Artificial Biological Funnel Design Enabled Valorization of Aromatic Derivatives into Catechol.

Aromatic resources, including lignin-, petroleum-, and plastic-derived aromatic compounds, show great potential as feedstocks for producing aromatic fine chemicals. However, the heterogeneity of lignin and the complex conversion pathways of these aromatic derivatives hinder their value enhancement. In this study, an engineered KT2440 was developed to efficiently convert diverse aromatic derivatives into catechol with an atom-economic conversion.

Prognostic significance of cold pressor test myocardial perfusion imaging in patients with ischemia and nonobstructive coronary arteries.

Correspondence To: Cunzhi Lu, MD. Department of Nuclear Medicine, Xuzhou Central Hospital, No. 199, Jiefangnan Road, Xuzhou 221009, China.

Cu/Li Heterotopic Doping to Enable Long-Term Cyclicity for P2-Type Nickel Manganese Based Sodium‑Ion Batteries.

P2-NaNiMnO is regarded as a viable cathode material for sodium ion batteries due to its high theoretical energy density. However, it also has challenges that impair its electrochemical performance, like the P2-O2 phase transition, the strong Jahn-Teller distortion effect, and the Na/vacancy ordering at high voltage. Here, an approach is proposed to use the Cu/Li binary doping modification of P2-NaNiMnO, which stabilizes the cathode structure by introducing Li into alkali metal sites and Cu at transition metal sites.

Highly Crystalline and Robust Donor-Acceptor Type Covalent Organic Frameworks for Long-life Sodium-Ion Battery Cathodes.

Covalent organic frameworks (COFs) hold great potential in sodium-ion battery cathodes. However, most reported COF-based electrodes show unsatisfying capacity and rate performance due to their limited redox site density, low crystallinity, and poor conductivity. Herein, a highly crystalline and robust donor-acceptor type COF with abundant redox active sites is developed by the polymerization of donor unit benzo[1,2-b:3,4-b″:5,6-b″']trithiophene-2,5,8-tricarbaldehyde) (BTT) and acceptor unit s-indacene-1,3,5,7(2H,6H)-tetrone (ICTO) (denoted as BTT-ICTO) for cathodic Na storage.

Performance Characterization of Recycled Carbon Fiber and Its Interfacial Bonding Properties with Cement Matrix.

Recycled carbon fiber, as a novel type of solid waste, possesses high tensile strength, structural stability, and low utilization rates. Recycling carbon fiber for use in cementitious materials presents an efficient solution. However, achieving good interfacial bonding between recycled carbon fiber and cementitious materials is crucial for its high-performance application in such materials.

A Rapid Systematic Review of U.S. Food and Drug Administration-Authorized COVID-19 Treatments.

Background: The coronavirus disease 2019 (COVID-19) pandemic era saw numerous treatments authorized for emergency use by the United States (US) Food and Drug Administration (FDA). The purpose of the review was to determine if convalescent plasma, antivirals, or monoclonal antibodies are associated with serious adverse events (SAEs) and, if so, which specific populations are at risk.

Methods: PubMed, ClinicalTrials.

Universal Single Atom Engineering Enhances Coulombic Efficiency of Ion Storage in Carbon Materials.

Metal single atoms are widely used to optimize the microstructure of carbon materials to improve their ion storage capacity and rate performance, but the impact on another key parameter, Coulombic efficiency (CE), is not sufficiently addressed and confirmed. Herein, a universal phenomenon is reported that carbon-loaded asymmetric sulfur-modified metal-N moiety (MN-S, M = Zn, Fe, Cu, and Ni) possesses higher CE than the symmetric MN moiety, and this phenomenon is applicable to various of carbon matrices, ions (Li, Na, and K), charge and discharge rates, and electrolyte formulations. The carbon-loaded asymmetric MN-S moiety exhibits larger CEs (0.

Novel feathery P/S Co-doped graphitic carbon nitride for highly efficient synergistic photocatalytic HO generation and tetracycline degradation.

Graphitic carbon nitride (g-CN) has garnered significant attention in photocatalytic pollutant degradation for its non-toxicity and cost-effectiveness. However, its limited photocatalytic performance has hindered its applications. Addressing this, we successfully synthesized a novel feathery multifunctional catalyst, phosphorus and sulfur co-doped g-CN (PS-CN), with an enlarged pore network through a hydrothermal method.

Development of a novel difficulty scoring system for laparoscopic liver resection procedure in patients with intrahepatic duct stones.

Background: For intrahepatic duct (IHD) stones, laparoscopic liver resection (LLR) is currently a reliable treatment. However, the current LLR difficulty scoring system (DSS) is only available for patients with hepatocellular carcinoma.

Aim: To explore the development of a DSS for IHD stone patients with LLR and the validation of its reliability.

Advances in the synthesis and properties of sulfur quantum dots for food safety detection and antibacterial applications.

Food safety is closely related to human health and has become a worldwide, pressing concern. Food safety analysis is essential for ensuring food safety. Sulfur quantum dots (SQDs), a new type of zero-dimensional metal-free nanomaterials, have recently become the focus of scientific research due to their good luminescence properties, dispersibility, biocompatibility, and inherent antibacterial properties.

Fully sp Carbon-Conjugated Covalent Organic Frameworks with Multiple Active Sites for Advanced Lithium-Ion Battery Cathodes.

Covalent organic frameworks (COFs) hold great promise for rechargeable batteries. However, the synthesis of COFs with abundant active sites, excellent stability, and increased conductivity remains a challenge. Here, chemically stable fully sp carbon-conjugated COFs (spc-COFs) with multiple active sites are designed by the polymerization of benzo[1,2-b:3,4-b':5,6-b'']trithiophene-2,5,8-tricarbaldehyde) (BTT) and s-indacene-1,3,5,7(2H,6H)-tetrone (ICTO) (denoted as BTT-ICTO).

Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future.

The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers.

A multifunctional thermosensitive hydrogel based on phototherapy for promoting the healing of dental extraction wounds.

Post-extraction wound infections are a common complication of dental extractions. More specifically, infection in the alveolar socket after tooth extraction accelerates the resorption and destruction of the alveolar bone, and ultimately affects the final restoration results. Currently, the main clinical treatment approaches applied to the socket after tooth extraction include mechanical wound debridement, chemical rinses (, chlorhexidine), filling of the extraction socket with absorbent gelatin sponges, and the systemic application of antibiotics.

Chromosome-level genome assemblies of and provide insights into pericarp dehiscence and anthocyanin biosynthesis in banana.

and are members of the Musaceae family and are indigenous to the South and Southeast Asia. They are very popular in the horticultural market, but the lack of genomic sequencing data and genetic studies has hampered efforts to improve their ornamental value. In this study, we generated the first chromosome-level genome assemblies for both species by utilizing Oxford Nanopore long reads and Hi-C reads.

Hybrid supercapacitors using metal-organic framework derived nickel-sulfur compounds.

Hypothesis: Metal-organic frameworks (MOFs) are highly suitable precursors for supercapacitor electrode materials owing to their high porosity and stable backbone structures that offer several advantages for redox reactions and rapid ion transport.

Experiments: In this study, a carbon-coated NiS composite (NiS@C-5) was prepared via sulfuration at 500 ℃ using a spherical Ni-MOF as the sacrificial template.

Finding: The stable carbon skeleton derived from Ni-MOF and positive structure-activity relationship due to the multinuclear NiS components resulted in a specific capacity of 278.

Pinpointing the Cl Coordination Effect on Mn-N-Cl Moiety Toward Boosting Reaction Kinetics and Suppressing Shuttle Effect in Li-S Batteries.

Single atom catalysts (SACs) are highly favored in Li-S batteries due to their excellent performance in promoting the conversion of lithium polysulfides (LiPSs) and inhibiting their shuttling. However, the intricate and interrelated microstructures pose a challenge in deciphering the correlation between the chemical environment surrounding the active site and its catalytic activity. Here, a novel SAC featuring a distinctive Mn-N-Cl moiety anchored on B, N co-doped carbon nanotubes (MnNCl@BNC) is synthesized.

Mobile-Delivered Mindfulness Intervention on Anxiety Level Among College Athletes: Randomized Controlled Trial.

Background: College athletes are a group often affected by anxiety. Few interventional studies have been conducted to address the anxiety issues in this population.

Objective: We conducted a mobile-delivered mindfulness intervention among college athletes to study its feasibility and efficacy in lowering their anxiety level and improving their mindfulness (measured by the Five Facet Mindfulness Questionnaire [FFMQ]).

Insensitivity of oncogenic EGFR R776L mutation to EGFR inhibitors in lung cancer.

Non-small cell lung cancers (NSCLC) account for 85 % of total lung cancers. Mutation in EGFRdrives the progress of NSCLSs with high mortality rate. Besides the common mutations in EGFR, which together comprise of 85 % of all EGFR mutations and respond to the targeted therapy of EGFR tyrosine kinase inhibitors (TKIs), many other low-frequency mutations of EGFR are existed in patients.

Isolation of a marine-derived yeast with potential applications in industrial nitrite utilizing.

The nitrite efficient utilization microorganism RZWP01 was identified. Using nitrite and ammonium as the sole nitrogen source, the nitrogen removal rate of RZWP01 was 97.4% and 87.

The Comprehensive Primary Care Plus Model and Health Care Spending, Service Use, and Quality.

Importance: Implemented in 18 regions, Comprehensive Primary Care Plus (CPC+) was the largest US primary care delivery model ever tested. Understanding its association with health outcomes is critical in designing future transformation models.

Objective: To test whether CPC+ was associated with lower health care spending and utilization and improved quality of care.

Medrysone promotes corneal injury repair by promoting M2-like polarization of macrophages.

Background: Accumulated evidence suggests that M2-like polarized macrophages plays an important role in reducing inflammation, promoting and accelerating wound healing process and tissue repair. Thus, M2-like TAMs (Tumour-associated macrophages) was an appealing target for therapy intervention.

Method: Flow cytometry and RT-PCR assay were used to detect the polarization of macrophages induced by Medrysone, and the rat corneal mechanical injury model was established to evaluate the efficacy of Medrysone in cornel repair.