Peritoneal Lavage Cytology Predicts Peritoneal Metastasis and is Associated with Poor Prognosis in Patients with Stage II-III Colorectal Cancer.

Background: Peritoneal lavage cytology (PLC) is used to detect peritoneal micrometastases in gastrointestinal malignancies, but its prognostic value in colorectal cancer (CRC) remains controversial, particularly in stage II-III. We aimed to evaluate the prognostic significance of PLC in predicting postoperative outcomes and peritoneal metastasis risk among patients with stage II-III CRC, thereby facilitating individualized treatment strategies.

Patients And Methods: A retrospective analysis was performed on 375 patients with stage II-III CRC who underwent curative resection with standardized intraoperative PLC between January 2017 and August 2018.

Diagnosis and Treatment of Bipolar Disorder Mixed State with Integration of Traditional Chinese Medicine and Western Medicine: Expert Consensus of Zhejiang Province in China.

Background: As a mixed state of depressive and manic syndrome, the concept of bipolar disorder has remained unclear to date. Treatment of mixed states is difficult due to clinical recognition and poor therapeutic ideas. Based on expert consensus, it is important to establish a new definition of bipolar disorder, understand the concept of its mixed state within the field of clinical psychiatry, and explore its diagnosis and treatment using Traditional Chinese Medicine and Western medicine.

Predictive value of inflammatory marker PLR in prostate cancer.

Purpose: This study aims to investigate the correlation between inflammatory markers and prostate cancer with a good-quality predictive model.

Methods: The original dataset was randomly split into a training set (70%) and a validation set (30%). Logistic regression was used to examine the related risk factors within the training set.

Anoikis and NETosis in colorectal cancer liver metastasis: the relationship and perspectives.

Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with metastatic spread being the primary reason for fatalities. Anoikis, a form of programmed cell death triggered by cell detachment from the extracellular matrix (ECM), and NETosis, a neutrophil cell death mode releasing extracellular traps (NETs), play critical roles in CRC liver metastasis (CRCLM). This review explores the mechanisms of anoikis and NETosis, their interplay, and genetic underpinnings in CRCLM.

Hydration performance and optimization of multi-solid waste composite calcined sewage sludge.

The rapid increase in sewage sludge (SS) production and the global pursuit of carbon neutrality have driven the demand for the high-value construction material utilization of SS. In this study, calcium-rich solid wastes-carbide slag (CS) and phosphogypsum (PG)-were co-calcined with SS at elevated temperatures (800-1000 °C) to address the insufficient cementitious activity of thermally activated sludge. The resulting products were used to replace 30% of ordinary Portland cement (OPC) in pastes.

Identification of quantitative trait loci for abdominal muscle content in red swamp crayfish (Procambarus clarkii) and potential application in molecular breeding.

Red swamp crayfish (Procambarus clarkii) is a prized aquatic product among consumers, abdominal muscle content being a crucial economic trait. Therefore, there is an urgent need to exploit the genetic basis of crayfish abdominal muscle content for breeding. In the present study, Quantitative Trait Locus (QTL) mapping was performed using 10 different populations (Pop1-Pop10), raised in water tanks, ponds, and rice-crayfish fields, using single- and multiple-culture models of full-sib families and natural populations, from 2020 to 2023.

Cuproplasia and cuproptosis in hepatocellular carcinoma: mechanisms, relationship and potential role in tumor microenvironment and treatment.

Background: Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper is vital in liver function, and HCC cells rely on it for growth and metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis.

Cloning of Toll3 and Toll4 and association analysis among their SNP haplotypes and disease resistance in red swamp crayfish (Procambarus clarkii).

With the expansion of the culture scale of red swamp crayfish (Procambarus clarkii), the high incidence of diseases has seriously threatened the development of its industry. In this study, PcToll3 and PcToll4 were respectively cloned and explored SNPs among the germplasm populations, which had been identified relating to disease resistance in crayfish based on our previous study. A total of 3036 bp and 2820 bp of the open reading frame of PcToll3 and PcToll4 encoded 1011 and 939 amino acids, respectively.

Pickering self-floating adsorbents: Natural tea polyphenol nanoparticle-based beads for efficient separation of cationic dyes with simple recovery.

Energy-efficient separation and recovery of adsorbents, particularly nano/micro-adsorbent materials, and effective adsorption of water-soluble ionic dyes continue to be crucial challenges in wastewater treatment. In this study, a novel water-suspended Pickering adsorbent with adsorption selectivity was developed using natural polyphenol nanomaterials. The preparation procedure is simple and cost-effective, involving ultrasonic emulsification and calcium alginate crosslinking without the use of complex equipment or expensive chemicals.

Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing precise immunoregulation.

Nonhealing chronic wounds are intractable clinical complications of diabetes and are characterized by high protease activity, severe oxidative stress and sustained inflammatory response. In this case, the development of functional hydrogel dressings to modulate the immune microenvironment is a well-known strategy, where the precise stimuli-responsive and spatiotemporally controlled release of bioactive molecules remains a huge challenge. Herein, we developed responsive hydrogels with self-regulated bioactive molecule release based on the protease activity in diabetic wound sites, to serve as a smart immune microenvironment modulator for accelerating wound healing.

Cooperation of R and Rab5 regulates crayfish anti-disease immune response by triggering apoptosis.

Toll-like receptors (TLRs) are involved in innate immunity in aquatic animals. The comprehensive regulation characteristic of TLRs in the immune of crayfish (Procambarus clarkii) has been less elucidated. In this study, we investigated the regulatory pathways of TLRs in the crayfish by identifying the proteins interacting with TLRs encoded by the resistance (R)-gene identified in our previous study.

A Library of Polyphenol-Amino Acid Condensates for High-Throughput Continuous Flow Production of Nanomedicines with Ultra-High Drug Loading.

Synthesizing high drug-loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large-scale engineered production of such nanomedicines presents even greater difficulties. This study presents a scalable library of polyphenol-amino acid condensates. By selecting amino acids, the library enables precise customization of key properties, such as carrier capacity, bioactivity, and other critical attributes, offering a versatile range of options for various application scenarios.

Enhanced YOLOv8 algorithm for leaf disease detection with lightweight GOCR-ELAN module and loss function: WSIoU.

Leaf disease detection holds significant application value in the agricultural domain, as timely and accurate detection of crop leaf disease targets is crucial for improving crop yield and quality. To handle varying crop leaf disease target sizes, occlusion issues, and detection errors in complex environments, the YOLOv8 structure has been enhanced. Firstly, to tackle the issues of target diversity and loss of image features, this paper designs the GOCR-ELAN lightweight module to replace some of the C2f modules in the Backbone, thereby reducing the parameters in the model and enhancing the network's feature extraction capability.

Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection.

Intrahepatic cholangiocarcinoma (ICC) ranks as the second most primary liver cancer that often goes unnoticed with a high mortality rate. Hepatectomy is the main treatment for ICC, but only 15% of patients are suitable for surgery. Despite advancements in therapeutic approaches, ICC has an unfavorable prognosis, largely due to lymph node metastasis (LNM) that is closely linked to the elevated recurrence rates.

Microenvironment-Responsive Antibacterial, Anti-Inflammatory, and Antioxidant Pickering Emulsion Stabilized by Curcumin-Loaded Tea Polyphenol Particles for Accelerating Infected Wound Healing.

Multiphase Pickering emulsions, including two or more active agents, are of great importance to effectively manage complicated wounds. However, current strategies based on Pickering emulsions are still unsatisfying since they involve only stabilization by inactive particles and encapsulation of the hydrophobic drugs in the oil phase. Herein, thyme essential oil (TEO) was encapsulated in the shell of functional tea polyphenol (TP)-curcumin (Cur) nanoparticles (TC NPs) to exemplarily develop a novel Pickering emulsion (TEO/TC PE).

Relationship between hearing loss and depression: A cross-sectional analysis from the National Health and Nutrition Examination Survey 2015-2018.

Background: Hearing loss is a prevalent issue resulting from loud noise exposure, aging, diseases, and genetic differences. As individuals age, the likelihood of experiencing hearing loss and depression escalates; yet, the link between hearing loss and the risk of depression remains ambiguous. This study explores the relationship between hearing and depression risk, taking into account sociodemographic and health-related factors.

Variant-Localized High-Concentration Electrolyte without Phase Separation for Low-Temperature Batteries.

Dual-ion batteries (DIBs) present great application potential in low-temperature energy storage scenarios due to their unique dual-ion working mechanism. However, at low temperatures, the insufficient electrochemical oxidation stability of electrolytes and depressed interfacial compatibility impair the DIB performance. Here, we design a variant-localized high-concentration solvation structure for universal low-temperature electrolytes (ν-LHCE) without the phase separation via introducing an extremely weak-solvating solvent with low energy levels.

Soft yet mechanically robust injectable alginate hydrogels with processing versatility based on alginate/hydroxyapatite hybridization.

The salient gelling feature of alginate via forming the egg-box structure with calcium ions has received extensive interests for different applications. Owing to the interfacial incompatibility of rigid inorganic solids with soft polymers, the requirement of overall stereocomplexation with calcium released from uniformly distributed solids in alginate remains a challenge. In this study, a novel alginate-incorporated calcium source was proposed to tackle the intractable dispersion for the preparation of injectable alginate hydrogels.

A comprehensive analysis of the prognostic and immunological role of in pan-cancer.

Background: Cancer is a common cause of death around the world. Immunotherapy plays a significant role in cancer treatment but still has limitations. The ankyrin-3 () gene has been shown to have a variety of biological roles and has also been shown to be closely linked to individual cancers.

Influences of carboxymethyl chitosan upon stabilization and gelation of O/W Pickering emulsions in the presence of inorganic salts.

The objective of this study was to investigate the effects of carboxymethyl chitosan (CMCS) on the stabilization and gelation of oil-in-water (O/W) Pickering emulsions (PEs) with polyphenol-amino acid particles in the presence of inorganic salts. The results revealed that the CMCS-induced depletion interactions contributed to improving the emulsification ability and interfacial adsorption efficiency of polyphenol-amino acid particles as well as constructing the network structures in the continuous phase. These relevant changes collectively resulted in elevating stability, viscosity and moduli of PEs.

pH-Responsive Carrier-Free Polyphenol Nanoparticles Assembled by Oxidative Polymerization with Enhanced Stability and Antioxidant Activity for Improved Bioaccessibility.

Encapsulation of plant polyphenols with micro-/nano-carriers for enhanced bioavailability has been well documented, but the preparation of these carriers and subsequent loading of polyphenols is a multiple process, which is generally complicated with potentially unexpected negative effects on the bioactivity of the polyphenols. Here, we reported a convenient method to assemble carrier-free polyphenol nanoparticles (NPs) based on oxidative coupling polymerization. The effectiveness was assessed with five different polyphenols including pyrocatechol (PY), catechin (CA), epigallocatechin gallate (EGCG), tannic acid (TA), and proanthocyanidin (PC).

Collagen Scaffolds Functionalized by Cu-Chelated EGCG Nanoparticles with Anti-Inflammatory, Anti-Oxidation, Vascularization, and Anti-Bacterial Activities for Accelerating Wound Healing.

Skin injury is a common health problem worldwide, and the highly complex healing process poses critical challenges for its management. Therefore, wound dressings with salutary effects are urgently needed for wound care. However, traditional wound dressing with a single function often fails to meet the needs of wound repair, and the integration of multiple functions has been required for wound repair.