IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPK to attenuate hypercholesterolemia.

Hypercholesterolemia is a significant risk factor for the development of atherosclerosis. 2',3',5'-Tri--acetyl- -(3-hydroxyphenyl) adenosine (IMM-H007), a novel AMPK agonist, has shown protective effects in metabolic diseases. However, its impact on cholesterol and triglyceride metabolism in hypercholesterolemia remains unclear.

Designing multi-metal-site nanosheet catalysts for CO photoreduction to ethylene.

Catalysts featuring multiple active sites hold significant potential for CO photoconversion to multi-carbon products. However, multi-metal-site catalysts typically face challenges with low yields and selectivity for ethylene production, with a lack of definitive design guidelines. Here we show that Bader charge can serve as a critical descriptor for delineating the structure-activity relationship of kesterite-like nanosheets in the reduction of CO to ethylene.

Effect of Silica Sol on the Preparation and Oxidation Resistance of MoSi@SiO.

The limited oxidation resistance of MoSi between 400 °C and 600 °C restricts its aerospace applications. This study develops a silica-sol derived core-shell MoSi@SiO composite to enhance the low-temperature oxidation resistance of MoSi. Acidic, neutral, and basic silica sols were systematically applied to coat MoSi powders through sol-adsorption encapsulation.

External Barrier and Internal Attack: Synergistic Effect of Microcapsule Fire Extinguishing Agent and Fine Water Mist on Suppressing Lithium-Ion Battery Fire.

When lithium-ion batteries experience thermal runaway, a large amount of heat rapidly accumulates inside, causing the internal pressure to rise sharply. Once the pressure exceeds the battery's safety valve design capacity, the valve activates and releases flammable gas. If ignited in a high-temperature environment, the escaping gas can cause a jet fire containing high-temperature substances.

Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity.

Introduction: Evidence of the benefits of cordycepin (Cpn) for treating obesity is accumulating, but detailed knowledge of its therapeutic targets and mechanisms remains limited. This study aimed to systematically identify Cpn's therapeutic targets and pathways in Western diet (WD)-induced obesity using integrated network pharmacology, transcriptomics, and experimental validation.

Methods: A Western diet (WD)-induced mice model was used to evaluate the effectiveness of Cpn in ameliorating obesity.

Conditional survival analysis and real-time prognosis prediction for prostate cancer patients.

To assess shifts in long-term survival outcomes for prostate cancer patients, the present study conducted conditional survival (CS) analysis and developed a personalized CS-nomogram to provide dynamic prognostic predictions. Data from 301,441 prostate cancer patients in the Surveillance, epidemiology, and end results (SEER) database were analyzed, with cancer-specific survival (CSS) estimated using the Aalen Johansen estimator. Key predictive factors, including tumor size, lymph node involvement, distant metastasis, and histological grade, were identified via LASSO and multivariable Cox regression analyses to construct the nomogram.

piR-RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX-1 Cytoplasm Localization.

PIWI-interacting RNAs (piRNAs), a novel category of small non-coding RNAs, are widely expressed in eukaryotes and deregulated in several pathologies, including cancer. Little is known about their function and mechanism in renal cell carcinoma (RCC) progression. Herein, a down-regulated piRNA in RCC, termed piR-hsa-28489 (designated as piR-RCC), is identified to impede RCC progression both in vivo and in vitro.

Deciphering the profiles and hosts of antibiotic resistance genes and evaluating the risk assessment of general and non-general hospital wastewater by metagenomic sequencing.

Hospital wastewater (HWW) is a substantial environmental reservoir of antibiotic resistance genes (ARGs) and poses risks to public health and aquatic ecosystems. However, research on the diversity, transmission mechanisms, pathogenic hosts, and risks of ARGs in different HWW types is limited. This study involved the collection of HWW samples from 15 hospitals in Hefei, China, which were subsequently categorized as general hospitals (GHs) and non-general hospitals (NGHs).

A Donor-Acceptor-Type Two-Dimensional Poly(Arylene Vinylene) for Efficient Electron Transport and Sensitive Chemiresistors.

Two-dimensional (2D) conjugated polymers and their layer-stacked 2D conjugated covalent organic frameworks, such as 2D poly(arylene vinylene)s (2D PAVs), are emerging as promising polymer semiconductors for electronics and photocatalysis. However, achieving narrow optical band gaps and efficient electron transport remains a significant challenge for this class of materials to enhance the device's performance. Here, we report a donor-acceptor-type 2D PAV (2DPAV-TBDT-IT, where TBDT = thienyl-benzodithiophene and IT = s-indacene-1,3,5,7(2H,6H)-tetraone) synthesized via an Aldol-type 2D polycondensation approach.

Proof of effect from Clean Air Actions on atmospheric alkylated polycyclic aromatic hydrocarbons.

Clean Air Actions were implemented in China in 2013 to reduce air pollutants in the atmosphere through stringent emission controls. Alkylated polycyclic aromatic hydrocarbons (Alk-PAHs), which are derivatives of polycyclic aromatic hydrocarbons, are highly toxic, and their levels have been affected after the implementation. This study-conducted in Harbin, a northeastern Chinese city-investigated the policy's impact by analyzing temporal variations in the concentrations of gaseous and particulate Alk-PAHs from 2014 to 2019.

Rational Construction of Layered Two-Dimensional Conjugated Metal-Organic Frameworks with Room-Temperature Quantum Coherence.

Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as an intriguing class of quantum materials due to their high crystallinity, persistent spin centers, and tunable structures and topologies. However, it remains unclear how to achieve long spin relaxation time at room temperature in 2D c-MOFs via a bottom-up design strategy. Herein, we design a hexahydroxytrithiatruxene ligand (HHTH) to minimize the influence of nuclear spin on electron spin relaxation while weakening -π conjugation to construct a "spin docking" for preserving spin centers, which enables the resulting 2D c-MOFs, NiHHTH, to exhibit quantum coherence and Rabi oscillations at room temperature.

Advances in synthetic strategies for two-dimensional conjugated polymers.

Two-dimensional conjugated polymers (2D CPs) are typically represented by 2D conjugated covalent organic frameworks (COFs) that consist of covalently cross-linked linear conjugated polymers, which possess extended in-plane π-conjugation and out-of-plane electronic couplings. The precise incorporation of molecular building blocks into ordered polymer frameworks through (semi)reversible 2D polycondensation methodologies enables the synthesis of novel polymer semiconductors with designable and predictable properties for various (opto)electronic, spintronic, photocatalytic, and electrochemical applications. Linkage chemistry lays the foundation for this class of synthetic materials and provides a library for subsequent investigations.

Electron-deficient two-dimensional poly(arylene vinylene) covalent organic frameworks: efficient synthesis and host-guest interaction.

Crystalline and porous 2D poly(arylene vinylene)s (2D PAVs), vinylene-linked 2D conjugated covalent organic frameworks, represent promising materials for electronic and electrochemical applications. Chemically robust 2D PAVs with strong electron affinity are highly desirable for effective host-guest charge transfer to achieve enhanced device performance. Herein, we report the efficient synthesis and host-guest interaction of two novel 2D PAVs incorporating electron-deficient bipyrazine units with a N-free 2D PAV as a reference.

Collaborative management of severe periodontal-endodontic lesion with intense lip sucking: a case report.

Background: Lip behaviors can lead to maxillofacial developmental disorders such as anterior open bite, posterior crossbite, increased overjet, and a higher risk of developing a Class II malocclusion. However, lip-sucking, a behavior often underreported and overlooked, may adversely affect the periodontal health of permanent teeth in adolescents under extreme conditions if not promptly identified and managed.

Case Presentation: We report a unique case of an 11-year-old boy with a severe periodontal-endodontic lesion on tooth 32, caused by prolonged, high-frequency, and high-intensity lip sucking.

Selenium-Substitution Strategy for Enhanced Mobility, Tunable Bandgap, and Improved Electrochemical Energy Storage in Semiconducting Conjugated Coordination Polymers.

Conjugated coordination polymers (c-CPs), a novel class of organic-inorganic hybrid materials, are distinguished by their unique structural characteristics and exceptional charge transport properties. The electronic properties of these materials are critically determined by the constituting coordination atoms, with electron-rich selenol ligands emerging as promising candidates for constructing high-mobility semiconducting c-CPs. Despite their potential, c-CPs incorporating selenium-substituted ligands remain scarce due to the synthetic challenges associated with both the ligands and the coordination polymers.

Integrated multi-omics analysis identifies a machine learning-derived signature for predicting prognosis and therapeutic vulnerability in clear cell renal cell carcinoma.

Aims: Clear cell renal cell carcinoma (ccRCC) shows considerable variation within and between tumors, presents varying treatment responses among patients, possibly due to molecular distinctions. This study utilized a multi-center and multi-omics analysis to establish and validate a prognosis and treatment vulnerability signature (PTVS) capable of effectively predicting patient prognosis and drug responsiveness.

Materials And Methods: To address this complexity, we constructed an integrative multi-omics analysis using 10 clustering algorithms on ccRCC patient data.

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis.

Background: Precision oncology's implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies. Dysregulated tryptophan metabolism has emerged as a crucial factor in tumor progression, encompassing immune suppression, proliferation, metastasis, and metabolic reprogramming. However, its precise role in clear cell renal cell carcinoma (ccRCC) remains unclear, and predictive models or signatures based on tryptophan metabolism are conspicuously lacking.

N-acetyltransferase 10 as a novel prognostic biomarker in papillary renal cell carcinoma: a machine learning and experimental validation study.

Background: N-acetyltransferase 10 () is a lysine acetyltransferase known for catalyzing the N4-acetylcytidine (ac4C) modifications on RNAs. Recent studies have associated with the pathogenesis of various cancers. However, its specific function and prognostic significance in papillary renal cell carcinoma (pRCC) remain poorly understood.

Two-Dimensional Conjugated Metal-Organic Frameworks for Photochemical Transformations.

Photochemical transformation represents an attractive pathway for the conversion of earth-abundant resources, such as HO, CO, O, and N, into valuable chemicals by utilizing sunlight as an energy source. Recently, two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as the focal points in the field of photo-to-chemical conversion due to their advantages in light harvesting, electrical conductivity, mass transport, tunable electronic and porous structures, as well as abundant active sites. In this review, we highlight various physical and chemical features of 2D c-MOFs that can contribute to enhanced photo-induced exciton generation, charge transport, proton migration and redox catalysis.

Detecting the Conduction Property of Proton Carriers at Different Relative Humidity Based on Postsynthetic MOF Nanosheets.

Exploring the transfer ability of proton carriers at different relative humidity (RH) is vital for the rational design and development of high-performance proton exchange membranes (PEMs). However, the highly humidity-dependent transfer channel and random carrier distribution disqualify most membrane materials. Herein, a series of MIL-53 metal-organic framework (MOF) nanosheets with stable, quantifiable pore structures and different conducting groups are prepared through postsynthetic ligand exchange, followed by spin coating to assemble lamellar membranes.

Skeletal Nitrogen Functionalization of Isostructural 2D Conjugated MOFs for Enhancement of the Dual-Ion Storage Capacity.

Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) are emerging as promising electrode materials for electrochemical energy storage devices. However, a viable path to realize superior dual-ion storage in 2D c-MOFs has remained elusive. Here, we report the synthesis of Cu(N-OHPTP) 2D c-MOFs (x=0,1,2; OHPTP=octahydroxyphenanthrotriphenylene) with precise aromatic carbon-nitrogen arrangements, based on the π-conjugated OHPTP ligand incorporated with one or two nitrogen atoms.

Metal-Phthalocyanine-Based Two-Dimensional Conjugated Metal-Organic Frameworks for Electrochemical Glycerol Oxidation Reaction.

Electrochemical glycerol oxidation reaction (GOR) is a promising candidate to couple with cathodic reaction, like hydrogen evolution reaction, to produce high-value product with less energy consumption. Two dimensional conjugated metal-organic frameworks (2D c-MOFs), comprising square-planar metal-coordination motifs (e.g.

WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression.

The methyltransferase Wilms' tumor 1-associated protein (WTAP) has been reported to be dysregulated in various tumors. However, its role in renal cell carcinoma (RCC) remains elusive. Here, we explored whether WTAP was upregulated in RCC specimens compared to normal tissues.

Photothermal CO conversion to ethanol through photothermal heterojunction-nanosheet arrays.

Photothermal CO conversion to ethanol offers a sustainable solution for achieving net-zero carbon management. However, serious carrier recombination and high C-C coupling energy barrier cause poor performance in ethanol generation. Here, we report a Cu/CuSe-CuO heterojunction-nanosheet array, showcasing a good ethanol yield under visible-near-infrared light without external heating.

Facile Synthesis and Properties of Highly Porous Quartz Fiber-Reinforced Phenolic Resin Composites with High Strength.

Lightweight and high-strength insulation materials have important application prospects in the aerospace, metallurgical, and nuclear industries. In this study, a highly porous silica fiber reinforced phenolic resin matrix composite was prepared by vacuum impregnation and atmospheric drying using quartz fiber needled felt as reinforcement and anhydrous ethanol as a pore-making agent. The effects of curing agent content on the structure, composition, density, and thermal conductivity of the composite were studied.