The association between playing Ma-jong, chess, and card games and cognitive function improvement in middle-aged and elderly Chinese: cross-sectional evidence from CHARLS.

Background: The relationship between participation in Ma-jong, chess, and card games (PMCC) and cognitive function improvement among middle-aged and elderly adults in China is not well-established. This study aims to investigate the potential association between PMCC participation and cognitive function improvement in this demographic, using data from the China Health and Retirement Longitudinal Study (CHARLS).

Methods: Data from the 2018 wave of CHARLS were analyzed.

ABCC3 mediates insecticide metabolism and functions as a receptor for Bt toxins in Plutella xylostella.

Plutella xylostella is a major global pest with increasing resistance to insecticides. ATP-binding cassette (ABC) transporters are implicated in the metabolism of insecticides, but their molecular mechanisms remain poorly understood. Here, we identified and characterized the role of P.

Clinical efficacy and radiological changes of proximal fibular osteotomy for medial compartment knee osteoarthritis: a systematic review and meta-analysis.

Objective: We aimed to analyze the clinical efficacy, safety, and radiological changes of proximal fibular osteotomy (PFO) for medial compartment knee osteoarthritis (MKOA).

Methods: Since the establishment of the databases, we searched all studies involving proximal fibular osteotomy in PubMed, Proquest, Scopus, and Web of Science. The outcomes of interest were visual analog scale (VAS), knee function scores, radiological results, and complication rates.

Alternating Interlayered Piezoelectric Self-Heterojunction Boosts Sono-Piezocatalytic Pyroptosis Oncotherapy.

Recombination of sono-generated charge carriers is a major barrier hindering the effectiveness of piezocatalytic oncotherapy. Herein, ultrathin oxygen vacancy-engineered self-heterojunction bismuth oxysilicate (O-BOS) nanosheets with alternating hetero-layered nanostructure are constructed for enhanced sono-piezocatalytic tumor therapy. Benefiting from its out-of-plane asymmetry, O-BOS features an exceptional electromechanical strain coefficient (d = 203 pm/V), highlighting its outstanding capability as a piezoelectric heterojunction for energy conversion.

An Overview of Seafood Allergens: Structure-Allergenicity Relationship and Allergenicity Elimination Processing Techniques.

Seafood (fish, crustacean, and mollusk) allergy represents a critical global health issue. Food processing offers a viable strategy for allergenicity mitigation and serves as a critical intervention for seafood allergy prevention. This paper reviews recent advances in seafood allergen research, with particular focus on molecular properties, epitopes, and structure-allergenicity relationships, which are foundations for designing processing technologies to mitigate allergenicity.

MicroRNA-361-3p Regulates Autophagy and Apoptotic Processes by Regulating PI3K/Akt Signaling in Parkinson's Disease.

MicroRNAs are closely related to the pathogenesis of Parkinson's disease (PD). The purpose of this study was to explore the effects of microRNA (miR)-361-3p on apoptosis and autophagy in 1-methyl-4-phenylpyridinium ion (MPP) induced PD cell models, and its potential mechanisms. SH-SY5Y cells were induced by 1.

Self-supported lignin-derived carbon coupling with Mo-doped NiO and NiCo alloy heterojunction stimulates lattice tensile strain and electron transfer for boosting ampere-level urea electrolysis.

Developing highly active lignin carbon-based electrocatalysts for urea electrolysis is critical but remains a considerable challenge. Herein, a self-supported lignin-derived carbon coupling with Mo-doped NiO and NiCo alloy heterojunction (Mo-NiO@NiCo/C) has suitable lattice tensile strain and rapid electron transfer, thereby achieving high catalytic performance for urea electrolysis under large current density. The operando electrochemical impedance results demonstrate that Mo-NiO@NiCo/C undergoes an indirect oxidation step during the urea oxidation reaction (UOR) and follows the Volmer-Heyrovsky mechanism during the hydrogen evolution reaction (HER).

Low-dimensional solid-state single-photon emitters.

Solid-state single-photon emitters (SPEs) are attracting significant attention as fundamental components in quantum computing, communication, and sensing. Low-dimensional materials-based SPEs (LD-SPEs) have drawn particular interest due to their high photon extraction efficiency, ease of integration with photonic circuits, and strong coupling with external fields. The accessible surfaces of LD materials allow for deterministic control over quantum light emission, while enhanced quantum confinement and light-matter interactions improve photon emissive properties.

Lactic acid bacteria fermentation: A novel and promising pathway to lower the uric acid production of seaweed food (Porphyra haitanensis).

Porphyra haitanensis is a highly nutritious and widely consumed seaweed food. However, it is a high-purine food, which can increase the risk of disease for individuals with hyperuricemia. To address this issue, three lactic acid bacteria strains, including Lactiplantibacillus plantarum, Lacticaseibacillus paracasei, and Lacticaseibacillus rhamnosus, are utilized to investigate the effects of fermentation on Porphyra haitanensis to reduce the purine content and the activity of xanthine oxidase (XOD) and adenosine deaminase (ADA).

Optimization of Interfacial Electrons and Compressive-Tensile Strains at Lignin-Derived Carbon-Supported Multiphase Ni/Cu/MoO Interfaces for Boosting Large Current-Density HER.

Developing efficient pH-universal hydrogen evolution electrocatalysts is critically needed yet challenged by pH-dependent. Here, a lignin-derived carbon-supported Ni/Cu/MoO heterostructure (Ni/Cu/MoO@LC) through multiphase interfaces design is engineered, which displays excellent electrochemical activity, featuring low potentials of -14.4/-201.

Screening and Interaction Analysis of Shark-Derived Nanobodies against Crayfish Major Allergen Pro c 2.

Pro c 2 (arginine kinase) is a major allergen in crayfish (). Shark-derived variable domains of new antigen receptors (VNARs) have advantages in developing allergen detection and immunotherapy. This study constructed a VNAR domain library from immunized with Pro c 2.

Finely tailoring the local ensembles in heterostructured high entropy alloy catalysts through pulsed annealing.

High-entropy alloys (HEAs) are promising catalysts particularly adept for reactions involving multiple intermediates and requiring multifunctional active sites. However, conventional syntheses often result in either (kinetically) random-mixing HEA or (thermodynamically) phase-separated composites-both fail to fine-tune local structures and further optimizing their performances. Here we present finely tailoring the local ensembles in HEA catalysts through rational composition design and sequential pulsed annealing.

Clinical evaluation of arthroscopic decompression of spinoglenoid notch cyst through a single posterior portal.

Purpose: This study aims to describe and evaluate the arthroscopic technique for decompressing spinoglenoid notch cyst (SGNC) using a single posterior working portal.

Methods: From January 2010 to March 2022, 20 patients with SGNC who were available for a minimum of 2 years of follow-up were included. All surgical procedures involved suprascapular nerve (SSN) decompression via a posterior portal.

Hypertrophic Cardiomyopathy: Genes and Mechanisms.

Hypertrophic cardiomyopathy (HCM) is a hereditary disease of the myocardium characterized by asymmetric hypertrophy (mainly the left ventricle) not caused by pressure or volume load. Most cases of HCM are caused by genetic mutations, particularly in the gene encoding cardiac myosin, such as , , and . These mutations are usually inherited autosomal dominantly.

Finely Tailoring Metal-Support Interactions via Transient High-Temperature Pulses.

Metal-support interactions (MSI) play a crucial role in enhancing the catalytic activity and stability of metal catalysts by establishing a stable metal-oxide interface. However, precisely controlling MSI at the atomic scale remains a significant challenge, as how to construct an optimal MSI is still not fully understood: Both insufficient and excessive MSI showed inferior catalytic performance. In this study, we propose finely tuning MSI using temporal-precise transient high-temperature pulse heating.

Telecom-Wavelength Single-Photon Emitters in Multilayer InSe.

The development of robust and efficient single-photon emitters (SPEs) at telecom wavelengths is critical for advancements in quantum information science. Two-dimensional (2D) materials have recently emerged as promising sources for SPEs, owing to their high photon extraction efficiency, facile coupling to external fields, and seamless integration into photonic circuits. In this study, we demonstrate the creation of SPEs emitting in the 1000-1550 nm near-infrared range by coupling 2D indium selenide (InSe) with strain-inducing nanopillar arrays.

Clinical value and role of long non-coding RNA PSMB8-AS1 in the progress of ischemic stroke in patients with hypertension.

Hypertension is a common risk factors for ischemic stroke (IS), with the widely involvement of long non-coding RNAs (lncRNAs). The expression pattern and clinical significance of lncRNA PSMB8-AS1 was examined in essential hypertension (EH) patients with or without IS, as well as its role and mechanism in IS-induced neuron cell injury. Serum PSMB8-AS1 levels in 260 EH cases without IS and 280 participants with IS were detected via reverse transcription - quantitative polymerase chain reaction (RT-qPCR).

Spacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3-4 medial unicompartmental knee osteoarthritis in patients younger than 65 years.

Background: Spacer-type tibial osteotomy have been proven a novel and effective osteotomy to treat osteoarthritis, while lack of comparison with other surgical methods in younger patients. This study aims to evaluate the short-term clinical outcomes of spacer-type tibial osteotomy versus open wedge high tibial osteotomy (OWHTO) and unicompartmental knee arthroplasty (UKA) for Kellgren-Lawrence (K-L) grade 3-4 osteoarthritis (OA) in patients younger than 65 years.

Methods: This retrospective study analyzed a total of 224 patients with K-L grade 3-4 knee OA treated from March 2018 to November 2020.

Squeeze pumping of lipids and insecticides by ABCH transporter.

ATP-binding cassette (ABC) transporter subfamily H is only identified in arthropods and zebrafish. It transports lipids and is related to insecticide resistance. However, the precise mechanisms of its functions remain elusive.

Superhydrophilicity and Electronic Modulation on Self-Supported Lignin-Derived Carbon Coupled with NiO@MoNi for Enhancing Urea Electrolysis.

Developing highly efficient biomass-derived carbon-based electrocatalysts remains challenging for urea electrolysis because most of these electrocatalysts show powder morphology, which can lead to Ostwald ripening during the reaction process, and its reaction mechanism should be further verified. Herein, self-supported lignin-derived carbon coupling NiO@MoNi heterojunction (NiO@MoNi/C) possesses superhydrophilic properties and electronic modulation, boosting the performance of urea electrolysis. Electrochemical results show that an indirect oxidation step for urea oxidation reaction (UOR) and Volmer-Heyrovsky mechanism for hydrogen evolution reaction (HER) occurs on the surface of NiO@MoNi/C.

Blockage of polycystin-2 alleviates myocardial ischemia/reperfusion injury by inhibiting autophagy through the Ca/Akt/Beclin 1 pathway.

Autophagy is a well-conserved self-protection process that plays an important role in cardiovascular diseases. Excessive autophagy during myocardial ischemia/reperfusion injury (MIRI) induces calcium overload and the overactivation of an autophagic response, thereby aggravating cardiomyocyte damage. Polycystin-2 (PC2) is a Ca-permeable nonselective cation channel implicated in the regulation of autophagy.

MoZn-based high entropy alloy catalysts enabled dual activation and stabilization in alkaline oxygen evolution.

It remains a grand challenge to develop electrocatalysts with simultaneously high activity, long durability, and low cost for the oxygen evolution reaction (OER), originating from two competing reaction pathways and often trade-off performances. The adsorbed evolution mechanism (AEM) suffers from sluggish kinetics due to a linear scaling relationship, while the lattice oxygen mechanism (LOM) causes unstable structures due to lattice oxygen escape. We propose a MoZnFeCoNi high-entropy alloy (HEA) incorporating AEM-promoter Mo and LOM-active Zn to achieve dual activation and stabilization for efficient and durable OER.

GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects.

Background: The process of bone healing is complex and involves the participation of osteogenic stem cells, extracellular matrix, and angiogenesis. The advancement of bone regeneration materials provides a promising opportunity to tackle bone defects. This study introduces a composite hydrogel that can be injected and cured using UV light.

Engineering of novel vanadium-doped NiN@CuCoN heterostructure for enhancing urea oxidation reaction at high current density.

Exploring highly effective nickel-based catalytic materials for urea oxidation reaction (UOR) at high current density remains a challenging task for urea electrolysis. Herein, the vanadium-doped NiN@CuCoN heterostructure with brush shape structure supported on copper foam (denoted as V-doped-NiN@CuCoN/CF) is prepared to serve as a highly-performing UOR electrocatalyst at high current density (E = 1.26/1.