Latent profile analysis for medication adherence in patients with chronic obstructive pulmonary disease.

Objective: This study examined the latent profile of medication adherence in patients with chronic obstructive pulmonary disease (COPD) and explored the influencing factors.

Methods: From October 2023 to January 2024, a quantitative cross-sectional study was conducted with 567 Chinese patients with COPD from 6 tertiary hospitals in Yunnan Province, Sichuan Province, Hubei Province, Shanghai and Chongqing, China, using demographic information and the medication compliance scale for COPD patients. Latent profile analyses were performed using Mplus 8.

High-Quality Perovskite Single Crystal Fabrication via Self-Assembled Microvesicles Assisted Localized Precursor Release.

The supersaturation degree of perovskite precursors is hardly controllable, usually leading to explosive nucleation, which is a great challenge for the solution growth of large-scale single crystals. In this work, a straightforward strategy is developed to simultaneously achieve precise nucleation control and significant growth acceleration of diverse perovskite single crystals through self-assembled propyl methacrylate-polyhedral oligomeric silsesquioxane (PMA-POSS) microvesicles. The microvesicles encapsulate high concentrations of perovskite precursors and achieve localized release via thermal polymerization-induced rupture.

Gadolinium-ceria hybrid system enables synergistic alleviation of oxidative stress and metabolic thrombo-inflammation for efficient ischemic stroke treatment.

Ischemic stroke is a primary cause of global death and long-term disability. However, current neuroprotective drugs are far from satisfactory in clinical practice. Compelling evidence has emerged that targeting conjoined multiple factors can bring comprehensive treatment.

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment.

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release.

Cadmium and pyrene in the soil modify the properties of earthworm-mediated soil.

Earthworms are pivotal in soil ecosystems due to their crucial role in shaping soil characteristics through casts and burrow walls. Previous research has predominantly focused on the direct impact of soil pollution on live earthworms, overlooking the subsequent effects on earthworm-mediated soil, such as casts and burrow walls. Using 2D-terraria as incubation containers and the geophagous earthworm species Metaphire guillelmi, this study assessed the change in various properties of earthworm-mediated soil in both uncontaminated soils and Cd- and Pye-contaminated soils.

Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy.

Background: The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern.

Methods: We reviewed our clinical experience with adoptive cellular CAR T-cell therapy at our institution since 2016 and ascertained the occurrence of second tumors. In one case of secondary T-cell lymphoma, a broad array of molecular, genetic, and cellular techniques were used to interrogate the tumor, the CAR T cells, and the normal hematopoietic cells in the patient.

Effects of cadmium and pyrene on earthworm-associated bacterial communities: Unveiling new perspectives for soil pollution management.

Earthworms are considered to be excellent bioindicators of soil pollution. In recent years, there has been increasing interest in examining the effects of soil pollution on earthworm-associated microbiomes, with a particular focus on the gut microbiomes. However, relatively little effort has been invested in comprehensively investigating other microbiomes associated with earthworms and their responses to soil pollution.

A negative capacitor emulator circuit and its application in chaotic circuits.

Negative capacitance usually exists in ferroelectric materials, and its instinct nonlinearity and negative capacitance render its potential applications. To date, the single negative capacitance device is commonly unavailable. Hence, it is necessary to build a negative capacitor emulator in hardware for further investigating its electrical characteristics and applications.

Biodegradable Chitosan-Based Membranes for Highly Effective Separation of Emulsified Oil/Water.

Efficient separation of oil droplets from oil/water emulsions is necessary for many energy and food industrial processes and for industrial wastewater treatment. Membrane microfiltration has been explored to address this issue because it is simple to operate and low in cost. However, filtration of oil droplets with a size around or less than 1 μm is still a major challenge.

Novel [F]-Labeled Meta-Bromobenzylguanidine Derivatives: Potential Positron Emission Tomography Imaging Probes for the Norepinephrine Transporter.

To develop novel norepinephrine transporter (NET)-targeting positron emission tomography (PET) probes with optimal pharmacokinetic properties, a series of -bromobenzylguanidine derivatives was synthesized. 4-Fluorodiethoxyethane-3-bromobenzylguanidine (compound ) showed relatively good affinity for the NET (IC = 1.00 ± 0.

Effect of urea feeding on transforming and migrating soil fluorine in a tea garden of hilly region.

The hilly region of western Sichuan is famous for producing Mengding-mountain tea in China. However, it is very easy to enrich fluorine (F) in tea, which recently raised people's concern on fluorosis. In this study, we simulated the local special climate conditions, especially the natural precipitation through column leaching experiment to investigate the effect of fertilization on F desorption from soil.

Preparation and biological evaluation of radioiodine-labeled triphenylphosphine derivatives as mitochondrial targeting probes.

The positive-charged lipophilic triphenylphosphonium cations (TPPs ) have been served as mitochondrial targeting vehicles for the delivery of various probes. In this study, we developed a new method for the preparation of radioiodine-labeled TPPs . Four I-labeled TPPs , [ I] 9-[ I] 12, were prepared from the corresponding triphenylphosphine phenylborate precursors of B 5-B 8 via an optimized copper-catalyzed one-step procedure in high radiochemical yield (>95%).