Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3.

Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood.

One-step synthesis of Bi/C-BiOCl composites: double defect regulation, band structure modulation, and visible light photocatalytic enhancement mechanisms.

The treatment of large amounts of wastewater resulting from the overuse of dyes in the paper, leather and food industries is of great ecological importance. BiOCl is a promising photocatalyst owing to its unique layered structure, strong chemical stability and resistance to photocorrosion. However, the advancement of its photocatalytic activity is significantly impeded by the limited utilization of visible light and the elevated recombination rates of photogenerated charge carriers.

Detection of a New Recombinant Rabbit Hemorrhagic Disease Virus 2 in China and Development of Virus-like Particle-Based Vaccine.

Rabbit hemorrhagic disease virus (RHDV) is a very virulent virus of the genus Lagovirus causing severe and fatal hepatitis in the European rabbit (). RHDV has two distinct genotypes: GI.1 (RHDV) and GI.

Regulation of placental development and function by ubiquitination.

The proper distribution of nutrients and metabolites between the mother and fetus is one important factor for successful pregnancy. As a bridge, the placenta plays a key role in sensing the nutritional needs of the fetus, coordinating the maternal nutrition supply, and enhancing its nutritional transport capabilities. Imperfect placental development can lead to pregnancy-related disorders such as preeclampsia, recurrent miscarriage, and/or fetal growth restriction, posing risks to both mother and child in the short and long term.

[Regulatory effect of electroacupuncture at "Neiguan" (PC6) on mitochondrial autophagy during the ischemia and reperfusion phases in rats with myocardial ischemia-reperfusion injury].

Objective: To investigate the regulatory effect of electroacupuncture (EA) at "Neiguan" (PC6) on mitochondrial autophagy in rats with myocardial ischemia-reperfusion injury (MIRI) at different phases (ischemia and reperfusion phases), and to explore the bidirectional regulatory effects of EA at "Neiguan" (PC6) and its potential mechanism.

Methods: Forty-five male SD rats were randomly divided into 6 groups according to the random number table method, namely, sham-operation group (=9), model-A group (=6), model-B group (=9), EA-A1 group (=6), EA-B1 group (=6), and EA-B2 group (=9). Except the rats in the sham-operation group, the MIRI model was established in the other groups with the physical ligation and tube pushing method.

Non-Fragile Estimation for Nonlinear Delayed Complex Networks with Random Couplings Using Binary Encoding Schemes.

This paper is dedicated to dealing with the design issue of a non-fragile state estimator for a type of nonlinear complex network subject to random couplings and random multiple time delays under binary encoding schemes (BESs). The BESs are put into use in the transmission of data from the sensor to the remote estimator. The phenomenon of bit errors is considered in the process of signal transmission, whose description utilizes a Bernoulli-distributed random sequence.

Metagenomic Next-Generation Sequencing Improves the Diagnosis Efficiency of Mixed Periprosthetic Joint Infections.

Purpose: To explore the clinical significance of metagenomic next-generation sequencing (mNGS) in the diagnosis of mixed periprosthetic joint infections (PJI).

Methods: The data pertaining to patients suspected of PJI who underwent arthroplasty at our hospital between January 2020 and June 2024 were analyzed. Patients included in the study were subjected to microbial culture and mNGS analyses to evaluate the efficacy of mNGS in diagnosing mixed PJIs.

Specific Detection of RHDV GI.1 and GI.2 by RT-LAMP-CRISPR/Cas12a Platform.

Rabbit hemorrhagic disease is a highly contagious and acute fatal disease caused by rabbit hemorrhagic disease virus (RHDV). The first outbreak of RHDV2 in 2020 has posed a serious threat to the rabbit breeding industry in China. An effective and specific detection strategy for RHDV GI.

Progress in the Research and Development of Biphenyl Small Molecules Targeting PD-1/PD-L1 as Potential Antitumor Drug Candidates.

Cancer remains a major global health challenge, and cancer immunotherapy has emerged as a promising treatment strategy. A key immune checkpoint in this approach is the interaction between PD-1 and PD-L1, which suppresses immune responses against tumor cells. Although monoclonal antibodies targeting PD-1/PD-L1 have shown significant therapeutic potential, their use is hampered by limitations such as high costs, extended half-lives, and the potential for immune-related side effects.

Neural connectivity and balance control in aging: Insights from directed cortical networks during sensory conflict.

Balance control is crucial for stability during daily activities, relying on the integration of sensory inputs from the visual, vestibular, and somatosensory systems. Aging impairs the efficiency of these systems, leading to an increased risk of falls; however, the neural mechanisms underlying this decline, particularly under sensory conflict, are not fully understood. This study investigated the effects of aging on neural connectivity and sensory integration during balance tasks.

P-doped and cyano-modified carbon nitride nanotubes for photocatalytic hydrogen evolution coupled with bisphenol A degradation.

The integration of photocatalytic wastewater treatment with solar-driven hydrogen (H) evolution offers a clean and sustainable solution for wastewater treatment by simultaneously purifying wastewater and generating clean energy. Consequently, this method has garnered increasing attention. Graphitic carbon nitride (g-CN) has been extensively used in photocatalysis, attributed to its abundant source and suitable bandgap.

ARID1A: Multiple functions in human pregnancy.

AT-rich interacting domain containing respectively protein 1 A (ARID1A), a key member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, has been shown to play an important role in various physiological processes and diseases including female reproductive tumors, such as ovarian cancer and breast cancer. In addition to the studies regarding ARID1A expression and function in cancer, recent findings elucidate its important role in maintaining normal tissue homeostasis and cell differentiation by controlling chromatin remodeling and transcription factors recruitment. In the context of human pregnancy, ARID1A has been implicated in several pregnancy-related complications, including gestational diabetes, preeclampsia, and intrauterine growth restriction.

Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study.

Background: Contezolid (CZD) is an analog of Linezolid (LZD) that has demonstrated potent in vitro and in vivo activity against tuberculosis (TB) while presenting a safer side-effect profile. In this study, we evaluated the early bactericidal activity (EBA) of CZD compared to LZD, with LZD serving as a control.

Methods: Naive, smear-positive pulmonary TB patients were enrolled and randomly assigned to receive either a 14-day monotherapy regimen of 600 mg LZD once daily (QD) or 800 mg CZD twice daily (BID).

The role of heart and neural crest derivatives-expressed protein factors in pregnancy.

Heart and neural crest derivatives-expressed protein 1 (HAND1) and Heart and neural crest derivatives-expressed protein 2 (HAND2), members of the Twist-family of basic Helix-Loop-Helix (bHLH) proteins, act as critical transcription factors that play a key role in various developmental processes, including placental development and fetal growth during pregnancy. This review aims to explore the current understanding of HAND1 and HAND2 in pregnant maintenance and their potential implications for maternal and fetal health. We will summarize the mechanisms of action of HAND1 and HAND2 in pregnancy, their expression regulation and association with pregnancy complications such as preterm birth and preeclampsia.

Tunable Optical Properties, Enhanced Photoluminescence, and Thermostability of CaO: Eu Phosphors by Codoping Cl Ions.

Europium-activated calcium oxide (CaO: Eu) phosphor shows great potential in the fabrication of light-emitting diodes (LEDs). However, its luminescent intensity and thermostability still need to be further enhanced. In this work, the photoluminescence property and thermostability of CaO: Eu were improved significantly by codoping a few of Cl ions into it.

Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing, China.

Objectives: The combined use of bedaquiline and delamanid (BDQ-DLM) is limited by an increased risk of prolonging the QTc interval. We retrospectively evaluated patients who received DLM/BDQ-containing regimens at a TB-specialized hospital. We aimed to present clinical efficacy and safety data for Chinese patients.

Near-atomic structures of RHDV reveal insights into capsid assembly and different conformations between mature virion and VLP.

Rabbit hemorrhagic disease virus (RHDV) poses a significant threat to rabbits, causing substantial economic losses in rabbit farming. The virus also endangers wild populations of rabbit species and the predatory animals that rely on rabbits as a food source, thereby disturbing the ecological balance. However, the structural understanding of RHDV has been limited due to the lack of high-resolution structures.

Nine months of bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine chemotherapy for rifampicin/multidrug-resistant tuberculosis: a multicenter, randomized, open-label non-inferiority trial in China.

Background: We concurrently developed a prospective study to assess clinical outcomes among patients receiving 9-month bedaquiline (BDQ)-containing regimens, aiming to provide valuable data on the use of this short-course regimen in China.

Methods: This open-label, randomized, controlled, multicenter, non-inferiority trial was conducted at sixteen hospitals, and enrolled participants aged 18 years and older with pulmonary rifampicin/multidrug tuberculosis. Participants were randomly assigned, in a 1:1 ratio.

CaMgNaGd(PO):Eu: A Single Eu-Doped Full-Spectrum White Light Emission Phosphor with High Color Rendering Index.

The multi-cationic site occupation control of rare earth doped phosphor materials is one of the key factors in achieving single-phase full-spectrum emission. In this work, the site distribution of Eu in CaNaGd(PO) (CNGP):%Eu phosphors with multi-cationic sites was determined. Under 385 nm excitation, CNGP:%Eu samples exhibited a cyan emission composed of three sub-Gaussian components.

3D/1D FeO@TiO/TC-TiO/SiO Magnetic Inorganic-Framework Molecularly Imprinted Fibers for Targeted Photodegradation.

To achieve a selective degradation of pollutants in a water body, 3D/1D magnetic molecularly imprinted fibers FeO@TiO/TC-TiO/SiO were fabricated by an electrospinning method. The molecularly imprinted layer was successfully prepared by a direct imprinting method using TiO as a functional monomer. FeO facilitates the catalyst recovery and light utilization.

A Comparative Study of SiO:Tb@GdO:Eu and Its Inverted Tb-Eu Core-Shell Phosphors.

How to effectively improve energy transfer efficiency and luminous intensity inspired us to synthesize a series of SiO:%Tb@GdO:%Eu samples, study their luminescence properties and interfacial energy transfer (IET), and compare with SiO:%Eu@GdO:%Tb. The results show that SiO:%Tb@GdO:%Eu can exhibit adjustable multicolor luminescence from red to green at different concentrations of Eu and Tb or under different excitation wavelengths, and there exists efficient IET from Tb to Eu in SiO:%Tb@GdO:%Eu and SiO:%Eu@GdO:%Tb, which improves the energy transfer efficiency and luminous intensity. In addition, the luminescence properties are different between SiO:3%Tb@GdO:3%Eu and SiO:3%Eu@GdO:3%Tb, and the energy transfer efficiency of Tb → Eu in SiO:3%Tb@GdO:3%Eu is obviously higher than that in SiO:3%Eu@GdO:3%Tb.