Global burden of autism spectrum disorders among population aged 70 years and older from 1990-2021, with projections to 2040: findings from the Global Burden of Disease Study 2021.

Autism spectrum disorders (ASD) is a lifelong neurodevelopmental condition that negatively affects older adults, yet it receives minimal priority and limited attention in research and healthcare services for this population. Using data from Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we estimated the prevalence and disability-adjusted life-years (DALYs) of ASD among population aged ≥70 years globally from 1990-2021, with projections to 2040. Decomposition analysis was conducted.

The heterogeneity of mortality burden of lower respiratory infection associated with ambient temperature and its drivers in China.

Ambient temperature is linked to an increased risk of lower respiratory infections (LRI) yet the evidence on the population and spatial heterogeneity of LRI mortality burden attributed to non-optimal temperatures and its socioeconomic drivers remain limited. Based on 1249,452 LRI deaths and related meteorological data collected from 2820 counties/districts during 2013-2022 in China, we conducted a time-stratified case-crossover analysis using distributed lag nonlinear model (DLNM) to examine the spatial and population heterogeneity of the association between temperature and LRI mortality. Additionally, we explored the driving factors of the spatial heterogeneity using eXtreme Gradient Boosting (XGBoost) and SHapley Additive exPlanation (SHAP) methods.

Feasibility and priority strategies for diabetes prevention and control in Chinese demonstration areas.

Background: Diabetes is a leading global public health challenge with 537 million cases worldwide in 2021 and significant economic and societal burdens. Despite global initiatives, feasibility constraints limit widespread implementation of diabetes prevention/control measures. The key to facilitating the implementation of diabetes prevention and control measures lies in prioritise them.

Hourly Relative Humidity and Fall Injuries in China: A Nationwide Case-Crossover Study Based on 4.19 Million Cases.

Falls represent a significant public health issue worldwide. Previous studies have demonstrated associations of temperature with fall risk, but the effect and burden of hourly relative humidity and fall morbidity have been rarely investigated. Fall data and meteorological data were collected from the National Injury Surveillance System during 2006-2021 in China.

The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment: An individually matched case-control study.

Introduction: The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment remain unclear.

Methods: We conducted a case-control study with 25,432 adults aged 60 years or older. We used multiple logistic regression to analyze the effects of combined visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment, while controlling for confounding factors.

Sudden cardiac arrest mortality in China: temporal trends and risk factors.

Background: Sudden cardiac death (SCD) accounts for more than half of all sudden death cases, posing a significant health burden in China. However, epidemiological data on SCD are scarce due to the lack of a central data registry and the heterogeneity of case definitions. This study aims to provide reliable estimates of the incidence and risk factors of SCD in China at the national and regional levels from 2013 to 2021, as well as the current status of prevention.

Effects of pre-operative continuing oral anticoagulants or antiplatelets on health outcomes among older patients with hip fracture: a systematic review and meta-analysis.

Unlabelled: Continuing antiplatelets during hip fracture surgery may be safe for older adults, while early surgery after discontinuation reduces hospital stay without adverse outcomes.

Purpose: The safety of continuing antiplatelets or direct oral anticoagulants (DOACs) before surgery in older patients with hip fractures remains uncertain. The feasibility of timely surgery after discontinuation also warrants further investigation.

Urban-rural disparity of low-temperature-related mortality from northernmost to southernmost regions in China.

Unresolved issues still exist regarding urban-rural disparity of temperature-related mortality among different regions. We collected daily all-cause mortality data from 7,439,777 individuals in 300 counties across six temperature zones in China, ranging from the coldest to hottest regions, from 2017 to 2021. Additionally, we obtained the daily average temperature, relative humidity, and concentrations of PM and O in these regions during the same period.

The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.

Background: Idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune diseases with variable long-term outcomes.

Objective: To determine the prognosis of IIM.

Methods: This multicenter, prospective cohort study included Chinese patients with IIM.

Legislative Status of Public-Access Cardiopulmonary Resuscitation - China, 2024.

Public-access cardiopulmonary resuscitation (CPR) ranks first in the "Prevention and Control of Major Diseases" section of the . However, Chinese patients who have experienced out-of-hospital cardiac arrest (OHCA) are reported to have a survival rate at discharge of only 0.35%.

Hypertension Control in China: Translation from Clinical Trial to Real-World Application - Preliminary Outcomes.

To evaluate the adaptability of the China Rural Hypertension Control Project (CRHCP) - a multifaceted village doctor-led intervention for blood pressure control in rural China - for widespread implementation in extension projects. This project comprises two phases: a pilot project and an extension project. It builds upon our CRHCP model, implementing a multi-level comprehensive hypertension management strategy targeting the general population across rural areas and township communities in China, aligning with national policies and local initiatives.

Zoonotic diseases in China: epidemiological trends, incidence forecasting, and comparative analysis between real-world surveillance data and Global Burden of Disease 2021 estimates.

Background: Zoonotic diseases remain a significant public health challenge in China. This study examines the temporal trends, disease burden, and demographic patterns of major zoonoses from 2010 to 2023.

Methods: This study analyzed data from China's National Notifiable Infectious Disease Reporting System (NNIDRS, 2010-2023) on nine major zoonoses, including echinococcosis, brucellosis, leptospirosis, anthrax, leishmaniasis, encephalitis (Japanese encephalitis), hemorrhagic fever, rabies, and schistosomiasis.

The incidence and influencing factors of type 2 diabetes mellitus in Chinese adults in 10 provinces: a prospective cohort study.

Background: Diabetes mellitus (DM) is an important public health problem that seriously affects the health of Chinese residents. Exploring the incidence of DM and its influencing factors in Chinese adults could help develop prevention and control strategies and measures. However, there was few national cohort study on DM incidence and its influencing factors in China.

Effect of Life's Essential 8 and Exposure to Solid Fuels for Cooking on Cardiovascular Disease Risk.

Background: Few studies have examined the association between Life's Essential 8 (LE8) scores and cardiovascular disease (CVD) risk in less-developed countries. In this study we aimed to assess the relationship between LE8 levels and CVD and evaluate whether LE8 modifies the association between exposure to solid cooking fuels and CVD.

Methods: A cross-sectional analysis was conducted using data extracted from the China Multi-Ethnic Cohort.

Changes in influenza-associated excess mortality in China between 2012-2019 and 2020-2021: a population-based statistical modelling study.

Background: The seasonal cycle of the influenza virus causes substantial morbidity and mortality globally. The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the circulation of influenza viruses can influence influenza-associated excess mortality. Given the few studies that have explored this topic, the objective of this study was to evaluate influenza-associated excess mortality in the Chinese mainland from 2012 to 2021 and quantify the changes from 2020 to 2021 compared with 2012-2019.

The temporal shift of temperature-related injury incidence risk and its driving factors in China: a nationwide case-crossover study from 2006 to 2021.

Background: Although several studies have demonstrated an association between ambient temperature and injury, the temporal trend of temperature-related injury risk remains unknown. This study aimed to examine changes in the effect of temperature on injury incidence and to explore its driving factors.

Methods: A time-stratified case-crossover study including over 11.

Burden of Headache Disorders in China and its Provinces, 1990-2021.

Objective: To analyze the prevalence and burden of headache disorders in China and its provinces from 1990 to 2021.

Methods: Using data from the Global Burden of Disease Study (GBD) 2021, the number of prevalent cases, prevalence rate, disability-adjusted life years (DALYs), and age-standardized DALY rates were analyzed by sex, age group, and province for headache disorders and their subtypes (migraine and tension-type headache [TTH]) between 1990 and 2021. Percentage changes during this period were also estimated.

Digital Therapeutics for Cognitive Impairment: Exploring Innovations, Challenges, and Future Prospects.

Recent advancements in cognitive neuroscience and digital technology have significantly accelerated the adoption of digital therapeutics for cognitive impairment. This viewpoint explores the innovative applications of digital therapeutics in the assessment, intervention, management, and monitoring of cognitive disorders while highlighting key challenges that impede their widespread integration into clinical practice. Drawing on the definition of cognitive digital therapeutics (CDTx) and the multistakeholder collaboration required for its development and implementation, this paper examines the role of digital technologies in cognitive health and explores challenges from multiple perspectives, including clinical practice, policy framework, user adoption, ethics and privacy, and data interoperability and system integration.

Ambient temperature and injury-related emergency department visits in China and its Provinces: a large national case-crossover study.

Background: Temperature-related risks on non-accidental morbidity or mortality have been well documented. However, limited studies have investigated the injury morbidity risk and burden attributed to ambient temperature.

Objective: The current study aimed to assess the injury morbidity risk and burden attributed to ambient temperature in China.

Mortality burden of protein-energy malnutrition associated with ambient temperature in China: a nationwide case-crossover study.

Background: In the context of global warming, the health effects of non-optimum temperatures have attracted increasing attention. Studies have shown that high temperatures increase risk of hospitalization for protein-energy malnutrition (PEM), yet the impact of non-optimum temperatures on PEM mortality is unknown.

Objectives: This study aims to quantitatively assess risk and burden of PEM-related mortality associated with short-term temperature exposure across 31 provinces in China.

Hypertension and diabetes on cognitive impairment: a case-control study in China.

Background: Cognitive impairment, hypertension and diabetes are prevalent chronic conditions in populations of older ages. Previous studies have shown that hypertension and diabetes are risk factors for the development of cognitive impairment. However, the impact of hypertension combined with diabetes (HD) and their cumulative effects on cognitive impairment remain unclear.

Transforming Care in China by Using Public-Private Partnerships to Unlock the Power of Patient-Centered Real-World Data.

The transformation of China's healthcare system is increasingly driven by the development of real-world data (RWD) and real-world evidence (RWE). In the context of the "Healthy China 2030" initiative, which emphasizes addressing the growing burden of non-communicable diseases (NCDs), this article assesses the current state and potential of RWD/RWE development. Key areas of focus include the policy environment, guideline systems, data foundations and tools, and talent development.