Wild-type p53 overexpression in -mutated acute myeloid leukemia: potential implications for disease biology and therapy response.

Not available.

Persisting Lyme Disease in the Pediatric Population.

A total of 101 patients with a clinical picture of persisting Lyme disease seen at the University of Connecticut Health Center and Boston Medical Center were recruited for the study to determine whether persistent infection is the likely cause. Brain SPECT imaging and responses to antibiotic treatments were recorded. Patients had more than 5 symptoms lasting more than 6 months.

Single-Cell Analysis Reveals a Critical Role for Macrophage Epsins in Regulating the Origin of Foam Cells in Atherosclerosis.

Background: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden foam cells and plaques within the arterial wall. Dysfunctional vascular smooth muscle cells (VSMCs), fibroblasts, endothelial cells, and macrophages contribute to disease progression. Here, we report that macrophage-specific expression of epsins, highly conserved endocytic adaptor proteins involved in clathrin-mediated endocytosis, accelerates atherosclerosis in Western diet-fed mice.

Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study.

Background: The estimated glucose disposal rate (eGDR) is a validated surrogate marker of insulin resistance. However, its association with stroke and dementia in nondiabetic populations remains insufficiently investigated.

Methods: This prospective cohort study included nondiabetic participants from the UK Biobank.

Preclinical Ischemic Stroke Multicenter (PRISM) Trials Collective Statement: Opportunities, Challenges, and Recommendations for a New Era.

Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.

A flexible linear circular bipolarization conversion metasurface based on graphene.

A flexible bipolarization conversion metasurface based on graphene is proposed in this paper, which can achieve single-band linear-to-linear (LTL) and dual-band linear-to-circular (LTC) polarization conversion. The polarization conversion ratio (PCR) and axial ratio (AR) are dynamically regulated by varying the sheet resistance () of graphene. When = 1400 Ω Sq, the designed metasurface achieves a single-band LTL polarization conversion of 7.

Comparative Effectiveness of TAVI Platforms and Surgical Aortic Valve Replacement: A Network Meta-Analysis of Randomized Controlled Trials.

Background: Evidence informing clinical guidelines assumes that all transcatheter aortic valve implantation (TAVI) devices have similar effectiveness, in other words, displaying a class effect across TAVI valves. We aimed to assess the comparative effectiveness of different TAVI platforms relative to other TAVI counterparts or surgical aortic valve replacement (SAVR).

Methods: MEDLINE/Embase/CENTRAL were searched from inception until April 2025, for randomized controlled trials comparing outcomes with different commercially available TAVI devices relative to other TAVI counterparts or SAVR.

Chronological differentiation of printed or handwritten text and stamps based on hyperspectral imaging and convolutional neural networks.

To address the technical challenges associated with determining the chronological order of overlapping stamps and textual content in forensic document examination, this study proposes a novel non-destructive method that integrates hyperspectral imaging (HSI) with convolutional neural networks (CNNs). A multi-type cross-sequence dataset was constructed, comprising 60 samples of handwriting-stamp sequences and 20 samples of printed text-stamp sequences, all subjected to six months of natural aging. Spectral responses were collected across the 400-1000 nm range in the overlapping regions.

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Respiratory syncytial virus (RSV) is a major pathogen causing acute respiratory infections, and the RSV fusion glycoprotein (F) has been identified as a key target for developing small-molecule inhibitors. Based on our prior identification of lonafarnib as an F protein inhibitor, medicinal chemistry efforts led to the development of , which exhibits significantly enhanced potency against both laboratory and clinical RSV isolates in cellular assays. Time-of-addition and SPR assays indicate that inhibits viral entry by targeting the RSV F protein, but has farnesyltransferase-independent antiviral efficacy.

The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas.

As essential sources of vegetables, oilseeds, and forage, Brassica crops exhibit complex epigenetic regulation mechanisms involving histone modifications, DNA modifications, RNA modifications, noncoding RNAs, and chromatin remodelling. The agronomic traits and environmental adaptability of crops are regulated by both genetic and epigenetic mechanisms, while epigenetic variation can affect plant phenotypes without changing gene sequences. Furthermore, the impact of epigenetic modifications on plant phenotype has accelerated the crop breeding process.

Quality Difference Analysis of Pomegranate Peels Based on Multidimensional Fingerprint With Chemical Pattern Recognition.

To evaluate the quality of pomegranate peels from different cultivars, pomegranate peel samples from 47 cultivars were compared and classified based on fingerprints and chemical components obtained using HPLC-PDA-MS/MS combined with chemometric methods. Three pattern recognition methods, namely, hierarchical cluster analysis, principal component analysis, and partial least square-discriminant analysis, were used to establish classification models. Results showed that the contents of 10 components from pomegranate peel were determined.

Copper-Catalyzed Coupling of -Acyl-'-Substituted Hydrazines with (Hetero)aryl Chlorides/Bromides.

The coupling of -acyl-'-substituted hydrazines with (hetero)aryl bromides and chlorides is efficiently catalyzed by CuI/4-hydroxy picolinamide and Cu(OAc)/6-hydroxy picolinohydrazide, respectively. Under these conditions, a broad range of (hetero)aryl halides and -acyl-'-substituted hydrazines react smoothly at 80-120 °C, affording the corresponding products in good to excellent yields in most cases.

Quantification of flagellar gait changes with combined shape mode analysis and swimming simulations.

Many different microswimmers propel themselves using flagella that beat periodically. The shape of the flagellar beat and swimming speed have been observed to change with fluid rheology. We quantify changes in the flagellar waveforms of in response to changes in fluid viscosity using (i) shape mode analysis and (ii) a full swimmer simulation to analyse how shape changes affect the swimming speed and to explore the dimensionality of the shape space.

Cutting-edge synthetic strategies for designing multifunctional electrocatalysts with exceptional activity towards efficient hydrogen production and green metrics assessment.

The transition to a net-zero carbon economy hinges on the development of sustainable, efficient, and economically viable energy technologies. Here, we present a green, electricity-free auto-combustion synthesis of a multifunctional FeNi@MnO@C electrocatalyst, demonstrating outstanding performance for OER, HER, OWS, UOR, UOS, and OWS in alkaline seawater with a required potential of 1.45, 0.

An Association Analysis of Anxiety and Psoriasis: Based on the NHANES Database.

Background: Psoriasis is linked with an elevated risk of anxiety disorders, and there may be a temporal relationship between the two. However, the association between anxiety status and its duration with psoriasis is unclear.

Objectives: The present work aimed to figure out the association between anxiety and the risk of psoriasis.

PATJ deficiency leads to cystic kidney disease and related ciliopathies.

Cystic kidney disease and related ciliopathies are caused by pathogenic variants in genes that commonly result in ciliary dysfunction. For a substantial number of individuals affected by those cilia-related diseases, the causative gene still remains unknown. Using massively parallel sequencing, we here identified a pathogenic bi-allelic variant in the gene encoding PALS1-Associated Tight Junction Protein (PATJ; also known as Inactivation-No-Afterpotential D-Like, INADL) in an individual with ciliopathy.

Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases.

The interleukin (IL)-1 pathway is a key mediator of inflammation and innate immune responses. Its dysregulation contributes to rheumatoid arthritis (RA) and autoinflammatory diseases (AIDs). In this study, we develop a recombinant adeno-associated virus (rAAV)-based gene therapy to deliver an inflammation-inducible, secreted human IL-1 receptor antagonist (sIL-1Ra) as a complementary approach to existing IL-1 blockers.

Elesclomol-Copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, partly due to cancer stem cells (CSCs) that drive progression and treatment resistance. We explored the therapeutic potential of inducing cuproptosis, a copper-dependent regulated cell death, in CSC-enriched PDAC models. Using human and murine PDAC models, we evaluated elesclomol, a copper transport enhancer.

Visual outcomes and cost-utility analyses of toric intraocular lens implantation in cataract patients over 80 with corneal astigmatism: a retrospective cohort study.

Introduction: This study aimed to assess visual and refractive outcomes and cost utility of toric intraocular lens (IOLs) implantation in cataract patients over 80 with corneal astigmatism.

Methods: Patients >= 80 years with corneal astigmatism >= 1.50 diopters (D) who underwent cataract surgery with toric or monofocal IOLs were enrolled.

Key Mediators Reducing Socioeconomic Inequality in Early Childhood Caries.

Objectives: Socioeconomic status (SES) has a significant effect on the burden of early childhood caries (ECC), yet addressing SES disparities remains challenging. This study aimed to identify and quantify the most impactful mediator linking SES effect to the occurrence of ECC using advanced causal mediation analysis, to inform targeted interventions that reduce SES-related disparities in ECC.

Methods: Data were drawn from the Study of Mothers' and Infants' Life Events, a cohort of 2,182 mother-child dyads recruited from Adelaide's 3 largest public hospitals (2013-2014).

Development of a lip colour chart across four ethnicities.

In the human face, the lips play a key role in social interactions and are a major element of makeup strategies. However, the amount of data available on lips, particularly relating to colour, is limited in comparison to that on skin. To gain a better understanding of lip colour, this study aimed to assess its diversity across four ethnicities (Asian Chinese, African American, Hispanic American and Caucasian American and French).

Host Immune Response to Respiratory Syncytial Virus Infection in Children.

Respiratory syncytial virus (RSV) is one of the leading causes of severe respiratory diseases in children, especially in infants. The immune responses induced by RSV infection are a fairly complex process that can contribute significantly to disease severity. Despite decades of research on RSV, many immune mechanisms remain to be explored.

Early itch relief with ivarmacitinib improves quality of life, working productivity, and sleep quality in patients with moderate-to-severe atopic dermatitis: a post hoc analysis of a phase III trial.

Background: Ivarmacitinib (SHR0302), a selective Janus kinase-1 inhibitor, is a novel treatment for moderate-to-severe atopic dermatitis (AD).

Objectives: This post hoc analysis evaluated the impact of early itch relief with ivarmacitinib on quality of life (QoL), working productivity, and sleep quality in affected patients.

Methods: Data from ivarmacitinib treatment groups in a phase III trial (NCT04875169) were analyzed.

TCA cycle-derived oncometabolites in cancer and the immune microenvironment.

Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydroxyglutarate (2-HG), succinate, and fumarate are the most well-characterized, acting as competitive inhibitors of α-ketoglutarate-dependent dioxygenases to alter DNA and histone methylation, cellular differentiation, and hypoxia signaling. More recently, itaconate, an immunometabolite predominantly produced by activated macrophages, has been recognized for its dual roles in modulating inflammation and tumor immunity.

Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis.

Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.

Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.