Dendrobium officinale Kimura et Migo regulates the proliferation and migration of colon adenocarcinoma via LGALS4.

Dendrobium officinale Kimura et Migo (DO) has demonstrated potential anti-colon adenocarcinoma (COAD) effects; however, its underlying mechanisms of action require further elucidation. In this study, DO (work concentrations of 0, 0.1, and 0.

Choreographing rhizosphere effect with agricultural practices for agroecology?

For sustainable agriculture, soil-plant interactions (i.e., the rhizosphere effect) is prominent focus, since they determine plant health and nutrition.

A calcium-decoding module translates volatile DMNT into jasmonic acid-mediated herbivore resistance in Camellia sinensis.

Plants employ sophisticated volatile-mediated signaling mechanisms to defend against herbivore attacks; however, the molecular pathways underlying these processes remain poorly understood. Herein, we unveil the molecular mechanism by which the herbivore-induced volatile (E)-4,8-dimethyl-1,3,7-nonatriene (DMNT) activates jasmonic acid (JA) biosynthesis in tea plants (Camellia sinensis). We demonstrate that DMNT triggers early signaling events in tea plants, characterized by a rapid influx of Ca2+ in mesophyll cells, which subsequently initiates a signaling cascade involving the CsCAMTA3 (calmodulin-binding transcription activator, CAMTA).

Downregulation of serum Foxc2 in dilated cardiomyopathy: association with disease severity and cardiac function.

Background: Dilated cardiomyopathy (DCM) is one of the most frequent non-ischemic causes of heart failure. Foxc2 has been implicated in cardiovascular disease and angiogenesis, but its role in DCM remains undefined. This study aimed to compare serum Foxc2 levels in DCM and non-DCM patients and to assess its clinical relevance.

C-Myc Overexpression in Adolescent and Young Adult Breast Cancer: Distinct From Older Adults With Relevantly Expressed Cholecystokinin B Receptor.

Breast cancer in adolescents and young adults has poorer clinical outcomes, but the role of MYC in this group remains unclear. We aimed to elucidate the characteristics of MYC expression in breast cancer among adolescents and young adults. MYC expression in 42 adolescents and young adults and 110 older adults were analyzed using immunohistochemistry, fluorescence in situ hybridization, quantitative polymerase chain reaction, and RNA sequencing.

Counterintuitive Impact of Polar Solubilizing Group Functionalization on Ligand Solubility and f-Block Element Affinity.

The design of multidentate hydrophilic ligands with high binding affinity and selectivity is fundamentally important for efficient metal separation and the development of highly stable radiopharmaceuticals. A widely adopted strategy involves introducing water-solubilizing groups into originally effective lipophilic ligands, aiming to preserve the metal-binding affinity while imparting aqueous solubility. In this work, we demonstrate that such an intuitive solubilization approach can fail if an appropriate hydrogen-bonding network is not established.

On the Design of Effective Water-Soluble Actinide-Masking Ligands Through Ligand Structure Modulation.

Water-soluble actinide-masking ligands are fundamentally important for achieving efficient lanthanide/actinide separation and for the development of water-soluble f-block complexes for bioimaging and radiopharmaceutical applications. However, the underlying design principles remain largely elusive, particularly in achieving a fine balance between ligand water solubility and metal affinity/selectivity. In this study, it is demonstrated that for the well-established phenanthroline diimine ligand framework, topological modifications can preserve water solubility but introduce significant rotational energy barriers.

Effects of soil labile carbon fractions and microbes on GHG emissions from flooding to drying in paddy fields.

Soil microorganisms and labile soil organic carbon (SOC) fractions are essential factors affecting greenhouse gas (GHG) emissions in paddy fields. However, the effects of labile SOC fractions and microorganisms on GHG emissions from flooding to drying after organic fertilizer replacing for chemical fertilizer remain unclear. Here, a long-term experiment was conducted with four treatments: chemical fertilization only (control), organic fertilizer substituting 25 % of chemical N fertilizer (NM1), 50 % of chemical N fertilizer (NM2), and NM2 combined with crop straw (NMS).

Mechanism of low-temperature tolerance in wucai induced by exogenous thermospermine.

Wucai is an important specialty vegetable, and its low-temperature tolerance is associated with a polyamine, thermospermine (T-Spm) according to our previous study. However, the mechanism underlying the effect of T-Spm has not been elucidated yet. In this study, we investigated the relationship between T-Spm and cold tolerance of wucai by exogenously applying T-Spm to wucai seedlings exposed to low-temperature stress with water application as control.

Association between coffee intake and serum α-Klotho levels in adults: a population-based study.

Background: Coffee is widely consumed in the US, linked to various health benefits, including reduced adiposity. α-Klotho is a circulating protein linked to the aging processes, associated with greater longevity, and confers protective effects against cardiovascular disease, chronic kidney disease, and neurodegenerative disorders. This study investigates the association between coffee (total, caffeinated, and decaffeinated) intake and serum α-Klotho (SαKl) levels.

Self-medication among university students in Guangdong province, China: a cross-sectional study using the KAP model.

Objective: Self-medication has emerged as a significant global public health concern. Despite possessing a certain level of medication knowledge, university students in China exhibit a high-risk profile regarding self-medication practices. This study aimed to systematically investigate the current status and influencing factors of self-medication among university students in Guangdong Province, China, thereby providing evidence-based recommendations for targeted intervention strategies.

(W/O/W) Double Emulsions-Filled Chitosan Hydrogel Beads for Topical Application.

The aim of this study was to develop double emulsions-filled chitosan hydrogel beads for topical application and to elucidate their skin penetration behavior. Double emulsions were prepared by a two-step emulsification method, and double emulsions-filled chitosan hydrogel beads were prepared by the extrusion method. The structure, stability, and skin penetration behavior were investigated.

Sex differences in the association between atherogenic index of plasma and α-klotho: insights from a community-based cohort.

Background: The Atherogenic Index of Plasma (AIP) is a marker of lipid imbalance and cardiovascular risk, while α-Klotho is an anti-aging protein involved in oxidative stress and inflammation regulation. Although both are linked to cardiovascular and metabolic health, the relationship between AIP and α-Klotho, particularly regarding sex differences, remains unclear.

Methods: We performed a cross-sectional analysis of a community-based cohort drawn from five consecutive cycles of the NHANES (January 2007 - December 2016).

Potential of miR-192-5p as a diagnostic marker for children with severe pneumonia and respiratory failure and its predictive value for prognosis.

Introduction: Severe pneumonia in children is a rapidly progressing respiratory system disease. If not promptly controlled, it can lead to respiratory failure, posing a serious threat to the child's life. This study investigated the diagnostic and prognostic potential of miR-192-5p in children with severe pneumonia and respiratory failure.

Genome wide identification and characterization of EPFL genes and its potential association with male sterility in Brassica rapa.

The epidermal patterning factor-like (EPFL) gene family, encoding cysteine-rich polypeptides (CRPs), regulates diverse developmental processes in plants, including the control of stomatal density and the guidance of pollen tube elongation. To investigate its potential association with male sterility in Brassica rapa, we performed a comprehensive genome-wide identification using bioinformatics approaches. Our analysis revealed 14 BrEPFL members distributed across 8 of the 10 chromosomes.

Enhanced neonicotinoid removal in constructed wetlands using Fungus-Fe/Mn biochar.

The environmental persistence and toxicity of neonicotinoids, such as imidacloprid (IMI) and thiamethoxam (THX), pose substantial threats to aquatic ecosystems. This study evaluated the performance of constructed wetlands (CWs) amended with a novel Fungus-Fe/Mn biochar substrate (synthesized by immobilizing the white-rot fungus Phanerochaete chrysosporium onto Fe/Mn-modified biochar) for enhanced removal of IMI and THX from simulated agricultural wastewater. CWs integrated with Fungus-Fe/Mn biochar demonstrated significantly improved removal efficiencies of 73.

Correction: Development and validation of an ARID1A-related immune genes risk model in evaluating prognosis and immune therapeutic efficacy for gastric cancer patients: a translational study.

[This corrects the article DOI: 10.3389/fimmu.2025.

Macroplastics in soybean cultivation: Neutral on plant growth but disruptive to nitrogen-fixing microbiome.

Macroplastics are an emerging yet underexplored pollutant in agricultural soils, with the potential to disrupt nitrogen (N) cycling through physical interference and microbial community shifts. While extensive studies have focused on microplastics, the effects of larger plastic debris (>2 cm) on soil-plant systems in legume cropping systems remain poorly understood. We conducted a 71-d mesocosm study utilizing N isotopic tracing and metagenomic sequencing to demonstrate how macroplastics influence soybean growth and soil-soybean continuum N cycling.

Micropollutant removal efficiency and microbial community of different hybrid constructed wetland systems.

Micropollutants (MPs), including antibiotics, neonicotinoids, and phthalic acid esters (PAEs), are increasingly detected in domestic wastewater, posing substantial environmental and public health risks. This study evaluates the removal performance and underlying microbial mechanisms in six pilot-scale hybrid constructed wetlands (HCWs), each employing different combinations of vertical flow (VF), horizontal flow (HF), and surface flow (SF) systems. A total of 25 MPs were monitored, with influent concentrations ranging from 0.

IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.

Atherosclerosis (AS) stands as the primary culprit behind the high morbidity and mortality globally. The aberrant proliferation, migration, and transdifferentiation of vascular smooth muscle cells (VSMCs) are recognized as the crucial factors in the development of atherosclerotic plaques. Interferon-induced transmembrane protein 1 (IFITM1) is verified as a cellular regulatory factor for various diseases but its regulatory role in VSMCs remains unclear.

Stepwise Structural Transformations of Coordination Polymers Caused by Ligands Replacements and Solid-State Photoreaction.

The structural transformations of coordination polymers not only contribute to structural diversity but also provide design strategies at the molecular level for developing a new generation of smart materials. In this work, a photoinert olefin-containing coordination chain {[Zn(HO)(5-NO-1,3-BDC)(3,3'-dpe)]·HO} () was prepared by the hydrothermal reaction between Zn(NO)·6HO, 1,2-di(pyridin-3-yl)ethene (3,3'-dpe), and 5-nitro-1,3-benzenedicarboxylic acid (5-NO-1,3-HBDC). After replacing the 5-NO-1,3-HBDC ligand in the solution of with 5-methyl-1,3-benzenedicarboxylic acid (5-Me-1,3-HBDC), a unique two-dimensional photoreactive coordination network [Zn(5-Me-1,3-BDC)(3,3'-dpe)] () was formed.

Mechanistic insights into phosphorus transformation mediated by and under long-term high-volume swine manure application in a wheat-rice rotation system.

Introduction: Understanding the impacts of sustained high-input swine manure on soil phosphorus (P), along with identifying and functionally characterizing P-associated microorganisms, can provide a scientific foundation for effective management of soil P in relation to swine manure application. This study provides novel insights into the functional roles of P-associated microorganisms in mediating phosphorus dynamics under long-term excessive swine manure application.

Methods: The study investigated the prolonged impact of high-volume swine manure application on soil P fractions over an 8-year continuous, randomized field trial involving rotating wheat (wet conditions) and rice (flooded conditions) crops.

The Strategies Microalgae Adopt to Counteract the Toxic Effect of Heavy Metals.

Besides biomass production, some microalgae have been used to treat wastewater contamination. However, in general, high concentrations of heavy metals significantly inhibit algal growth. We thus need to find ways to promote the resistance of microalgae to heavy metals, increase their growth rate under stress, and achieve coupling of heavy metal removal and biomass production simultaneously.

Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion.

The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for the delivery of curcumin in functional foods. Curcumin-loaded NLC-filled hydrogel beads based on calcium alginate were developed using the extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities were studied to confirm the feasibility of this delivery system.

Development and validation of an ARID1A-related immune genes risk model in evaluating prognosis and immune therapeutic efficacy for gastric cancer patients: a translational study.

Background: Mutations in the ARID1A gene, an integral component of the SWI/SNF complex, are prevalent, affecting prognosis and immune response in several malignancies, including gastric cancer (GC). The aim of this study was to identify ARID1A mutation-associated immune genes to construct an ARID1A-related immune gene risk model (ARM).

Methods: GSEA and ssGSEA were used to explore the involved biological pathways and the degree of immune cell infiltration, respectively.