Intrinsic Bright and Robust Phosphorescence in Sulfur Quantum Dots Enabled by π-Conjugation Engineering and Covalent Matrix Anchoring.

Achieving efficient and stable intrinsic room-temperature phosphorescence (RTP) in sulfur quantum dots (SQDs) is vital for the advancement of metal-free afterglow materials but remains scarcely explored due to the inherent challenge of low triplet state formation efficiency. Herein, an ingenious approach is presented for constructing a phosphorescent SQDs-based system (π-SQDs-MA) by integrating π-conjugated units with covalent confinement in a metaboric acid (MA) matrix. Remarkably, π-SQDs-MA exhibits intense intrinsic green RTP with a high efficiency of 19.

Case Report: Clinical impact of and vs. and germline double heterozygosity in ovarian cancer: a comparative case study.

Ovarian cancer (OC) is a highly heterogeneous malignancy influenced by germline genetic factors, with mutations being well-established risk factors. Germline double heterozygosity (GDH), particularly involving rare combinations, remains poorly understood. This study presents the first report of GDH in a case of Chinese OC patients and compares their clinical characteristics and treatment responses to a patient with GDH.

Gut microbiota regulates serum metabolites in mice with nonalcoholic fatty liver disease via gut metabolites: mechanisms involving branched-chain amino acids and unsaturated fatty acids.

Introduction: In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut metabolites in mice with NAFLD changed significantly.

Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.

Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from Salvia miltiorrhiza, has been widely used to treat cardiovascular and cerebrovascular disorders, owing to its antioxidant and anti-inflammatory properties.

Hydration performance and optimization of multi-solid waste composite calcined sewage sludge.

The rapid increase in sewage sludge (SS) production and the global pursuit of carbon neutrality have driven the demand for the high-value construction material utilization of SS. In this study, calcium-rich solid wastes-carbide slag (CS) and phosphogypsum (PG)-were co-calcined with SS at elevated temperatures (800-1000 °C) to address the insufficient cementitious activity of thermally activated sludge. The resulting products were used to replace 30% of ordinary Portland cement (OPC) in pastes.

Effects of cardioneuroablation for vasovagal syncope: ganglionated plexus localization by tentative anatomical ablation and high-frequency electrical stimulation.

Background: Cardioneuroablation is increasingly being adopted as a treatment for vasovagal syncope (VVS). Identification of the cardiac ganglionated plexus (GP) is a critical factor influencing the outcome of the procedure. This study sought to compare the efficacy of tentative anatomical ablation (TAA) and high-frequency electrical stimulation (HFS) in locating the GP.

Unveiling the gut's plastic predicament: How micro- and nano-plastics drive distinct toxicological pathways in Enchytraeus crypticus.

The gut microenvironment is crucial for maintaining health of its host. However, there is currently limited mechanistic understanding of how stress from microplastics (MPs) and nanoplastics (NPs) alter this environment and its resulting biotoxicity. Here, we systematically investigated the biological responses - from physiology to pathology and from molecular interactions to phenotypic changes - of the soil invertebrate Enchytraeus crypticus exposed to environmentally relevant concentrations of polystyrene MPs (50 μm) and NPs (100 nm).

Fermented Gastrodia elata Bl. Intervenes gut microbiota and amino acid metabolism in zebrafish to promote 5-HT homeostasis against sleep disturbances.

Sleep disturbances (SD) is a prevalent health issue in modern society. Consequences involve negative impacts on numerous aspects of physical, psychological, and daily life. This study aimed to elucidate the protective effects of Fermented Gastrodia elata Bl.

Overlooked yet critical pathways for microplastics input to soil and groundwater system: Transport mechanisms and simulation predictions in landfill environments.

Microplastics (MPs) have emerged as critical environmental pollutants in landfill ecosystems, where their transport into soil and groundwater present considerable ecological risks. However, the influence of landfill environments on the fate of MPs remains poorly understood. This study systematically investigated the transport mechanisms of MPs in two landfill soils, focusing on the interplay between microplastic properties (density, size, and polymer type) and landfill environmental conditions (temperature, salinity).

Zinc ions trigger PANoptosis-like cell death in magnetic hyperthermia therapy of magnesium based implant for hepatocellular carcinoma.

The treatment of hepatocellular carcinoma (HCC) is a worldwide urgent and pressing challenge. Magnetic hyperthermia therapy (MHT) is a relatively new therapeutic strategy for tumors in resent years, especially magnesium (Mg) implants with eddy thermal effect can be employed for MHT to therapy tumor. PANoptosis is a new type of programmed cell death (PCD), driven by Caspases and RIPKs through the formation of PANoptosomes.

Discontinuous wavelength-scanning interferometry with an unknown gapped spectrum.

Depth-resolved wavelength-scanning interferometry (DRWSI) has emerged as a powerful topographic technique for simultaneously measuring multiple surfaces. Conventional DRWSI requires the laser to emit a continuous spectrum; however, ensuring this condition is often challenging. This Letter presents a discontinuous DRWSI measurement approach that can automatically predict the missing intensity within the gapped spectrum without requiring any prior knowledge.

Detection of X-ray emission from a bright long-period radio transient.

Recently, a class of long-period radio transients (LPTs) has been discovered, exhibiting emission thousands of times longer than radio pulsars. These findings, enabled by advances in wide-field radio surveys, challenge existing models of rotationally powered pulsars. Proposed models include highly magnetized neutron stars, white-dwarf pulsars and white-dwarf binary systems with low-mass companions.

Maternal exposure to polystyrene nanoplastics during gestation and lactation impaired skeletal growth in progeny mice by inhibiting neutrophil extracellular trap formation.

Microplastics and nanoplastics are widely distributed in the natural environment and shown to accumulate in living organisms. While their potential impact on human health has been investigated, significant uncertainties remain regarding their toxic effects and mechanisms of interaction with the human skeletal system. We examined the potential effects of polystyrene nanoplastics (PS-NPs, 100 nm) on skeletal health and the underlying molecular mechanisms using the human RAW264.

Identifying the germline variation spectrum and predisposition genes in Chinese ovarian cancer using whole exome sequencing.

Background: Next-generation sequencing (NGS) allows for the simultaneous sequencing of multiple cancer predisposition genes. We assessed the frequency and spectrum of germline variations in individuals with ovarian cancer (OC), using whole exome sequencing (WES).

Methods: A total of 92 patients with OC, with or without a family history of cancer, were consecutively recruited between May 2020 and September 2023.

Diverse Perspectives Illuminate the Intestinal Toxicity of Traditional and Biodegradable Agricultural Film Microplastics to under Varying Exposure Sequences.

The widespread use of plastic agricultural films necessitates a thorough evaluation of environmental risks posed by soil microplastics (MPs). While the intestinal tract is a critical site for MP interactions in soil organisms, current research predominantly focuses on overall physiological responses, overlooking organ-specific toxic mechanisms. To address this gap, we exposed earthworms () to polyethylene (PE) and biodegradable polylactic acid (PLA) MPs sourced from agricultural films at an environmentally realistic concentration of 1.

A Potassium-Doped Perovskite-Based Nanocomposite as an Efficient Bifunctional Oxygen Electrocatalyst for Rechargeable Zn-Air Batteries.

Bifunctional oxygen electrocatalysts play a crucial role in the performance of rechargeable zinc-air batteries (ZABs), directly impacting key parameters such as capacity, round-trip efficiency, and durability. The ideal electrocatalysts for ZAB air electrodes must exhibit high catalytic activity for both oxygen reduction and oxygen evolution reactions in alkaline medium. This study presents a potassium-ion doping strategy to engineer the electron and defect structures of the perovskite oxide main phase, promoting phase separation to form a nanocomposite consisting of a perovskite phase and a secondary phase with an intergrowth structure.

The diphenylpyrimidine derivative as a novel HDAC6 inhibitor alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways.

Atopic dermatitis (AD) is a systemic immune disease that primarily affects infants and children, characterized by recurring severe pruritus and chronic eczema. Studies have demonstrated that histone deacetylase 6 inhibitors (HDAC6is) can exhibit anti-inflammatory activities by regulating the acetylation level of target proteins. Building on these findings, our research focused on a synthetic diphenylpyrimidine derivative, specifically 15b, which we identified as a potent HDAC6i and an effective anti-inflammatory agent.

Nanoplastics pre-exposure to microbial consortium influencing their ability to degrade pollutants: "Stagnation effect" and "Self-recovery".

Nanoplastics (NPs) coexist with microorganisms in global water environmental systems, showing spatial-temporal differentiation. Therefore, studying the behavior of microorganisms previously exposed to NPs is particularly important. With 2,4-dichlorophenol (DCP)-degrading microflora as model microorganisms, this study found that higher dose (10, 100 mg/L) of polystyrene NPs pre-exposure inhibited bacterial DCP degradation prolonging the stagnation period, while lower dose (1 mg/L) of NPs on the contrary stimulated their degradation ability.

Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk.

Background: Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer. Thus, high-mobility group box 1 (HMGB1) might influence the risk and poorer prognoses of colorectal cancer (CRC).

Aim: This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis (LNM) of CRC.

Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase.

Lung adenocarcinoma (LUAD) is a common malignant tumor in the lung that seriously endangers the health of people worldwide. The neutrophil-associated inflammatory microenvironment contributes to the activation of tumor cells. In this study, we report a role of tumor-associated neutrophils (TANs) promote tumor progression of LUAD by crosstalk between neutrophils and tumor cells.

Harnessing Cation Disorder for Enhancing Ionic Conductivity in Lithium Inverse Spinel Halides.

Halides are promising solid-state electrolytes for all-solid-state lithium batteries due to their exceptional oxidation stability, high Li-ion conductivity, and mechanical deformability. However, their practicality is limited by the reliance on rare and expensive metals. This study investigates the LiMgCl inverse spinel system as a cost-effective alternative.

Training modalities for elder sarcopenic obesity: a systematic review and network meta-analysis.

Introduction: Sarcopenic obesity (SO) is a condition characterized by the coexistence of age-related obesity and sarcopenia. This systematic review and network meta-analysis (NMA) aimed to compare the effects of different training modalities, such as aerobic training (AT), resistance training (RT), combined resistance with AT (CT), and multicomponent training (MCT) on body composition, muscle strength, and physical performance in elderly patients with SO.

Methods: We electronically searched randomized controlled trials, published from inception to March 2024 in PubMed, Embase, Cochrane Library, Web of Science and Scopus.

Stress Relaxation and Creep Response of Glassy Hydrogels with Dense Physical Associations.

Various glassy hydrogels are developed by forming dense physical associations within the matrices, which exhibit forced elastic deformation and possess high stiffness, strength, and toughness. Here, the viscoplastic behaviors of the glassy hydrogel of poly(methacrylamide--methacrylic acid) are investigated by stress relaxation and creep measurements. We found that the characteristic time of stress relaxation of the glassy gel is much smaller than that of amorphous polymers.

Preparation and mechanical performance of fluorite tailings geopolymer precursor under alkaline heat activation.

As one of the bulk solid wastes in the Yellow River basin in China, fluorite tailings urgently need to be utilized as resources. In this paper, NaOH and NaCO were used for alkali thermal activation of ground fluorite tailings under different temperature conditions, and the reactivity was analyzed by XRD, SEM and compressive strength after hydration, so as to evaluate the feasibility of fluorite tailings as geopolymer precursor. The results show that the fluorite tailings can exhibit certain reactivity under alkaline heat excitation, and significant amorphous glass phase can be detected.

Aging Dynamics of Polyvinyl Chloride Microplastics in Three Soils with Different Properties.

Microplastic (MP) contamination in soil has been of great concern, but the dynamic aging process and potential pathways of MPs in natural soil systems remain poorly understood. Herein, poly(vinyl chloride) microplastics (5% w/w) were weathered for 12 months in sandy soil, silty clay, and silt loam. The results showed that the continuous increase of C═O and O-H groups (rate constant, = 0.