Molecular Engineering Empowers Phenanthraquinone Organic Cathodes with Exceptional Cycling Stability for Lithium- and Aqueous Zinc-Ion Batteries.

Organic electrode materials have garnered great attention in recent years, owing to their resource sustainability, structural diversity, and superior compatibility with various ionic species. Among them, quinone-based compounds have attracted particular interest. Notably, compared with para-quinone analogs (e.

Comparative mitogenomics of the eulipotyphlan species (Mammalia, Eulipotyphla) provides novel insights into the molecular evolution of hibernation.

Hibernation is an elaborate response strategy employed by numerous mammals to survive in cold conditions that involves active suppression of metabolism. Despite the role of mitochondria as energy metabolism centers during hibernation, the adaptive and evolutionary mechanisms of mitochondrial genes in hibernating animals, like hedgehogs in eulipotyphlan species, are not yet fully understood. In this study, we sequenced and assembled mitochondrial genomes of the hibernating four-toed hedgehog () and the non-hibernating Asian house shrew ().

Atomistic Mechanism of Defect Self-Passivation in Metal Halide Perovskites.

Passivating detrimental defects is essential for improving perovskite solar cells (PSCs) performance. While hydrogen interstitials are often considered harmful, their role in defect passivation remains unclear. Using nonadiabatic molecular dynamics, we uncover a self-passivation mechanism between hydrogen (H) and bromine (Br) interstitials in all-inorganic CsPbBr perovskites.

Guishen-erxian Decoction can improve ovarian function in rats with premature ovarian failure by inhibiting oxidative stress and granulosa cell DNA fragmentation mediated by the PI3K/Akt/FOXO3a pathway.

Background: The aim of this study was to establish a rat model of premature ovarian failure (POF) with cyclophosphamide (CTX), and explore the molecular basis of POF and the mechanism of Guishen-Erxian Decoction (GSEXD) to improve POF from the perspective of oxidative stress regulation of ovarian granulosa cell (OGC) DNA fragmentation.

Method: The study utilized SD rats to establish a POF model via CTX. Rats were divided into Control, POF group, three GSEXD dosage groups (low, medium, high), and a GSEXD+PI3K agonist group to assess GSEXD's therapeutic effects on oxidative stress, DNA fragmentation and ovarian damage.

Targeting the ERα DBD-LBD interface with mitoxantrone disrupts receptor function through proteasomal degradation.

The estrogen receptor (ER or ERα) remains the primary therapeutic target for luminal breast cancer, with current treatments centered on competitive antagonists, receptor down-regulators, and aromatase inhibitors. Despite these options, resistance frequently emerges, highlighting the need for alternative targeting strategies. We discovered a novel mechanism of ER inhibition that targets the previously unexplored interface between the DNA-binding domain (DBD) and ligand-binding domain (LBD) of the receptor.

Correction: Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots.

Correction for 'Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots' by Shuang E , , 2018, , 12788-12796, https://doi.org/10.1039/C8NR03453B.

Tuning the Electronic Structure in the MoS/SrTiO Heterojunction via Phase Evolution of the SrTiO Substrate.

The coupling between transition metal dichalcogenides (TMDCs) and SrTiO has recently emerged as a fertile platform for discovering interfacial phenomena, where particle interactions, lattice coupling, and dielectric screening give rise to interesting physical effects. These hybrid systems hold significant promise for two-dimensional (2D) electronics, ferroelectric state control, and metastable phase engineering. However, effective modulation of the interfacial electronic structure remains a critical challenge.

Phage-nanomaterial platforms for precision antimicrobial therapy: from design to therapeutic application.

The rapid increase in multidrug-resistant (MDR) bacteria and biofilm-associated infections has intensified the global need for innovative antimicrobial strategies. Phage therapy offers promising precision against MDR pathogens by utilizing the natural ability of phages to specifically infect and lyse bacteria. However, their clinical application is hampered by challenges such as narrow host range, immune clearance and limited efficacy within biofilms.

Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study.

Background: The estimated glucose disposal rate (eGDR) is a validated surrogate marker of insulin resistance. However, its association with stroke and dementia in nondiabetic populations remains insufficiently investigated.

Methods: This prospective cohort study included nondiabetic participants from the UK Biobank.

New strategies to enhance the efficacy of PD-1/PD-L1 inhibitors in treating microsatellite stable colorectal cancer.

Immune checkpoint therapy has demonstrated significant potential in the treatment of various solid tumors. Among these, tumor-induced immunosuppression mediated by programmed cell death protein 1 (PD-1) represents a critical checkpoint. PD-1/programmed death-ligand 1 (PD-L1) inhibitors have been proven to exhibit substantial efficacy in solid tumors such as melanoma and bladder cancer.

Season of Blood Pressure Measurement Screening and All-Cause Mortality: A Community-Based Prospective Cohort Study.

Background: The association between season of screening blood pressure (BP) measurement and adverse outcomes has not been examined among populations without prior physician-diagnosed hypertension. We aimed to investigate the association between the season of screening clinic BP measurement and the risk of all-cause mortality.

Methods: This was a prospective cohort study, and data were analyzed from an ongoing community hypertension screening program in Shanghai between 2018 and 2024.

Optimization of Nitrogen Application and Root Biomass Modulates 2-Acetyl-1-Pyrroline Biosynthesis in Fragrant Rice.

The rice root system mediates nutrient uptake while adapting to tillage, management, and environmental changes. While optimized nitrogen (N) supply is known to enhance 2-acetyl-1-pyrroline (2-AP) biosynthesis in fragrant rice, the underlying mechanisms linking nitrogen availability, root development, and their combined effects on physiological processes and aroma formation remain unclear. To address this knowledge gap, we conducted a pot experiment employing two fragrant rice cultivars (Huahangxiangyinzhen and Qingxiangyou19xiang) under three nitrogen regimes (0, 1.

Observational and Experimental Evidence on the Interaction Between Fine Particulate Matter and Shared Genetic Variants Across Atherosclerotic Cardiovascular Disease Subtypes.

Background: Previous studies have suggested that the associations between ambient air pollution and atherosclerotic cardiovascular diseases (ASCVD) differ by genotype. A genome-wide approach provides a more comprehensive understanding of this relationship on a genomic scale.

Methods: Using data from ≈300 000 UK Biobank participants, we conducted a genome-wide interaction analysis on 10 745 802 variants.

Photocatalytic cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes to access 3-(2,2,2-trifluoroethyl)-3-indoles.

A visible-light-catalyzed three-component cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes is developed to build a series of 3-(2,2,2-trifluoroethyl)-3-indoles. This protocol features mild reaction conditions using an 18 W blue LED as the light source at room temperature. The desired 3-indole products can be successfully transformed into valuable tetrahydroindole scaffolds through either reduction or cross-coupling reactions.

Modulating Placental Functionality in Preeclampsia With siRNA Nanocomplexes.

Background: Early-onset preeclampsia poses significant risks to maternal and fetal health, necessitating a deeper understanding of its molecular mechanisms and effective therapeutic strategies.

Methods: Utilizing data from genome-wide association study and Mendelian randomization analysis, we investigated the relationship between mitochondrial DNA copy number and preeclampsia. Transcriptome sequencing, in vitro experiments, and animal studies were conducted to explore the roles of SENP3 and SETD7 in preeclampsia pathogenesis.

A flexible linear circular bipolarization conversion metasurface based on graphene.

A flexible bipolarization conversion metasurface based on graphene is proposed in this paper, which can achieve single-band linear-to-linear (LTL) and dual-band linear-to-circular (LTC) polarization conversion. The polarization conversion ratio (PCR) and axial ratio (AR) are dynamically regulated by varying the sheet resistance () of graphene. When = 1400 Ω Sq, the designed metasurface achieves a single-band LTL polarization conversion of 7.

Design of Z-scheme WSSe-XS (X = Zr and Hf) heterostructures as photocatalysts for efficient solar water splitting.

Transition metal dichalcogenides (TMDs) have been extensively studied as efficient photocatalysts for water splitting. However, the utilization efficiency of photogenerated carriers remains a major limitation for their practical applications. An effective approach to address this issue is the construction of Z-scheme heterostructures.

Environmental impact analysis of the synergistic recycling process of waste three-way catalysts and waste LiCoO batteries.

Waste three-way catalysts (TWCs) and waste LiCoO batteries represent critical environmental challenges due to hazardous components yet contain high-value resources, and their recycling has garnered widespread attention. We propose a novel 'waste-to-waste' synergistic recycling where spent LiCoO batteries reconstruct mineral phases of waste TWCs, enabling co-recovery of platinum group metals and Li/Co without traditional oxidants. However, the environmental performance of this process still requires further analysis.

Stratified profiling of azoospermia: Differentiating histological subtypes with seminal plasma metabolic signatures.

Non-obstructive azoospermia (NOA), characterized by impaired spermatogenesis and the complete absence of sperm in the ejaculate, represents one of the most severe forms of male infertility. Current diagnostic strategies rely on invasive procedures such as testicular sperm extraction, underscoring the urgent need for reliable, non-invasive alternatives. In the present study, we performed untargeted metabolomic profiling of human seminal plasma to identify biomarker panels capable of stratifying azoospermia subtypes through a stepwise approach.

perspectives on surface photocatalysis: advances, challenges, and opportunities.

Surface photocatalysis holds significant promise for converting solar energy into chemical fuels and addressing environmental challenges. While calculations provide critical insights into the thermodynamic and kinetic aspects of catalytic reactions, applying these methods to surface photocatalysis remains challenging. In this work, we discuss the key challenges that need to be addressed when using calculations to understand surface photocatalytic processes, the reasons behind these challenges, and the potential directions and opportunities for overcoming them in the future.

SIRT3-FOXO3a Isoforms Forge Nuclear-Mitochondrial Links to Combat Sepsis-Induced Cardiomyopathy Oxidative Stress in Mice.

Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis. The relationship between SIC and protein acetylation, particularly the balance between acetylation and deacetylation in cardiomyocyte subcellular structures, as well as how nuclear-mitochondrial coordination maintains standard antioxidant stress capacity, remains unclear. This study focused on exploring the nuclear-mitochondrial regulatory mechanisms formed by the interplay of Sirtuin 3 (SIRT3) and Forkhead box O3a (FOXO3a).

Electrically Conductive Hydrogels for Wound Healing.

Wound healing is a complex, tightly regulated process involving a range of enzymes, growth factors, and cytokines that coordinate cellular activities essential for tissue repair and wound closure. However, in cases of extensive or severe injury, the intrinsic repair mechanisms are often insufficient, underscoring the need for advanced therapeutic strategies to accelerate healing and minimize scar formation. Electrically conductive hydrogels (ECHs), combining the advantageous properties of hydrogels with the physiological and electrochemical characteristics of conductive materials, present a safer and more convenient alternative to traditional electrode-based electrical stimulation (ES) for treating chronic and nonhealing wounds.

Correlation between maternal serum uric acid, cystatin C, and coagulation indices during pregnancy and clinical features of early-onset pre-eclampsia and its prognostic analysis.

Objective: This study investigated the relationship of maternal serum uric acid, cystatin C (CysC), and coagulation indices [international normalized ratio (INR) and fibrinogen (FIB)] during pregnancy with clinical features and prognosis of early-onset pre-eclampsia.

Methods: Patients with pre-eclampsia (n = 133) were retrospectively selected, with clinical features and maternal uric acid, CysC, INR, and FIB levels collected. The relationship between clinical features and maternal uric acid, CysC, INR, and FIB was analyzed by Pearson's and Spearman's analyses.

A cationization strategy to simultaneously enhance reactive oxygen species generation and mitochondria targeting ability for enhanced photodynamic therapy.

Mitochondria-targeted photodynamic therapy (PDT) circumvents the short lifetime and action radius limitation of reactive oxygen species (ROS) and greatly improves the anticancer PDT efficacy. However, current approaches require different molecular engineering strategies to separately improve ROS production and introduce mitochondria targeting ability, which involve tedious synthetic procedures. Herein, we report a facile one-step cationization strategy that simultaneously improves the ROS generation efficiency and introduces mitochondria targeting ability for enhanced PDT.