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Six sesquiterpene derivative compounds (1-6), including one new 7R-sydowic acid (1) and five known compounds (2-6) were isolated from the secondary metabolites of Aspergillus sydowii-HB. The structures were determined by NMR spectroscopy and ESI-MS analysis, and the configuration of compound 1 was confirmed through DP4 calculation and NMR chemical shift. All the isolated compounds (1-6) were tested for their cytotoxic activities. The possible biosynthetic pathways for compounds (1-6) were also postulated.
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http://dx.doi.org/10.1002/mrc.70035 | DOI Listing |
Acta Crystallogr E Crystallogr Commun
September 2025
Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
In the structure of the title compound, CHN·CHNOS·CHNOS, the central pyridinic rings are approximately coplanar to the benzo-thia-zole moieties. The phenyl groups are appreciably angled to the central rings [inter-planar angles of 57.30 (3)° for the anion and 79.
View Article and Find Full Text PDFACS Omega
September 2025
Department of Horticultural Science, Texas A&M University, College Station, Texas 77843, United States.
The limited water solubility and environmental instability of natural pesticidal compounds impede their broader agricultural use. This study reports an amphiphile-assisted nanoprecipitation method to imbibe azadirachtin-rich neem seed extract (NSE) within a glycine carrier matrix, yielding a stable nanocomposite biopesticide. The formulation, prepared using polyoxyethylene sorbitan monooleate as a stabilizer and glycine as the matrix former, followed by lyophilization, exhibited a hydrodynamic diameter of ∼8 nm when redispersed in water.
View Article and Find Full Text PDFPhytochemistry
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of Ch
Six undescribed sesquiterpene esters, euphoresulins A-F, along with fourteen known daucane analogues were isolated from the aerial parts of Euphorbia esula growing in Uzbekistan. Their structures were determined on the basis of extensive spectroscopic analyses, with absolute configurations established by comparison of experimental and calculated ECD data, in addition to single-crystal X-ray diffraction crystallography. Euphoresulins A-F (1-6) presented sesquiterpene ester types of daucane for euphoresulins A-D (1-4) and aromadendrane for euphoresulins E-F (5-6).
View Article and Find Full Text PDFBioorg Chem
September 2025
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address:
Chemical investigation of the twigs and leaves of Euphorbia tirucalli afforded six undescribed tigliane glycosides, tirucalosides A-F (1-6), together with 12 known diterpenoids (7-18). Compound 1 represents a rare carbon skeleton bearing a 5/7/5/4-fused ring system, while compound 6 contains an unusual seco-glucoside substitution. Their structures were determined by a combination of an extensive spectroscopic analysis and acid hydrolysis experiment.
View Article and Find Full Text PDFPhytochemistry
September 2025
HUN-REN-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös Str. 6, 6720, Szeged, Hungary; Department of Pharmacognosy, University of Szeged, Eötvös Str. 6, 6720, Szeged, Hungary. Electronic address:
Previously undescribed steroids vernomigeodiins A-D (1-4), were isolated from the African medicinal plant Vernoniastrum migeodii along with known sterols 5-10 and the tripeptide aurantiamide acetate (11). The isolated steroids featured a stigmastane skeleton with a unique conjugated Δ-diene segment and a highly oxidized side chain, occasionally forming a bi- or tricyclic ring system. Sterols 1-3, 5-9 are glucosylated, whereas 4 and 10 are aglycons.
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