Predicting HIV self-testing intentions among Chinese college students: a dual-model analysis integrating health belief constructs and machine learning prioritization.

Introduction: As college students emerge as a key HIV-vulnerable population in China, HIV self-testing (HIVST) presents a critical strategy for enhancing detection rates and enabling timely intervention. While observational studies have identified multifactorial influences on HIVST willingness, few investigations integrate behavioral theory with machine learning approaches among college students. This study aims to fill this gap by exploring the determinants of HIVST willingness among college students using the Health Belief Model (HBM) and random forest analytics.

Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.

Background: Plant experience exposure to short term low temperature during early spring. In response, it activates various mechanisms to cope with the changing environment. This response involves in the regulation of related genes and hormones, increase signaling cross-talks, antioxidants and osmolytes accumulation to protect the plant from damage.

Understanding the Modification Process of Montmorillonite by Cetyltrimethylammonium via Molecular Dynamics Simulation: Insights into Structure Evolution and Thermodynamic Mechanism.

Cetyltrimethylammonium bromide (CTAB)-modified montmorillonite (MMT) exhibits enhanced adsorption capacity for both anionic and nonpolar contaminants. However, the structure evolution and underlying thermodynamic mechanism during the modification process remain poorly understood. This paper employs molecular dynamics to simulate the adsorption behavior and drying process during CTAB-MMT modification at varying dosages.

ABA promotes fatty acid biosynthesis and transport to boost arbuscular mycorrhizal symbiosis in apple roots.

The roots of most land plants form symbioses with arbuscular mycorrhizal (AM) fungi. The fungus promotes nutrient uptake from the soil while receiving plant-derived photosynthates as lipids and sugars. Nutrient exchange must be regulated by both partners; however, the mechanisms underlying the regulation of lipid supply from the plant to the AM fungus remain unclear.

Analysis of Multi-Target Synergistic Mechanism of Coix Seed Therapy for Herpes Zoster Based on Machine Learning and Network Pharmacology.

Objective: To explore the efficacy and mechanism of Coix seeds in treating herpes zoster (HZ) using an integrated computational approach.

Methods: Network pharmacology, molecular docking, and machine learning were employed. Disease-related targets were collected from multiple databases, and intersection targets with Coix seed were analyzed via PPI, GO, and KEGG enrichment.

Lipocalin 2 Facilitates the Initial Compromise of the Blood-Brain Barrier Integrity in Chronic Cerebral Hypoperfusion.

Aims: Vascular cognitive impairment (VCI) is primarily attributed to vascular risk factors and cerebrovascular disease. Chronic cerebral hypoperfusion (CCH) initiates in the early stages of VCI and contributes to blood-brain barrier (BBB) disruption. Nevertheless, the precise molecular mechanisms underlying this process remain elusive and warrant further investigation.

Single-molecule manipulation and detection by WGM-coupled photonic nanojets.

Optical manipulation and detection of single molecules, such as biomolecules and bacterial viruses, are crucial in single-molecule mechanics and biosensing. The interaction between light and individual molecules is weak due to the size of biomolecules (≤ 10 nm) being significantly smaller than the wavelength (λ) of light. This limitation results in a reduced optical gradient force and diminished detection sensitivity of light on biomolecules.

Role of EFNAs in Shaping the Tumor Immune Microenvironment and Their Impact on Pancreatic Adenocarcinoma Prognosis.

Purpose: Due to the highly heterogeneous and immunosuppressed tumor microenvironment (TME), pancreatic adenocarcinoma (PAAD) has limited therapeutic options and an abysmal prognosis. Ephrin A 1-5 (EFNA1-5) have been shown to regulate tumorigenesis and metastasis in various cancers, but its role in PAAD remains unclear.

Methods: We comprehensively analyzed gene expression levels in pan-cancer and PAAD using the GEPIA and HPA databases.

Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis.

Cancer stem cells (CSCs) are widely acknowledged as primary mediators to the initiation and progression of tumors. The association between microbial infection and cancer stemness has garnered considerable scholarly interest in recent years. Porphyromonas gingivalis (P.

Intercellular Tunneling Nanotubes as Natural Biophotonic Conveyors.

Tunneling nanotubes (TNTs), submicrometer membranous channels that bridge and connect distant cells, play a pivotal role in intercellular communication. Organelle transfer within TNTs is crucial in regulating cell growth, signal transmission, and disease progression. However, precise control over individual organelle transport within TNTs remains elusive.

Activatable fluorescent probes for atherosclerosis theranostics.

The onset of atherosclerosis (AS) is insidious, and early stage patients have atypical clinical symptoms. After being diagnosed in late stage, it is often prone to sudden and fatal cardiovascular events. Therefore, it is highly desirable to develop precise and efficient diagnosis and therapy strategies of AS.

Alicyclic Polyimide With Multiple Breakdown Self-Healing Based on Gas-Condensation Phase Validation for High Temperature Capacitive Energy Storage.

Polymer dielectrics with combined thermal stability and self-healing properties are specifically desired for high-temperature film capacitors. The high thermal stability of conventional polymers benefits from the abundance of aromatic rings in the molecule backbone, but the high carbon content sacrifices their self-healing properties. Here, analicyclic polyimide with a high glass transition temperature (256 °C) and wide energy bandgap (4.

Sleep disorders among frontline nurses after the COVID-19 outbreak: a large-scale cross-sectional study.

This large-scale cross-sectional multicenter study aims to investigate the prevalence of sleep disorders among frontline nurses in China after the COVID-19 pandemic and to identify potential influencing factors contributing to these sleep disturbances. A total of 2065 frontline nurses from 27 provinces in China participated in an online survey conducted through the Wenjuan Xing platform. Data on demographic characteristics, work-related factors, and mental health assessments, including the Pittsburgh Sleep Quality Index (PSQI), Zung Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS), were collected.

Phosphorylation of the transcription factor SlBIML1 by SlBIN2 kinases delays flowering in tomato.

Brassinosteroids (BRs) are well known for their important role in the regulation of plant growth and development. Plants with deficiency in BR signaling show delayed plant development and exhibit late flowering phenotypes. However, the precise mechanisms involved in this process require investigation.

Dual-/multi-organelle-targeted AIE probes associated with oxidative stress for biomedical applications.

monitoring of biological processes between different organelles upon oxidative stress is one of the most important research hotspots. Fluorescence imaging is especially suitable for biomedical applications due to its distinct advantages of high spatiotemporal resolution, high sensitivity, non-invasiveness, and monitoring capabilities. However, most fluorescent probes can only achieve light-up imaging of single organelles, thus the combined use of two or more probes is usually required for monitoring biological processes between organelles, which can suffer from tedious staining and washing procedures, increased cytotoxicity and poor photostability.

Modulating Elasticity of Liposome for Enhanced Cancer Immunotherapy.

Cancer immunotherapy has emerged as a promising approach to cancer treatment in recent years. The physical and chemical properties of nanocarriers are critical factors that regulate the immune activation of antigen-presenting cells (APCs) in the tumor microenvironment (TME). Herein, we extensively investigated the behavior of liposome nanoparticles (Lipo-NPs) with different elasticities, focusing on their interaction with immune cells and their transport mechanisms from tumors to tumor-draining lymph nodes (tdLNs).

Fabrication of Non-Wetting Mg(OH) Composites with Photoresponsive Capabilities and Their Environmental Restoration Performance.

Water pollution seriously affects the development of society and human life. There are various kinds of pollutants, including soluble pollutants and insoluble floaters on the water surface. Herein, the photocatalyst semiconductor BiOCl and superhydrophobic functional particles Mg(OH) were deposited on the surfaces of canvas and polyester felt to construct superhydrophobic canvas and polyester felt.

Genome-Wide Association Studies of Growth Trait Heterosis in Crossbred Meat Rabbits.

The application of heterosis can not only effectively improve the disease resistance and meat quality of livestock, but also significantly enhance the reproduction and growth of livestock and poultry. We conducted genome-wide association studies using data from F2 crossbred meat rabbits to screen out candidate genes with significant dominant effects associated with economic trait variation. High-throughput sequencing technology was used to obtain SNPs covering the whole genome to evaluate the homozygosity of the population genome, and analyze the number, length, frequency, and distribution of ROHs in the population.

Cellulose-derived carbon scaffolds with bidirectional gradient FeO distribution: Integration of green EMI shielding and thermal management.

Cellulose papers (CPs) possess a pore structure, rendering them ideal precursors for carbon scaffolds because of their renewability. However, achieving a tradeoff between high electromagnetic shielding effectiveness and low reflection coefficient poses a tremendous challenge for CP-based carbon scaffolds. To meet the challenge, leveraging the synergistic effect of gravity and evaporation dynamics, laminar CP-based carbon scaffolds with a bidirectional gradient distribution of FeO nanoparticles were fabricated via immersion, drying, and carbonization processes.

Examining the complex relationship between Urbanization and ecological environment in ecologically fragile areas: a case study in Southwest China.

The sustainable development of ecologically fragile areas and the implementation of regional coordinated development strategies cannot be separated from the coordinated development and common progress of urbanization and the ecological environment, and this is particularly the case in Southwest China. This study examines the interplay between urbanization and the ecological environment across 26 cities in Southwest China from 2009 to 2019, utilizing 30 statistical indicators to analyze their coupling coordination relationship and its spatiotemporal evolution. The Entropy TOPSIS method, the coupling coordination degree model, and the obstacle factors model were used to calculate the subsystem score, coupling coordination degree, and obstacle factors, respectively.

Volume development changes in the occipital lobe gyrus assessed by MRI in fetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood.

Objective: This study was to systematically assess the occipital lobe gray and white matter volume of isolated ventriculomegaly (IVM) fetuses with MRI and to follow up the neurodevelopment of participants.

Method: MRI was used to evaluate 37 IVM fetuses and 37 control fetuses. The volume of gray and white matter in each fetal occipital gyrus was manually segmented and compared, and neurodevelopment was followed up and assessed in infancy and early childhood.

The Regulatory Network of hnRNPs Underlying Regulating Alternative Splicing in Tumor Progression.

One of the hallmarks of cancer is metabolic reprogramming in tumor cells, and aerobic glycolysis is the primary mechanism by which glucose is quickly transformed into lactate. As one of the primary rate-limiting enzymes, pyruvate kinase (PK) M is engaged in the last phase of aerobic glycolysis. Alternative splicing is a crucial mechanism for protein diversity, and it promotes precursor mRNA splicing to produce dominance, resulting in low expression.

Preparation of Hydrophobic Au Catalyst and Application in One-Step Oxidative Esterification of Methacrolein to Methyl Methacrylate.

The water produced during the oxidative esterification reaction occupies the active sites and reduces the activity of the catalyst. In order to reduce the influence of water on the reaction system, a hydrophobic catalyst was prepared for the one-step oxidative esterification of methylacrolein (MAL) and methanol. The catalyst was synthesized by loading the active component Au onto ZnO using the deposition-precipitation method, followed by constructing the silicon shell on Au/ZnO using tetraethoxysilane (TEOS) to introduce hydrophobic groups.

Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice.

Background: Neutral cholesterol ester hydrolase 1 (NCEH1) plays a critical role in the regulation of cholesterol ester metabolism. Deficiency of NCHE1 accelerated atherosclerotic lesion formation in mice. Nonetheless, the role of NCEH1 in endothelial dysfunction associated with diabetes has not been explored.