Optimization of ciliary body cyclophotocoagulation settings: a randomized and controlled pilot study.

Objective: To compare the efficacy of different settings in continuous-wave transscleral cyclophotocoagulation (CW-TSCPC).

Design: Prospective, randomized, triple-blind clinical trial in a single tertiary center.

Participants: Adult glaucoma patients who need continuous wave-transscleral cyclophotocoagulation to control intraocular pressure (IOP) or prevent or treat ocular pain/discomfort secondary to increased IOP.

Circulating miRNAs as potential liquid biomarkers for pediatric gliomas.

Background: Current diagnostic and monitoring of pediatric brain tumors rely on invasive tissue biopsies and imaging, highlighting the need for non-invasive alternatives. For that matter, liquid biopsy is a promising method. This pilot study investigated the potential of circulating miRNAs to serve as non-invasive biomarkers of pediatric glioma tumors.

Rate of germline pathogenic sequence variants in cancer susceptibility genes in an Israeli pediatric and adolescent cancer cohort: a single institute experience.

Unlabelled: Multi-cancer predisposition gene panel testing (MCPGT) enables simultaneous deep-coverage genotyping of multiple CPGs (cancer predisposing genes) and detects germline pathogenic sequence variants (PSVs). Reported PSV carrier rates among pediatric and adolescent cancer patients range from 8 to 17.6%, with variability attributed to ethnic background, the number of genes tested, cancer phenotypes, and patient selection criteria.

Raphin-1 mediates the survival and sensitivity to radiation of pediatric-type diffuse high-grade glioma via phosphorylated eukaryotic initiation factor 2α-dependent and -independent processes.

The primary treatment for fatal pediatric-type diffuse high-grade glioma (PED-DHGG) which harbor the H3K27M or H3G34R/V mutation is radiation, but it provides only short-term relief. Inhibitors of phosphorylated eIF2α (PeIF2α) phosphatase-namely raphin-1 and salubrinal-decrease survival of PED-DHGG cell lines and sensitize them to radiation. However, although both drugs increase PeIF2α, they have different effects on common targets and different targets altogether.

Pediatric Extreme Thrombocytosis: Etiology, Management, and Outcomes.

Background And Objective: Extreme thrombocytosis (EXT) is defined as a platelet count >1000×10/L. The aim of the current study was to evaluate the etiology, management, and outcome of pediatric patients with EXT, focusing on thrombotic complications.

Study Design: We conducted a retrospective study at a large tertiary center, examining cases of pediatric EXT identified from electronic medical records over a 5-year period.