V-Induced Low-Spin State Mn Suppresses Jahn-Teller Distortion for High-Performance Aqueous Zinc Ion Batteries.

The Jahn-Teller distortion caused by high-spin state Mn (t e ) is a major limiting factor for improving both the specific capacity and cycling stability of MnO cathodes in aqueous zinc-ion batteries. Thus, an intrinsic strategy for optimizing MnO involves the effective elimination of the high-spin state Mn (t e ) during electrochemical process. Herein, we focus on structural design that constructed NHVO-coated MnO (Mn@V) nanorods to achieve the low-spin state of Mn (t e ) and inhibit the Jahn-Teller distortion.

Retracted: Transplantation of Recombinant Vascular Endothelial Growth Factor (VEGF)189-Neural Stem Cells Downregulates Transient Receptor Potential Vanilloid 1 (TRPV1) and Improves Motor Outcome in Spinal Cord Injury.

Retraction Notice: This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Yun Zeng, Heng Han, Bing Tang, Jie Chen, Dan Mao, Min Xiong. Transplantation of Recombinant Vascular Endothelial Growth Factor (VEGF)189-Neural Stem Cells Downregulates Transient Receptor Potential Vanilloid 1 (TRPV1) and Improves Motor Outcome in Spinal Cord Injury.

Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosis.

There is a significant gap in multi-omics studies on keloids, especially concerning the interaction between fibroblasts and super-enhancers (SEs). Identifying novel biomarkers within the epigenetic landscape could greatly improve keloid management. In this study, we investigated gene expression at both transcriptional and translational levels to identify potential biomarkers and employed CUT&Tag technology to validate SE-associated genes and upstream transcription factors (TFs).

Highly Proton-Conductive Solid-State Electrolyte Based on Covalent Organic Framework for Proton Battery Application.

Solid-state proton batteries are emerging as promising technologies for energy storage. However, efficient solid-state protonic electrolyte development remains in its early stages. Herein, we report the preparation and potential application of a high-performance covalent organic framework (COF)-based protonic electrolyte for solid-state proton batteries.

A methodological design and an empirical study for assessing the maturity of an UASR based on the AHP-EWM and the FSEM fusion model.

A multi-model fusion evaluation method based on indexes construction is discussed in this paper for evaluating the maturity level of an Uncertainty Analysis System for Radiotherapy (UASR). First, a system for evaluating the capability maturity of the UASR is established. Second, three first-level evaluation indicators for people, technology and process are constructed, and twelve second-level evaluation indicators are formed under the three first-level indicators.

Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble.

A machine learning model was developed and validated to predict postoperative complications in patients with acute type A aortic dissection (ATAAD) who underwent total arch replacement combined with frozen elephant trunk (TAR + FET), with the goal of improving postoperative survival quality and guiding clinical treatment. We retrospectively analyzed data from 635 ATAAD patients who underwent TAR + FET surgery at our institution between January 2018 and October 2023. Based on the International Aortic Arch Surgery Study Group definition of Major Adverse Outcomes (MAO), the entire dataset was divided into 160 patients with MAO and 475 patients without MAO.

Enzymatic property and stabilization mechanism of LysBT1, a novel polyextremotolerant endolysin with a C-terminal S-layer homology domain.

Phage-encoded endolysins are getting increasing attention because of their potential to serve as alternative antimicrobials to combat antibiotic-resistant bacteria. Here, we report a novel endolysin LysBT1, which is encoded by a prophage of thermophilic WF146 and comprises an N-acetylmuramoyl-L-alanine amidase domain and an S-layer homology (SLH) domain not found in known endolysins. LysBT1 is not only extremely thermostable, retaining more than 60% activity after 1 h incubation at 95°C, but also highly stable over a wide pH range of 4.

Comparative study on the effect of different high-frequency chest wall oscillation and back patting modes on sputum excretion in patients with severe pneumonia.

Background: The effect of different backslapping parameters on sputum discharge in SP patients is unclear.

Objective: To investigate the effects of different back-patting modes on sputum clearance from the lungs of SP patients. To provide a theoretical basis for future clinical care and development of critical care robots.

Coupling Dimethylglyoxime to Enhance Coordination Bonds of Pd Single-Atom Catalyst for Solving Stability and Activity Conflict.

Regulating the strength of coordination bonds plays an important role in synergizing the activity and stability of single-atom catalysts (SACs) but is often limited due to coordination atoms from the inorganic carrier lattice being tough to modify. It is fascinating yet rarely explored to immobilize organic molecules on lattice atoms for modulating the character of coordination bonds. Herein, a valid inorganic-organic coupling strategy is developed to enhance Pd-O coordination bonds within Pd-SAC for reconciling activity and stability.

Deglet Noor date derived polysaccharides lower blood glucose levels and modulate the gut microbiota in a streptozotocin-induced type-1 diabetic mouse model.

Diabetes mellitus is a chronic metabolic disorder marked by insulin deficiency and hyperglycemia. At present, pharmacotherapy involving synthetic diabetic agents is widely used, but it comes with side effects. In contrast, natural compounds like polysaccharides show promising anti-diabetic activity and are increasingly used alongside conventional therapies, especially in developing countries.

Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

Background: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain (VLA1553), with viraemic vaccine recipients theoretically able to transmit VLA1553 to mosquitoes with ensuing onward transmission. We thus evaluated VLA1553 transmission from artificial blood meals to Aedes albopictus mosquitoes, and onward transmission to mice.

Site-Specific Spin State Modulation in Spinel Oxides for Enhanced Nonradical Oxidation.

Spinel oxides hold tremendous potential for driving advanced oxidation processes, yet the underlying mechanism for maximizing their activity remains unclear. In this study, we leverage tetrahedral and octahedral site interactions in MnCoO to modulate the spin states, specifically spin alignment and spin moment, thereby enhancing periodate (PI) activation and catalytic performance in contaminant degradation. Through combined experimental and density functional theory (DFT) analyses, we elucidate the role of spin alignment at synergetic tetrahedral and octahedral sites in facilitating quantum spin exchange interactions (QSEI) with an efficient electronic spin channel for charge transfer.

Recognizing the state of aerobic granular sludge over its life-cycle in a continuous-flow membrane bioreactor with an artificial intelligence approach.

The continuous-flow aerobic granular sludge-membrane bioreactor (AGS-MBR) system represents an efficient and sustainable technology for wastewater treatment. AGS, a spherical or ellipsoidal granular sludge formed through microbial self-aggregation under aerobic conditions, progresses through four distinct life-cycle stages in the AGS-MBR system: initial, growth, mature, and cleaved. Accurate identification and classification of these stages are crucial for optimizing AGS-MBR operations and maintaining system stability; however, traditional monitoring methods are labor-intensive and error-prone.

Helical Perovskite Nanowires with Strong Circularly Polarized Luminescence Self-Assembled from Red-Emitting CsPbI Quantum Dots Following Chiral Ligand Exchange.

Circularly polarized luminescence (CPL) of chiral perovskite nanocrystals is crucial for applications such as spin-polarized light-emitting diodes and chiral photodetectors. However, the reported luminescence dissymmetry factors are often too low for practical applications; it is also important for CPL wavelengths to cover the red emission range for display applications. Herein, we realized helical perovskite nanowires self-assembled from red-emitting CsPbI quantum dots (QDs) with a strong CPL signal around 640 nm, which was enabled by chiral ligand R-/S-binaphthyl phosphoric acid.

Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak.

Human infections with the Japanese encephalitis virus (JEV) are a leading cause of viral encephalitis. An unprecedented outbreak of JEV genotype 4 was recently reported in Australia, with an isolate (JEV) obtained from a stillborn piglet brain. Herein we conduct a thorough characterization of JEV in three different mouse strains and in human cortical brain organoids (hBOs), and determined the ability of JEV to be neutralized by sera from humans vaccinated with IMOJEV.

Evolution of Zika virus in -deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness.

N-linked glycosylation of flavivirus envelope proteins is widely viewed as being required for optimal folding, processing and/or transit of envelope proteins, and the assembling virons, through the endoplasmic reticulum (ER) and the Golgi. Zika virus (ZIKV) has a single N-linked envelope glycan located adjacent to the fusion loop. Herein we show that independent serial passage of ZIKV in mice for 223 or 386 days generated two unique envelope glycan-deficient mutants, ZIKV-V153D and ZIKV-N154D, respectively.

Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer.

Background: This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.

Material And Methods: A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GPR27 expression was assessed using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry.

Ladder-Like Built-In Electric Field Enhances Self-Assembly, Carrier Separation and Ultra-Efficient Photocatalytic Oxygen Reduction.

Semiconductor heterojunctions can significantly enhance the separation of photogenerated charge carriers, among which Z-type heterojunctions are more conducive to photocatalysis due to their special transfer paths and strong oxidizing and reducing properties. However, introducing efficient active sites has always been a significant challenge in the improvement of heterogeneous photocatalysts. Herein, through in-depth analysis of the reaction mechanism and structural characteristics, single atom catalysts and heterojunctions are ingeniously integrated using built-in electric fields.

Precise Engineering of Asymmetric Tri-Active Sites by Symbiotic Strategy for Photocontrolled Directional Reforming of Biomass.

Sunlight-driven production of high-value chemicals from renewable resources represents a pivotal driver toward achieving sustainable energy supply. However, fundamental barriers include inadequate use of light energy and insufficient understanding of reactive oxygen species (ROS) regulating mechanisms in photocatalytic processes. To address this, a novel symbiotic strategy for the design of Cu/TiO single-atom catalysts (SACs) supported by density functional theory (DFT) calculations was proposed.

Prediction methodology of air absorbed dose rates for Chinese cities with deep learning models.

Air absorbed dose rate is a key indicator of environmental radiation exposure. In China, automated environmental radiation monitoring systems have been established in multiple cities to continuously measure air absorbed dose rates. Nevertheless, developing effective preventive strategies based solely on data monitoring remains challenging.

Association and mediation between circulating inflammatory proteins and skin fibrosis.

Objective: Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating inflammatory proteins (CIPs) and skin fibrosis remains unclear. To investigate this potential association and mediated effect, Mendelian randomization (MR) and two-step MR were used.

A study on the effectiveness of multiple intraoperative disinfections and bacteriological monitoring in reducing postoperative intracranial infection rates in transnasal endoscopic skull base surgery.

Objective: This study aims to evaluate the clinical significance of multiple intraoperative sterilizations and bacteriological surveillance in reducing postoperative intracranial infections during transnasal endoscopic skull base surgery.

Methods: This study collected clinical data from 1002 patients undergoing transnasal endoscopic skull base surgery between January 2016 and January 2024. Patients were divided into a routine sterilization group (367 patients) and a multiple sterilization group (635 patients) based on the sterilization method.

Noncanonical amino acids as prophage inducers for protein regulation in bacteria-based delivery systems.

Unlabelled: Genetically engineered bacteria represent a promising drug delivery tool for disease treatment. The development of new strategies for specific and independent protein regulation is necessary, especially for combination protein drug therapy. Using the well-studied phage λ as a model system, we applied onanonical mino cid (ncAAs) as novel inducers for protein regulation in a bacteria-based delivery system.