Channelization and flow depletion shift benthic macroinvertebrate and fish communities in urban rivers.

Aquatic ecosystems worldwide are increasingly affected by human activities, with urbanization representing a major source of environmental stress. Channelization and flow depletion are key stressors in urban aquatic ecosystems. However, the combined effects of these factors on benthic macroinvertebrate and fish communities in urban rivers remain poorly understood.

Identification of water sources of mine water bursts based on the FPS-DT model.

To effectively identify the source of water in coal mines and prevent water-related accidents, this paper utilises the hydrochemical characteristics of the aquifers Shanxi Hanzui Coal Mine. The fuzzy C-means (FCM) clustering method is employed to classify water sample data, followed by principal component analysis (PCA) for dimensionality reduction to extract key features. The SMOTE algorithm is then applied to address the issue of class imbalance.

Evaluation of NaTto Red Yeast Rice on Regulating Blood Lipid (ENTRY) Study: A Multicenter, Double-Placebo, Double-Blinded, Randomized Controlled Trial in Chinese Adults.

Background: Statins are the first line of treatment for dyslipidemia, but their side effects often reduce medication compliance. Natto and red yeast rice are natural ingredients with lipid-lowering effects. However, the efficacy of Natto Red Yeast Rice (NRYR) supplement in combination with statins in regulating blood lipid levels has not been fully evaluated.

The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m A-SNPs and Mendelian Randomization.

Objective: N6-methyladenosine (m A) is a common epigenetic modification in eukaryotes. In this study, we explore the potential impact of m A-associated single nucleotide polymorphisms (m A-SNPs) on heart failure (HF).

Methods: Data from genome-wide association studies (GWAS) investigating HF in humans and from m A-SNPs datasets were used to identify HF-associated m A-SNPs.

The comparison of anticrystallization effects of cellulose derivatives with polyvinylpyrrolidone and poloxamer on andrographolide: In vitro and in vivo characterization.

Cellulose derivatives play important roles in the development of pharmaceutical oral solid formulations. Owing to their high molecular weight and functional groups, these polymers can interact with water-insoluble drug crystals, influencing not only the drug's physicochemical properties but also its absorption efficiency. In this study, an anticrystallization experiment was designed to compare the inhibitory effects of cellulose derivatives (methylcellulose (MC), hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC)) with those of polyvinylpyrrolidone (PVP) and poloxamer (F68) on the crystallization of model drugs (andrographolide, AG).

Effect of freeze-thaw cycles on mechanical performance of loess soil stabilized with nano magnesium oxide.

Construction in northwest China is generally packed with issues linked to loess soil with poor engineering properties and day-night and seasonal freeze-thaw (FT) actions. This study explored the potential benefits of nano-MgO (NM) as an innovative solution for improving mechanical properties of loess. To this end, a series of unconfined compression test (UCT) and nuclear magnetic resonance tests (NMRT) were conducted.

Long-term Fine Particulate Matter Exposure and Coronary Artery Disease: Unraveling Cardiometabolic Pathways and Modification of Genetic Susceptibility.

Aims: Which cardiometabolic risk factors (CMRFs) primarily mediate the association between long-term fine particulate matter (PM2.5) exposure and coronary artery disease (CAD) incidence, and whether participants with high genetic risks of CMRFs are more susceptible remains unclear.

Methods: This study was based on the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China.

Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade.

Migratory functionalization of C-H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest. Herein, a palladium-catalyzed migratory cyclization of α-bromoalkene derivatives ArXCBr=CH, in which X denotes a phosphorus (P(O)R), silicon (SiR), sulfur (SO), carbon (C(O)), nitrogen (NTs), or oxygen-based moiety, affording various benzoheterocyclic compounds has been developed. Mechanistic investigations have demonstrated that the cyclization reaction proceeds through an unexpected cascade, with trans-1,2-palladium migration between sp carbons being a key step of catalytic cycle.

Impact of resting heart rate and predicted cardiovascular risk on mortality in nearly 110,000 Chinese adults.

Background: The association of mortality with resting heart rate (RHR) and predicted risk of incident cardiovascular disease (CVD) has not been comprehensively elucidated.

Objective: The purpose of this study was to evaluate the individual and combined impacts of RHR and predicted CVD risk on mortality among Chinese adults.

Methods: A total of 108,257 Chinese adults underwent follow-up during 1992 to 2015.

Association between physical activity and incident atherosclerotic cardiovascular disease is modified by predicted cardiovascular risk: The China-PAR project.

Background: It remains unclear whether the cardiovascular benefits of physical activity (PA) vary across populations with different predicted atherosclerotic cardiovascular disease (ASCVD) risks. This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.

Methods: A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project were included, with a median follow-up of 6.

Association between NT-proBNP levels and risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies.

Background And Aims: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a well-established biomarker in clinical practice, particularly for heart failure, but its role in predicting atrial fibrillation (AF) risk is not fully understood. This meta-analysis aimed to evaluate the association between NT-proBNP levels and AF incidence, and to explore the potential of NT-proBNP in enhancing AF risk prediction models.

Methods: We systematically searched databases (PubMed, Embase, Cochrane Library, Web of Science and Scopus) up to August 2024 for prospective studies that reported associations between baseline NT-proBNP levels and incident AF.

Synthesis of Amide-Containing Indolo[2,1-]isoquinoline Derivatives via Palladium-Catalyzed Cascade Reactions.

A convenient palladium-catalyzed cascade cyclization reaction for the construction of amide-containing indolo[2,1-]isoquinolines from 2-aryl--propenyl indoles with aromatic amines and chloroform is described. A variety of amide-containing indolo[2,1-]isoquinoline compounds have been successfully synthesized in moderate to good yields in which chloroform is employed as the source of CO.

Osimertinib treatment response in a patient with lung adenocarcinoma harboring two rare EGFR mutations: A case report.

Epidermal growth factor receptor () mutations have emerged as the most well-studied oncogenic alterations in advanced non-small cell lung cancer. The presence of single common or rare mutations and extra complex mutations correlates with the response sensitivity to tyrosine kinase inhibitors. Therefore, given the lack of evidence for the emergence of rare mutation types, the pathogenic mechanisms of uncommon mutations and the optimal treatment strategies remain to be explored further.

Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-]isoquinolines.

An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1-]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1-]isoquinoline products in good yields and enantioselectivities.

Discordant High Remnant Cholesterol With LDL-C Increases the Risk of Stroke: A Chinese Prospective Cohort Study.

Background: Previous studies focusing on assessing the effects of remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-C) on stroke may not consider their mutual influence. We aimed to explore the associations of RC and discordant high RC with LDL-C with stroke, ischemic stroke (IS), and hemorrhagic stroke.

Methods: This prospective cohort study was conducted based on 3 cohorts of the China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) project.

Childhood trauma, psychache, and depression among university students: a moderated mediation model.

Background: Childhood trauma is a potential threat to depression and can have a lifelong impact on the mental health of university students. Our study aimed to construct a moderated mediation model to explore the relationship between childhood trauma, psychache, ambivalence over emotional expression, physical activity, and depression in university students.

Methods: A cross-sectional study was conducted in three universities in China, recruiting 476 university students using self-report questionnaires.

The relationship between self-compassion, coping style, sleep quality, and depression among college students.

Background: The prevalence of sleep quality problems and depression in the college student population has attracted widespread attention. However, the factors influencing this are still unclear. The objective of this study was to investigate the associations between self-compassion (S-C), sleep quality (SQ), and depression (DEP) among college students and examine the mediating effects of coping style (CS) between the variables.

Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial.

Individuals with a high degree of salt sensitivity (SS) have a greater risk of cardiovascular disease (CVD), but whether SS fosters CVD by influencing metabolomics homeostasis remains unclear. This study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs, based on the MetaSalt study, which was a dietary salt-intervention trial conducted at four centers in China in 2019. A total of 528 participants were recruited and underwent 3 days of baseline observations, a 10-day low-salt intervention, and a 10-day high-salt intervention.

Kinetic Resolution of P-Chiral Phosphindole Oxides through Rhodium-Catalyzed Asymmetric Arylation.

Highly efficient kinetic resolution of P-chiral phosphindole oxides via rhodium-catalyzed asymmetric arylation under mild conditions is described. Selectivity factors of up to 569 were achieved by employing chiral as a ligand. The transformation of the enantiopure benzophosphole derivative into a useful P-chiral bisphosphine ligand is also demonstrated.

Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance.

The relationship of fine particulate matter (PM) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR).

Rhodium-Catalyzed Asymmetric Addition to 4- or 5-Carbonyl-cycloenones through Dynamic Kinetic Resolution: Enantioselective Synthesis of (-)-Cannabidiol.

The reaction of 4/5-carbonyl-cycloalkenone or its achiral isomer with organoboronic acid in the presence of a chiral diene (,)-Fc-tfb-rhodium catalyst gave disubstituted -cycloalkanone with high diastereo- and enantioselectivity. This highly efficient dynamic kinetic resolution is achieved by fast racemization of through the formation of a dienolate followed by kinetic resolution with the chiral catalyst. The utility is demonstrated by the synthesis of key intermediates en route to (-)-cannabidiol.