Dual antibiotic PLGA microspheres for the treatment of traumatic osteomyelitis.

Traumatic osteomyelitis (TO) treatment remains challenging due to biofilm formation and poor antibiotic penetration. We developed poly(lactic-co-glycolic acid) (PLGA) microspheres co-loaded with moxifloxacin/rifampicin (M/R-P) to address these limitations. Key findings: In vitro: The microspheres showed (1) no cytotoxicity (CCK-8 assay; live/dead staining; cytoskeletal staining; SEM visualization), and (2) no inhibition of osteogenic potential (ALP activity).

Asymmetric Protocols for Mode Pairing Quantum Key Distribution with Finite-Key Analysis.

The mode pairing quantum key distribution (MP-QKD) protocol has attracted considerable attention for its capability to ensure high secure key rates over long distances without requiring global phase locking. However, ensuring symmetric channels for the MP-QKD protocol is challenging in practical quantum communication networks. Previous studies on the asymmetric MP-QKD protocol have relied on ideal decoy state assumptions and infinite-key analysis, which are unattainable for real-world deployment.

Risk factors for elbow stiffness after surgery for AO / OTA type C distal humerus fractures.

Objective: The aim of this study is to identify risk factors for elbow stiffness following surgery for AO/OTA type C distal humerus fractures with a follow-up investigation.

Methods: Data were collected from patients who underwent treatment for AO/OTA type C distal humerus fractures between March 2015 and March 2022.The patients were divided into a stiffness group and a control group based on whether their elbow flexion-extension or rotation range of motion was less than 100°at the final follow-up.

Retrospective analysis of open reduction and locking plate fixation in three and four part proximal humeral fractures with efficacy and complications.

Three- and four-part proximal humeral fractures are common in young and elderly populations. Open reduction and fixation with a locking plate is a commonly used surgical technique; however, it is associated with a high incidence of complications. This study aimed to retrospectively evaluate the clinical effectiveness of open reduction and fixation with a locking plate for treating three- and four-part proximal humeral fractures and to analyze potential risk factors for complications.

Gamma-glutamyl transferase-to-lymphocyte ratio as a prognostic marker in patients with hepatocellular carcinoma undergoing hepatectomy.

Background: We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio (GLR) as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma (HCC) across different time periods and developed a predictive model based on this.

Aim: To evaluate the prognostic accuracy of GLR for overall survival (OS) in patients with HCC and its impact over time.

Methods: This study enrolled 301 patients with HCC treated with curative hepatectomy.

Robust convex biclustering with a tuning-free method.

Biclustering is widely used in different kinds of fields including gene information analysis, text mining, and recommendation system by effectively discovering the local correlation between samples and features. However, many biclustering algorithms will collapse when facing heavy-tailed data. In this paper, we propose a robust version of convex biclustering algorithm with Huber loss.

Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury.

Spinal cord injury (SCI), characterized by the disruption of neural pathways and an increase in inflammatory cell infiltration, leads to profound and lasting neurological deficits, with a high risk of resulting in permanent disability. Currently, the therapeutic landscape for SCI is notably sparse, with limited effective treatment options available. Methylprednisolone (MP), a widely used clinical anti-inflammatory agent for SCI, requires administration in high doses that are associated with significant adverse effects.

Synthesis and Characterization of a New Aluminosilicate Molecular Sieve from Aluminosilica Perhydrate Hydrogel.

A novel structure aluminosilicate molecular sieve, named BUCT-3, was prepared by dynamic hydrothermal synthesis, and the critical factor to obtain the new structure is using an active silicon and aluminum source, aluminosilica perhydrate hydrogel. Meanwhile, only high content of O-O bonds can ensure the pure phase of BUCT-3. Through the characterization of x-ray powder diffraction (XRD), Fourier transform infrared spectra (FTIR), scanning electron microscopy (SEM), and so on, some structure and morphology information of BUCT-3 molecular sieves as well as the special silicon and aluminum source was obtained.

Reference-frame-independent measurement-device-independent quantum key distribution with mismatched-basis statistics.

The source flaw associated with the basis vector in the reference-frame-independent measurement-device-independent quantum key distribution (RFI-MDI-QKD) has not been systematically studied. As a result, it is often assumed that bit error is equal to phase error, which is not theoretically rigorous. Here, we propose a postprocessing method to estimate the phase error rate from the discarded mismatched-basis statistics, where the qubit source does not need to be characterized in detail.

Combination of multiple functional markers to improve diagnostic accuracy.

Combination of multiple biomarkers to improve diagnostic accuracy is meaningful for practitioners and clinicians, and are attractive to lots of researchers. Nowadays, with development of modern techniques, functional markers such as curves or images, play an important role in diagnosis. There exists rich literature developing combination methods for continuous scalar markers.

Detector-device-independent quantum secret sharing with source flaws.

Measurement-device-independent entanglement witness (MDI-EW) plays an important role for detecting entanglement with untrusted measurement device. We present a double blinding-attack on a quantum secret sharing (QSS) protocol based on GHZ state. Using the MDI-EW method, we propose a QSS protocol against all detector side-channels.

Feasible attack on detector-device-independent quantum key distribution.

Recently, to bridge the gap between security of Measurement-device-independent quantum key distribution (MDI-QKD) and a high key rate, a novel protocol, the so-called detector-device-independent QKD (DDI-QKD), has been independently proposed by several groups and has attracted great interest. A higher key rate is obtained, since a single photon bell state measurement (BSM) setup is applied to DDI-QKD. Subsequently, Qi has proposed two attacks for this protocol.

Experimental single qubit quantum secret sharing in a fiber network configuration.

We present a robust single-photon quantum secret sharing (QSS) scheme with phase encoding in three-party implementations and a design way of more parties over a 50 km single-mode fiber network using a single QSS protocol. This scheme automatically provides perfect compensation for birefringence. A high visibility of 99.

Experimental circular quantum secret sharing over telecom fiber network.

We present a robust single photon circular quantum secret sharing (QSS) scheme with phase encoding over 50 km single mode fiber network using a circular QSS protocol. Our scheme can automatically provide a perfect compensation of birefringence and remain stable for a long time. A high visibility of 99.

True random number generator based on discretized encoding of the time interval between photons.

We propose an approach to generate true random number sequences based on the discretized encoding of the time interval between photons. The method is simple and efficient, and can produce a highly random sequence several times longer than that of other methods based on threshold or parity selection, without the need for hashing. A proof-of-principle experiment has been performed, showing that the system could be easily integrated and applied to quantum cryptography and other fields.

Quantum key distribution based on phase encoding in long-distance communication fiber.

A robust two-way quantum key distribution system based on phase encoding is demonstrated in 50 km and 100 km commercial communication fiber. The system can automatically compensate for birefringence effects and remain stable over 23 h. A low quantum bit error rate and high visibility are obtained.

Quantum key distribution based on phase encoding and polarization measurement.

A one-way quantum key distribution scheme based on intrinsically stable Faraday-mirror-type Michelson interferometers with four-port polarizing beam splitters has been demonstrated that can compensate for birefringence effects automatically. The encoding is performed with phase modulators, but decoding is accomplished through measurement of the polarization state of Bob's photons. An extinction ratio of about 30 dB was maintained for several hours over 50 km of fiber at 1310 nm without any adjustment to the setup, which shows its good potential for practical systems.

Random number generation based on the time of arrival of single photons.

We report the demonstration of a new type of true random number generator based on the random distribution of the time interval between photons from a single-photon-like source. The experimental setup is simple and robust against mechanical and temperature disturbances. With improved detector resolution and efficiency, the random number bit rate could be increased by more than an order of magnitude to satisfy practical requirements.