A Stability-Aware Dual-Head Network with Prototype-Based Consistency for Semi-Supervised Medical Image Segmentation.

Semi-supervised semantic segmentation for medical images has evolved through time. While it can leverage the unlabeled data to significantly improve the segmentation performance, it still suffers the problems of intra-class variance and the consequent class-domain distribution misalignment along with costly training. In this paper, a stability-aware dual-head architecture is proposed to synergize prototype-based and Fully Convolutional Network (FCN) methodologies.

EXPRESS: The Predictive Value of C-reactive Protein Combined with Platelets for the Progression and Prognosis of Sepsis: A Retrospective Cohort Study.

This retrospective cohort study aimed to explore the predictive value of the C-reactive protein (CRP)/platelet count (PLT) ratio for sepsis progression and prognosis. A total of 237 sepsis patients admitted to the ICU between January 2019 and November 2024 were divided into survivor (n=157) and non-survivor (n=80) groups based on 28-day outcomes. Intergroup comparison, ROC curve analysis, survival analysis, LASSO regression analysis, and Cox regression analysis were employed to evaluate the impact of clinical data, dynamic CRP/PLT ratios (on days 1 and 7), and change degree [(CRP/PLT day 7 - CRP/PLT day 1)/CRP/PLT day 1] on the progression and prognosis of sepsis.

X-Ray Irradiation of Pseudomonas aeruginosa Induces Biogenesis of Outer-Inner Membrane Vesicles With Potential as a Vaccine Against Acute Pneumonia.

Many bacteria produce extracellular vesicles (EVs) that play critical roles in various biological processes and hold significant potential for biomedical applications. However, the mechanisms underlying EV biogenesis remain incompletely understood. Using transmission electron microscopy, we demonstrate that X-ray irradiation induces outward blebbing of the inner membrane in Pseudomonas aeruginosa PAO1 (P.

Emodin Alleviates Sepsis-Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL-10.

Sepsis is a life-threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation. Neutrophil extracellular traps (NETs) formation bridges these two pathological processes. Through both in vivo and in vitro experiments, it is observed that Emodin, a natural anthraquinone derivative derived from Dahuang, significantly ameliorates the cytokine storm and coagulation abnormalities induced by sepsis, demonstrating remarkable efficacy in inhibiting NETs formation.

Clinical analysis on comparison of outcomes between partial splenic artery embolization and splenectomy for management of grade II-III splenic injury in blunt trauma.

Background: The spleen is also the largest lymphoid organ and has important immune and haematopoietic functions. Traumatic splenic rupture often results in haemorrhagic shock and is life-threatening. In the past, total splenectomy was performed for various degrees of splenic injury, which caused great harm to the patient.

The study of epidermal wax of different apple varieties and functional analysis of MdMYB94 regulating wax biosynthesis.

Cuticular wax plays a crucial role in reducing water loss, enhancing pathogen resistance, and improving the surface appearance of apple fruit. However, limited research has focused on wax biosynthesis during fruit development in apple. In this study, we investigated the wax biosynthesis of four apple cultivars 'Fumei', 'Fuxing', 'Fuli', and 'Fuji'.

Postoperative myelitis subsequent to cervical spine radiofrequency ablation: a case report.

Commonly used minimally invasive treatment for cervical spondylotic diseases, cervical spine radiofrequency ablation (RFA) provides benefits of faster recovery and less trauma. However, data on the monitoring and management of postoperative complications, especially severe adverse events like myelitis, is limited. This case report details a 75-year-old female patient with a medical history of hypertension, cerebral infarction, and hyperlipidemia who subsequently developed myelitis after undergoing cervical spine radiofrequency ablation (RFA).

Replication and Virulence in Cattle of the First Lumpy Skin Disease Virus Isolated in Xinjiang, China (2019).

Before 2012, lumpy skin disease (LSD) was primarily confined to African countries. However, it rapidly spread to the Middle East and Southeast Europe, reaching the Balkans, the Caucasus, and the Russian Federation by 2015. The first confirmed case in China was reported on August 10, 2019, in Yili, Xinjiang, and on August 26, the Chinese government officially notified the World Organization for Animal Health (WOAH) of the outbreak.

Efficacy and validation of a clinical predictive model for chronic atrophic gastritis in patients: a multi-center retrospective analysis.

Background: Chronic atrophic gastritis (CAG) is a major digestive disorders, and prognosis is determined by many social-demographic and clinicopathologic characteristics. This study aimed to identify risk factors and construct a predictive model for better diagnosis of CAG.

Methods: We utilized a multi-center retrospective analysis, including 539 cases of CAG patients diagnosed and treated in Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2018 to December 2024 as training dataset, and 230 clinical data diagnosed with CAG from Hefei Second People's Hospital from April 2018 to November 2024 as validation dataset to establish the predictive model.

Sang Zhu Yang Zheng herbal tea: A multi-faceted approach to immunomodulation in the prevention and treatment of respiratory tract infectious diseases.

Ethnopharmacological Relevance: Dysregulation of the upper respiratory tract microbiota, host metabolite profiles, and immune lymphocyte subpopulations is critical in the pathogenesis of respiratory tract infectious diseases (RTIs). Sang Zhu Yang Zheng herbal tea (SZYZ) has emerged as a promising intervention for RTIs, yet its underlying mechanism remains unclear.

Aim Of The Study: This study aims to investigate the immunomodulatory mechanisms of SZYZ underlying its role in the prevention and treatment of RTIs.

Development and validation of a clinical model to predict low-grade intraepithelial neoplasia in chronic atrophic gastritis patients: a retrospective observational multicenter analysis.

Background: Chronic atrophic gastritis (CAG), an early stage of gastric cancer, is a major digestive disorder, and the prognosis of CAG is determined by many sociodemographic and clinicopathologic subject characteristics. This retrospective observational multicenter analysis was conducted to explore risk factors and construct a predictive model for low-grade intraepithelial neoplasia (LGIN) in patients with CAG.

Methods: The training dataset included 317 CAG patients diagnosed and treated in the Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2018 to January 2025.

Probiotic-mediated tumor microenvironment reprogramming with protease-sensitive interleukin-15 and photothermal therapy.

T cell inadequacy or exhaustion often causes the failure of immune checkpoint blockade (ICB)-based immunotherapy. Interleukin-15 (IL-15) has been used to prime the tumor microenvironment (TME) to boost the efficiency of immunotherapy. However, its clinical application is hindered by systemic toxicity and low intratumoral concentrations.

Advances in Isorhamnetin Treatment of Malignant Tumors: Mechanisms and Applications.

Isorhamnetin (ISO) is a natural flavonoid compound that has become a main research topic in recent years due to its multitargeted antitumor properties. In this paper, we systematically review the molecular basis of the inhibition of malignant tumors by ISO, including through the regulation of the cell cycle, PI3K/AKT/mTOR pathway, MAPK pathway, apoptosis/autophagy-related pathways, and the tumor microenvironment. We also explore its synergistic effects with chemotherapy/targeted therapies and its potential for clinical translation.

Unveiling the Role of Cathepsins on Lung Function in Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis.

Background: Cathepsins are a group of proteases that can degrade the extracellular matrix of the lungs, leading to lung tissue destruction and remodeling in chronic obstructive pulmonary disease (COPD). However, the causal relationship between cathepsins and COPD remains unclear.

Methods: We performed a two-sample Mendelian randomization (MR) analysis using genetic instruments for nine cathepsins (B, E, F, G, H, L2, O, S, and Z) and lung function measures (FVC, FEV1, FEV1/FVC, and PEF) in COPD.

CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers.

Gastrointestinal (GI) cancers are a leading cause of cancer morbidity and mortality worldwide. Despite advances in treatment, cancer relapse remains a significant challenge, necessitating novel therapeutic strategies. In this study, we engineered nanobody-based chimeric antigen receptor (CAR) natural killer (NK) cells targeting cadherin 17 (CDH17) for the treatment of GI tumors.

Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer.

Identifying the population at risk of rapid progression from hormone-sensitive prostate cancer (HSPC) to lethal castration-resistant prostate cancer (CRPC) is a challenge. This work has highlighted important prognostic insights based on proteomics data, magnetic resonance imaging (MRI) and histopathological specimens. We retrospectively developed a multi-omics-based model based on 77 patients with HSPC.

Clinical Characteristics of Non-Lactational Mastitis of Accessory Breast: A Case-Series Study.

Background: Non-lactational Mastitis of Accessory Breast (NLM-AB) is a rare condition with limited research, leading to diagnostic challenges. Its clinical and demographic characteristics are poorly defined, and it is often confused with non-lactational mastitis (NLM), hindering effective diagnosis and treatment.

Objective: This study aims to clarify the features of NLM-AB, distinguish it from NLM, and address key knowledge gaps to improve clinical diagnosis and patient management.

Public Opinion Propagation Prediction Model Based on Dynamic Time-Weighted Rényi Entropy and Graph Neural Network.

Current methods for public opinion propagation prediction struggle to jointly model temporal dynamics, structural complexity, and dynamic node influence in evolving social networks. To overcome these limitations, this paper proposes a public opinion dissemination prediction model based on the integration of dynamic time-weighted Rényi entropy (DTWRE) and graph neural networks. By incorporating a time-weighted mechanism, the model devises two tiers of Rényi entropy metrics-local node entropy and global time-step entropy-to effectively quantify the uncertainty and complexity of network topology at different time points.

A Precision-Guided "Trojan Horse" for Tissue-Cell-Bacteria Targeted Therapy of Intestinal Infections.

infections, characterized by strong invasiveness, are prone to causing serious systemic transmission, posing a significant threat to public health. This study proposes a "Trojan horse" strategy for oral treatment of infection utilizing a "micro-nano composite" platform with intestinal microenvironment responsiveness, host cell targeting, and bacterial membrane fusion characteristics. The oral composite microspheres release silicasomes in response to elevated matrix metalloproteinase-9 (MMP9) levels at infected intestinal sites.

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies.

The outbreak of monkeypox virus (MPXV) was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and the zoonotic disease caused by viral infection was renamed as "Mpox" on November 28, 2022. Currently, there is no approved vaccine or specific antiviral treatment for Mpox, and a main preventive strategy against MPXV infection remains the smallpox vaccine. Although there was an emergency use authorization (EUA) of Brincidofovir and Tecovirimat for the clinical treatment of clade II Mpox, while Tecovirimat failed to reduce the duration of Mpox lesions among patients infected with clade I Mpox in the Democratic Republic of the Congo (DRC).

Preparation of Active On-Demand Antibacterial Hydrogel Epidermis Electrodes Based on Flora Balance Strategy for Intelligent Prostheses.

Hydrogel epidermis electrodes have demonstrated remarkable potential for stable electrophysiological signal acquisition in the field of intelligent prostheses. However, current hydrogel electrodes face challenges in providing on-demand antibacterial effects due to dynamic skin conditions, such as sweating, which may induce skin inflammation, thus limiting their practical applications. Herein, an active on-demand antibacterial hydrogel electrode is prepared by encapsulating () into the hydrogel electrode based on the strategy of flora balance.

Stoichiometry-engineered phase transition in a two-dimensional binary compound.

Due to complex thermodynamic and kinetic mechanism, phase engineering in nanomaterials is often limited by restricted phases and small-scale synthesis, hindering material diversity and scalability. Here, we demonstrate the exploration to unlock the stoichiometry as a degree of freedom for phase engineering in the Pd-Te binary compound. By reducing diffusion rates, we effectively engineer the stoichiometry of the reactants.

Application and accuracy analysis of raw one way inter-satellite link observations of BDS-3 full operational constellation.

The Ka-band Inter-Satellite Links (ISL) has been introduced as an innovative measurement technique for orbit determination (OD) and time synchronization (TS) of the global BeiDou Navigation Satellite System (BDS-3), complementing traditional L-band ground-satellite tracking. For the first time, OD and TS have been conducted for the entire full-operational constellation of BDS-3 using raw one-way ISL data. The normal equation (NEQ) accumulation technique is employed to estimate critical parameters, such as the ISL hardware delays (Ka-biases), to derive long-term average solutions.