Effects of anaesthesia on cognitive function in young and aged mice: Role of c-Fos expression in hippocampal neuron excitability.

Objective: This study aims to investigate the effects of anaesthesia and surgical procedures on the cognitive function of both young and aged mice. It will also explore the role and mechanisms of c-Fos expression in altering hippocampal neuron excitability and its relationship with perioperative neurocognitive disorders in mice.

Methods: In this study, we used a murine laparotomy model to assess cognitive behavioural changes in both young and aged mice at 1, 3, and 7 days post-surgery.

The insight in wheat starch entanglement behavior and its effect on starch gel in aqueous solution.

The objective of this study is to investigate the behavior of starch entanglement and to elucidate the starch gelation process from the entanglement perspective. This study established a starch entanglement system based on overlap, entanglement, and concentrated concentrations in aqueous solution. Select the temperature at which starch is prone to form gel (4 °C) and the temperature at which starch begins to gelatinize (60 °C) for entanglement.

Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution.

Thymosin β4 (Tβ4) plays a critical role in breast cancer progression, yet its molecular mechanism remains unclear. In this study, we identified that Tβ4 is significantly upregulated in breast cancer tissues and cell lines, and its high expression correlates with poor clinical outcomes. Functionally, Tβ4 promotes breast cancer cell proliferation, migration, epithelial-mesenchymal transition (EMT), and angiogenesis while inhibiting apoptosis.

The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.

Synaptic plasticity is fundamental for cognitive development and brain function. Aluminium nanoparticles (AlNPs), widely used in industrial and consumer products, pose potential neurotoxic risks, particularly during early neurodevelopment. However, their effects on synaptic plasticity and cognitive outcomes remain poorly understood.

Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin.

Introduction: Autoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies. Its incidence rises annually, yet no standardized animal model fully mimics human AIT. Given unclear pathogenesis and lack of targeted immunotherapies, researchers invest significant time in developing suitable models.