Physics-informed neural network for hydraulic prediction in open-channel water transfer projects with sparse monitoring data.

Open-channel water transfer projects play a crucial role in addressing regional water supply-demand imbalances, and real-time, comprehensive, and accurate acquisition of their hydrodynamic spatiotemporal evolution is essential for ensuring safety and efficiency of water conveyance and optimizing scheduling strategies. While hydraulic monitoring systems and numerical simulations are potential solutions, the former struggles to balance the number of monitoring points with cost constraints to achieve comprehensive and economically feasible measurements, and the latter requires clear boundary conditions and key parameters that often pose challenges in practical scenarios. This paper presents a Physics-Informed Neural Network (PINN)-based method applied to predicting hydraulic transients in open channels, incorporating sparse monitoring data and physical laws.

Detection of a New Recombinant Rabbit Hemorrhagic Disease Virus 2 in China and Development of Virus-like Particle-Based Vaccine.

Rabbit hemorrhagic disease virus (RHDV) is a very virulent virus of the genus Lagovirus causing severe and fatal hepatitis in the European rabbit (). RHDV has two distinct genotypes: GI.1 (RHDV) and GI.

Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling.

Ethnopharmacological Relevance: The roots of Oxybaphus himalaicus Edgew. is a traditional Tibetan herbal medicine with kidney reinforcing and tonifying effects, which is commonly applied to treat nephritis. Boeravinone C has been identified as one of the primary constituents of O.

Himalaflavones F and G, two new flavonoids from the roots of Edgew with anti-inflammatory activity.

Himalaflavones F () and G (), two new flavonoids, along with eight known ones ()were isolated from the roots of Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method.

Herpetosin A, a nor-cucurbitane triterpenoid with a 5/6/6/5 ring system from .

Two previously undescribed triterpenoids, herpetosin A () and herpetosin B (), together with two known compounds, cucurbitacin B () and dihydrocucurbitacin E (), were isolated from the seeds of Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound exhibited anti-proliferative effect with IC values of 4.

Real-Time Visualization of Infiltration and Retention of Microplastics with Different Shapes in Porous Media.

Infiltration and retention of microplastics in porous media are important for understanding their fate in environments and formulating treatment measures. Given porous media opacity, knowledge is usually obtained indirectly by monitoring microplastic concentration in the effluent and measuring microplastic distribution after removing grains in layers. In this study, real-time visualization of infiltration and retention of microplastics in porous media under vertical water flow is performed using an improved reflective index matching method, considering the different shapes and densities of microplastics and size ratios between microplastics and grains.

Ptehosides A-I: Nine undescribed iridoids with in vitro cytotoxicity from the whole plant of Pterocephalus hookeri (C.B. Clarke) Höeck.

Nine previously undescribed iridoids, ptehosides A-I (1-9), together with 12 known ones (10-21), were isolated from Pterocephalus hookeri (C.B. Clarke) Höeck.

Novel Recombinant Rabbit Hemorrhagic Disease Virus 2 (RHDV2) is Circulating in China within 12 Months after Original RHDV2 Arrival.

Rabbit hemorrhagic disease (RHD) causes lethal fulminant hepatitis in rabbits. Two different genotypes (GI.1 and GI.

The synergy of thanatin and cathelicidin-BF-15a3 combats Escherichia coli O157:H7.

Escherichia coli O157:H7 is a pathogen that commonly causes foodborne illness and represents a health hazard to consumers. The combined use of synergistic antimicrobial peptides (AMPs) is a promising way to improve the microbiological safety of foods. In this study, we detected the synergistic interactions between thanatin and BF-15a3 to reduce their usage and obtain more efficient antibacterial activity.

Environmental and anthropogenic factors affect bacterial community and nitrogen removal in the Yarlung Zangbo River.

Microorganisms play a critical role in the process of nitrogen removal in aquatic environment, which is regulated by multiple environmental factors. As a high-altitude region, the Qinghai-Tibet Plateau has unique composition of bacterial communities due to its unique geographical conditions, which may affect the nitrogen conversion of Plateau rivers. However, the regulation of nitrogen removal by environmental factors and bacterial community in high-altitude rivers has been rarely reported.

Multifractal dimensions of soil particle size distribution reveal the erodibility and fertility of alpine grassland soils in the Northern Tibet Plateau.

Climate change and human activities have seriously degraded alpine grassland, potentially affecting soil particle size distribution (PSD) and further influencing the nutrient levels and erodibility of soil. Predicting the fertility and erodibility of alpine soil using multifractal dimensions of soil PSD could be used to enhance the management and restoration of degraded alpine grasslands. In the present study, we evaluated three types of alpine grasslands: alpine meadow (AM), alpine steppe (AS), and alpine desert steppe (ADS).

Biodegradation of 2-ethylhexyl-4-methoxycinnamate in river sediments and its impact on microbial communities.

Numerous studies have evaluated the toxicity and endocrine disrupting properties of organic UV filters for aquatic organisms, but little is known about their biodegradation in river sediments and their impact on microorganisms. We have set up the sterile and microbiological systems in the laboratory, adding 2-ethylhexyl-4-methoxycinnamate (EHMC), one of organic UV filters included in the list of high yield chemicals, at concentrations of 2, 20 and 200 μg/L, and characterized the microbial community composition and diversity in sediments. Monitoring of EHMC degradation within 30 days revealed that the half-life in the microbial system (3.

Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.

Background: Pterocephalus hookeri (C. B. Clarke) Höeck, a Tibetan medicine widely used for treatment of rheumatoid arthritis, was recorded in Chinese Pharmacopoeia (2020 version) with slight toxicity.

Ptehoosines A and B: Two new sesamin-type sesquilignans with antiangiogenic activity from Pterocephalus hookeri (C.B. Clarke) Höeck.

Two undescribed sesamin-type sesquilignans ptehoosines A (1) and B (2), together with 4 known lignans (3-6), were isolated from Pterocephalus hookeri (C.B. Clarke) Höeck which was widely used as traditional Tibetan medicine for treatment of rheumatoid arthritis.

[Plant community and soil nutrient of alpine meadow in different degradation stages on the Tibetan Plateau, China.].

We examined soil physical and chemical properties and plant community characteristics of four alpine meadows at different degradation stages in Damxung County, Lhasa City, Tibet Autonomous Region, China, with the method of spatial sequence instead of time succession. The results showed that soil organic carbon, total nitrogen, available phosphorus, available potassium, ammonium, nitrate, and water content showed a decreasing trend as the degree of soil degradation increased, while pH showed an increasing trend. Plant community height, richness, diversity index and evenness index of the moderately degraded meadow were the highest.

Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from aherndt.

Three undescribed prenylated benzoic acid derivatives berberisides A-C () and a new clerodane glycoside berberiside D () were isolated from Aherndt. Their structures were elucidated on the basis of extensive NMR and HR-ESI-MS analysis. The cytotoxic activities of all isolates were studied against lung carcinoma A549, hepatocellular carcinoma HepG2 and breast carcinoma MDA-MB-231 cell lines.

Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.

Background: In our previous study, we demonstrated the hepatoprotective effect of Herpetospermum pedunculosum in cholestatic rats. A bioassay-guided study also led to the identification and isolation of a lignan, dihydrodiconiferyl alcohol (DA) from the seeds of H. pedunculosum.

Changes of nitrogen deposition in China from 1980 to 2018.

China has experienced a dramatic change in atmospheric reactive nitrogen (Nr) emissions over the past four decades. However, it remains unclear how nitrogen (N) deposition has responded to increases and/or decreases in Nr emissions. This study quantitatively assesses temporal and spatial variations in measurements of bulk and calculated dry N deposition in China from 1980 to 2018.

Ethyl acetate extract of herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats.

Background: Traditionally, seeds of Herpetospermum pedunculosum were used to treat liver disease or cholepathy. Up to date, their protecting effect against cholestasis was remain unclarified.

Purpose: To investigate the efficacy, possible mechanisms, and active constituents of the ethyl acetate extract from the seeds of Herpetospermum pedunculosum (HPEAE), studies were carried out using cholestasis rat model induced by α-naphthylisothiocyanate (ANIT).

Himalaflavone A-E, five new flavonoids from .

Five previously undescribed flavonoids (-) and ten known ones () were isolated from the roots of . Their structures were elucidated by spectroscopic experiments including NMR, HRESIMS and ECD. The cytotoxic activities of all isolated compounds were assayed against human lung carcinoma A549 cells and human hepatocellular carcinoma HepG2 cells .

Pharmacokinetics and tissue distribution study of herpetotriol in rats by ultrahigh-performance liquid chromatography with tandem mass spectrometry.

Herpetotriol, a typical lignan in Wall's seeds that has long been used to treat icterhepatitis and indigestion and other related diseases in Tibet, is of potential hepatoprotection. This study aims to study the pharmacokinetics features of herpetotriol, including the blood drug concentration - time curve and tissue distribution. The ultrahigh-performance liquid chromatography with tandem mass spectrometry method was established to detect herpetotriol concentration in plasma and tissues, and the method showed good linearity from 10 to 2000 ng/mL ( ≥ 0.

Chemical compositions of fog and precipitation at Sejila Mountain in the southeast Tibetan Plateau, China.

Chemical compositions of fog and rain water were measured between July 2017 and September 2018 at Sejila Mountain, southeast Tibet, where fog events frequently occurred in original fir forests at altitude 3950 m. Fog water samples were collected using a Caltech Active Strand Cloud Collector (CASCC), and rain samples were collected using a precipitation gauge. Differences were observed between fog water and rain composition for most analyzed ions.

Allopolyploid origin in Rubus (Rosaceae) inferred from nuclear granule-bound starch synthase I (GBSSI) sequences.

Background: Polyploidy and hybridization are ubiquitous in Rubus L., a large and taxonomically challenging genus. Chinese Rubus are mainly concentrated into two major sections, the diploid Idaeobatus and the polyploid Malachobatus.