Harmine derivative ZLWH-38 ameliorates the therapeutic efficacy of colistin against XDR-Ab pneumonia by suppressing inflammatory responses.

Background: Acinetobacter baumannii (Ab), especially extensively drug-resistant Ab strains (XDR-Ab), poses a significant threat to clinical medicine due to its high mortality rate and limited treatment options. Harmine derivatives exhibit potent anti-inflammatory and immunomodulatory effects. In this study, we aimed to investigate whether the harmine derivative ZLWH-38 combined with colistin could enhance therapeutic efficacy against XDR-Ab pneumonia by suppressing inflammatory responses.

Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib.

DILI (drug-induced liver injury) remains a critical liability in drug discovery and development. However, there are few in vitro and preclinical models to predict DILI, and the knowledge of DILI molecular targets is even more limited. The lapatinib () prescription label carries a black box warning for idiosyncratic hepatotoxicity and this has prompted numerous studies aimed at understanding the underlying molecular mechanisms.

Mixing of zeolite facilitates re-sequestration of heavy metals via generated Fe-(oxyhydr)oxides in sediments in the presence of NO compared to capping.

Under nitrate-rich conditions, microbially-driven nitrate reduction (as electron acceptor) mediates the transformation of oxidizable heavy metal (HM) species into acid-soluble and reducible fractions, concomitant with enhanced metal mobilization into overlying water. This study investigates the impact of zeolite application modes-capping and mixing-on controlling HM release with NO addition. Compared to capping, mixing provides a more sustained inhibition of upward HMs release from sediment.

Rectal sensory-motor alterations: a clinical perspective on anorectal disorders. The correlation between rectal sensation and motility in different anorectal diseases.

Background: Patients with anorectal diseases commonly exhibit abnormalities in rectal sensation and/or rectal motility. However, the relationship between rectal sensation and motility in these pathological processes is unclear. We aim to explore this association.

Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer's Disease.

Background: Alzheimer's disease (AD) is a multifactorial neuropathology characterized by the accumulation of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs) and cholinergic system dysfunction. At present, there is no effective treatment strategy for AD. Our previous research showed that ZJQ-3F acts as an inhibitor of AChE/BACE1/GSK3β, and showed good blood-brain barrier permeability, appropriate bioavailability and oral safety.

Performance Characterization of Recycled Carbon Fiber and Its Interfacial Bonding Properties with Cement Matrix.

Recycled carbon fiber, as a novel type of solid waste, possesses high tensile strength, structural stability, and low utilization rates. Recycling carbon fiber for use in cementitious materials presents an efficient solution. However, achieving good interfacial bonding between recycled carbon fiber and cementitious materials is crucial for its high-performance application in such materials.

Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study.

Background: Esophageal cancer (ESCA) poses a significant challenge in oncology because of the limited treatment options and poor prognosis. Therefore, enhancing the therapeutic effects of radiotherapy for ESCA and identifying relevant therapeutic targets are crucial for improving both the survival rate and quality of life of patients.

Aim: To define the role of the transcription factor Snail family transcriptional repressor 1 (SNAI1) in ESCA, particularly its regulation of radiosensitivity.

Enhanced photocatalytic H generation and Cr(VI) reduction by a sheet-on-sheet Cd(OH)/CdS nanocomposite.

The advancement of efficient photocatalysts is essential for tackling global energy and environmental issues. In this work, a unique sheet-on-sheet Cd(OH)/CdS photocatalyst was synthesized a facile solution strategy, demonstrating significantly improved photocatalytic performance for H generation and Cr(VI) reduction. The optimal 5% Cd(OH)/CdS obtained an impressive H production rate of 3475 μmol g h under visible light, marking a 6.

Photosynthetic performance and sucrose metabolism in superior and inferior rice grains with overlapping growth stages under water stress.

Drought stress at jointing and booting stages of plant development directly affects plant growth and productivity in rice. Jointing and booting stages may overlap in high-latitude areas where water deficits occur. However, little is known about the effects of photosynthesis on grain sucrose metabolism and the differences of sucrose metabolism strategies between superior and inferior grains under different drought stress was unclear.

The Decline of Sensory-Motility Coordination in Rectal Evacuation due to Pelvic Floor Dysfunction.

Background: Constipation, a common defecatory disorder, exhibits various symptoms and individual variability. Abnormalities in rectal sensation and/or motility are prevalent among patients. However, the mechanisms linking rectal sensation and motility, and their impact on rectal evacuation function, remain poorly understood.

Study on lightweight rice blast detection method based on improved YOLOv8.

Background: Rice diseases that are not detected in a timely manner may trigger large-scale yield reduction and bring significant economic losses to farmers.

Aims: In order to solve the problems of insufficient rice disease detection accuracy and a model that is lightweight, this study proposes a lightweight rice disease detection method based on the improved YOLOv8. The method incorporates a full-dimensional dynamic convolution (ODConv) module to enhance the feature extraction capability and improve the robustness of the model, while a dynamic non-monotonic focusing mechanism, WIoU (weighted interpolation of sequential evidence for intersection over union), is employed to optimize the bounding box loss function for faster convergence and improved detection performance.

Morphology Effect of FeWO Boosting Efficiency of Photocatalytic Uranium Extraction under Visible Light and Mechanism Investigation.

Wolframite (FeWO) is a type of polyoxometalate known for its high chemical stability and electronic properties, which makes it an excellent photocatalyst. While FeWO has been widely utilized in the domain of organic catalysis, there are currently no documented reports regarding its use in the degradation of U(VI). In this study, the effect of changing the microscopic morphology of the FeWO catalyst to enhance its photocatalytic activity was explored.

Crystal- and Pore-Size Dependent Iodine Adsorption Properties in MOFs.

Metal-organic frameworks (MOFs) with unique pore architectures and electron-rich sites exhibit an unprecedented iodine capture property. In this contribution, the crystal-size and pore-size-dependent iodine adsorption behavior in MOFs ranging in crystal size from nanometers to micrometers with mesoporous and microporous structures is reported. Nano-sized MOFs have much higher iodine adsorption capacities and rates than Micro-sized MOFs.

The Overexpression of RTN4 Significantly Associated With an Unfavourable Prognosis in Patients With Lower-Grade Gliomas.

Gliomas, the most prevalent primary malignancy of the central nervous system, is characterised by its high mortality rates and unfavourable prognosis. Despite extensive research, the underlying mechanisms of glioma pathogenesis remain elusive. The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases provided the lower-grade gliomas (LGG) transcriptome and related clinical data, which were downloaded separately.

Postoperative concurrent chemoradiotherapy plus apatinib for patients with high-grade glioma: a retrospective cohort study.

Background: Radiotherapy plus temozolomide followed by adjuvant temozolomide was the standard treatment for high-grade gliomas. This study aimed to explore the effectiveness and safety of the addition of apatinib in patients with high-grade gliomas after surgery.

Methods: In this retrospective cohort study, patients with high-grade glioma [World Health Organization (WHO) grade III or IV] treated with apatinib and concurrent chemoradiotherapy (cCRT) after surgery from October 2017 to February 2021 were reviewed.

KDELR3 overexpression as a novel prognostic and diagnostic biomarker in glioma: comprehensive bioinformatic analysis insights.

Glioma, the most prevalent primary intracranial malignancy among adults, is distinguished by its high morbidity and recurrence rates, posing a considerable threat to patients' quality of life and survival prospects. Consequently, the pursuit of efficacious molecular prognostic markers holds paramount importance. The exploration of the role of the KDELR3 kinase family in various neoplastic conditions constitutes an emerging area of research.

The biocompatibility of gallium-based liquid metals with blood and serum.

Excellent biocompatibility of liquid metals is the basis for developing biomedical applications, such as implantable devices, drug delivery, and tumor therapy. Especially, a systematic study to reveal the influence of gallium-based liquid metals on the composition of blood while they are used in the human body is vital but missing. Here, the compatibility of three kinds of frequently used gallium-based liquid metals with human blood and serum was explored systematically.

Construction of heterogeneous MOF-on-MOF for highly efficient gaseous iodine sequestration under static conditions.

Considering the unexpected nuclear power waste emission and potential nuclear leakage, the exploration of robust materials for the effective capture and storage of radioactive iodine is of great importance but still remains a challenge. In this work, we report the rational synthesis of functionalized NH-UiO-66-on-ZIF-67 architecture to enhance the static adsorption and retention of volatile iodine. Such MOF-on-MOF heterostructures was fabricated through seeding ZIF-67 core on the surface of NH-UiO-66 satellite via a facile polyvinylpyrrolidone (PVP) regulated internal extended growth strategies.

Discovery of a novel Xanthone derivative P24 for anti-AD via targeting sTGFBR3.

Soluble transforming growth factor beta receptor 3 (sTGFBR3) antagonist is a new focus in the research and development of Alzheimer's disease (AD) drugs. Our previous studies have identified sTGFBR3 as a promising new target for AD, with few targeted antagonists identified. In this study, we performed structural modeling of sTGFBR3 using AlphaFold2, followed by high-throughput virtual screening and surface plasmon resonance assays.

Perspectives of Ferroelectric Wurtzite AlScN: Material Characteristics, Preparation, and Applications in Advanced Memory Devices.

Ferroelectric, phase-change, and magnetic materials are considered promising candidates for advanced memory devices. Under the development dilemma of traditional silicon-based memory devices, ferroelectric materials stand out due to their unique polarization properties and diverse manufacturing techniques. On the occasion of the 100th anniversary of the birth of ferroelectricity, scandium-doped aluminum nitride, which is a different wurtzite structure, was reported to be ferroelectric with a larger coercive, remanent polarization, curie temperature, and a more stable ferroelectric phase.

Enhanced adsorption dynamics and thermal stability of radioactive Sr(II) by lamellar Nb-doped sodium vanadosilicate via self-assembly and conditional natroxalate intercalation.

To promote the environmentally friendly and sustainable development of nuclear energy, it is imperative to address the treatment of wastewater generated by the nuclear industry. This necessitates the enhancement of fission product reclamation efficiency post-treatment. This study aims to combine defect control and confined self-assembly strategies for the precise design of interlayer spacing (14.