Photo-Healable and Stretchable Fibers from Upcycled TPEE and Azopolymers by Harnessing Solid-to-Liquid Photoisomerization.

The increasing emphasis on environmental sustainability has driven the development of products derived from recycled plastics; however, their applications remain largely confined to packaging and beverage containers due to high recycling costs and limited economic viability. This study focuses on upcycling plastic waste by depolymerizing and repolymerizing waste polyethylene terephthalate (PET) into thermoplastic polyester elastomers (TPEE). To enhance the functional properties of the resulting material, an azobenzene-containing polymer (PAzo) is incorporated, leveraging its reversible photoinduced solid-to-liquid phase transition under ultraviolet and visible light irradiation.

NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer.

Human gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance mechanism could reveal new approaches for improving GC treatment efficacy.

CXCL13 as a Prognostic Biomarker and Modulator of the Tumor Microenvironment in Colorectal Cancer.

Objectives: Immunotherapy yields limited results in patients with colorectal cancer (CRC), emphasizing the need for a deeper understanding of the immune landscape within the tumor microenvironment. Although the C-X-C motif chemokine ligand 13 (CXCL13) recruits B cells and promotes tertiary lymphoid structure (TLS) formation, its immune function and prognostic value in CRC remain unclear. This study investigated the impact of CXCL13 on patient outcomes and CRC immune landscape.

Causal Effects Between Anxiety-Depressive and Subjective Tinnitus in Europe: A Bidirectional Mendelian Randomization Study.

Unlabelled: This study aimed to explore the potential causal relationship between anxiety-depression and tinnitus using a bidirectional mendelian randomization (MR) approach. Utilizing genetic data from five UKB datasets, one IEU dataset, one EBI dataset encompassing traits linked to anxiety and depressive states, and tinnitus data sourced from the FinnGen project, we conducted two-sample MR analyses. Instrumental variables were selected based on stringent criteria, including genome-wide significance, clumping to ensure independence, and the exclusion of palindromic Single Nucleotide Polymorphisms and those associated with confounders.

miR-34c-3p targets FOXO3 to promote pancreatic carcinoma progression.

MicroRNAs (miRNAs) have been a popular subject of tumor research including pancreatic carcinoma (PC). MicroRNA-34c-3p (miR-34c-3p) is a member of miR-34c cluster, which is strongly associated with tumorigenesis. Nonetheless, miR-34c-3p has not been explored in PC.

Dual-Network Deep Learning for Accelerated Head and Neck MRI: Enhanced Image Quality and Reduced Scan Time.

Background: Head-and-neck MRI faces inherent challenges, including motion artifacts and trade-offs between spatial resolution and acquisition time. We aimed to evaluate a dual-network deep learning (DL) super-resolution method for improving image quality and reducing scan time in T1- and T2-weighted head-and-neck MRI.

Methods: In this prospective study, 97 patients with head-and-neck masses were enrolled at xx from August 2023 to August 2024.

Migraine and cochlear disease: A 2-sample bidirectional Mendelian randomized study.

This study aimed to explore the potential causal relationship between migraine and cochlear disease by using a bidirectional Mendelian randomization (MR) approach. We searched datasets related to migraine in the FinnGen database and genome-wide association studies catalog. We conducted 2-sample MR analyses.

Erratum: cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence: Erratum.

[This corrects the article DOI: 10.7150/ijbs.86227.

Predictive for patients with pneumonia in pediatric intensive care unit.

Introduction: Pneumonia is globally recognized as a significant disease burden, particularly among pediatric patients in intensive care units (ICU), where its etiology is complex and prognosis often poor.

Methods: Data were extracted from a pediatric-specific intensive care (PIC) database, selecting 795 pediatric pneumonia patients in ICUs (2010-2018). After applying rigorous inclusion/exclusion criteria, 543 cases formed the study cohort.

Achieving Intrinsically Self-Healing Fabrics with Breathability, Surface Self-Repairing, and Underwater Adhesion via Nanoparticle-Polymer Gel Synergistic Coatings.

Self-healing fabrics have attracted increasing attention as a sustainable solution to extend fabric lifespan and reduce material waste. However, most reported self-healing fabrics rely on extrinsic systems with limited healing cycles, or intrinsic polymers that compromise breathability due to irreversible layer adhesion. In this work, a simple and scalable dip-coating method is reported to fabricate intrinsically self-healing fabrics that retain their porous structure and air permeability.

Wearable and stretchable electronics enabled by MXene-PVA films layer-by-layer assembly with integrated UV, thermal, and mechanical sensing.

We integrate MXene with polyvinyl alcohol (PVA) through a meticulous layer-by-layer assembly process, not only enhancing the mechanical flexibility and robustness of MXene but also significantly improving its environmental stability. The MX-PVA films exhibit multi-responsiveness to UV light, temperature, and mechanical pressure, highlighting their potential for use in wearable electronics.

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.

Cyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. However, the effectiveness of CDK5 in macrophages on cutaneous wound healing remains inadequately characterized.

MEMS-Based Portable Reflection Confocal Microscope for In Vivo Skin Imaging.

This study aims to develop a portable reflective confocal microscope (PCRM) based on MEMS micro-mirrors for in vivo skin imaging. The design of PCRM is intended to overcome the limitations of traditional invasive biopsies and bulky desktop microscopes, enabling handheld operation and access to hard-to-reach skin areas. This research innovatively integrates MEMS technology into the PCM through precise mechanical design, using an 830 nm laser and a commercial Olympus objective lens, achieving a lateral resolution of 1.

Causal relationships between brain functional networks and tinnitus: A bidirectional 2-sample Mendelian randomization study.

This study aimed to discuss the potential causal relationship between brain functional networks and tinnitus using a bidirectional Mendelian randomization (MR) approach. Using genetic data from 6 datasets linked to brain functional networks, and tinnitus data sourced from the FinnGen project, we conducted 2-sample MR analyses. Instrumental variables (IVs) were selected based on stringent criteria, including genome-wide significance, clumping to ensure independence, and exclusion of palindromic single-nucleotide polymorphisms (SNPs) and those associated with confounders.

Multiomics: Two-Sample, Bidirectional, Multivariate and Mediated Mendelian Randomization Analysis of Allergic Rhinitis.

Unlabelled: This study investigates the potential causal relationships among immune cells, plasma liposomes, and plasma metabolites in allergic rhinitis (AR) using a two-sample bidirectional multivariate and mediated Mendelian Randomization (MR) approach. Genetic data from five GWAS datasets covering traits linked to immune cells, plasma liposomes, plasma metabolites, and AR were used. Instrumental variables were selected based on strict criteria to ensure independence and exclude confounders.

Organ preservation: current limitations and optimization approaches.

Despite the annual rise in patients with end-stage diseases necessitating organ transplantation, the scarcity of high-quality grafts constrains the further development of transplantation. The primary causes of the graft shortage are the scarcity of standard criteria donors, unsatisfactory organ preservation strategies, and mismatching issues. Organ preservation strategies are intimately related to pre-transplant graft viability and the incidence of adverse clinical outcomes.

Unplanned reinterventions after congenital cardiac surgery and hospital mortality: A report from the Pediatric Cardiac Critical Care Consortium (PC).

Objectives: Unplanned cardiac reinterventions after congenital cardiac surgery may complicate the postoperative course. We sought to identify incidence rates and risk factors for unplanned cardiac reinterventions and associations between unplanned cardiac reinterventions and hospital mortality.

Methods: Patients in the Pediatric Cardiac Critical Care Consortium registry undergoing an index cardiac operation from February 2019 to January 2022 were included.

Ensuring internal quality control practices in medical Laboratories: IFCC recommendations for practical applications based on ISO 15189:2022.

This document describes the guidance on implementing and monitoring an IQC strategy that fulfills the requirements of the Standard ISO 15189:2022. It also explores the practical application of these principles in daily IQC processes within medical laboratories. The goal is to provide a practical, user-friendly resource that not only explains the Standard's requirements but also equips laboratory professionals with the tools and knowledge needed to enhance diagnostic reliability.

Generalized hybrid coronary revascularization vs. conventional off-pump coronary artery bypass grafting for multivessel coronary artery disease.

Background: Hybrid coronary revascularization (HCR) has been demonstrated as a safe and effective revascularization strategy in selected patients with multivessel coronary artery disease; however, the inclusion criteria are too strict.

Objectives: This study was conducted to compare in-hospital and midterm outcomes after generalized HCR and off-pump coronary artery bypass (OPCABG) in patients with multivessel coronary artery disease.

Methods: We proposed a generalized idea of HCR.

WTAP-mediated mA methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML.

Wilms' tumor 1-associated protein (WTAP) is a key N6-methyladenosine (mA) methyltransferase that is upregulated in t(8;21) acute myeloid leukemia (AML) under hypoxia inducible factor 1α-mediated transcriptional activation, promoting leukemogenesis through transcriptome-wide mA modifications. However, the specific substrates and intrinsic regulatory mechanisms of WTAP are not well understood. Here, we provide evidence that PHD finger protein 19 (PHF19) overexpression is regulated by WTAP-mediated mA modification and promotes cell cycle progression by altering chromatin accessibility.

Icariin inhibition of NLRP3 mediated Leydig cell pyroptosis and insulin resistance ameliorates spermatogenesis disorders in obese mice.

Obesity, characterized by excessive body fat accumulation due to energy metabolism imbalance, has emerged as a significant risk factor for male infertility. Icariin (ICA), a principal constituent of Epimedium, has demonstrated potential in improving obesity and enhancing testicular spermatogenesis. This study aimed to elucidate the role and underlying mechanisms of ICA in mitigating obesity-induced male infertility through the suppression of inflammation and insulin resistance.

Evaluating dynamic contrast-enhanced MRI for differentiating HER2-zero, HER2-low, and HER2-positive breast cancers in patients undergoing neoadjuvant chemotherapy.

Objectives: To quantitatively assess the differences in parameters of dynamic contrast-enhanced MRI (DCE-MRI) in HER2-zero, HER2-low, or HER2-positive tumors, and to build optimal model for early prediction of HER2-low breast cancer (BC).

Materials And Methods: Clinical and DCE-MRI data from 220 BC patients receiving neoadjuvant chemotherapy (NACT) were retrospectively analyzed. Quantitative and semi-quantitative DCE-MRI parameters were compared in the HER2-zero, HER2-low, or HER2-positive groups before and after early NACT.

Stress Relaxation and Creep Response of Glassy Hydrogels with Dense Physical Associations.

Various glassy hydrogels are developed by forming dense physical associations within the matrices, which exhibit forced elastic deformation and possess high stiffness, strength, and toughness. Here, the viscoplastic behaviors of the glassy hydrogel of poly(methacrylamide--methacrylic acid) are investigated by stress relaxation and creep measurements. We found that the characteristic time of stress relaxation of the glassy gel is much smaller than that of amorphous polymers.