A Stability-Aware Dual-Head Network with Prototype-Based Consistency for Semi-Supervised Medical Image Segmentation.

Semi-supervised semantic segmentation for medical images has evolved through time. While it can leverage the unlabeled data to significantly improve the segmentation performance, it still suffers the problems of intra-class variance and the consequent class-domain distribution misalignment along with costly training. In this paper, a stability-aware dual-head architecture is proposed to synergize prototype-based and Fully Convolutional Network (FCN) methodologies.

The pre- and post-COVID-19 pandemic dengue fever patterns in southeastern coastal China in 2019 and 2024: molecular evolution and strain replacement.

Background: The evolutionary dynamics of dengue virus type 1 (DENV-1) in non-endemic settings such as southeastern coastal China where outbreaks predominantly stem from imported cases, remains insufficiently defined, particularly in relation to lineage displacement dynamics.

Methods: Ninety-three DENV-1 isolates (56 from 2019, 37 from 2024) collected in southeastern coastal China underwent whole-genome sequencing. Phylogenetic relationships were inferred using maximum likelihood methods under the GTR + G + I model.

Intervention of Astragalus Membranaceus Extract in rats of spinal cord injury: a systematic review and meta-analysis.

Objective: Spinal cord injury (SCI) causes motor, sensory and autonomic dysfunction below the level of injury and its incidence is increasing every year. Astragalus Membranaceus Extract (AME) has received attention in spinal cord injury in recent years, but its specific effects in spinal cord injury are unclear.

Methods: Databases of PubMed, Embase, WOS, Cochrane Library, FMRS, Clinical trial, CNKI, VIP, and WangFang were searched from their establishment to December 1, 2024 using the following terms: "Astragalus propinquus," "Huang qi," " Bunge," "Spinal cord injuries," "spinal cord diseases," "spinal cord trauma.

Functional brain networks predicting different symptoms of schizophrenia based on connectome-based predictive modeling: A multi-site fMRI study.

Previous findings on brain functional alterations across different symptoms of schizophrenia (SCZ) patients had yielded inconsistent results. Small sample sizes could contribute to this inconsistency. To overcome this limitation, we conducted a multi-site study to explore the neural mechanisms underlying different symptoms in SCZ.

Prevalence, Antimicrobial Resistance, and Genotypic Characterization of Diarrheagenic in Foodborne Diarrhea Cases in Wenzhou Based on Whole-Genome Sequencing.

Although can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases. The study aims to investigate the prevalence, antimicrobial resistance, and genotyping of diarrheagenic (DEC) in foodborne diarrhea cases in Wenzhou City in 2023, providing a scientific foundation for the monitoring and prevention of bacterial foodborne diseases. Fecal samples from patients with diarrhea were collected from four sentinel hospitals for the isolation of DEC.

Kcc-ReHo and Cohe-ReHo in bipolar disorder: their associated genes and potential for diagnosis and treatment prediction.

The neural mechanisms underlying resting-state cerebral functional activity in bipolar disorder (BD) and the effects of pharmacotherapy on it remain unclear. This study investigated changes in local brain activity in BD patients (BDPs) following treatment, evaluated the diagnostic and prognostic potential of regional homogeneity (ReHo), and explored associated genes and biological processes. Resting-state fMRI data and clinical variables were collected from 68 BDPs (at baseline and after 3 months of pharmacotherapy) and 80 healthy controls (HCs).

VIRMA-mediated mA modification regulates forebrain formation through modulating ribosome biogenesis.

-Methyladenosine (mA) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of mA modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the mA methyltransferase complex, is highly expressed in the embryonic brain and various cancers.

Spatiotemporal variations and driving mechanisms of carbon storage in Central Asia: Insights from the PLUS-InVEST models and machine learning.

Against the backdrop of global climate change and rapid socioeconomic advancement, significant land use/cover changes(LUCC) in Central Asia have profoundly impacted terrestrial ecosystem carbon storage(CS). However, the assessment and spatiotemporal dynamics of CS in Central Asia remain inadequately understood. This study systematically examined the spatiotemporal dynamics of LUCC and CS in Central Asia from 1990 to 2020, and anticipated CS in 2030 under 3 SSP-RCP scenarios using an combined structure consisting of the land use harmonization 2(LUH2) dataset, the patch-generating land use simulation(PLUS) model, and the integrated valuation of ecosystem services and tradeoffs(InVEST) model.

Decreased left brain specialization in bipolar disorder patients and its association with neurotransmitter and genetic profiles: A longitudinal study.

Brain specialization plays a crucial role in human behavior and cognition. Previous studies have suggested abnormal specialization in psychiatric disorders; however, the specialization patterns of bipolar disorder (BD) and the effects of medication on these changes remain unclear. According to Crow's hypothesis regarding the key role of language in the origin of psychoses, BD patients (BDPs) may exhibit abnormal language-related specialization.

Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment.

Objectives: The resting-state cerebral functional activity underlying chronic insomnia disorder (CID) remains inconsistent, and the effects of pharmacotherapy on such activity are unclear.

Methods: Imaging data and clinical variables were acquired from 82 patients with CID and 54 healthy controls (HCs). Patients were assigned to receive either modified Suanzaoren decoction (MSZRD) or estazolam treatment for six weeks.

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI.

Objectives: High body mass index (BMI), encompassing overweight and obesity, is a well-established risk factor for developing breast cancer (BC). The underlying mechanisms linking elevated BMI to increased BC risk involve metabolic reprogramming and chronic inflammatory microenvironments regulated by cellular networks within breast white adipose tissue (WAT). However, the complicated landscape and specific cell chat leading to BC-related adipose microenvironment remained unclear.

Isolation and Characterization of a Porcine Getah Virus Strain from Sichuan Province.

Following its initial documented emergence in Hunan's swine facilities in 2017, GETV has inflicted considerable financial damage upon China's pork production sector. Beyond its impact on swine, GETV also poses a potential risk to other animal species and public health, primarily due to its mosquito-borne transmission. Between September 2020 and May 2021, a GETV outbreak occurred on a commercial swine farm in Sichuan Province, where affected animals exhibited movement disorders, neurological symptoms, and mild diarrhea, with severe cases resulting in mortality.

HDAC4 suppresses porcine epidemic diarrhea virus infection through negatively regulating MEF2A-GLUT1/3 axis- mediated glucose uptake.

Porcine epidemic diarrhea virus (PEDV), a porcine enteropathogenic coronavirus, causes severe diarrhea and death in neonatal piglets. Histone deacetylase 4 (HDAC4), a member of class IIa deacetylases, controls a wide range of physiological processes, but, little is known about its role in PEDV infection. Here, we report a novel strategy by which PEDV manipulates HDAC4.

An innovation scalp acupuncture prescription for post-stroke aphasia: A neuroimaging-based validation study.

Background And Objective: The coexistence of speech disorders in stroke patients can negatively impact their quality of life and rehabilitation outcomes. Scalp acupuncture (SA) has shown potential as a non-pharmacological treatment for post-stroke aphasia (PSA). As the location of SA in PSA treatment is controversial, this study aims to utilize neuroimaging techniques for identifying and validation the promising target.

Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.

Riemeralla anatipestifer, a predominant bacterium with multidrug resistance, has caused tremendous economic losses in the poultry farming industry. However, there are few studies on its identification, pathogenic mechanisms, and virulence factors and effective and systematic prevention and control strategies. The emergence and spread of antibacterial resistance has prompted increased focus on R.

Fronto-Parietal and Language Network Connectivity and Its Association With Gene Expression Profiles in Bipolar Disorder Before and After Treatment.

Background: The resting-state functional connectivity (FC) patterns of the fronto-parietal network (FPN) and language network (LN) underlying bipolar disorder (BD) are obscure. This study aimed to uncover abnormal FC patterns of FPN and LN underlying BD and their evolution following treatment.

Methods: Imaging data at rest state and clinical variables were acquired from 82 patients with BD (with 43 finishing the follow-up) and 88 healthy controls (HCs).

G3BP1 Regulates the Cell Cycle by Promoting IFNβ Production to Promote PCV2 Replication and Promotes Nuclear Transfer of Viral Proteins by Direct Binding.

Porcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it is widely prevalent in pig farms, leading to huge economic losses for the pig industry. Currently, the ability of PCV2 to enhance its own replication by using the antiviral inflammatory factors IFNα, IFNβ, and IL-2 and its complex immune escape mechanism remain unclear, which has attracted wide attention. Research has indicated that GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is involved in the innate immune response to a variety of viruses, primarily by regulating and composing stress granules (SGs) to inhibit viral replication.

Potential associations between altered brain function, cognitive deficits and gene expressing profiles in bipolar disorder across three clinical stages.

Aims: We aimed to determine the relationship between altered brain imaging characteristics, cognitive function and profiles of gene expression of bipolar disorder (BD).

Methods: Functional magnetic resonance imaging (fMRI) was presented in three groups of BD participants (depressed, manic and euthymic) and healthy controls. Regional Homogeneity (ReHo) and region of interest based functional analysis combining with neuroimaging-transcription association analysis were utilized to investigate abnormalities and their correlation with clinical symptoms.

Unlocking Biochar's Potential: Innovative Strategies for Sustainable Remediation of Heavy Metal Stress in Tobacco Plants.

Tobacco, being a globally cultivated crop, holds significant social and economic importance. Tobacco plants are susceptible to the adverse effects of heavy metals (HMs), particularly cadmium (Cd), which hinders root development, disrupts water balance, and impedes nutrient absorption. Higher concentrations of HMs, especially Cd, naturally accumulate in tobacco leaves due to complex interactions within the plant-soil continuum.

Whole-Genome Sequencing Analysis of Antimicrobial Resistance, Virulence Factors, and Genetic Diversity of from Wenzhou, China.

species are important foodborne pathogens worldwide. pathogenicity is associated with multiple virulence factors and enhanced antimicrobial resistance. To determine the molecular characteristics and genetic correlations of , 24 strains of isolated from different sources (raw poultry, human stool, and food) in the Wenzhou area were investigated to determine the distribution of antimicrobial resistance and virulence determinants using whole-genome sequencing (WGS).

Infection Status, Etiological Analysis of spp. in Foodborne Diarrhea Patients from 2019 to 2023 in Wenzhou.

The infection status and etiological analysis of spp. from foodborne diarrhea patients in Wenzhou were carried out to provide the etiological basis for healthy diet and clinical treatment. isolates ( = 41) collected from foodborne diarrhea patients were identified using the automatic bacteriologic analyzer and mass spectrometer.

Analysis of foodborne outbreaks in Wenzhou City, China, 2012-2022.

Foodborne diseases are ongoing and significant public health concerns. This study analysed data obtained from the Foodborne Outbreaks Surveillance System of Wenzhou to comprehensively summarise the characteristics of foodborne outbreaks from 2012 to 2022. A total of 198 outbreaks were reported, resulting in 2,216 cases, 208 hospitalisations, and eight deaths over 11 years.

Vegetation changes and influencing factors in different watersheds of Henan Province based on GEE and geographic detectors.

Clarifying vegetation changes and the driving factors can provide references for ecological restoration and sustainable social development. We analyzed vegetation distribution and trend changes in Henan Province and its basin zoning (Haihe River basin zoning, Yellow River basin zoning, Huaihe River basin zoning, Yangtze River basin zoning), with fractional vegetation cover data from 2000 to 2020 based on the Google Earth Engine platform, and by combining Theil-Sen Median trend analysis, Mann-Kendall test, and Hurst index. We also utilized factor detection and factor interaction to explore the individual and mutual influences of natural and anthropogenic factors on vegetation at different scales.