Scalable matrix ring data center interconnect based on FSO technology.

To address escalating data center traffic and scalability issues, this paper introduces a novel hybrid data center network (DCN) architecture using free-space optics (FSO). The proposed three-layer matrix ring topology employs wired intra-layer links and wireless FSO inter-layer connections, reducing cabling and end-to-end delay. An optimized FSO link allocation strategy based on priority principles further enhances performance.

Enhanced stability and anticancer activity of (-)-epicatechin gallate and procyanidin B2: Synergistic effects of natural deep eutectic solvent-based ovalbumin glycation and non-covalent complexation.

In this study, glycated ovalbumin (GOVA) with a high degree of grafting (90.2 %) was prepared via response surface methodology (RSM) in natural deep eutectic solvents (NADES). The interactions between GOVA and (-)-epicatechin gallate (ECG) or procyanidin B2 (PB2) were compared using fluorescence spectroscopy and molecular docking.

Functional Food Ge-Zhi Soup Ameliorates Acute Liver Injury Through the AKT/GSK3β/PPARα Pathway.

Ge-Zhi soup (GZS), mainly consisting of (Willd.) Ohwi and Lindl. seeds, is a traditional functional food widely consumed globally and has been proven to have considerable potential in preventing acute liver injury (ALI).

A universal and versatile terahertz field manipulation mechanism by manipulating near-infrared phases with a dislocation scheme.

This paper presents a universal and versatile terahertz (THz) wavefront-phase manipulation by manipulating the two-dimensional phases of the near-infrared pulses. The near-infrared manipulation enables independent controls of two kinds of wavefront-phases with a two-dimensional phase modulator along two orthogonal directions. An implementation strategy of the near-infrared manipulation is further introduced by a dislocation scheme including two plates with conjugated-phase functions to output two collinear pulses with orthogonal polarizations and conjugated modulated phases.

Follicular fluid cytokine phenotypes reflect underlying etiologies for infertility.

To determine if the follicular fluid (FF) cytokine phenotype reflects underlying etiologies for infertility and oocyte/embryo quality. The study subjects comprised infertile women with diminished ovarian reserve (DOR, n = 42), tubal factor infertility (TFI, n = 72), and repeated implantation failures (RIF, n = 15). Controls were women with male factor infertility (MFI, n = 30).

Under Pressure: A Quality Improvement Initiative to Reduce Rhabdomyolysis and Hospital-Acquired Pressure Injuries Following Retroperitoneal Surgery.

Introduction: Present a retrospective quality improvement analysis assessing the incidence and factors associated with elevated creatine kinase (CK) levels, clinical rhabdomyolysis, and hospital-acquired pressure injuries (HAPIs) following complex retroperitoneal surgeries before and after the implementation of The Pink Pad for intraoperative positioning.

Methods: We performed a retrospective analysis of 364 patients who underwent renal or retroperitoneal surgery in the lateral decubitus position between July 2018 through July 2023. The 2 cohorts-pre-and post-Pink Pad utilization-were analyzed, each with 2.

Two novel trimethoprim resistance genes, and , identified in phage-plasmids.

Phage-plasmids carry a significant burden of clinically relevant antibiotic resistance genes (ARGs). Intriguingly, the majority of these ARGs are found within plasmids with phage features, with a single exception residing in a phage genome with plasmid features. Therefore, we speculate that phage genomes with plasmid features, whose sequences are highly homologous to bacterial plasmids, may carry novel ARGs.

Effectiveness of the polluter-pays principle under the CLC: A comparative analysis of four models for oil pollution damage claims.

The 1969 Civil Liability Convention (CLC) establishes a strict liability framework for oil-spilling vessels, integrating the polluter-pays principle with a limited liability cap for oil pollution damages. This structure is based on three pillars: strict liability, liability limitation, and compulsory insurance, creating a robust compensation model for oil pollution in maritime contexts. Importantly, the CLC allows victims to seek further compensation beyond its provisions.

Construction of Sonosensitizer-Drug Co-Assembly Based on Deep Learning Method.

Drug co-assemblies have attracted extensive attention due to their advantages of easy preparation, adjustable performance and drug component co-delivery. However, the lack of a clear and reasonable co-assembly strategy has hindered the wide application and promotion of drug-co assembly. This paper introduces a deep learning-based sonosensitizer-drug interaction (SDI) model to predict the particle size of the drug mixture.

The Protective Effects of Modified Dachaihu Decoction against LPS-induced Acute Lung Injury Modulating PI3K/Akt Signalling Pathway.

Background: Modified Dachaihu decoction (MDD) is a herbal prescription that has shown promising therapeutic benefits in ameliorating pulmonary diseases in clinical practice. However, the detailed mechanisms remain unclear.

Objective: This study aimed to elucidate the lung-protective effects of MDD against acute lung injury (ALI) and the involvement of underlying mechanisms.

FlexiPlasma Microcatheter-Embolic Material (FPM-EM) Platform: A Non-Inflammatory Pyroptosis Strategy for Precision Hepatocellular Carcinoma Therapy.

Hepatocellular carcinoma (HCC) remains a global challenge, with conventional locoregional therapies like transarterial chemoembolization (TACE) lacking tumor specificity and promoting metastasis and inflammation. Cold atmospheric plasma (CAP) offers a tumor-selective ablation strategy but suffers from limited tissue penetration. To overcome this, the FlexiPlasma microcatheter (FPM) is developed, integrating flexible non-metallic microtubes and ring-shaped electrodes for precise CAP delivery to deep tumors.

Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system.

Spiral ganglion neurons (SGNs) carry sound information from the cochlea to the hindbrain, and innervate either inner or outer hair cells. Type II SGNs (SGNIIs) extend peripheral afferents towards outer hair cells, which make a characteristic 90° turn towards the cochlear base and innervate multiple outer hair cells. It has been shown that the planar cell polarity (PCP) pathway acts non-autonomously in the cochlear epithelium to guide SGNII peripheral afferent turning.

Artificial intelligence: A key fulcrum for addressing complex environmental health issues.

Environmental health (EH) is a complex and interdisciplinary field dedicated to the examination of environmental behaviours, toxicological effects, health risks, and strategies for mitigating harmful environmental factors. Traditional EH research investigates correlations between risk factors and health outcomes through control variables, but this route is difficult to address complex EH issue. Artificial intelligence (AI) technology not only has accelerated the innovation of the scientific research paradigm but also has become an important tool for solving complex EH problems.

The impact of timing perception strategy on intertemporal decision-making in older adults: the role of subjective time perception.

With the global aging population, an increasing number of researchers are interested in the intertemporal choice issues faced by older adults. Previous studies have examined how age-related differences in time perception affect intertemporal choices. However, the impact of time perception strategy on intertemporal decision-making among older adults remains unclear.

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment.

The intricate interactions between the host immune system and its microbiome constituents undergo dynamic shifts in response to perturbations to the intestinal tissue environment. Our ability to study these events on the systems level is significantly limited by in situ approaches capable of generating simultaneous insights from both host and microbial communities. Here, we introduce Microbiome Cartography (MicroCart), a framework for simultaneous in situ probing of host and microbiome across multiple spatial modalities.

KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA.

Background: Krüppel-like factor 5 (KLF5) is recognized as a tumor mediator in multiple types of tumors. Nevertheless, whether KLF5 plays a role in gallbladder cancer (GBC) remains to be elucidated. This study aims to clarify the role of KLF5 in the proliferation, migration and angiogenesis in GBC cells.

Elastase-targeting biomimic nanoplatform for neurovascular remodeling by inhibiting NETosis mediated AlM2 inflammasome activation in ischemic stroke.

Neutrophil elastase (NE) is a protease released by activated neutrophils in the brain parenchyma after cerebral ischemia, which plays a pivotal role in the regulation of neutrophil extracellular traps (NETs) formation. The excess NETs could lead to blood-brain barrier (BBB) breakdown, overwhelming neuroinflammation, and neuronal injury. While the potential of targeting neutrophils and inhibiting NE activity to mitigate ischemic stroke (IS) pathology has been recognized, effective strategies that inhibit NETs formation remain under-explored.

Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling.

Intercellular signaling mediated by evolutionarily conserved planar cell polarity (PCP) proteins aligns cell polarity along the tissue plane and drives polarized cell behaviors during tissue morphogenesis. Accumulating evidence indicates that the vertebrate PCP pathway is regulated by noncanonical, β-catenin-independent Wnt signaling; however, the signaling components and mechanisms are incompletely understood. In the mouse hearing organ, both PCP and noncanonical Wnt (ncWnt) signaling are required in the developing auditory sensory epithelium to control cochlear duct elongation and planar polarity of resident sensory hair cells (HCs), including the shape and orientation of the stereociliary hair bundle essential for sound detection.

Exposure to organophosphate esters and early menopause: A population-based cross-sectional study.

Organophosphate esters (OPEs), increasingly used as new flame retardants and plasticizers in various products, have been found to have reproductive toxicity with overt endocrine disruption potential, yet the relationship between OPEs and early menopause remains unexplored. In the present study, we included 2429 women who participated in the U.S.

TTFDNet: Precise Depth Estimation from Single-Frame Fringe Patterns.

This work presents TTFDNet, a transformer-based and transfer learning network for end-to-end depth estimation from single-frame fringe patterns in fringe projection profilometry. TTFDNet features a precise contour and coarse depth (PCCD) pre-processor, a global multi-dimensional fusion (GMDF) module and a progressive depth extractor (PDE). It utilizes transfer learning through fringe structure consistency evaluation (FSCE) to leverage the transformer's benefits even on a small dataset.

Kidney targeting and modulating macrophage polarization through AMPK signaling: Therapeutic mechanism of berberine in uric acid nephropathy.

Uric acid nephropathy (UAN), caused by a common metabolic disorder resulting from hyperuricemia (HUA), has an increasing incidence. Previous studies have shown that berberine (BBR) has clear urate-lowering and anti-inflammatory effects in UAN mice, but its mechanism needs to be further clarified. Therefore, Potassium Oxonate (PO) combined with hypoxanthine (HX) induced UAN mice model and MSU induced THP-1 cells polarization model were adopted to investigate the mechanism of BBR on UAN in terms of tissue distribution and molecular pharmacology.

Rac1 and Nectin3 are essential for PCP-directed axon guidance in the peripheral auditory system.

Our sense of hearing is critically dependent on the spiral ganglion neurons (SGNs) that connect the sound receptors in the organ of Corti (OC) to the cochlear nuclei of the hindbrain. Type I SGNs innervate inner hair cells (IHCs) to transmit sound signals, while type II SGNs (SGNIIs) innervate outer hair cells (OHCs) to detect moderate-to-intense sound. During development, SGNII afferents make a characteristic 90-degree turn toward the base of the cochlea and innervate multiple OHCs.