphorylation (OXPHOS) complex subunits, plays a critical role in regulating mitochondrial function.

Patient-reported outcomes of the prognostic nutritional index for resectable esophageal squamous cell carcinoma.

Background: The prognostic nutritional index (PNI) involves both the nutritional status and immune function as crucial factors linked to the prognosis of various gastrointestinal cancers. The relationship between the PNI and postoperative quality of life (QOL) in patients with esophageal cancer (EC) has not been examined. This study sought to examine the effects of the PNI on the postoperative patient-reported outcomes (PROs) of patients with esophageal squamous cell carcinoma (ESCC).

Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis.

Background: Colorectal cancer (CRC) is a prevalent global malignancy where gut microbiota plays a key role. Streptococcus gallolyticus (Sg), a gut commensal and opportunistic pathogen, is associated with CRC. This study investigates the impact of the supernatant derived from Sg cultures (hereafter referred to as Sgsup) on CRC progression and examines the underlying mechanisms.

Correlation of the Triglyceride-Glucose Index with Clinical Prognosis of Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy.

Objective: The aim of this study is to investigate the correlation between the triglyceride-glucose (TyG) index, a surrogate index of insulin resistance, and the clinical prognosis of patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT).

Methods: This retrospective study analyzed clinical data of 284 patients with AIS who underwent MT. Patients were divided into a good prognosis group modified Rankin Scale ([MRS] score ≤2) and a poor prognosis group ([modified Rankin Scale] score >2) based on their outcomes 90 days post-MT.

Temporomandibular joint disc position affects condylar bone modeling-A randomized controlled clinical trial.

Backgrounds: The primary controversy surrounding the treatment of anterior disc displacement (ADD) of temporomandibular joints (TMJ) stems from the unclear relationship between disc position and condylar adaptation. The long-term impact of varying disc position on condylar bone remodeling remains poorly understood.

Methods: A randomized controlled clinical trial was conducted to evaluate the effects of different disc positions on condylar bone modeling/remodeling at baseline (T0) and after an 18-month-follow-up (T1).

Triglyceride-Glucose Index Predicts Instability in the Natural History of Intracranial Aneurysms: Insights From a Large-Scale Chinese Multicenter Cohort.

Background: The triglyceride-glucose (TyG) index is associated with various cerebrovascular diseases. However, the association between the TyG index and the instability (growth or rupture) of unruptured intracranial aneurysms (UIAs) remains underexplored.

Methods: This multicenter retrospective analysis used data from 2 prospective Chinese cohorts with UIAs.

Clinical efficacy of magnet-assisted removal for dental high-speed dental handpiece broken Burs in mandibular third molar surgery: a retrospective study.

Background: Breakage and displacement of the high-speed dental handpiece bur is one of the intraoperative complications during mandibular third molar extraction. The retained metallic fragments can trigger issues such as pain and infection. Traditional retrieval methods require extensive tissue dissection, increasing the risk of nerve injury and postoperative complications.

Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation.

Background: The aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR's effect on the odontogenic or osteogenic differentiation ability of neural crest cells (s).

Methods: We used gene p75NTR knockout (p75NTR) mice and wildtype (p75NTR) mice embryos as a model.

Physicochemical properties, aroma compounds, non-volatile metabolites and their potential correlation in fermented Sichuan-style sausage.

To assess the modulation of on aroma compounds, non-volatile metabolites, and their potential correlation in Sichuan-style sausage, in this study, an isolated strain was used as starter cultures to prepare Sichuan-style sausages at different inoculum levels (10, 10, and 10 CFU/g). The results showed that fermented sausages exhibited reduced total plate counts and stronger antioxidant activity compared to control sausage. UHPLC-MS/MS metabolomics identified 1047 metabolites, of which 930 were characterized.

The cortisol awakening response: predicting self-reported daily stress reactivity.

Background And Objectives: The cortisol awakening response (CAR) refers to a phenomenon characterized by a significant increase in cortisol levels following morning awakening. Previous studies have shown that an aberrant CAR is associated with stress-related disorders. However, there is a lack of prospective longitudinal studies examining whether individual differences in the CAR can predict daily stress reactivity.

The association of triglyceride glucose index and postoperative outcome in patients with severe spontaneous intracerebral hemorrhage: a multiple-center cohort study.

The triglyceride-glucose (TyG) index, a marker of insulin resistance, reflects combined lipid and glucose dysregulation, which may exacerbate severe spontaneous intracerebral hemorrhage (SSICH) outcomes. The association of TyG index and postoperative outcome of SSICH patients hasn't been extensively studied. This study aimed to investigate whether the high TyG index was associated with increased risk of poor outcomes in SSICH patients.

Bio-inspired lotus-fiber and mussel-based multifunctional hydrogels for wound healing: super-stretchability, self-healing, adhesion and antibacterial properties.

Hydrogel-based wound dressings, which facilitate rapid wound closure and healing, are essential for effective wound management. However, the development of an ideal hydrogel that possesses excellent mechanical properties, effective self-healing capabilities, tissue adherence and antimicrobial characteristics for wound dressing presents a significant challenge in clinical settings. Inspired by lotus-fiber and mussel, we synthesized a novel multifunctional hydrogel composed of bacterial cellulose-reinforced dopamine-grafted oxidized hyaluronic acid/polyacrylamide (OHA-DA/PAM/BC).

Influence of Formation Lower Limit on the Physical Properties of Shrinkage Pores in a Tight Sandy Conglomerate Sample.

For shrinkable pore-developed sandy conglomerate formation, the identification of the formation lower limit is of great significance in characterizing the physical properties. In this paper, a 3D gray image of a shrinkage pore-developed sandy conglomerate sample is obtained with micro-CT scanning, the maximum class spacing algorithm is used for binarization segmentation to construct the 3D shrinkage pore digital rock, and the corresponding shrinkage pore network model is extracted through the maximum ball algorithm. By applying the shrinkage pore network model, different formation lower limit RT values are set to eliminate the pores and throats below the lower limit value, and the corresponding shrinkage pore network model is built to calculate the physical parameters.

Erratum: Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells: Erratum.

[This corrects the article DOI: 10.7150/jca.58524.

Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.

Importance: The safety and effectiveness of combining surgical peripheral iridectomy (SPI) with goniosynechialysis (GSL) and goniotomy (GT) vs trabeculectomy for intraocular pressure (IOP) reduction remains unknown.

Objective: To investigate the safety and effectiveness at 1 year of SPI + GSL + GT vs trabeculectomy in advanced primary angle-closure glaucoma (PACG) without cataract.

Design, Setting, And Participants: This noninferiority randomized clinical trial was conducted at 8 tertiary eye centers in China.

PSAT1 regulated by STAT4 enhances the proliferation, invasion and migration of ovarian cancer cells via the PI3K/AKT pathway.

Epithelial ovarian cancer, the most prevalent form of ovarian cancer, is a health concern worldwide. Phosphoserine aminotransferase 1 (PSAT1), as the rate‑limiting enzyme in serine synthesis, is key in the conversion of 3‑phosphoglycerate to serine. The present study explored the role of PSAT1 expression in epithelial ovarian tumors.

Evaluation of an anti-HCV chemiluminescence assay: Enhancing diagnostic accuracy and reducing false positives in hepatitis C screening.

Objectives: Detection of antibodies is recommended for the diagnosis and effective treatment of hepatitis C. This study evaluated the performance of a new chemiluminescence assay for detecting hepatitis C virus (HCV) antibodies and compared it with previous assays using a comprehensive set of routine and borderline samples.

Methods: A total of 2,216 serum samples were included in this study, comprising of 2,121 routine clinical samples and 95 borderline cases (COI range: 0.

Chromosome-Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology.

The leafcutter bee Megachile rotundata is the world's most intensively managed solitary bee, owing to its easy manipulation and high pollination efficacy. Here, a high-quality chromosome-level M. rotundata genome, covering 280.

Loss of SCRG1 in chondrocytes inhibits osteoarthritis by promoting autophagy activity in the temporomandibular joint through inhibition of neurokine receptors.

Background: To investigate how scrapie responsive gene 1 (SCRG1) contributes to the development of temporomandibular joint osteoarthritis (TMJOA).

Methods: Western blotting was used to identify protein expression. Proinflammatory cytokine levels were assessed by means of an enzyme-linked immunosorbent test.

Outcome of Goniotomy Over 120, 240 and 360 Degrees in Juvenile Open Angle Glaucoma: A Multicenter Study.

Prcis: 240-degree and 360-degree goniotomy (GT) demonstrated similar efficacy in intraocular pressure (IOP) reduction, both outperforming 120-degree GT in patients with juvenile open angle glaucoma (JOAG) at postoperative 6-month follow-up.

Objective: To compare the surgical efficacy and safety of 120-degree, 240-degree, and 360-degree GT for patients with JOAG.

Patients And Methods: This multicenter retrospective study included 102 eyes of 102 patients with JOAG, who underwent GT with a follow-up of at least 6 months.

Learning needs of residents in oral and maxillofacial surgery outpatient clinics: a dual-source survey study.

Background: Standardized residency training for dental residents is a clinical skills development program designed for newly graduated dental students. A significant conflict arises between patients' expectations for high-quality medical services and residents' need to enhance their skills through hands-on clinical practice. This study aims to explore the current situation and needs of resident doctors in the outpatient department of oral and maxillofacial surgery, based on patient dissatisfaction feedback and a comprehensive questionnaire survey among resident doctors.

Survival impact and risk factors of skeletal muscle loss during first-line EGFR-TKIs therapy in advanced lung adenocarcinoma patients.

Purpose: The impact of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) on muscle mass in individuals with advanced lung cancer has yet to be fully delineated. This study aimed to examine the dynamics of skeletal muscle mass during EGFR-TKIs targeted therapy, elucidate its clinical relevance, and explore the potential mechanisms.

Methods: We retrospectively recruited 104 patients with EGFR-mutant advanced lung adenocarcinoma who received icotinib or afatinib as first-line treatment.

Macromolecular and cytological changes in fission yeast G0 nuclei.

When starved of nitrogen, cells of the fission yeast Schizosaccharomyces pombe enter a quiescent 'G0' state with smaller nuclei and transcriptional repression. The genomics of S. pombe G0 cells has been well studied, but much of its nuclear cell biology remains unknown.