Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective.

This study examines the integration of narrative medicine (NM) into primary healthcare (PHC) settings, evaluating its role in enhancing medical humanities education within grassroots healthcare institutions. Through a comprehensive literature review and case analysis, the research investigates the current state, challenges, and practical barriers to embedding NM into PHC systems, while proposing targeted strategies for improvement. The findings suggest that NM fosters stronger doctor-patient trust, enhances healthcare quality, and promotes humanistic care.

Lactate-to-albumin ratio index correlates with the occurrence and prognosis of acute kidney injury complicated by cardiac surgery.

Background: The lactate-to-albumin ratio (LAR) is a novel biomarker associated with poor prognosis in critical illnesses. However, its relationship with cardiac surgery associated acute kidney injury (AKI) and prognosis remains unclear. This study aimed to investigate this relationship using data from the MIMIC database.

A universal and versatile terahertz field manipulation mechanism by manipulating near-infrared phases with a dislocation scheme.

This paper presents a universal and versatile terahertz (THz) wavefront-phase manipulation by manipulating the two-dimensional phases of the near-infrared pulses. The near-infrared manipulation enables independent controls of two kinds of wavefront-phases with a two-dimensional phase modulator along two orthogonal directions. An implementation strategy of the near-infrared manipulation is further introduced by a dislocation scheme including two plates with conjugated-phase functions to output two collinear pulses with orthogonal polarizations and conjugated modulated phases.

Prevalence of Atrial Fibrillation and Intervention Therapy in Cardiac Amyloidosis.

Atrial fibrillation (AF) is a common and serious arrhythmia that frequently complicates cardiac amyloidosis (CA), a rare condition characterized by amyloid deposits in the heart. The coexistence of AF in CA patients significantly increases the risk of heart failure, stroke, and other life-threatening complications; however, the therapeutic approach to managing AF in CA patients remains underexplored. Thus, this review discusses the features of AF in CA patients, recent research on the development of effective treatment options, and strategies for future therapies.

Association between cardiometabolic index and cardiovascular disease: evidence From the NHANES 2007-2018.

Background: Although the cardiometabolic index (CMI) has gained recognition as a new tool for evaluating metabolic health, the relationship between CMI and cardiovascular disease (CVD) remains unclear. This research sought to explore the potential association between CMI and CVD.

Methods: Participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) were selected.

The potential degradability of persistent organic pollutants (POPs) in soil: a perspective from soil aggregates.

Aggregates are the fundamental units of soil structure. Clarifying the distribution characteristics of soil organic carbon (SOC), microbial properties (e.g.

Clean Interfaces in Twisted Bilayer Graphene via Elastocapillary-Driven Directional Motion of Nanodroplets.

Layered van der Waals (vdW) materials, characterized by an ultrahigh surface-to-volume ratio and weak interlayer interaction, readily encapsulate ambient contaminants, resulting in the formation of nanodroplets. These intercalated nanodroplets disrupt the interlayer coupling, thereby degrading the material's physical properties. Consequently, achieving an ultraclean vdW interface over a substantial area, particularly in suspended vdW materials, presents a significant challenge.

Curcumin Analog J7 Attenuates Liver Fibrosis and Metabolic Dysregulation in a Rat Model of Type 2 Diabetes via Modulation of TGF-β/Smad and NF-κB/BCL-2/BAX Pathways.

Objective: To evaluate the therapeutic potential of the curcumin analog J7 in protecting the liver and regulating glucose and lipid metabolism in rats with type 2 diabetes.

Methods: Bioinformatics methods were used to identify signaling pathways linked to diabetic liver disease. Diabetic rats were treated with curcumin, low-dose J7, or high-dose J7, and liver function and fibrosis were assessed through biochemical analyses, histopathology, immunohistochemistry, and ELISA.

Large-Area Ultrathin Covalent-Organic Framework Membranes for Surface-Enhanced Raman Scattering: Optimal Performance Through Thickness Control.

Exploration and construction of novel π-conjugated organic semiconductors with low cost, small background interference, and excellent performance as surface-enhanced Raman scattering (SERS) substrates is one of the current focuses for the development of SERS technology. Based on precise control over synthesis conditions, a series of large-area tetraphenylporphyrin-based 2D covalent-organic framework membranes (2D-porphyrin-COFs) with high uniformity and precisely controllable thickness are constructed as SERS substrates. The delicate balance among the intensity of the substrate interference, the degree of π-conjugation extension, and the proportion of the edge-on channels within the total exposed region results in the optimal SERS performance of ultrathin multilayer 2D-porphyrin-COFs with the thickness between 5.

YY1 as a mediator to enhance the resistance of KRAS mutant colorectal cancer cells to cetuximab.

Cetuximab has been indicated as the mainstay of metastatic colorectal cancer (CRC) therapy, of which application was impeded by chemoresistance that was casually attributed to KRAS mutation. This study sought to determine whether YY1 mediated the resistance of CRC cells harbouring KRAS mutation (KRASmut) to cetuximab. The expression of YY1 between cetuximab response and resistance was investigated in cancerous tissues from CRC patients received cetuximab therapy comprising eight KRAS wild-type (KRASwt) and 12 KRASmut.

Retrospective analysis of survival and safety of bevacizumab biosimilar and original drug combination chemotherapy in non-small cell lung cancer.

Introduction: The advent of bevacizumab has considerably transformed the therapeutic landscape for non-small cell lung cancer (NSCLC) patients devoid of specific genetic mutations. A pivotal milestone has been reached with the recent approval of a bevacizumab biosimilar, following rigorous phase III clinical investigations, poised to augment NSCLC therapeutic strategies.

Methods: This retrospective analysis encompasses a large-scale study conducted between January 2021 and December 2023, involving 1058 NSCLC patients (metastatic or locally advanced stages).

Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis.

Background: Obstructive sleep apnea (OSA) is a common sleep disorder. Inflammatory factors and plasma metabolites are important in assessing its progression. However, the causal relationship between them and OSA remains unclear, hampering early clinical diagnosis and treatment decisions.

Precious-Metal-Free Mo-MXene Catalyst Enabling Facile Ammonia Synthesis Via Dual Sites Bridged by H-Spillover.

To date, NH synthesis under mild conditions is largely confined to precious Ru catalysts, while nonprecious metal (NPM) catalysts are confronted with the challenge of low catalytic activity due to the inverse relationship between the N dissociation barrier and NH ( = 1-3) desorption energy. Herein, we demonstrate NPM (Co, Ni, and Re)-mediated MoCT MXene (where T denotes the OH group) to achieve efficient NH synthesis under mild conditions. In particular, the NH synthesis rate over Re/MoCT and Ni/MoCT can reach 22.

A miniaturized ultra-wideband filter with high rejection and selectivity based on dual-notch bands.

A novel compact and highly selective Ultra Wide Band (UWB) filter is proposed using multimode resonator (MMR) technology. To begin with, the filter's ultra-wideband performance is achieved by coupling a stepped-triangular multimode resonator with input-output feedlines. Furthermore, dual-notch band characteristics are realized at 6.

TTFDNet: Precise Depth Estimation from Single-Frame Fringe Patterns.

This work presents TTFDNet, a transformer-based and transfer learning network for end-to-end depth estimation from single-frame fringe patterns in fringe projection profilometry. TTFDNet features a precise contour and coarse depth (PCCD) pre-processor, a global multi-dimensional fusion (GMDF) module and a progressive depth extractor (PDE). It utilizes transfer learning through fringe structure consistency evaluation (FSCE) to leverage the transformer's benefits even on a small dataset.

Cadmium and pyrene in the soil modify the properties of earthworm-mediated soil.

Earthworms are pivotal in soil ecosystems due to their crucial role in shaping soil characteristics through casts and burrow walls. Previous research has predominantly focused on the direct impact of soil pollution on live earthworms, overlooking the subsequent effects on earthworm-mediated soil, such as casts and burrow walls. Using 2D-terraria as incubation containers and the geophagous earthworm species Metaphire guillelmi, this study assessed the change in various properties of earthworm-mediated soil in both uncontaminated soils and Cd- and Pye-contaminated soils.

Discrimination of Xylene Isomers by Precisely Tuning the Interlayer Spacing of Reduced Graphene Oxide Membrane.

Separating xylene isomers is a challenging task due to their similar physical and chemical properties. In this study, we developed a molecular sieve incorporating a reduced graphene oxide (rGO) membrane for the precise differentiation of xylene isomers. We fabricated GO membranes using a vacuum filtration technique followed by thermal-induced reduction to produce rGO membranes with precisely controllable interlayer spacing.

LM-1 Affects Multiple Cell Biological Processes in to Suppress Rice Blast.

, one of the most destructive rice pathogens, causes significant losses during the rice harvest every year. has been explored in many crops as a potential biocontrol agent. However, the mechanisms of controled rice blast are not fully understood.

A new agent for contrast-enhanced intravascular ultrasound imaging in vitro: polybutylcyanoacrylate nanoparticles with drug-carrying capacity.

This study prepared and evaluated polymeric polybutylcyanoacrylate (PBCA) nanoparticles (NPs) that can be used as a new agent for contrast-enhanced intravascular ultrasound (IVUS) imaging with drug delivery capacity. The nanoformulation was successfully developed using suspension polymerisation and characterised in terms of size, size distribution, zeta potential, morphology, stability, toxicity effects, imaging effects and drug release study. The results showed that the nanoparticles were round and hollow, with a particle diameter of 215.

Direct space-time manipulation mechanism for spatio-temporal coupling of ultrafast light field.

Traditionally, manipulation of spatiotemporal coupling (STC) of the ultrafast light fields can be actualized in the space-spectrum domain with some 4-f pulse shapers, which suffers usually from some limitations, such as spectral/pixel resolution and information crosstalk associated with the 4-f pulse shapers. This work introduces a novel mechanism for direct space-time manipulation of ultrafast light fields to overcome the limitations. This mechanism combines a space-dependent time delay with some spatial geometrical transformations, which has been experimentally proved by generating a high-quality STC light field, called light spring (LS).

Anisotropic mechanical properties of α-MoO nanosheets.

The mechanical behaviors of 2D materials are fundamentally important for their potential applications in various fields. α-Molybdenum trioxide (α-MoO) crystals with unique electronic, optical, and electrochemical properties, have attracted extensive attention for their use in optoelectronic and energy conversion devices. From a mechanical viewpoint, however, there is limited information available on the mechanical properties of α-MoO.

Inetetamab combined with tegafur as second-line treatment for human epidermal growth factor receptor-2-positive gastric cancer: A case report.

Background: Human epidermal growth factor receptor-2 (HER-2) plays a vital role in tumor cell proliferation and metastasis. However, the prognosis of HER2-positive gastric cancer is poor. Inetetamab, a novel anti-HER2 targeting drug independently developed in China, exhibits more potent antibody-dependent cell-mediated cytotoxicity than trastuzumab, which is administered as the first-line treatment for HER2-positive gastric cancer in combination with chemotherapy.

Quantitative analysis of contrast-enhanced ultrasound in neoadjuvant treatment of locally advanced rectal cancer: a retrospective study.

Purpose: To explore the clinical value of contrast-enhanced ultrasound (CEUS) quantitative analysis in the evaluation and prognosis of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC).

Methods: Eighty-three consecutive patients undergoing neoadjuvant chemoradiotherapy and total mesorectal excision for LARC were retrospectively included. According to pathological results, patients were categorized into complete or incomplete response groups.

Risk factors and an early predictive model for Kawasaki disease shock syndrome in Chinese children.

Background: Kawasaki disease shock syndrome (KDSS), though rare, has increased risk for cardiovascular complications. Early diagnosis is crucial to improve the prognosis of KDSS patients. Our study aimed to identify risk factors and construct a predictive model for KDSS.