Scalable Solvent-Free Synthesis of a Linear Heteroaromatic Trimer with Crystallization-Induced Phosphorescence.

The polymerization mechanism and the identification of key oligomer intermediates during the thermal condensation of benzoguanamine (BG) remain unclear. Herein, we report a novel mixed thermal condensation strategy using BG and a pre-synthesized dimer to selectively synthesize the trimer (BG) with a significantly enhanced yield. Comprehensive characterization techniques confirm the formation of a linear molecular structure for (BG).

Enantioselective Construction of Fused N-Heterocycles Sequential Annulation and Catalytic Transfer Hydrogenation.

Herein, we report the first regio- and enantioselective synthesis of tetrahydropyrido[2,3-]pyrazines using a chiral iridacycle catalyst. Pyridyl diamines and diketones undergo sequential annulation and asymmetric transfer hydrogenation of the generated pyrido[2,3-]pyrazine intermediates. This method provides diverse fused N-heterocycles in high yields (up to 95%) and enantioselectivity (98.

Reversible Manipulations of Triangular-Shaped Mirror Twin Boundary Loops in Ultrathin NiTe.

High-density mirror twin boundaries (MTBs) embedded in two-dimensional (2D) transition metal dichalcogenides (TMDCs) have emerged as fascinating platforms for exploring charge density wave and Tomonaga-Luttinger liquid-related issues. However, the reversible manipulation of high-density MTBs in 2D TMDCs remains challenging. Herein, we report the first fabrication of high-density MTB loops in ultrathin 1T-NiTe on the SrTiO(001) substrate, by postannealing as-grown 1T-NiTe under Te-deficient conditions.

Spatial Distortion-Engineered Cationic Ru-Covalent Organic Framework Overcoming Aggregation-Caused Quenching for Synergistic Photodynamic/Photothermal Anti-Infective Therapy.

Decades of antibiotic misuse have spurred an antimicrobial resistance crisis, creating an urgent demand for alternative treatment options. Although phototherapy has therapeutic potential, the efficacy of the most advanced photosensitizers (PS) is essentially limited by aggregation-induced quenching, which significantly reduces their therapeutic effect. To address these challenges, we developed a cationic metallocovalent organic framework (CRuP-COF) via a solvent-mediated dual-reaction synthesis strategy.

P,N Hemilabile Ligand-Enabled Palladium-Catalyzed Dearomative Allylation of α-(Trialkylsilyl) Benzyl Chlorides.

The first dearomative allylation of -(trialkylsilyl) benzyl chlorides with allyltributylstannane via RSi-Pd-π-benzyl intermediates is described. The reactions proceeded smoothly in the presence of a specific P,N hemilabile ligand to generate vinylsilanes bearing an allyl group in satisfactory to good yields. Systematic evaluation of phosphine ligands identified ESPmin and % Vbur (min) as key parameters correlating ligand structure with catalytic activity.

Laboratory-Simulated UV-Triggered Transformation of Ambroxol in Aquatic Environments: Photoproduct Characterization and Ecological Risk to Model Aquatic Species.

Ambroxol (AMB), a common expectorant, enters aquatic environments via wastewater, yet its ecological risks remain unclear. Under UV exposure (15 mJ·cm, λ = 185-400 nm), AMB undergoes photolysis, among the photoproducts, 4-((2-amino-3-bromobenzyl)amino) cyclohexanol (P1) and 2-amino-3,5-dibromobenzaldehyde (DBA) are major species, comprising over 50% of the total photoproduct peak area at the photolytic plateau. Acute toxicity tests with AMB, P1, and DBA in four aquatic species at different trophic levels revealed: the highest sensitivity in (LC = 0.

Discovery of Highly Efficient Novel Potential Succinate Dehydrogenase Inhibitors Containing a Stilbene Group for Management of Sheath Blight of Rice and Sclerotinia Stem Rot of Oilseed Rape.

In the search for novel succinate dehydrogenase inhibitors (SDHIs) fungicides for managing rice sheath blight (RSB) and sclerotinia stem rot (SSR), 28 pyrazole-4-carboxamides incorporating stilbene or diphenylacetylene scaffolds were synthesized and evaluated for antifungal activities. The results showed that compound exhibited the most promising antifungal efficacy against and with EC (half maximal effective concentration) values of 0.004 and 0.

CuCo-Embedded Nitrogen-Doped Carbon as a Bifunctional Catalyst for Efficient Rechargeable Zinc-Ethanol/Air Batteries.

The oxygen evolution reaction (OER) in conventional zinc-air batteries (ZABs) involves a complex multielectron transfer process, leading to slow reaction kinetics, high charging voltage, and low energy efficiency. To address these limitations, a zinc-ethanol/air battery (ZEAB) system that strategically replaces the OER with the ethanol oxidation reaction (EOR) possessing a lower thermodynamic potential has been proposed. Herein, a bimetallic catalyst CuCo-embedded nitrogen-doped carbon (CuCo-20%-1), derived from a Cu/Co/Cd co-coordinated metal-organic precursor, is synthesized and exhibits an excellent performance for both EOR and ORR.

The USP8/CEP55/CHMP6 Axis Orchestrates Triple-Negative Breast Cancer Progression by Regulating Ferroptosis and Macrophage M2 Polarization.

Background: Triple-negative breast cancer (TNBC) carries a substantial risk of recurrence and metastasis, posing significant threats to patients' health and quality of life. Centrosomal protein 55 (CEP55) has been demonstrated to exhibit elevated expression levels in TNBC. However, its molecular regulatory mechanism in TNBC remains unclear.

The lifespan trajectories of brain activities related to conflict-driven cognitive control.

Cognitive control is fundamental to human goal-directed behavior. Understanding its trajectory across the lifespan is crucial for optimizing cognitive function throughout life, particularly during periods of rapid development and decline. While existing studies have revealed an inverted U-shaped trajectory of cognitive control in both behavioral and anatomical domains, the age-related changes in functional brain activities remain poorly understood.

Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles.

Type 2 diabetes (T2D) is characterized by persistent and unresolved tissue inflammation caused by the infiltration and dysregulation of immune cells. Current therapeutics targeting inflammatory immune cells for T2D remain limited. In this study, we analyzed single cell RNA from metabolic organs in T2D, revealing increased macrophage accumulation and a pathogenic macrophage subpopulation defined as NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammatory and metabolically activated macrophages.

Overall safety evaluation of the risk signals of sacubitril/valsartan: A postmarketing pharmacoepidemiology study from 2015 to 2024.

Background: Sacubitril/valsartan is a widely used cardiovascular agent characterized by its dual inhibition of the renin-angiotensin-aldosterone system and neprilysin. However, existing evidence on the safety of sacubitril/valsartan is primarily limited to clinical studies; this results in an inability to provide a timely update on associated adverse events.

Aim: To mine and systematically describe adverse events related to sacubitril/valsartan from September 2015 to June 2024 using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Computer Tomography (CT)-guided Percutaneous Core-needle Biopsy for the Diagnosis of Pancreatic Tumors Using a Blunt-tip Needle Technique.

Rationale And Objectives: To investigate the performance of CT-guided percutaneous CNB for the diagnosis of pancreatic tumors using a blunt-tip needle technique.

Materials And Methods: This is a retrospective cohort study included 103 consecutive patients (64 males and 39 females; mean age 61±12.3 years；range 21-86) who underwent CT-guided percutaneous CNB of pancreatic lesions using a blunt-tip needle technique between October 2021 and October 2023.

Comparison of Diagnostic Accuracies of Radiomics and Non-radiomics Model for Preoperative Prediction of Macrotrabecular-Massive Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Rationale And Objectives: The diagnostic value of traditional imaging methods and radiomics in predicting macrotrabecular-massive hepatocellular carcinoma (MTM HCC) is yet to be ascertained. Therefore, this meta-analysis aims to compare the diagnostic performance of radiomics and conventional imaging techniques for MTM HCC.

Materials And Methods: Comprehensive publications were searched in PubMed, Embase, Web of Science, and Cochrane Library up to 28 February 2025.

Fractional-order adaptive fuzzy decentralized tracking control for steer-by-wire system.

The steer-by-wire (SbW) system, as the core component of vehicle steering, needs to track the front wheel angle accurately. To mitigate the angle tracking accuracy degradation caused by D-Q axes coupling, time-varying motor electrical parameters, and load disturbance, a fractional-order adaptive fuzzy decentralized tracking control (FAFDTC) strategy is proposed in this paper. First, considering time-varying motor parameters, D-Q axes coupling, and fractional-order characteristics of components, a fractional-order SbW interconnected system is constructed to enhance its ability to characterize nonlinearities, time-varying dynamics, and system coupling.

Dynamic surface-based distributed practical predefined-time cooperative control for flight formation of a novel small tandem-rotor wheeled UAV.

A novel practical predefined-time sliding mode control strategy is proposed for the flight formation of a small tandem-rotor wheeled UAV (TRW-UAV) with unknown upper bound external disturbances and uncertainties in this paper. Firstly, a new predefined-time sliding mode surface is proposed to guide all errors of the position and velocity loops to converge to the origin in a predefined-time. Furthermore, a dynamic surface control approach is utilized to circumvent the higher-order differentiation when controlling the actuator loop.

Suspension gravity offloading system with event-triggered ESO-based robust MPC.

For space missions such as extraterrestrial sample collection, robotic rover exploration, and astronaut landings, the complex terrain and diverse gravitational environments make ground-based micro-low-gravity experimental systems essential for testing and validating spacecraft performance as well as supporting astronaut training. The suspended gravity unloading (SGO) system is a key device commonly used to simulate micro-low-gravity environments. However, the SGO system faces challenges due to model uncertainty and external disturbances, which limit improvements in control accuracy.