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Article Abstract
Migratory functionalization of C-H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest. Herein, a palladium-catalyzed migratory cyclization of α-bromoalkene derivatives ArXCBr=CH, in which X denotes a phosphorus (P(O)R), silicon (SiR), sulfur (SO), carbon (C(O)), nitrogen (NTs), or oxygen-based moiety, affording various benzoheterocyclic compounds has been developed. Mechanistic investigations have demonstrated that the cyclization reaction proceeds through an unexpected cascade, with trans-1,2-palladium migration between sp carbons being a key step of catalytic cycle. To the best of our knowledge, this type of metal migration has not been reported previously.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982304 | PMC |
| http://dx.doi.org/10.1038/s41467-025-58633-5 | DOI Listing |
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