Tumor Microenvironment-Activated Fe-Doped Dendritic Mesoporous Organosilica Nanocomposites as Ferroptosis Inducers for Enhanced Immunotherapy.

Dendritic mesoporous organosilica (DMOS) nanoparticles are widely used to transport therapeutic agents to cancer sites and rapidly release them owing to their rapid biodegradability in the tumor microenvironment (TME). However, the role of these DMOS nanoparticles as nanocarriers is limited, and their applications remain relatively simple. In this study, Fe-doped dendritic mesoporous organosilica (Fe-DMOS) nanoparticles are designed as a new type of ferroptosis inducer and are combined with sodium hyaluronate-modified calcium peroxide to form TME-responsive nanocomposites.

Sarcoplasmic reticulum-mitochondrial calcium communication: A new target for cardiovascular therapy.

Cardiovascular disease (CVD) remains a leading cause of mortality and disability globally. Various cardiovascular diseases are often associated with ion dyshomeostasis within and outside cardiomyocytes, such as sodium ions, calcium ions and potassium ions. Calcium ions (Ca) not only participate in the contractile activity of cardiomyocytes and smooth muscle cells, but also participate in the tricarboxylic acid cycle as a cellular energy source, and act as a second messengers during many biological processes.

Sof t Bio-Electroactive Hydrogels for Musculoskeletal Tissue Repair and Rehabilitation.

Musculoskeletal tissue repair and rehabilitation face significant challenges in effectively repairing injured tissues and achieving functional recovery. Recent advancements highlight the crucial role of electrical conductivity in modulating cellular activity, promoting tissue repair, and enhancing recovery. This understanding leads to the development of bio-electroactive materials that combine biocompatibility with electrical conductivity to interact with biological systems.

Photothermal Anti-icing Coatings Composed of Spherical Multiwalled Carbon Nanotube Modified Particles: Synergistic High-Efficiency Deicing and Superior Thermal Conductivity.

The accumulation of ice on exposed surfaces in freezing conditions creates substantial operational difficulties for critical infrastructure across aviation, energy networks, and transportation systems, elevating risks of dangerous situations. This study focuses on the development of a photothermal superhydrophobic anti-icing coating with enhanced thermal conductivity, low cost, and simple fabrication. The coating combines passive anti-icing properties with active deicing capabilities, utilizing carboxylated MWCNTs modified with 1,1,2,2-perfluorodecyltrimethoxysilane (FDTS) to form micron particles (CMPs).

A physics-informed deep learning approach to predicting bilateral ground reaction forces and centre of pressure from a single forceplate during gait.

Background: Measuring bilateral ground reaction forces (GRFs) and centre of pressure (COP) is essential in gait analysis, requiring subjects to step each foot sequentially onto a separate forceplate. However, this requirement often causes multiple trial attempts, especially in patients with neuromusculoskeletal disorders. Consciously targeting the forceplates could also alter walking mechanics, leading to unnatural gait patterns.

Dual Strategy of Ca Influx and Collagen Denaturation to Remodel the Extracellular Matrix and Amplify Sonopiezoelectric Therapy.

Extracellular matrix (ECM), a core member of tumor microenvironment, is ≈1.5-fold harder than the surrounding normal tissues. Regulating the stiffness of ECM can significantly impact physiological activities of tumor cells, such as growth, differentiation, and migration.

Single-cell RNA sequencing generates an atlas of normal tibia cartilage under mechanical loading conditions.

Chondrocytes in articular cartilage can secrete extracellular matrix to maintain cartilage homeostasis. It is well known that articular cartilage chondrocytes are sensitive to mechanical loading and that mechanical stimuli can be translated to biological processes. This study provides deep insight into the impact of mechanical loading on chondrocytes via single-cell RNA sequencing (scRNA-seq).

Anchoring Ru single-atoms on MXene achieves dual-enzyme activities for mild photothermal augmented nanocatalytic therapy.

Single-atom catalysts with abnormally high catalytic activity have garnered extensive attention and interest for their application in tumor therapy. Despite the advancements made with current nanotherapeutic agents, developing efficient systems for cancer treatment remains challenging due to low activity, uncontrollable behavior, and nonselective interactions. Herein, we have constructed Ru single-atom-anchored MXene nanozymes (Ru-TiCT-PEG) with a mild photothermal effect and multi-enzyme catalytic activity for synergistic tumor therapy.

Lighting Up Dual-Aptamer-Based DNA Logic-Gated Series Lamp Probes with Specific Membrane Proteins for Sensitive and Accurate Cancer Cell Identification.

Accurate identification of cancer cells under complex physiological environments holds great promise for noninvasive diagnosis and personalized medicine. Herein, we developed dual-aptamer-based DNA logic-gated series lamp probes (Apt-SLP) by coupling a DNA cell-classifier (DCC) with a self-powered signal-amplifier (SSA), enabling rapid and sensitive identification of cancer cells in a blood sample. DCC is endowed with two extended-aptamer based modules for recognizing the two cascade cell membrane receptors and serves as a DNA logic gate to pinpoint a particular and narrow subpopulation of cells from a larger population of similar cells.

China's municipal wastewater policies enhanced seafood safety and offset health risks from atmospheric mercury emissions in the past four decades.

The neurotoxin methylmercury in seafood threatens food safety worldwide. China has implemented stringent wastewater policies, established numerous treatment facilities and enforced rigorous water quality standards to address pollution in its waterways. However, the impact of these policies on seafood safety and methylmercury exposure remains unknown.

Cure the Incurable: Update of Treatment in Inherited Neuromuscular Disorders.

Originally thought to be incurable, huge therapeutic progress has been made in recent years in the field of inherited neuromuscular disorders. Approaches aiming to rescue the underlying pathophysiology, i.e.

Coassembly of Dual-Modulated AIE-ESIPT Photosensitizers and UCNPs for Enhanced NIR-Excited Photodynamic Therapy.

Aggregation-induced emission (AIE) photosensitizers are promising for photodynamic therapy, yet their short excitation wavelengths present a limitation. In this study, we develop a series of organic photosensitizers with dual modulation capabilities based on excited-state intramolecular proton transfer (ESIPT) and AIE. Notably, we synthesize near-infrared (NIR)-excited photosensitive nanoparticles through a coassembly strategy utilizing upconversion nanoparticles (UCNPs) and amphiphilic polymers.

Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.

Objectives: This study aimed to investigate the effects of silencing Ras homolog family member C (RhoC) on the proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT) of salivary adenoid cystic carcinoma (SACC) and its molecular mechanisms.

Methods: A total of 27 SACC lesions and normal salivary gland tissues that were surgically resected at Qingdao Municipal Hospital from January 1, 2019 to March 1, 2024 were selected, and the expression levels of RhoC were detected by Western blot and immunohistochemistry. Three small interfering RNA (siRNAs) were designed to target the RhoC gene sequence, transfected into SACC-LM and SACC-83 cell lines, and evaluated for transfection efficiency.

GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects.

Background: The process of bone healing is complex and involves the participation of osteogenic stem cells, extracellular matrix, and angiogenesis. The advancement of bone regeneration materials provides a promising opportunity to tackle bone defects. This study introduces a composite hydrogel that can be injected and cured using UV light.

A multi-objective optimal control approach to motor strategy changes in older people with mild cognitive impairment during obstacle crossing.

Background: Mild cognitive impairment (MCI) may lead to difficulty maintaining postural stability and balance during locomotion. This heightened susceptibility to falls is particularly evident during tasks such as obstacle negotiation, which demands efficient motor planning and reallocation of attentional resources. This study proposed a multi-objective optimal control (MOOC) technique to assess the changes in motor control strategies during obstacle negotiation in older people affected by amnestic MCI.

Injectable hybrid nanofibrous spheres made of PLA and nano-hydroxyapatite for cell delivery and osteogenic induction.

Introduction: Nanofibrous spheres, with their injectable format and biomimetic three-dimensional topologies that emulate the complexity of natural extracellular environments, have become increasingly attractive for applications in biomedical and regenerative medicine. Our research contributes to this growing field by detailing the design and fabrication of a novel series of polylactic acid/nano-hydroxyapatite (PLA/nHA) hybrid nanofibrous spheres.

Methods: These advanced structures were created by integrating electrospinning and electrospray techniques, which allowed for precise control over the nanofibrous spheres, especially in size.

Injectable GelMA Hydrogel Microspheres with Sustained Release of Platelet-Rich Plasma for the Treatment of Thin Endometrium.

Platelet-rich plasma (PRP) intrauterine infusion has been demonstrated to be effective in treating thin endometrium and achieving pregnancy. However, the rapid release of growth factors limits its effectiveness in clinical applications, and thus, multiple intrauterine infusions are often required to achieve therapeutic efficacy. In this study, a GelMA hydrogel microsphere biomaterial is developed using droplet microfluidics to modify the delivery mode of PRP and thus prolong its duration of action.

Four Birds with One Stone: A Bandgap-Regulated Multifunctional Schottky Heterojunction for Robust Synergistic Antitumor Therapy upon Endo-/Exogenous Stimuli.

Considering the profound impact of structure on heterojunction catalysts, the rational design of emerging catalysts with optimized energy band structures is required for antitumor efficiency. Herein, we select titanium nitride (TiN) and Pt to develop a multifunctional Schottky heterojunction named Pt/H-TiN&SRF (PHTS) nanoparticles (NPs) with a narrowed bandgap to accomplish "four birds with one stone" involving enzyo/sono/photo three modals and additional ferroptosis. The -grown Pt NPs acted as electron traps that can cause the energy band to bend upward and form a Schottky barrier, thereby facilitating the separation of electron/hole pairs in exogenous stimulation catalytic therapy.

Damage Characteristics Analysis of Laser Ablation Triple-Junction Solar Cells Based on Electroluminescence Characteristics.

To study the physical property effects of the laser on GaInP/GaAs/Ge solar cells and their sub-cell layers, a pulsed laser with a wavelength of 532 nm was used to irradiate the solar cells under various energy conditions. The working performance of the cell was measured with a source meter. The electroluminescence (EL) characteristics were assessed using an ordinary and an infrared camera.

Methacrylated Carboxymethyl Chitosan Scaffold Containing Icariin-Loaded Short Fibers for Antibacterial, Hemostasis, and Bone Regeneration.

Bone defects typically result in bone nonunion, delayed or nonhealing, and localized dysfunction, and commonly used clinical treatments (i.e., autologous and allogeneic grafts) have limited results.

The efficacy and safety of Xiao-Ban-Xia-Tang in the treatment of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.

Background: Chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent and critical side effects due to chemotherapeutics. In China, Xiao-Ban-Xia-Tang (XBXT) has already been applied extensively to prevent and treat CINV. However, there is limited testimony on the effectiveness and safety of this purpose, and there was no correlative systematic review.

Temporal and Spatial Distribution Characteristics of Crosstalk Lines Generated by Irradiating Progressive Scan Charge-Coupled Device Camera with Continuous Laser.

To study the interference effect of the laser in motion mode on a CCD, the continuous laser with the wavelength of 532 nm at different motion speeds was used to scan the CCD. The experimental results show that the crosstalk phenomenon produced by static and dynamic irradiation is significantly different. When the continuous laser statically radiates the CCD, the vertical crosstalk line is observed in the output image.

Oxygen Vacancy Piezoelectric Nanosheets Constructed by a Photoetching Strategy for Ultrasound "Unlocked" Tumor Synergistic Therapy.

Piezoelectric dynamic therapy (PzDT) is an effective method of tumor treatment by using piezoelectric polarization to generate reactive oxygen species. In this paper, two-dimensional Cu-doped BiOCl nanosheets with surface vacancies are produced by the photoetching strategy. Under ultrasound, a built-in electric field is generated to promote the electron and hole separation.

Enhancing tendon-bone integration and healing with advanced multi-layer nanofiber-reinforced 3D scaffolds for acellular tendon complexes.

Advancements in tissue engineering are crucial for successfully healing tendon-bone connections, especially in situations like anterior cruciate ligament (ACL) restoration. This study presents a new and innovative three-dimensional scaffold, reinforced with nanofibers, that is specifically intended for acellular tendon complexes. The scaffold consists of a distinct layered arrangement comprising an acellular tendon core, a middle layer of polyurethane/type I collagen (PU/Col I) yarn, and an outside layer of poly (L-lactic acid)/bioactive glass (PLLA/BG) nanofiber membrane.