Coffee-Ring Suppression in Inkjet-Printed Perovskite Films Enabled by a Shape-Anisotropic Nanorod Solute Strategy.

Achieving uniform perovskite thin films via inkjet printing remains a significant challenge due to the pervasive coffee-ring effect. Here, we present a solute engineering strategy that incorporates shape-anisotropic perovskite nanorods into a single-solvent ink formulation, effectively suppressing coffee-ring formation and yielding ultraflat films with an average roughness (Ra) as low as 0.226 nm.

Lattice-matched molecular-anchor design for high-performance perovskite quantum dot light-emitting diodes.

Perovskite quantum dot light-emitting diodes have rapidly achieved high external quantum efficiencies of over 25%; however, hindered by limited operating stability originating from surface defects or ion migration in quantum dots. Here, we design a lattice-matched anchoring molecule, tris(4-methoxyphenyl)phosphine oxide (TMeOPPO-p), to anchor the multi-site defects and stabilise the lattice. The target quantum dots exhibit high exciton recombination features with near-unity photoluminescence quantum yields (97%), and the as-fabricated quantum dot light-emitting diodes present a maximum external quantum efficiency of up to 27% at 693 nm, a low efficiency roll-off (over 20% at a current density of 100 mA cm for the typical device) and an operating half-life of over 23,000 h.

Preclinical models in the study of lymph node metastasis.

Lymph node metastasis (LNM) is a crucial risk factor influencing an unfavorable prognosis in specific cancers. Fundamental research illuminates our understanding of tumor behavior and identifies valuable therapeutic targets. Nevertheless, the exploration of fundamental theories and the validation of clinical therapies hinge on preclinical experiments.

Integrating network pharmacology, IPA, and molecular docking to reveal the anti-osteoporosis effects of EA and EB via the FAK pathway.

Osteoporosis is a widespread condition among the elderly, with a particularly high incidence in postmenopausal women aged 50 and above. This disease significantly increases the risk of fractures, adversely affecting the quality of life. , a traditional Chinese medicinal herb, has been widely used in the treatment of osteoporosis due to its diverse therapeutic properties.

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.

Schwann cells are pivotal in generating a pro-regenerative microenvironment for long-gap peripheral nerve injury (PNI) repair via their orchestrated behaviors, including cell migration, proliferation, and secretion. Bioceramics can release bioactive ions to regulate "repair" cells for regenerating damaged tissues. Herein, bioceramic akermanite (AT) is screened and found to significantly enhance Schwann cell proliferation, migration, and secretion by activating the PI3K/AKT and MAPK/ERK signaling pathways.

[Clinical Characteristics and Prognostic Analysis of Newly Diagnosed Acute Myeloid Leukemia Patients with and Gene Mutations].

Objective: To retrospectively analyze the clinical characteristics, co-mutated genes in newly diagnosed acute myeloid leukemia (AML) patients with and gene mutations, and the impact of and mutations on prognosis.

Methods: The clinical data and next-generation sequencing results of 80 newly diagnosed AML patients treated at our hospital from December 2018 to December 2023 were collected. The clinical characteristics, co-mutated genes of and , and the impact of and mutations on prognosis in newly diagnosed AML patients were analyzed.

Genomic insights into the reticulate evolution of viviparous Phrynocephalus lizards on the Qinghai-Tibetan Plateau.

The contribution of hybridization to the speciation and diversification of organisms remains a topic of ongoing debate. While ancient reticulate events have been increasingly recognized as a common feature in evolutionary history of many species, the role of hybridization in driving adaptation, especially in extreme environments, is still unclear. The viviparousPhrynocephaluslizards present an excellent system to investigate this question, which are distributed across the Qinghai-Tibetan Plateau (QTP) with most species occurring above 2,300 m above sea level.

Elevated Cancer Prevalence Identified at Specific Anatomical Sites Among People With Myotonic Dystrophy Using a Population-Based Sample.

Introduction/aim: To optimize patient care and cancer screening in myotonic dystrophy (DM), it is crucial to clarify cancer risks by DM type to guide targeted screening and prevention efforts. This study describes the prevalence of cancer among individuals diagnosed with DM from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet), and compares it to cancer prevalence in the US Surveillance, Epidemiology, and End Result (SEER) data.

Methods: This retrospective cohort study used 2008-2019 medical records data on 1229 individuals diagnosed with DM (DM1: 81.

Gradient boosting: A computationally efficient alternative to Markov chain Monte Carlo sampling for fitting large Bayesian spatio-temporal binomial regression models.

Disease forecasting and surveillance often involve fitting models to a tremendous volume of historical testing data collected over space and time. Bayesian spatio-temporal regression models fit with Markov chain Monte Carlo (MCMC) methods are commonly used for such data. When the spatio-temporal support of the model is large, implementing an MCMC algorithm becomes a significant computational burden.

Correction: pH-Triggered nanoreactors as oxidative stress amplifiers for combating multidrug-resistant biofilms.

Correction for 'pH-Triggered nanoreactors as oxidative stress amplifiers for combating multidrug-resistant biofilms' by Lei Huang , , 2021, , 4662-4665, https://doi.org/10.1039/D1CC00247C.

Preparation of highly-efficient Fe, N co-doping biochar from spent coffee grounds for the degradation of antibiotics via Fenton-like reaction.

With the overuse of antibiotics, the aquatic environment has been heavily polluted, which has serious negative impacts on various organisms. AOPs degradation system is a promising treatment approach for wastewater of antibiotics. Herein, an efficient, stable and low-cost Fe, N co-modified biochar derived spent coffee ground was developed for activation of PMS to remove TC.

Phosphorus Vacancy-Induced Built-In Electric Field for Electromagnetic Properties Modulation.

Anion vacancy engineering represents an effective strategy to construct built-in electric fields (BIEFs) for the purpose of modulating electromagnetic (EM) properties. However, the in-depth and systematic comparative analysis of the effects of various anionic vacancies on defect-induced polarization is still lacking. In this work, the effects of defect-induced polarization resulting from group VA anion vacancies, particularly phosphorus vacancies (V), are compared to the anion vacancies of other elements.

Mapping the intersection of HIV and Alzheimer's disease: a bibliometric analysis of emerging research trends.

Background: HIV and Alzheimer's disease (AD) are significant global health challenges with overlapping neuroinflammatory and protein aggregation mechanisms. Understanding their intersection is critical for advancing therapeutic strategies, particularly in aging populations.

Objective: This study aims to provide a comprehensive bibliometric analysis of research trends at the intersection of HIV and AD, identify emerging themes, and highlight key contributors in this interdisciplinary field.

3,3'-diindolylmethane, from cruciferous vegetables, ameliorates cigarette smoke-induced inflammatory amplification in CIA model mice by targeting the AhR/NF-κB crosstalk.

Environmental factors are important inducement triggering Rheumatoid Arthritis (RA). Smoke exposure would worse RA by aggravating RA inflammation and bone damage. Previous studies have demonstrated that a plant-based diet can improve RA patients' clinical symptoms.

Hump-inspired ingestible magnetic capsules enable circular nutrition storage and supply for short bowel syndrome treatment.

Parenteral nutrition and intestinal transplantation, essential clinical interventions for short bowel syndrome (SBS) patients, are limited by various complications such as impaired intestinal barrier, metabolic disorder, catheter-associated infection, and allogenic rejection, leading to inferior therapeutic outcomes. Here, inspired by the camel hump, an ingestible magnetic capsule (IMC) consisting of thermosensitive hydrogel microparticles (MPs) based on poly(N-isopropylacrylamide) and acrylamide and a magnetic shell made of NdFeB and polyvinyl alcohol is proposed to enable circular nutrition storage and supply to optimize enteral nutrition for SBS treatment. Thermosensitive hydrogel MPs absorb excessive fluid and subsequently release nutrients in response to the heat generated by the photothermal effect of the magnetic shell under near-infrared irradiation.

HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma.

Background: Despite advances in the treatment of multiple myeloma, a proportion of patients still hardly achieve desired prognosis. Although microtransplant (MST) has proved promising results in treating several hematological malignancies, it has not been studied in multiple myeloma.

Methods: We performed a retrospective analysis of multiple myeloma patients treated with MST at our institution.

TOP-Zn Steric Hindrance Effect Enables Ultra-Uniform CsPbX Quantum Dots for Wide-Color Gamut Displays.

Perovskite quantum dots (PQDs) are expected to be an ideal candidate for wide-color gamut displays owing to their high color purity. However, their color purity is challenged by remarkable spectral broadening due to non-uniform size distribution and crystal defects. Here, a ligand-ion (TOP-Zn) complex-modulating nucleation strategy is proposed to depress spectral broadening.

Genomic and metabolomic insights into the antimicrobial compounds and plant growth-promoting potential of Bacillus velezensis B115.

The B115 strain, isolated from the inter-root soil of healthy plants in a continuous cropping site of Panax notoginseng, was identified as Bacillus velezensis B115 by 16S rDNA sequence comparison and comparative genomic analysis. B115 is a strain of beneficial microorganisms present in the inter-root zone of plants, with favorable plant growth-promoting properties and antagonistic effects against the plant pathogen Fusarium oxysporum. However, the whole genome of B115 remains unclear, thus restricting its potential applications.

Comparative Assessment of the Impacts of Wildland-Urban Interface Fire Ash on Growth of the Diatom .

Fires at the wildland-urban interface (WUI) result in the release of ash into the atmosphere that can be transported for long distances and deposited on land and in oceans. Wildfire ash has the potential to increase phytoplankton biomass in the open ocean by providing both major nutrients and trace metals. However, fires that originate at the WUI contain potentially toxic concentrations of metals such as Ti, Cr, Cu, Pb, and Zn, especially in coastal oceans close to WUI fires, where ash deposition rates are high.

PICBayes: Bayesian proportional hazards models for partly interval-censored data.

Partly interval-censored (PIC) data arise frequently in medical studies of diseases that require periodic examinations for symptoms of interest, such as progression-free survival and relapse-free survival. Proportional hazards (PH) model is the most widely used model in survival analysis. This paper introduces our new R package which implements a set of functions for fitting the PH model to different complexities of partly interval-censored data under the Bayesian semiparametric framework.

Current status and future perspectives of the diagnostic of plant bacterial pathogens.

Diagnostic of plant bacterial pathogens underwent a leapfrog development from culture-based strategies to culture-free detection. Conventional diagnostics, such antibody- and PCR-based methods, are sensitive to identify pre-enriched pathogens in naturally infected crops at the late stage. However, they suffer from shortcomings relating to rapidity, signal strength, and a significant reduction in sensitivity in real plant extract.

Molecule-induced ripening control in perovskite quantum dots for efficient and stable light-emitting diodes.

Perovskite quantum dots (QDs) show an excellent application perspective in semiconductor optoelectronic devices. However, problems of ligand loss during the growth, purification, film formation, and storage process always induce the aggregation and ripening of QDs, adversely affecting QDs' and QD-based devices' performance. Here, we use a bidentate molecule to control ripening toward a notable performance boost in CsPbI QDs.

The path winds along isolation and analyses of fetal nucleated red blood cells in maternal peripheral blood: Past, present, and future toward non-invasive prenatal diagnosis.

Traditional prenatal diagnosis detects fetal disorders through invading uterus to access fetal cells, which may cause maternal complications, fetal injury, or even miscarriage. Safe and convenient non-invasive prenatal testing (NIPT) by analyzing fetal materials (cell-free DNA/RNA, cells, and extracellular vesicles) that circulate in maternal peripheral blood attracts great attention and has been applied in risk evaluation of several fetal disorders. Among those fetal analytes, fetal nucleated red blood cells (fNRBCs) comprise entire fetal genome, possess distinct membrane antigens, and have a lifespan limited in every single gestation.

Semantic lossless encoded image representation for malware classification.

Combining artificial intelligence with static analysis is an effective method for classifying malicious code. Due to the development of anti-analysis techniques, malicious code commonly employs obfuscation methods like packing, which result in garbled assembly code and the loss of original semantics. Consequently, existing pre-trained code language models are rendered ineffective in such scenarios.

Detecting monogenic disorders in utero non-invasively based on fetal nucleated red blood cells highly-purified by multi-functional magnetic nanoparticles.

Background: Fetal monogenic disorders cause gestation anomalies, birth defects or infant mortality. Implementing non-invasive prenatal testing (NIPT) of these diseases benefits timely intervention while avoids high risk of inducing maternal complications and fetal injuries. However, fetal materials used for current NIPT (e.