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We report the demonstration of a new type of true random number generator based on the random distribution of the time interval between photons from a single-photon-like source. The experimental setup is simple and robust against mechanical and temperature disturbances. With improved detector resolution and efficiency, the random number bit rate could be increased by more than an order of magnitude to satisfy practical requirements.
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http://dx.doi.org/10.1364/ao.44.007760 | DOI Listing |
Encephale
September 2025
Université de Reims Champagne-Ardenne, C2S, Reims, France; Groupe Hospitalier Paul-Guiraud, GHT Psy Sud, Boulogne-Billancourt, France. Electronic address:
Objectives: This systematic review aims to evaluate the impact of cognitive-behavioral and metacognitive therapies on cognitive and clinical insight into early schizophrenia disease.
Methods: A comprehensive literature review was conducted across several databases, including Pubmed, PsycINFO, and Cochrane Library, focusing on studies published between 2006 and May 2024. The studies selected for this review were either randomized controlled trials (RCTs), cross-sectional studies, or exploratory studies.
J Pain Symptom Manage
September 2025
School of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
Background: Pain management in palliative care, especially among cancer patients, remains a critical challenge that significantly affects patient quality of life. Virtual Reality (VR) has emerged as a promising non-pharmacological intervention that could revolutionize pain management strategies in this vulnerable population. This systematic review and meta-analysis evaluate the effectiveness of VR interventions, focusing exclusively on randomized controlled trials to provide a comprehensive assessment of VR as a therapeutic tool.
View Article and Find Full Text PDFContemp Clin Trials
September 2025
Weill Cornell Medicine Center for Global Health, New York, NY, USA.
Introduction: Preclinical and clinical study data show that combining bedaquiline (B or BDQ), moxifloxacin (M), and pyrazinamide (Z), known as BMZ, has potent antimicrobial activity that might shorten treatment duration for drug-susceptible pulmonary tuberculosis.
Methods/design: We describe the design of Tuberculosis Trials Consortium (TBTC) Study 38/CRUSH-TB (NCT05766267), an open-label multicenter international randomized controlled phase 2C trial that compares two four-month regimens, BMZ plus rifabutin (Rb) (2BMZRb/2BMRb) or BMZ plus delamanid (D or DLM) (2BMZD/2BMD), with standard 6-months isoniazid, rifampin, pyrazinamide, and ethambutol (HRZE). All drugs are administered seven days per week, under direct observation, at least five days per week.
Can J Ophthalmol
September 2025
Département d'Ophtalmologie et d'Ophtalmologie et d'Oto-Rhino-Laryngologie-Chirurgie Cervico-Faciale, Faculté de Médecine, Université Laval, QC, Canada; Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, Centre Hospitalier Universitaire de Québec-Université Laval, QC, Canada.
Objective: To compare the efficacy of different settings in continuous-wave transscleral cyclophotocoagulation (CW-TSCPC).
Design: Prospective, randomized, triple-blind clinical trial in a single tertiary center.
Participants: Adult glaucoma patients who need continuous wave-transscleral cyclophotocoagulation to control intraocular pressure (IOP) or prevent or treat ocular pain/discomfort secondary to increased IOP.
Lancet Rheumatol
September 2025
National Institute for Health and Care Research Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. Electronic address:
Background: The optimal treatment strategy in early psoriatic arthritis remains unknown. We aimed to assess whether the combination of methotrexate and golimumab plus corticosteroids is superior to methotrexate plus corticosteroids in reducing disease activity in early, untreated psoriatic arthritis.
Methods: We did a double-blind, randomised, placebo-controlled, parallel-group, single-centre study in adults with treatment-naïve active psoriatic arthritis.