Case Report: Clinical impact of and vs. and germline double heterozygosity in ovarian cancer: a comparative case study.

Ovarian cancer (OC) is a highly heterogeneous malignancy influenced by germline genetic factors, with mutations being well-established risk factors. Germline double heterozygosity (GDH), particularly involving rare combinations, remains poorly understood. This study presents the first report of GDH in a case of Chinese OC patients and compares their clinical characteristics and treatment responses to a patient with GDH.

Medial temporal lobe cavernous malformation associated with epilepsy misdiagnosed as gastrointestinal disease: A case report.

A middle-aged (46 years old) woman had been experiencing recurrent upper abdominal distension, nausea, and belching over a 2-year period. She underwent extensive gastrointestinal evaluations, including endoscopy, chest computed tomography, and abdominal ultrasound; she was diagnosed with chronic gastritis and treated with omeprazole (20 mg bid) and mosapride (5 mg tid) for 1 month, with no symptom relief. For further diagnosis and treatment, she visited The Second Hospital of Longyan in April 2023.

Realizing Superior Energy Storage Performance and Ultrafast Discharge Rate in NaNbO-Based Ceramics by Multiscale Manipulation.

Dielectric capacitors exhibit great promise for use in advanced energy storage devices. Nevertheless, realizing a large energy storage density () and high efficiency (η) remains an arduous challenge. In this work, a multiscale manipulation strategy was employed by integrating polar-nanoregions (PNRs) regulation at the nanoscale and grain-structure regulation at the microscale to enhance energy storage performance of NaNbO-based ceramics.

An Adaptive Solid-State Synapse with Bi-Directional Relaxation for Multimodal Recognition and Spatio-Temporal Learning.

The brain's unique processing power, such as perception, understanding, and interaction with the multimodal world, is achieved through diverse synaptic functionalities, which include varied temporal responses and adaptation. Although specific functions in brain-like computing have been successfully realized, emulating multimodal recognition and spatio-temporal learning remain significant challenges due to the difficulties in achieving multimodal signal processing and adaptive long-term plasticity in a single electronic synapse. Here, a purely electrically-modulated ferroelectric tunnel junction (FTJ) memristive synapse which realizes multimodal recognition and spatio-temporal pattern identification, through the integration of oxygen vacancies migration and ferroelectric polarization switching mechanisms, providing bi-directional relaxation and adaptive long-term plasticity simultaneously in the isolated device.

Polar topology in self-assembled PbTiO ferroelectric nano-islands.

The topological domains in ferroelectrics have garnered significant attention for their potential applications in nanoelectronics. However, current research is predominantly limited to rhombohedral BiFeO materials. To validate the universality of topological domains in non-rhombohedral ferroelectrics, it is crucial to explore the existence and characteristics of topological states in alternative material systems.

Achieving High Piezoelectric Performance Across Multidomains Design in K(Ta,Nb)O-Based Lead-free Single Crystals.

In light of environmental issues, the lead-free ferroelectric single crystal K(TaNb)O (KTN) has attracted considerable interest due to its excellent piezoelectric properties. This research focus on improving the piezoelectric performance of KTN by engineering domains through polarization in the [011] direction. The full-matrix parameters of KTN crystals after polarization along the [011] direction were determined.

The utilization of cytology for intraoperative diagnosis of primary central nervous system lymphoma.

To investigate the diagnostic value of intraoperative cytology and rapid immunocytochemistry in primary central nervous system lymphoma. 254 cases of lymphoma and 82 cases of non-lymphoma were collected from 2010 to 2023. Frozen section(FS) was using alone in 44 cases during 2010-2014, FS and intraoperative cytology(IC) were using in 251 cases during 2015 to 2022.

Large Piezoelectricity Induced by Internal Stress in (K,Na)NbO Single Crystals.

Achieving a high piezoelectric response and excellent stability is essential for practical applications of ferroelectric materials. Herein, large piezoelectricity of = 167 pC/N and = 0.52 is found in a KNaNbO lead-free ferroelectric single crystal without poling, which is comparable to the artificially poled KNN crystals.

Lipid metabolites abnormally expressed in pelvic fluid as potential biomarkers for ovarian cancer: A case-control study.

Background: Ovarian cancer is insidious and usually detected in advanced stages of the disease. As the ovaries are pelvic organs, changes in their pelvic fluid metabolites may be associated with ovarian cancer.

Methods: Metabolomic changes in the pelvic fluid were detected using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in patients with ovarian cancer, ovarian cysts and uterine fibroids.

Ultralow Strain-Induced Emergent Polarization Structures in a Flexible Freestanding BaTiO Membrane.

The engineering of ferroic orders, which involves the evolution of atomic structure and local ferroic configuration in the development of next-generation electronic devices. Until now, diverse polarization structures and topological domains are obtained in ferroelectric thin films or heterostructures, and the polarization switching and subsequent domain nucleation are found to be more conducive to building energy-efficient and multifunctional polarization structures. In this work, a continuous and periodic strain in a flexible freestanding BaTiO membrane to achieve a zigzag morphology is introduced.

Giant Electroresistance in Ferroelectric Tunnel Junctions via High-Throughput Designs: Toward High-Performance Neuromorphic Computing.

Ferroelectric tunnel junctions (FTJs) have been regarded as one of the most promising candidates for next-generation devices for data storage and neuromorphic computing owing to their advantages such as fast operation speed, low energy consumption, convenient 3D stack ability, etc. Here, dramatically different from the conventional engineering approaches, we have developed a tunnel barrier decoration strategy to improve the ON/OFF ratio, where the ultrathin SrTiO (STO) dielectric layers are periodically mounted onto the BaTiO (BTO) ferroelectric tunnel layer using the high-throughput technique. The inserted STO enhances the local tetragonality of the BTO, resulting in a strengthened ferroelectricity in the tunnel layer, which greatly improves the OFF state and reduces the ON state.

Investigating the influence of primary uterine tumor site on pelvic and para-aortic lymph node metastatic pattern and evaluating the risk factors for lymph node metastases in endometrial carcinoma: A retrospective study.

To assess the metastatic pattern in pelvic and para-aortic lymph nodes in relation with the primary uterine tumor site and to evaluate risk factors for lymph node metastases. 212 patients with endometrial cancer who underwent surgical treatment from December 2014 to December 2019 were selected. The clinical and pathological data were retrospectively analyzed.

Automatic and label-free detection of meningioma in dura mater using the combination of multiphoton microscopy and image analysis.

Significance: To prevent meningioma recurrence, it is necessary to detect and remove all corresponding tumors intraoperatively, including those in the adjacent dura mater.

Aim: Currently, the removal of meningiomas from the dura mater depends solely on cautious visual identification of lesions by a neurosurgeon. Inspired by the requirements for resection, we propose multiphoton microscopy (MPM) based on two-photon-excited fluorescence and second-harmonic generation as a histopathological diagnostic paradigm to assist neurosurgeons in achieving precise and complete resection.

METTL14 and FTO mediated mA modification regulate PCV2 replication by affecting miR-30a-5p maturity.

The epigenetic modification of the N6-methyladenosine (mA) methylation plays an important role in virus infection and replication. However, its role in Porcine circovirus type 2 (PCV2) replication has not been well studied. Here, we demonstrated that mA modifications are increased in PK-15 cells after PCV2 infection.

Complete genome and pathogenesis of a novel recombinant Senecavirus A isolate in P.R. China.

Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) was first isolated from the USA in 2002. This study isolated an SVA strain from a pig herd in Shandong Province, PR China and designated it SVA-CH-SDGT-2017. The full-length genome, excluding the poly(A) tails of the SVA isolates, was 7280 nucleotides long, with the genomic organization resembling and sharing high nucleotide identities of 90.

B-Site Nanoscale-Ordered Structure Enables Ultra-High Tunable Performance.

Tunable devices constructed by ferroelectric thin films are often desired to possess a low dielectric loss while maintainging a high dielectric tunability over a broad operating temperature range in applications, for example, resonators, filters, or phase shifters. However, it is difficult to simultaneously achieve these characteristics by traditional strategies, such as doping and strain modifying. Here, we demonstrate that the dielectric tunability of the sol-gel-prepared Pb(ScNb)(MgNb)O (PSNMN) thin film can be almost doubled from ~47% to ~80.

Domain Switching in BaTiO Films Induced by an Ultralow Mechanical Force.

Low-energy switching of ferroelectrics has been intensively studied for energy-efficient nanoelectronics. Mechanical force is considered as a low-energy consumption technique for switching the polarization of ferroelectric films due to the flexoelectric effect. Reduced threshold force is always desirable for the considerations of energy saving, easy domain manipulation, and sample surface protection.

Resection-inspired histopathological diagnosis of cerebral cavernous malformations using quantitative multiphoton microscopy.

Cerebral cavernous malformation (CCM) is prone to recurring microhemorrhage, which can lead to drug-resistant epilepsy. Surgical resection is the first choice to control seizures for CCM-associated epilepsy. At present, removal of resection-related tissue only depends on cautious visual identification of CCM lesions and perilesional yellowish hemosiderin rim by the neurosurgeon.

Introducing AgNPs-VB composites as the dual signal quenching of CeO-AuNPs-g-CNQDs hybrids for ultrasensitive "on-off" electrochemiluminescence immunosensing of prostate specific antigen.

An ultrasensitive resonance energy transfer based "on-off" switch electrochemiluminescence (ECL) immunosensing strategy was proposed and applied for prostate specific antigen (PSA) detection. In detail, self-enhancing nanohybrids of nano-CeO and AuNPs decorated graphitic carbon nitride quantum dots (CeO-AuNPs-g-CNQDs) were synthesized, which produced high ECL emission with coreactant KSO for "switch-on" state. Noticeably, due to the reversible Ce↔ Ce reaction, nano-CeO could serve as highly-efficient coreaction accelerator and induce the decomposition of SO into SO, which endowed the g-CNQDs/KSO system with enhanced ECL emission.

A Clinicopathological and Molecular Analysis of Sellar/Suprasellar Neurocytoma Mimicking Pituitary Adenoma.

Objective: To investigate the clinicopathological characteristics, molecular genetic characteristics and prognosis of extraventricular neurocytoma located in the sellar/suprasellar region.

Methods: Seven archived tumor samples derived from 4 patients with neurocytoma in the sellar/suprasellar region were collected from the First Affiliated Hospital of Fujian Medical University and the Affiliated Hospital of Qingdao University and retrospectively analyzed for clinical manifestations, imaging features, and histopathological features. Neuronal and pituitary biomarkers and molecular features were detected in these tumor tissues by immunohistochemistry and FISH or Sanger sequencing.

Whole-Genome/Exome Sequencing Uncovers Mutations and Copy Number Variations in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System.

Identification of key genetic alterations is of importance in the targeted therapies of primary central nervous system lymphoma (PCNSL). However, only a small number of studies have been carried out in PCNSL. In this study, we further described the genetic mutations and copy number variations (CNVs) in PCNSL patients using whole-genome/exome sequencing (WGS/WES), as well as revealed their associations with patients' clinicopathological features and prognosis.

CRISPR/Cas9-Mediated Knockout of the and Genes in BHK-21 Cell Promoted Seneca Virus A Replication and Enhanced Autophagy.

RNA interference (RNAi) is a major form of antiviral defense in host cells, and Ago2 and Dicer are the major proteins of RNAi. The Senecavirus A (SVA) is a reemerging virus, resulting in vesicular lesions in sows and a sharp decline in neonatal piglet production. In this study, CRISPR/Cas9 technology was used to knock out Ago2 and Dicer genes in BHK-21 cell lines used for SVA vaccine production.

Simultaneously achieving giant piezoelectricity and record coercive field enhancement in relaxor-based ferroelectric crystals.

A large coercive field (E) and ultrahigh piezoelectricity are essential for ferroelectrics used in high-drive electromechanical applications. The discovery of relaxor-PbTiO crystals is a recent breakthrough; they currently afford the highest piezoelectricity, but usually with a low E. Such performance deterioration occurs because high piezoelectricity is interlinked with an easy polarization rotation, subsequently favoring a dipole switch under small fields.

High-Energy Storage Properties over a Broad Temperature Range in La-Modified BNT-Based Lead-Free Ceramics.

The development of high-performance energy storage materials is decisive for meeting the miniaturization and integration requirements in advanced pulse power capacitors. In this study, we designed high-performance [(BiNa)Ba]LaTiO (BNT-BT-La) lead-free energy storage ceramics based on their phase diagram. A strategy combining phase adjustment and domain control via doping was proposed to enhance the energy storage performance.

Observation of Clinicopathologic Features of Pituitary Adenoma With Neuronal Differentiation.

Objective: To investigate the clinicopathologic features of pituitary adenoma with neuronal differentiation.

Methods: Four patients with mixed gangliocytoma-pituitary adenomas between January 2011 and January 2021 and 111 new-onset patients with adenomas between January 2019 and June 2021 who attended the First Affiliated Hospital of Fujian Medical University were included in the study. The histological and immunohistochemical findings were analyzed.