Effects of anaesthesia on cognitive function in young and aged mice: Role of c-Fos expression in hippocampal neuron excitability.

Objective: This study aims to investigate the effects of anaesthesia and surgical procedures on the cognitive function of both young and aged mice. It will also explore the role and mechanisms of c-Fos expression in altering hippocampal neuron excitability and its relationship with perioperative neurocognitive disorders in mice.

Methods: In this study, we used a murine laparotomy model to assess cognitive behavioural changes in both young and aged mice at 1, 3, and 7 days post-surgery.

Zinc ions coordinated carboxymethyl chitosan hydrogel doped with ellagic acid for accelerative diabetic wound healing.

Diabetic wound healing remains a critical clinical challenge due to persistent inflammation derived from long-term hyperglycemia. To address this challenge, we reported a zinc ion coordinated CMCS hydrogel for pH responsive delivery of ellagic acid to fulfill diabetic wound management. The incorporation of zinc ions and EA reinforce the hydrogel network via coordination and hydrogen bonding, and confer a pH-responsive release of EA under simulative wound microenvironment.

The efficacy and safety of remimazolam for the management of emergence agitation: a randomized, double-blind, placebo-controlled study.

Introduction: Emergence agitation (EA) is a common postoperative complication characterized by confusion, disorientation, and restless behavior that can lead to self-harm, the removal of medical devices, and other adverse events. This randomized, double-blind, placebo-controlled study was designed to assess the efficacy and safety of a novel benzodiazepine, remimazolam, in the management of EA.

Methods: A total of 219 adults experienced EA (Riker Sedation-Agitation Scale SAS score ≥5) after otolaryngological surgery were randomly assigned (1:1:1 ratio) to receive one of the following three treatments: 2.

[Analysis the influencing factors and risk warning of the therapeutic efficacy of multi plane low temperature plasma radiofrequency ablation for OSAHS].

To analyze the efficacy, influencing factors, and risk warning of multi-plane low-temperature plasma radiofrequency ablation（MLT-RFA） in the treatment of obstructive sleep apnea hypopnea syndrome（OSAHS）. A total of 118 OSAHS patients admitted from October 2022 to June 2024 were selected as the research subjects. They were divided into mild group（=46）, moderate group（=52）, and severe group（=20） according to the severity of their condition.

The association between weight-adjusted-waist index and serum neurofilament light chain: Results from NHANES 2013 to 2014.

Neurofilament light chain (NfL) is an important biomarker for neuronal damage, widely used in the study of neurodegenerative diseases. The weight-adjusted-waist index (WWI), as a measure of abdominal obesity, is closely related to metabolic diseases. However, the association between WWI and NfL has not been systematically investigated.

Specific genomic alterations and aggressive clinical features of sporadic thyroid carcinomas in children and adolescents: findings from an in-house cohort study.

Introduction: Papillary thyroid carcinoma is the most common pathological subtype of thyroid cancer in both children/adolescents (TCCA) and adults (TCA). TCCA manifests more aggressive and invasive behaviors than TCA, which may be attributed to specific genomic alterations.

Methods: To better understand the specific molecular, pathological and clinical manifestations of TCCA, we retrospectively analyzed a cohort of 60 patients with sporadic papillary thyroid carcinoma, including 20 TCCAs and 40 TCAs.

Application of Brucella type IV secretion proteins VirB1, VirB5, and VirB6 in the serological diagnosis of brucellosis.

Brucellosis, a significant zoonotic infectious disease caused by Brucella spp., necessitates the development of efficient, rapid, accurate, and cost-effective diagnostic methods. This study evaluated the diagnostic value of Brucella Type IV secretion proteins VirB1, VirB5, and VirB6 for human brucellosis serological diagnosis.

Lumbar punctures based on computerized tomography scans combined with precise calculations: a new lumbar puncture technique for spinal muscular atrophy patients with scoliosis.

Objective: We report our experience performing lumbar punctures using a novel technique in (Spinal muscular atrophy) SMA patients with scoliosis.

Methods: A retrospective case series was conducted at the Department of Neurology at Xuzhou Central Hospital from January 2022 to August 2024. Patients diagnosed as SMA combined with scoliosis underwent 58 lumbar punctures using a novel guidance technique.

Diagnostic Value of Neutrophil CD64 Index in Diabetic Foot Osteomyelitis.

Objective: This study aims to assess the value of the Neutrophil CD64 (nCD64) index as a novel, rapid biomarker for the diagnosis of Diabetic foot osteomyelitis (DFO), with the goal of enhancing the accuracy of early detection.

Methods: A total of 142 hospitalized patients with type 2 diabetes complicated by diabetic foot infection were included. Participants were categorized into a Non-DFO group (84 cases) and a DFO group (58 cases) based on the presence or absence of osteomyelitis.

Molecular diagnostic technology: beyond analytical accuracy.

Infectious diseases cause high morbidity and mortality, and early, effective antimicrobial therapy improves outcomes. However, conventional microbiology methods like culture are slow and insensitive. Emerging molecular diagnostics-such as multiplex PCR (mPCR), droplet digital PCR (ddPCR), and metagenomic next-generation sequencing (mNGS)-offer rapid, accurate pathogen identification.

Effects of pericapsular nerve group block and fascia Iliaca compartment block on postoperative analgesia and early rehabilitation in elderly patients undergoing total hip arthroplasty.

Background: Total hip arthroplasty (THA) is a common procedure in elderly patients that requires effective postoperative analgesia to enhance recovery and minimize complications. This study compares the effects of pericapsular nerve group block (PENG) and fascia iliaca compartment Block (FICB) on postoperative analgesia and early rehabilitation in elderly patients undergoing THA.

Methods: This retrospective observational study was conducted from January 2021 to December 2023 and included 216 elderly patients scheduled for THA.

Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population.

Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a multi-stage condition with significant public health implications. The oxidative balance score (OBS), which integrates dietary and lifestyle pro-oxidants and antioxidants, offers a novel approach for evaluating oxidative stress in relation to CKM stages and outcomes. This study aimed to investigate the association between OBS and advanced CKM stages, as well as its relationship with all-cause mortality in a US population.

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5.

Okanin is a natural product with few known biological activities. Its anti-cancer effects and the underlying mechanisms are investigated. It is found that okanin inhibits cancer cell growth (25-50 µm) with minimal effects on non-cancerous colorectal cells except at much higher doses (i.

Risk factors for comorbid hypertension and depression in the elderly: Evidence from the China health and retirement longitudinal study.

As the aging process accelerates, an increasing number of elderly individuals are experiencing psychological issues, particularly those with hypertension. Identifying the risk factors for comorbid hypertension and depression in the elderly is crucial for improving their quality of life. The China Health and Retirement Longitudinal Study is a survey conducted among older adults in China, collecting general data from middle-aged and elderly individuals, including age, gender, marital status, education level, smoking and drinking habits, and the presence of hypertension.

Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis.

Background: Clear cell renal cell carcinoma (KIRC) is the most aggressive renal carcinoma subtype of renal carcinoma, characterized by high mortality, early metastasis, and resistance to treatment. Ammonia-induced cell death (AICD) has recently been identified as a novel metabolic mechanism influencing tumor progression, yet its prognostic implication and regulatory networks in KIRC remain underexplored.

Methods: Transcriptomic and clinical information from the TCGA-KIRC cohort and the validation cohort (E-MTAB-1980) were analyzed.

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma.

Background: The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC).

Methods: A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models.

Analysis of Similarities and Differences between Biatrial Remodeling Through Electro-Anatomic Mapping in Patients with Atrial Fibrillation.

Background: This study aims to explore the association between LA and RA remodeling and their influences on ablation efficacy in AF patients.

Methods: The study involved AF patients undergoing their first catheter ablation using CARTO 3 system. After isolating pulmonary veins, three-dimensional electro-anatomical mapping (3D-EAM) of LA and RA was conducted during sinus rhythm.

Association Between Time in Targeted Blood Glucose Range With All-Cause Mortality in Critically Ill Patients With Heart Failure.

Objectives: Heart failure (HF) patients in ICU experience high mortality rates, often complicated by glycemic dysregulation. Time in targeted blood glucose range (TTBR) provides a comprehensive assessment of glycemic control, but its association with outcomes in critically ill HF patients remains unclear.

Methods: This retrospective cohort study analyzed 5396 critically ill HF patients from the MIMIC-IV database.

Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma.

This study investigates the active component Mannose-B from Codonopsis pilosula and its effect on human trophoblast cell function, particularly focusing on the regulation of Laminin Subunit Beta 1 (LAMB1) expression and its implications in subchorionic hematoma (SCH). Key genes involved in SCH pathology were identified through RNA sequencing and bioinformatics analysis. Network pharmacology was utilized to screen active components in Codonopsis pilosula and their critical targets.

Developing and validating a prognostic model to predict ICU mortality in patients with sepsis-associated thrombocytopenia: a retrospective cohort study based on MIMIC-IV.

Objective: Given the high morbidity and mortality of patients with sepsis-associated thrombocytopenia (SATP) in the intensive care unit, this study retrospectively analysed the influencing factors for poor prognosis in patients with SATP using the MIMIC database, constructed a nomogram model and verified the predictive performance of the model.

Design: A retrospective cohort study.

Setting: The data from MIMIC-IV, V.

Prognostic significance of cold pressor test myocardial perfusion imaging in patients with ischemia and nonobstructive coronary arteries.

Correspondence To: Cunzhi Lu, MD. Department of Nuclear Medicine, Xuzhou Central Hospital, No. 199, Jiefangnan Road, Xuzhou 221009, China.

Preoperative decompression for left-sided obstructive colorectal cancer: a comparative study between a stent and a decompression tube.

Introduction: Stents and decompression tubes (DTs) are both commonly utilized for preoperative decompression in patients with left-sided obstructive colorectal cancer (OCRC). However, the comparative effectiveness and oncological safety of these 2 approaches remain uncertain.

Aim: The aim of this study was to compare clinical performance and long-term oncological outcomes of preoperative stent and DT insertion in patients with left-sided OCRC.

Novel molecular strategies for preeclampsia management: a pathophysiological and therapeutic perspective.

Aim: The objective of this study was to explore emerging pharmacological approaches for the prevention and treatment of PE, with a focus on novel molecular targets.

Methods: A review of current literature on oxidative stress, inflammation, and endothelial dysfunction in PE, along with investigational therapies undergoing preclinical and clinical evaluation.

Results: PE is strongly associated with oxidative stress and inflammation, leading to impaired placentation and maternal endothelial dysfunction.

[Double J-tube indwelling after transurethral seminal vesiculoscopy reduces recurrence of ejaculatory duct obstruction].

Objective: To introduce a surgical method involving the indwelling of double-J tubes (DJT) in the seminal vesicles after transurethral seminal vesiculoscopy (TSV) in order to reduce the recurrence of refractory ejaculatory duct obstruction (EDO).

Methods: This randomized controlled trial included 67 EDO patients undergoing TSV in our hospitals, 27 with (the trial group) and 29 without postoperative indwelling of DJTs in the seminal vesicles (the control group). We collected the general information on the patients and TSV-related parameters, including age, body mass index (BMI), preoperative use of antibiotics, history of urinary tract disease, operation time, hospital stay and intra- and postoperative complications, and performed comparative analyses particularly on the surgical effect, complications, recurrence rate and time to recurrence in the two groups of patients.