Obinutuzumab combined with bendamustine for the treatment of hairy cell leukemia variant: a case report and literature review.

Hairy cell leukemia variant (HCL-v) is a rare and more aggressive subtype of B-cell leukemia. While it shares certain clinical features with classical hairy cell leukemia (HCL-c), HCL-v typically follows a more malignant course and responds poorly to conventional therapies. We report a case of HCL-v in a 57-year-old male who was admitted with splenomegaly and abnormal blood counts.

Acute myeloid leukemia with plasmacytoid dendritic cell proliferation: A case report and literature review.

The present study describes a rare case of plasmacytoid dendritic cell-associated acute myeloid leukemia (pDC-AML). A 70-year-old male patient was diagnosed with pDC-AML and underwent induction chemotherapy using the venetoclax + azacitidine (VA) regimen. After 3 weeks of treatment, bone marrow examination indicated a morphologic leukemia-free state (MLFS); however, the patient experienced persistent cytopenia, which was further complicated by severe pneumonia and gastrointestinal bleeding, both of which improved following treatment.

Aquaporin 1 as a target of Astragalus Polysaccharides alleviates transport stress-induced renal ion homeostasis disorders in newly hatched chickens.

Transport stress (TS) caused adverse health outcomes that include body weight loss, dehydration, and renal impairment, possibly stemming from the disorder of ions and water homeostasis. Astragalus Polysaccharides (APS), the bioactive substances extracted from the dried roots of Astragalus membranaceus, have been shown to exhibit an anti-stress effect. However, the role of APS in TS-induced renal pathological processes remains unclear.

Tau Oligomers in Alzheimer's Disease: Modulation Effect of Osmolytes on Amplified Brain-Derived Tau Oligomers.

Tau is bound to microtubules and plays a key role in their assembly and spatial organization. Under pathological conditions, tau detaches from the microtubules and develops a propensity to self-aggregate into soluble tau oligomers (TauO), paired helical filaments, and neurofibrillary tangles. Recent studies have revealed that TauO is the toxic species responsible for seeding, propagation, and development of tauopathies.

Multi-dimensional fouling process analysis and anti-fouling strategies for catalytic membranes in long-term water treatment.

Catalytic membrane fouling remains a key scientific issue that limits its long-term utilization in practice. This study investigated the fouling issues of catalytic membranes during the degradation of organic pollutants in river water, with a focus on the fouling mechanisms of catalytic membranes due to ion mineralization, organic matter accumulation, and microbial adhesion. We aimed to explore the multi-dimensional fouling processes and anti-fouling mechanisms of catalytic membranes, by embedding Ni-doped AgFeO into protonic acid-modified polyaniline (PANI) to comprehensively enhance the membrane's anti-fouling properties.

Bio-promoter-driven conversion of 4-chlorophenol into utilizable carbon source: Enhancing electron supply-consume and attenuating bio-toxicity.

4-chlorophenol (4-CP), a toxic organic compound, poses dual challenges in biological wastewater treatment: disrupting denitrification and remaining underutilized as potential carbon sources. Transforming 4-CP into a utilizable carbon source not only mitigates its inhibitory effects on denitrification but also supports microbial metabolism for enhanced nitrogen removal. This study presents a composite bio-promoter integrating a basic bio-promoter (growth factor and antidote) with phosphomolybdic acid (PMo) to convert 4-CP into utilizable carbon source by enhancing electron supply-consume and attenuating bio-toxicity.

Proteomic analysis of duck meat: Effect of air-drying time on key aroma formation.

The air-drying process, an essential step in duck processing, significantly enhances the aroma intensity. However, the role of proteins in aroma formation of air-dried duck meat is unknown. The proteomics and volatilomics approach is applied to investigate how the protein metabolism pathways regulate the aroma development of ducks.

Analysis of Proteins and Piwi-Interacting RNA Cargo of Extracellular Vesicles (EVs) Isolated from Human Nose Organoids and Nasopharyngeal Secretions of Children with RSV Infections.

Respiratory syncytial virus (RSV) is the leading cause of respiratory infections in children. Extracellular vesicles (EVs), released by airway epithelial cells, contain proteins and different families of non-coding RNAs (EV cargo) that can modulate the responses of target cells to viral infection. Nasal mucosa is a primary site of viral entry and the source of EVs present in the upper airway secretions.

Biomimetic Nanochannel Nanofibers with Enhanced Superhydrophilicity for Efficient Moisture-Wicking Fabrics.

Unidirectional moisture-wicking fabrics have garnered significant attention due to their ability to swiftly transport sweat away from the surface of the human skin, thereby enhancing the thermal and moisture comfort of athletes, boiler workers, and other individuals engaged in high-temperature occupations. However, existing nylon/polyester moisture-wicking fabrics lack rapid transport, causing discomfort. Therefore, inspired by bamboo fiber, multistage water-conducting fibrous membranes with superhydrophilic nanochannel and asymmetric wettability are prepared via multistep electrospinning and soaking treatment.

Mechanistic insights into nitrogen removal performance and electron competition with mixed electron donor supply in a biofilm electrode reactor.

In this study, a unique electrode configuration in the form of an "inverted T" was developed in the biofilm electrode reactor (BER), enabling superior nitrogen removal via the synergistic effect of hydrogen autotrophic denitrification and heterotrophic denitrification. In contrast to the sole heterotrophic denitrification in the biofilm reactor (BR), weak electric stimulation in the BER system promoted hydrogen production as well as electron transport and utilization, resulting in a notable 20% improvement in removal efficiency for both influent COD/N ratios. Conversely, notable accumulation occurred under both COD/N ratios, with concentrations ranging from 6.

Pain Management in Mild Traumatic Brain Injury: Central Sensitization as a Multispecialty Challenge.

Background: Several studies indicate that approximately two-thirds of individuals with mild traumatic brain injury (mTBI) will develop chronic pain, which is often debilitating and a primary factor in long-term disability. Patients with mTBI can suffer concurrently from multiple pain types, such as chronic neuropathic (central or peripheral), nociceptive, or nociplastic pain; however, the prevailing pain types in mTBI patients remain undetermined. This knowledge void limits the formulation of effective therapies for mTBI-related pain.

Construction of stable niches for denitrifiers using 3D bioprinting for efficient nitrogen removal.

The denitrification process is the core of biological nitrogen removal technology, but its efficacy is limited by the fragile ecological niches of denitrifying bacteria. This study successfully created three-dimensional (3D) denitrification living materials by the controllable and biocompatible 3D bioprinting technology, enabling the construction of artificial 3D microscale structures that facilitate microenvironments for the efficient dynamic reactions of denitrifying bacteria. By developing the double network structure of sodium alginate-gelatin, the bioink with easy extrusion and robust mechanical properties was obtained.

Regulation of microcurrent on carbon and nitrogen metabolism in denitrification under low carbon-to-nitrogen ratio: Optimizing carbon flux distribution.

Synergy of autotrophic and heterotrophic denitrification can achieve low-carbon and high-efficient nitrogen removal. However, it remains unclear how microcurrent-driven hydrogen autotrophic denitrification regulates carbon flux distribution (nitrogen reduction, poly-β-hydroxyalkanoate (PHA) storage, and cell growth) in heterotrophic denitrification. This work compared biofilm reactor with biofilm electrode reactor under different carbon-to-nitrogen (C/N) ratios (10 - 3).

Impact of Variability in Blood Pressure and Heart Rate on Beta-Blocker Adherence.

Adherence to antihypertensive medications is essential for blood pressure (BP) control, influencing long-term outcomes in hypertensive patients. This study examines the association between visit-to-visit variability in BP and heart rate (HR) and its effect on adherence to beta-blocker therapy among outpatients. Conducted across 160 hospitals in China from January 1, 2011, to December 31, 2011, this study included 9225 hypertensive outpatients prescribed metoprolol succinate.

Electro-activation of peroxymonosulfate by novel CoO/sludge biochar cathode for sulfamethoxazole removal: cobalt-mediated synergistic effect and mechanism.

Sludge biochar (SBC) has emerged as a value-added solid waste-derived catalyst for peroxymonosulfate-based advanced oxidation processes (PMS-AOPs). This study developed a cobalt oxide-modified SBC composite electrode supported on nickel foam (Co/SBC@NF), establishing an electro-enhanced Co/SBC@NF-PMS system (E-Co/SBC@NF-PMS) for efficient sulfamethoxazole (SMX) degradation. The integrated system synergistically combined electrochemical activation with heterogeneous catalysis to optimize PMS utilization.

HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma.

Background: Despite advances in the treatment of multiple myeloma, a proportion of patients still hardly achieve desired prognosis. Although microtransplant (MST) has proved promising results in treating several hematological malignancies, it has not been studied in multiple myeloma.

Methods: We performed a retrospective analysis of multiple myeloma patients treated with MST at our institution.

A Novel Missense Variant of in Juvenile Polyposis Syndrome: Assessment of Structural and Functional Alternations.

Juvenile polyposis syndrome (JPS) is a rare precancerous condition associated with a high susceptibility to colorectal cancer. The genetic basis of JPS has been reported to lie in germline mutations in BMPR1A or SMAD4, resulting in diverse clinical manifestations and an elusive underlying mechanism. We firstly utilized a 139-gene next-generation sequencing (NGS) panel to detect the germline variants and further employed various prediction tools to assess the pathogenicity and functional alternations.

Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus.

Cadmium, a ubiquitous toxic metal and environmental pollutant, is associated with several renal metabolic disorders and disrupts the homeostasis of kidneys in humans and animals. However, the precise molecular mechanism remains poorly elucidated. The present study investigated the role of the ATF4-CHOP nuclear transcriptional axis and its interactions with cellular pathways in cadmium-induced nephrotoxicity.

Pathogenic oligomeric Tau alters neuronal RNA processes through the formation of nuclear heteromeric amyloids with RNA-binding protein Musashi1.

Alzheimer's disease (AD) is marked by cytoplasmic proteinopathies, primarily involving misfolded Tau protein. Pathogenic Tau species, such as soluble oligomers and fibrils, disrupt RNA metabolism, though the mechanisms are unclear. Recent research indicates that RNA has a crucial role in Tau aggregation.

Mechanisms of NO production in salinity-adapted partial nitritation systems for high-ammonia wastewater treatment.

Partial Nitritation/Anammox (PN/A) can achieve green, economical, and efficient biological nitrogen removal; however, the PN process contributes significantly to nitrous oxide (NO, the third most important greenhouse gas) emissions. Balancing the stability of PN systems while reducing NO emissions, particularly under varying salinity conditions, is a key challenge in applying PN/A for high-salinity and high-ammonia wastewater treatment. This study explored the long-term effects of salinity on PN performance and NO emissions in PN systems treating high-ammonia wastewater.

Association between physical activity and incident atherosclerotic cardiovascular disease is modified by predicted cardiovascular risk: The China-PAR project.

Background: It remains unclear whether the cardiovascular benefits of physical activity (PA) vary across populations with different predicted atherosclerotic cardiovascular disease (ASCVD) risks. This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.

Methods: A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project were included, with a median follow-up of 6.

Fatigue analysis of railway catenary dropper based on its stress incorporating displacement loading and fluctuating wind load.

In this paper, a simple chain suspension catenary model is constructed. The acting force of pantograph is reduced to a displacement loading. The stress and fatigue life of railway catenary dropper incorporating displacement loading and fluctuating wind load are studied.

Evaluation of nitrous oxide reduction in solid carbon source-driven counter-diffusional biofilm denitrification system.

Solid carbon-driven biofilm system can provide sufficient carbon source for denitrification, while its counter-diffusional structure could inevitably induce the delayed carbon-nitrogen contact and electron transport, further affecting carbon footprints mainly contributed by nitrous oxide (NO) at wastewater treatment plants (WWTPs). However, the detailed understanding of NO dynamics during solid-phase denitrification (SPD) has not been disclosed. In this work, a fixed bed bioreactor driven by polycaprolactone (PCL) was constructed and operated over 180 days, achieving 97 %-99 % of total nitrogen (TN) removal efficiency.

Alectinib combined with VRCD and BV monoclonal antibody for the treatment of ALK-positive large B-cell lymphoma: a case report and literature review.

We report a case of a 53-year-old male patient who was diagnosed with anaplastic lymphoma kinase-positive large B-cell lymphoma. A pathological examination showed plasma-cell immunophenotype negative for mature B-lymphocyte markers. The patient received three cycles of an "alectinib + Vincristine + Rituximab + Cyclophosphamide + Doxorubicin (VRCD) " regimen.