Incidentally detected renal leiomyosarcoma with inferior vena cava tumor thrombus: a case report with review of the literature.

Kidney cancer is the 14th most common cancer worldwide. On the basis of the histological characteristics of kidney cancers, most kidney cancers are renal cell carcinomas. Renal leiomyosarcoma (LMS) is extremely rare and malignant and accounts for less than 1% of all kidney cancer cases.

Association between Systemic Immune-Inflammation Index and female breast cancer based on NHANES data (2001-2018): A cross-sectional study.

Worldwide cancer statistics have shown that breast cancer dominates female cancer incidence and remains a leading cause of death. The Systemic Immune-Inflammation Index (SII) is a new prognostic indicator of systemic inflammation used to assess systemic immune-inflammatory response levels in the human body. It is associated with the prognosis of various diseases, such as malignant tumors, cardiovascular diseases, and autoimmune diseases.

Structure Elucidation and Complete NMR Spectral Assignments of New Sesquiterpenes Isolated From Marine Derived Fungus Aspergillus sydowii-HB.

Six sesquiterpene derivative compounds (1-6), including one new 7R-sydowic acid (1) and five known compounds (2-6) were isolated from the secondary metabolites of Aspergillus sydowii-HB. The structures were determined by NMR spectroscopy and ESI-MS analysis, and the configuration of compound 1 was confirmed through DP4 calculation and NMR chemical shift. All the isolated compounds (1-6) were tested for their cytotoxic activities.

Prognostic role of Naples prognostic score in lung cancer: a meta-analysis.

To clarify the association of pretreatment Naples prognostic score (NPS) with long-term survival among lung cancer patients. EMBASE, Web of Science, PubMed and CNKI databases were searched up to April 16, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS).

Invasive Pseudomembranous Tracheobronchitis Accompanied With Fever and Hemoptysis: A Case Report.

Pseudomembranous tracheobronchitis is a relatively rare disease, and it is very easy for clinicians to misdiagnose. It is particularly necessary for the patient presenting with recurrent pyrexia and hemoptysis in the absence of clear-cut pulmonary radiological findings to receive a bronchoscopy.

Altered Immune Profiles in Non-Failing Heart Donors With Induced Long QT Syndrome: A Potential Risk Factor for Cardiac Allograft Vasculopathy.

Introduction: Cardiac allograft vasculopathy (CAV) develops more aggressively in recipients of hearts from brain-dead (BD) donors with induced long QT syndrome (iLQTS), yet the underlying mechanisms remain poorly understood. In this study, we employ a multi-omics and experimental framework to explore the role of neuro-immune interactions in non-failing donor hearts affected by iLQTS.

Methods: Single-nuclei RNA sequencing (snRNA-seq) compared four iLQTS and four non-arrhythmic non-failing donor hearts.

Factors associated with symptom relief in patients with irritable bowel syndrome: a retrospective cohort study.

Background: Symptom relief in irritable bowel syndrome (IBS) varies widely, influenced by demographic, clinical, and psychosocial factors. Identifying factors associated with symptom relief can enhance management strategies for IBS patients.

Objective: This study aimed to examine factors associated with symptom relief in a cohort of IBS patients, focusing on the role of demographic, lifestyle, psychological, and physiological characteristics.

VGRCOT: a one-tube visual detection method for group B combining RPA and CRISPR/Cas12a for point-of-care testing in reproductive health.

Group B (GBS) is a significant pathogen that causes perinatal infections, seriously threatening the health of pregnant women and newborns. Prophylactic antibiotic treatment for pregnant women who screen positive for GBS can notably reduce the incidence and fatality of neonatal infections. Herein, we developed a isual nucleic acid method for BS that integrates PA and RISPR/Cas12a in a ne-ube setup, termed VGRCOT.

Rapid Plasmid-Mediated Acquisition of Erythromycin Resistance via in : A 72-Hour Clinical Evolution.

Purpose: To investigate the genomic mechanisms driving rapid erythromycin resistance emergence in during clinical management of urinary tract infections.

Methods: Longitudinal analysis of four isolates (C1-C4) from an ICU patient with candida coinfection was conducted using CLSI M45-A3-guided microbroth dilution and comparative whole-genome sequencing. Phylogenetic reconstruction (27 housekeeping genes) confirmed clonal origin, while CARD/PIPdb/ISfinder databases characterized resistome dynamics.

Association between neutrophil-lymphocyte ratio and female breast cancer: an observational study from NHANES 2001-2018 with external validation.

Background: In the 21st century, breast cancer is the most frequent malignant tumor threatening women's health. Previous research has confirmed that inflammatory response processes play key roles in tumor occurrence, development, and metastasis. The neutrophil-to-lymphocyte ratio (NLR), an emerging disease biomarker, has become a focus of cancer research.

Integrating GEO Database, Mendelian Randomization, and Molecular Docking to Identify HLA-C as a Potential Therapeutic Target for Periodontitis.

Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissues, ultimately resulting in tooth loss. Current treatments primarily focus on mitigating inflammation and alleviating symptoms, but they often lack specificity. This study aims to explore the molecular mechanisms of periodontitis using gene expression databases (GEOs) and bioinformatics methods, combined with Mendelian randomization (MR) analysis, to identify key therapeutic targets.

Identifying intervention targets in the COVID-19 pandemic-related psychopathological network among adolescents: A simulating intervention study.

Objective: Network approaches to the pandemic-related psychopathology could help identify the effective targets for interventions in adolescents. However, previous studies involved only limited forms of psychopathology related to stress and trauma and relied on the traditional centrality analysis. This study aimed to identify more effective intervention targets of pandemic-related psychopathological symptoms in a large-scale sample of adolescents using a newly developed network-based simulation intervention technique.

MRI features of primary cardiac lymphoma: case report and literature review.

Purpose: This study aimed to further enhance the understanding of the imaging features of primary cardiac lymphoma (PCL), improve preoperative diagnostic accuracy, and reduce the misdiagnosis rates.

Methods: This study reports on a case of a 63-year-old man who presented with 3-day-long dizziness and bilateral lower limb edema. Initial transthoracic echocardiography detected a 4.

Predicting circadian syndrome by obesity indices in middle-aged and older Chinese: evidence from the China Health and Retirement Longitudinal Study.

Objective: To predict the optimal cut-off values for screening and predicting circadian syndrome (CircS) in a middle-aged and older population using 11 obesity-related indices.

Methods: Data was obtained from the China Health and Retirement Longitudinal Study (CHARLS) database, including 9265 middle-aged and older people. We examined 11 indices, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), weight-adjusted-waist index (WWI), and cardiometabolic index (CMI).

The prognostic and clinicopathological value of HALP score in non-small cell lung cancer.

Objective: The prognostic role of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in non-small cell lung cancer (NSCLC) has been widely reported, but the results remain controversial. Therefore, we aim to evaluate the prognostic and clinicopathological value of the HALP score in NSCLC through a pooled analysis.

Methods: We conducted a comprehensive literature search of PubMed, Embase, Web of Science, Cochrane Library, and the ClinicalTrials.

Causal Association Between Genetically Predicted Ankle Spacing Width and Risk of Age-Related Bone Mineral Density.

While observational studies suggest associations between ankle spacing width (ASW, defined as the horizontal distance between the medial malleoli under weight-bearing conditions) and osteoporosis (OP), fractures, and falls, causal evidence remains limited. This gap hinders the translation of ASW measurements into clinical risk stratification tools. This study aimed to investigate the causal relationships between ASW indicators and site-/age-specific bone mineral density (BMD), bone fracture and fall risks.

and co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study.

Background: Recent or ongoing use of antibiotics causes diarrhea. Probiotic yogurt is generally used in antibiotic-induced diarrhea as adjuvant therapy. In recent times, there have been no clear recommendations or guidelines for the course of treatment of probiotics in preventing antibiotic-induced diarrhea in infants and young children in mainland China.

The current status and influencing factors of quality of life of chronic wound patients based on Wound-QoL scale: A cross-sectional study.

This study aims to establish the current quality of life (QoL) of patients with chronic wounds and identify the factors influencing it. Convenience sampling was employed, and 223 patients with chronic wounds were recruited from a tertiary hospital in Deyang City between April 2023 and January 2024. Patients completed a demographic characteristics questionnaire, the Wound-QoL, the modified Barthel Index, and the Hospital Anxiety and Depression Scale.

Analysis of the demand for "Internet + nursing services" and its influencing factors among orthopaedic patients in Zhejiang, a developed area of China.

Background: The "Internet + nursing services" model has been applied to various diseases and has been accepted by an increasing number of people, especially in the context of chronic disease management. This model has achieved some results. However, it is still less commonly used in orthopeadic patients.

Capsaicin inhibits the biofilm of Klebsiella pneumoniae by targeting the transcriptional regulator SdiA.

Pneumonia, particularly when caused by the bacterium Klebsiella pneumoniae, presents a major global health challenge. This gram-negative bacterium is a notable pathogen in healthcare-associated infections, leading to severe conditions such as urinary tract infections, pneumonia, and the bloodstream infections, mainly in immunocompromised subjects. The bacterium's ability to resist multiple antibiotics complicates the treatment, posing a major concern in hospital settings.

A comprehensive overview of triptolide utilizing nanotechnology and its potential applications in prostate diseases.

Triptolide (TPL) demonstrates a broad spectrum of biological and pharmacological activities, with its primary effects encompassing anti-inflammatory and anti-tumor properties, thereby rendering it applicable in the treatment of various diseases. However, the toxicity associated with TPL has considerably limited its clinical application. In recent years, the advancement of functional nanotechnology has created new opportunities for the application of TPL.

TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia.

Benign prostatic hyperplasia (BPH) is an age-related condition in men with a poorly defined etiology. Chronic inflammation is increasingly recognized as a key contributor to BPH progression; however, the underlying mechanisms remain incompletely understood. This study aimed to elucidate the role of a TNF-α-induced inflammatory microenvironment in regulating BPH progression.

Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is primarily characterized by deficits in social interaction, impaired communication, restricted interests, and repetitive behaviors. The prevalence of ASD has been steadily increasing, establishing it as one of the leading causes of disability among children worldwide. Although the precise pathogenesis of ASD remains unclear, factors such as genetic predisposition, environmental exposures, immune dysregulation, and neurodevelopmental abnormalities are collectively believed to contribute to its onset.

Pyroptosis in Alzheimer's Disease: Mechanisms and Therapeutic Potential.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid plaques, neurofibrillary tangles (NFTs), and neuroinflammation. Recent research has revealed that pyroptosis, an inflammatory programmed cell death (PCD), plays a crucial role in AD pathology. The pyroptosis signaling cascade triggered by β-amyloid (Aβ) and hyperphosphorylated tau protein leads to the release of proinflammatory cytokines, forming a "neuroinflammation-neurodegeneration" vicious cycle.