Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer.

Background: In China, lung cancer stands as the leading cause of cancer-related deaths, often resulting in brain metastases (BM) that severely compromise patients' quality of life and reduce survival outcomes. The delivery of drugs to the brain is further complicated by the blood-brain barrier (BBB). To address this, we developed EGFR single-chain fragment variable (scFv)-modified macrophage membrane liposomes (scFv-MML) encapsulating LPCAT1 siRNA (scFv-MML@LPCAT1si) as a targeted therapy for non-small cell lung cancer (NSCLC) BM.

Recent Development in Emerging 2D Rare Earth Materials: Compositions, Syntheses, and Applications.

2D rare earth (RE) materials have recently attracted extensive research interests owing to the unique optical, electronic, and magnetic properties, exhibiting great potential applications in next-generation lighting, optoelectronics, and magnetic devices. However, reviews on 2D RE materials are rare and only focus on certain families despite their importance. Herein, a comprehensive review of the recent progress of 2D RE materials is presented, covering structures, properties, syntheses, and applications.

Predictive and early warning analysis of infectious gastroenteritis based on the BiLSTM-BiGRU model.

Appropriate use of scientific early-warning infectious disease surveillance methods plays a vital role in disease control and prevention. Recently infectious gastroenteritis has become an important public health problem. In consideration of meteorological factors strongly linked with the incidence of infectious gastroenteritis, we obtained data on the number of infectious gastroenteritis cases and meteorological data from January 2008 to June 2023, a total of 808 weeks.

Study on the Electro-Optical Properties of Polymer-Dispersed Liquid Crystals Doped with Cellulose Nanocrystals.

The present study focuses on the effect of doping KH560-modified cellulose nanocrystals (CNCs) on the electro-optical characteristics of polymer-dispersed liquid crystals (PDLCs). PDLC films were fabricated through the polymerization-initiated phase separation (PIPS) process and doped with CNC nanoparticles at various concentrations. At low concentrations, the CNCs at the interface, by virtue of their unique chiral characteristics, induce an orderly arrangement of liquid crystal molecules.

Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis.

The objective is to explore the potential pathogenesis and therapeutic mechanism of Yinchenhao decoction (YCHD) in intrahepatic cholestasis of pregnancy (ICP) by focusing on the regulatory role of exosomal miR-370-3p on target genes TM9SF4 and KIT. Exosomes were isolated from the serum samples of normal pregnant women (control), patients with ICP, HTR-8/SVneo cells, and Sprague-Dawley (SD) pregnant rats via differential centrifugation. Characterization of these exosomes was performed using electron microscopy, nanoparticle tracking analysis (NTA), and western blotting.

Disentangling extracellular current of electroactive bacteria with oblique-incidence reflection difference imaging.

Understanding the extracellular electron transfer (EET) process of electroactive bacteria is of great significance. It is critical yet challenging to differentiate the partial currents from direct (DET) and mediated electron transfer (MET) pathways in the integrated EET current. Herein the EET current of model exoelectrogen is successfully disentangled by using spatiotemporally-resolved oblique-incidence reflection difference (OIRD) technique coupled with polyaniline (PANI)-based dual electrode.

Understanding the strain effect in alkaline hydrogen oxidation reaction over well-defined Ru surfaces: insights into catalyst design.

Surface strain has general impacts on the electronic structure and catalytic properties of catalyst surfaces. However, accurately deciphering the strain effect in many catalytic processes, such as the alkaline hydrogen oxidation reaction (HOR), remains a long-standing challenge due to the difficulty in isolating the strain and ligand effects in most catalytic systems. Here the Ru(111) surfaces are designed and constructed epitaxially growing five atomic layers of Ru onto Pd octahedra and Pd icosahedra, respectively, providing the model surfaces to explore the strain effect.

Integrated Lipidomics and Network Pharmacology to Reveal the Mechanisms of Franch in the Treatment of Liver Fibrosis in Mice.

Franch (SMF) has been proven to be an effective Chinese herbal medicine (CHM) to treat liver fibrosis. However, the in-depth mechanism remains unclear. In this study, a strategy integrating lipidomics and network pharmacology was developed to reveal the active components, targets, and pathways of SMF against dimethylnitrosamine (DMN)-induced liver fibrosis in mice.

Regio-, Diastereo-, and Enantioselective Hydrosilylation of Alkyl gem-Difluoroalkenes to Construct Carbon and Silicon Stereogenic Centers.

The asymmetric hydrofunctionalization of aliphatic alkenes without auxiliary or stabilizing groups presents a significant challenge in modern organic synthesis. We report herein the nickel-catalyzed enantioselective hydrosilylation of alkyl-substituted gem-difluoroalkenes, which enables the generation of chiral α-difluoromethylsilanes with excellent regio- and enantioselectivity. Moreover, the simultaneous construction of carbon- and silicon-stereogenic centers was achieved with excellent diastereo- and enantioselectivity using prochiral silanes.

Selective Reductive Coupling of Formaldehyde into Carbohydrate Precursors.

Direct and highly selective conversion of formaldehyde to multicarbon (C) products is a highly desirable but challenging approach to synthesize carbohydrate precursors. In this study, we investigated the use of environmentally friendly imidazolium-based ionic liquids (ILs)-NHC to promote formaldehyde coupling under a base-free condition. The highly selective conversion of formaldehyde into glycolaldehyde precursor (GP) and dihydroxyacetone precursor was achieved through a one-pot, two-step process with [BHMIm][OAc] as a crucial intermediate.

Imitating and following: The impact of resilient leadership on employee workplace adversarial growth.

Adversity does not bring hardship and suffering, but also an opportunity for personal growth and self-improvement. Organizations and managers expect employees to make positive changes in response to workplace challenges and adversity. Based on Social Learning Theory, the study aims to investigate the influence mechanism and boundary condition of resilient leadership on employee workplace adversarial growth through a two-wave survey of 303 Chinese employees.

JAK3/STAT5A-dependent IL-8 regulation drives ESCC angiogenesis and is suppressed by dihydroartemisinin.

The tumor microenvironment plays a crucial role in tumor angiogenesis, yet the mechanism by which the microenvironment promotes tumor angiogenesis in esophageal squamous cell carcinoma (ESCC) is unclear. Here, transcriptomics revealed that IL-8 was the most significantly upregulated in HUVECs induced by ESCC cell supernatants, and the JAK3/STAT5A pathway was activated to regulate IL-8 during this process. Moreover, targeting JAK3 suppressed ESCC angiogenesis.

Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues.

The bottom-up construction of cell-like entities or protocells is essential for emulating cytomimetic behaviours within artificial cell consortia. Complex coacervate microdroplets are promising candidates for primordial cells; however, replicating the complex cellular organization and cell-cell interactions using membraneless coacervates remains a major challenge. To address this, we developed membrane-bound coacervate protocells by interfacial assembly of metal-organic framework nanoparticles around coacervate microdroplets.

CircSLC22A3 inhibits the invasion and metastasis of ESCC via the miR-19b-3p/TRAK2 axis and by reducing the stability of mA-modified ACSBG1 mRNA.

Background: Esophageal squamous cell carcinoma (ESCC) is a major contributor to cancer-related deaths, driven by its invasive and metastatic nature. Circular RNAs (circRNAs) are increasingly recognized as regulators of cancer progression, primarily through miRNA sponging and interactions with RNA-binding proteins. Their dysregulation has been linked to the development of in various cancers.

TCPTP inhibition as a novel therapeutic strategy for esophageal squamous cell carcinoma: discovery and efficacy of COH29.

Esophageal squamous cell carcinoma (ESCC) is a malignant tumor that poses a serious threat to human health and is often associated with poor prognosis. Therefore, it is urgent to explore new therapeutic strategies to improve the survival rate of patients with ESCC. T cell protein tyrosine phosphatase (TCPTP) has been reported as a complicated factor in cancer.

Liquid Metal-Tannic Acid-Modified Cotton Yarn Prepared with Twist-Assisted Deposition Technique for Textile Electronics.

The past decade has witnessed the rapid growth of electronic textiles with a variety of textile-based smart devices being developed. However, the development of one-dimensional conductors that exhibit both excellent mechanical and electrical properties, while being compatible with conventional textile techniques, remains a challenge. Herein, a conductive cotton yarn was constructed using liquid metal as the conductive filler and tannic acid (TA) as the immobilizing linker via a twist-assisted deposition technique, in which eutectic gallium-indium alloy (EGaIn) droplets were effectively modified on cotton plies by using TA, followed by moderate twisting.

Tandemly Repeated G-Quadruplex Structures in the Pseudorabies Virus Genome: Implications for Epiberberine-Based Antiviral Therapy.

G-quadruplex (G4) structures have emerged as critical regulatory elements in viral genomes and represent potential targets for antiviral intervention. In this study, we identified and characterized G4 structures in the unique long (UL) region of the Pseudorabies virus (PRV) genome, highlighting their role as novel antiviral targets. Bioinformatic analysis revealed two guanine-rich regions (R1 and R2) that form stable G4 structures, as confirmed by fluorescence assays, circular dichroism (CD) spectroscopy, and immunofluorescence staining.

SRPK1 Activation Facilitates Gli3 Phosphorylation and Promotes Metastasis in Esophageal Squamous Cell Carcinoma.

Esophageal squamous cell carcinoma (ESCC) stands out as one of the most malignant digestive tumors, with its prognosis marred by frequent metastasis and recurrence. However, the mechanism behind ESCC metastasis remains elusive, impeding therapeutic advancements. SRPK1 emerges as an independent prognostic marker for ESCC patients.

p38 mediated ACSL4 phosphorylation drives stress-induced esophageal squamous cell carcinoma growth through Src myristoylation.

The comprehension of intricate molecular mechanisms underlying how external stimuli promote malignancy is conducive to cancer early prevention. Esophageal squamous cell carcinoma (ESCC) is considered as an external stimuli (hot foods, tobacco, chemo-compounds) induced cancer, characterized by stepwise progression from hyperplasia, dysplasia, carcinoma in situ and invasive carcinoma. However, the underlying molecular mechanism governing the transition from normal epithelium to neoplastic processes in ESCC under persistent external stimuli has remained elusive.

Enhanced flocculation performance and coal slurry water by using starch-based flocculant with rich charges and its flocculation mechanism.

A cationic starch-based flocculant as an efficient and environmentally friendly flocculant is designed for the improvement of flocculation performance of coal slurry water by the method of combining grafting and etherification. Structure and properties of the obtained samples are characterized by XRD, FTIR, NMR, and TG. Effects of grafting conditions and etherification conditions on intrinsic viscosity and cationic degree are investigated.

Studies Related to the Proposed Biotransformation of Bohemamine D into the Co-occurring Marine Natural Product Spinoxazine B.

The 1,3-oxazin-6-one-containing spinoxazines A and B ( and , respectively) have been isolated from the marine-derived strain SNB-048 and, by another group, from the Solar Saltern-derived sp. KMF-004. Two distinct pathways have been proposed for the conversion of the co-occurring pyrrolizidine alkaloid bohemamine D () into compound .

Effectiveness of immunoprophylaxis for preterm infants of mothers having chronic hepatitis B virus infection: A retrospective study.

Background: The effectiveness of immunoprophylaxis for preterm infants delivered by hepatitis B virus(HBV)-infected mothers remains unclear. This study aimed to investigate the effectiveness of immunoprophylaxis in preterm infants.

Methods: Infants delivered by HBV-infected mothers between January 1, 2016 and December 31, 2018 were enrolled, Preterm infants received hepatitis B vaccine immediately after birth and at one, two and seven months while full-term infants received vaccine immediately after birth and at one and six months.

DEA-based centralized resource allocation with a balance between efficiency and equity: evidence from healthcare services across 31 provinces in China.

In the context of increasing investment in healthcare, the key issue of China's healthcare system reform is how to maximize output and ensure the equity of resource allocation. The generalized DEA-based resource allocation model (Model 1) pursues the maximization of DMU efficiency in resource allocation without considering equity, and it could yield a multi-solution problem by considering only the outputs instead of the inputs in the objective function. Thus, a DEA-based centralized resource allocation model with a balance between efficiency and equity (Model 2) is proposed, in which efficiency and equity are measured by output and input indicators in the objective function simultaneously, this could be more consistent with the essence of the DEA method.

Myocardial Lipidomics Revealed Glycerophospholipid and Sphingolipid Metabolism as Therapeutic Targets of Qifu Decoction Against Heart Failure.

Qifu decoction (QFD) has shown potential benefits in treating heart failure. However, the potential mechanism of QFD remains unclear. In this study, myocardial lipidomics, based on ultra-high-performance liquid chromatography coupled with an electrospray ionization hybrid quadrupole Orbitrap mass spectrometry (UPLC-ESI-Q-Exactive/MS), was employed to identify potential therapeutic targets of QFD for treating heart failure in a mice model induced by ligating the left anterior descending coronary artery.