Cascade-penetrating domino-ferroptosis nano inducer synergizes with sonodynamic therapy for anaplastic thyroid cancer.

Ferroptosis, an iron-dependent, nonapoptotic form of regulated cell death, has become a new approach for antitumor treatment. However, the insufficient accumulation and poor penetration of ferroptosis inducers deep in tumors greatly limit their therapeutic effects. In this study, we constructed a cascade penetrating metal‒polyphenol ultrasonic molecular probe, FeCur-PFP@IR780-LIP (FCIPL).

Enhanced Bifunctional Electrocatalysis of VN via D-Band Engineering for Rechargeable Zn-Air Batteries.

The insufficient d-electron density in V metal atoms limits O dissociation, constraining the kinetics and activity of the oxygen reduction reaction and the oxygen evolution reaction in VN-based catalysts. Herein, Co dopant was employed to modulate the electronic characteristics of the d-orbitals and associated free energy of VN, thereby further enhancing its catalytic activity. XPS and XANES spectra revealed that Co atoms replaced V and strongly bonded with neighboring N atoms, effectively regulating the local electronic structure.

Lithium nucleation modulated by light induced nanowelding to improve lithium metal anode collectors.

Lithium metal (Li) has been regarded as one of the most ideal anode materials for next-generation high-energy-density batteries, but the problem of uncontrollable growth of Li dendrites leading to poor cycling stability of Li-metal batteries has seriously limited the practical application and development of Li-metal batteries. Uniform deposition of lithium is the key to solve this problem, but it is difficult to realize on commercial copper collectors (CuCCs). In this study, a simple and efficient strategy is adopted: the lithophilic surface modification of CuCCs with AgNWs, and the innovative introduction of photoluminescent nano-welding technology to achieve the stability of the silver nanowire network structure and improve the electrochemical performance.

Fabrication of thermally activated lead-zinc tailings/sodium alginate composites for high-efficiency adsorption of Cu/Cd.

Wastewater containing Cu and Cd poses a huge threat to the surrounding environment and human safety. To treat such wastewater, this study developed a novel composite adsorbent (LZT@SA) from thermally activated LZT and sodium alginate (SA). LZT was thermally activated at 850 °C (LZT).

Inverse design of terahertz metasurfaces for multi-channel holographic imaging based on the modified gradient descent method.

In recent years, research on terahertz metasurfaces has made significant progress and is evolving towards multifunctional integration. Traditional forward design methods have gradually exposed efficiency bottlenecks in multifunctional design due to their high computational complexity. The proposal of the inverse design paradigms has brought revolutionary breakthroughs in the design efficiency of multifunctional metasurfaces and greatly reduced the design threshold.

Value of anatomical partitioning of the retroperitoneal space in determining the origin of neurogenic tumors.

Background: To analyze the anatomical partitioning of the retroperitoneal space and determine the distribution patterns of primary retroperitoneal neurogenic tumors (PRNTs).

Methods: Retrospectively analyze the clinical data and CT data of 401 patients with single-injection PRNT confirmed by surgical pathology, including 103 cases of neuroendocrine origin, 148 cases of neuroectodermal origin, and 150 cases of peripheral nerve origin. The retroperitoneal space was divided into the anterior pararenal space, posterior pararenal space, perirenal space, and great vessel space.

Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia.

Ethnopharmacological Relevance: Panax notoginseng, documented in Sheng Nong's Herbal Classic, has long been used to relieve pain. Its major bioactive component, ginsenoside Rg1, exhibits diverse pharmacological activities, but its role in chronic neuropathic pain (CNP) remains poorly understood.

Aim Of The Study: This study endeavors to decipher the analgesic functions of Ginsenoside Rg1 and explore the molecular mechanisms that underlie them.

Elephant Cathelicidin-Derived Peptides Inhibit Herpes Simplex Virus 1 Infection.

Herpes simplex virus type 1 (HSV-1) is a globally prevalent pathogen that can infect a variety of animal species as well as humans. However, existing antiviral therapies are constrained in their capacity to effectively target viral latency and prevent recurrent infections. Antimicrobial peptides (AMPs), particularly cathelicidins, as part of innate immune system have demonstrated broad-spectrum efficacy against viral pathogens.

Genome-wide association and epidemiological evidence linking air pollution to aging mechanisms.

This study aimed to investigate the effects of air pollution on aging and aging-related diseases, focusing on potential causal relationships and molecular mechanisms. The first part involved a comprehensive analysis of global studies, examining the associations among PM exposure, telomere length, and sarcopenia incidence. The second part employed Mendelian randomization (MR) analysis to explore potential causal association between PM exposure and shorter telomere length.

Progress on the Attenuation Mechanism and Modification of the Cobalt-Free Spinel LiNiMnO.

Cobalt-free LiNiMnO (LNMO) has recently emerged as a highly promising cathode material owing to its benefits of a high operating voltage platform (≈4.7 V vs Li), high theoretical energy density (≈650 Wh kg), eco-friendliness, and resource abundance. However, it has also demonstrated low cycle and poor rate performances.

Automated radiotherapy treatment planning guided by GPT-4Vision.

. Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier artificial intelligence (AI) models offer promising avenues for addressing the challenges in planning and clinical decision-making.

A Multimodal Adaptive Optical Microscope For Imaging from Molecules to Organisms.

Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple imaging modalities within complex native microenvironments. Yet, achieving this comprehensive view is challenging because microscopes optimized for specific tasks typically lack versatility due to inherent optical and sample handling trade-offs, and frequently suffer performance degradation from sample-induced optical aberrations in multicellular contexts. Here, we present MOSAIC, a reconfigurable microscope that integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics.

Wheat Yield, N Use Efficiency, Soil Properties, and Soil Bacterial Community as Affected by Long-Term Straw Incorporation and Manure Under Wheat-Summer Maize Cropping System in Southern Shanxi Province, China.

Straw incorporation and manure are recognized as a sustainable farming practice to enhance soil fertility and improve crop yields. However, the effects of straw incorporation in combination with manure on productivity, soil nutrient status, N use efficiency (NUE), and the bacterial community are not well understood in wheat-summer maize rotation systems in the southern Shanxi Province. The five treatments were (1) CK, no fertilization; (2) NP, inorganic N and P fertilizers; (3) NPM, mineral N and P fertilizers plus chicken manure; (4) SNP, mineral N and P fertilizers plus maize straw; and (5) SNPM, mineral N and P fertilizers plus maize straw and chicken manure.

Shikonin nasal spray film preparation promoted the repair of nasal mucosal injury by the interaction of shikonin with interleukin-6.

Introduction: Nasal spray films, an innovative formulation in recent years, have garnered significant acclaim from patients with nasal mucosal injury because it integrate the benefits of spray and film formulation, offering ease of application while reducing the risk of droplet formation and further inhalation into the throat. Furthermore, Lithospermum erythrorhizon is a traditional Chinese medicine frequently employed in the management of dermal injuries, and our previous work suggested its major compound, shikonin, possesses the capacity to promote the repair of nasal mucosal injury. Notwithstanding these encouraging results, research on the development of shikonin nasal spray film preparation (SNSF) and its bioactivity mechanism remains limited.

Microplastics, plastics, and their products exposures and cancer: a pooled analysis.

Objective: This meta-analysis aims to evaluate the impact of microplastic pollutant exposure on cancer risk by analyzing data from existing cohort and case-control studies.

Methods: The researchers systematically searched PubMed, Embase, and the Cochrane Library on 30 June 2024 to identify relevant studies. The analysis focused on cancer incidence and mortality, with subgroup analyses performed for different types of cancers and microplastic pollutants, and dose-response analysis for further investigation.

Process Optimization for the Preparation of the Lithium Iron Phosphate Precursor FePO·2HO by Anodic Oxidation Method.

Iron phosphate (FePO·2HO) was synthesized via anodic oxidation using nickel-iron alloy composition simulates from laterite nickel ore as the anode and graphite electrodes as the cathode, with phosphoric acid serving as the electrolyte. A uniform experimental design was employed to systematically optimize the synthesis parameters including voltage, electrolyte concentration, electrolysis time, and degree of acidity or alkalinity (pH). The results indicate that the addition of cetyltrimethylammonium bromide (CTAB) surfactant effectively modulated the morphology of the anodic oxidation products.

Factors influencing postoperative complications in patients with gastric cancer: A retrospective study.

Background: Gastric cancer is a malignancy with high morbidity and mortality rates. Surgical intervention, particularly gastrectomy, is essential for curative treatment but carries a substantial risk of complications. Identifying key risk factors and understanding complication profiles are crucial for improving outcomes and guiding perioperative management.

Human perturbations to mercury in global rivers.

Mercury compounds are potent neurotoxins that pose threats to human health, primarily through fish consumption. Rivers, critical for drinking water and food supply, have seen rapid increases in mercury concentrations and export to coastal margins since the Industrial Revolution (~1850). However, patterns of these changes remain understudied, limiting assessments of environmental policies.

Genetically engineered extracellular vesicles expressing decoy protein TACI provide a therapeutic effect in systemic lupus erythematosus mouse model.

The suppression of B-cell activation and autoantibody production through immunotherapy has garnered substantial interest in advancing systemic lupus erythematosus (SLE) treatments. Although SLE patients do benefit from current therapies, no efficient therapeutic approaches are available to a substantial number of patients. In this study, we developed extracellular vesicles to express a fusion protein of the transmembrane activator and cyclophilin ligand interaction molecule (TACI).

Advanced Porous SiO/PAA Microarchitectures: A Sustainable Approach to High-Capacity and Ultra-Stable Anodes.

Silicon suboxide (SiO) anode materials are sought to substitute graphite-based anodes due to their high theoretical capacity and lower volume expansibility. Present chemical vapor deposition industrial production inevitably produces about 15 wt % submicro SiO wastes. To improve the reuse of submicro SiOx wastes in a more economical, efficient, and sustainable way, present research focuses on exploring spherical porous SiO/poly(acrylic acid) (PAA) microparticles via a spray-drying process to enhance resilience and adhesivity.

Studys on the effect of decidual stromal cells and trophoblast cells on cytokine secretion by decidual NK cells.

Unexplained recurrent pregnant loss (URPL) is associated with immune imbalance at the maternal-fetal interface. Decidual immune cells regulate the response of the maternal immune system to the fetus. However, the effect of decidual stromal cells (DSCs) and trophoblast cells on cytokine secretion by decidual NK cells remains unclear.

Combining with immunotherapy is an emerging trend for local treatment of colorectal cancer liver metastases: a bibliometric analysis.

Background: A growing body of evidence has demonstrated the expanding role of local treatment in managing colorectal cancer liver metastases (CRCLM). To identify current research trends and forecast future directions, we conducted a bibliometric analysis to examine global collaboration patterns and academic influence across countries, institutions, journals, and authors.

Materials And Methods: Relevant articles and reviews on CRCLM local therapies were systematically retrieved from the Web of Science Core Collection.

Advanced Electrolyte Additives for Enhanced Homogeneous Sulfur Fixation in Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries are regarded as leading contenders for next-generation energy storage owing to their exceptional theoretical energy density. However, severe sulfur electrode depletion causes rapid capacity fading and compromised cycling stability. Electrolyte engineering effectively enables homogeneous sulfur fixation, improving battery performance.

Global trends in tumor-associated neutrophil research: a bibliometric and visual analysis.

Background: Tumor-associated neutrophils (TANs) play crucial roles in tumor progression, immune response modulation, and the therapeutic outcomes. Despite significant advancements in TAN research, a comprehensive bibliometric analysis that objectively presents the current status and trends in this field is lacking. This study aims to fill this gap by visually analyzing global trends in TANs research using bibliometric and knowledge mapping techniques.

Effect of one-stitch method of temporary ileostomy on the surgical outcomes and complications after laparoscopic low anterior resection in rectal cancer patients: a propensity score matching analysis.

Purpose: The purpose of this current study was to explore whether one-stitch method (OM) of temporary ileostomy influenced the surgical outcomes after laparoscopic low anterior resection (LLAR).

Methods: We retrospectively identified rectal cancer (RC) patients who underwent LLAR plus temporary ileostomy in a single teaching hospital from Jan 2011 to June 2023. According to the different methods of ileostomy, the patients were divided into the OM group and the traditional method (TM) group.