Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia.

Ethnopharmacological Relevance: Panax notoginseng, documented in Sheng Nong's Herbal Classic, has long been used to relieve pain. Its major bioactive component, ginsenoside Rg1, exhibits diverse pharmacological activities, but its role in chronic neuropathic pain (CNP) remains poorly understood.

Aim Of The Study: This study endeavors to decipher the analgesic functions of Ginsenoside Rg1 and explore the molecular mechanisms that underlie them.

Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway.

To investigate the potential of emodin in promoting nerve regeneration following PNI by targeting macrophage polarization, NLRP3 inflammasome activation, autophagy, and the EGFR/PI3K/Akt/mTOR pathway. A cohort of 78 male Sprague-Dawley rats was used to develop models of sciatic nerve damage, with an additional 18 rats in the sham surgery group. The rats were randomly assigned to eight groups: Sham, Control, PNI + Emodin (20 mg/kg), PNI + Emodin (80 mg/kg), PNI + MCC950 (10 mg/kg), PNI + Rapamycin (2 mg/kg), PNI + Emodin (80 mg/kg) + 3-MA (15 mg/kg), and PNI + Emodin (80 mg/kg) + NSC 228155 (5 mg/kg).