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Appropriate use of scientific early-warning infectious disease surveillance methods plays a vital role in disease control and prevention. Recently infectious gastroenteritis has become an important public health problem. In consideration of meteorological factors strongly linked with the incidence of infectious gastroenteritis, we obtained data on the number of infectious gastroenteritis cases and meteorological data from January 2008 to June 2023, a total of 808 weeks. We constructed a BiLSTM-BiGRU model to fit and predict the incidence of infectious gastroenteritis in Tokyo, Japan, to improve the prediction accuracy and early warning efficiency of infectious gastroenteritis, provide references for relevant departments to formulate infectious disease prevention and control measures in advance, and make emergency preparations. For this purpose, we also used three optimization algorithms for parameter tuning and constructed a moving percentile control chart warning model. The results show that the BiLSTM-BiGRU model performed better than mainstream deep learning methods. Among the three selected optimization algorithms, the Grey Wolf Optimization algorithm performed the best, with an R of 0.85, and led to reductions of 11.90 % in RMSE, 12.44 % in MAE, and 16.18 % in MAPE, respectively. We found that the GWO-BiLSTM-BiGRU model can fit and predict the number of infectious gastroenteritis cases in Tokyo accurately. Relevant departments should be alert to the high incidence of infectious gastroenteritis during weeks 3-5 each year based on the prediction and warning results.
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http://dx.doi.org/10.1016/j.idm.2025.07.016 | DOI Listing |
Mil Med
September 2025
Soldier Centered Medical Home-CAB, Desmond Doss Health Clinic, Wahiawa, Hawaii, HI 96786, United States.
Guillain-Barré Syndrome (GBS) is an acute immune-mediated inflammatory demyelinating polyradiculopathy of the peripheral nerves often provoked by a preceding upper respiratory or gastrointestinal infection. Guillain-Barré Syndrome usually presents with symmetrical lower limb ascending weakness and decreased deep tendon reflexes. Here, we describe a case of an uncommon presentation of GBS presenting with upper extremity neuropathy and cranial nerve palsy in a 36-year-old Caucasian Army pilot.
View Article and Find Full Text PDFVet Microbiol
September 2025
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Rotavirus (RV) is a major cause of gastroenteritis in both humans and many mammals, including livestock. However, information regarding RV in sheep remains limited, particularly in China. This study reports the first isolation and characterization of the G8-P[1]-I2-R2-C2-M2-A11-N2-T6-E2-H3 type sheep RV strain (GS13) in China.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Safety and Quality of Meat, Max Rubner-Institute, Federal Research Institute of Nutrition and Food, Kulmbach, Bavaria, Germany.
Background: According to surveillance data, Campylobacter enteritis (CE) has been the most frequently notified bacterial gastrointestinal disease in Germany and Europe for many years. Presumably, the total number of cases is underestimated because an unknown number of cases is not diagnosed and some diagnosed cases are not reported in the surveillance system. The aim of this study was to estimate the disease and economic burden of CE and its related sequelae in Germany.
View Article and Find Full Text PDFJ Exp Med
November 2025
Department of Microbiology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Tissue-resident memory T cells (TRM) remain in nonlymphatic barrier tissues for extended periods and are deeply involved in immune memory at the site of inflammation. Here, we employed multilayered single-cell analytic approaches including chromatin, gene, and protein profiling to characterize a unique CD4+ TRM subset present in the inflamed gut mucosa of Crohn's disease patients. We identified two key transcription factors, RUNX2 and BHLHE40, as regulators of pathologically relevant CD4+ TRM.
View Article and Find Full Text PDFVirulence
December 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.
is a food-borne zoonotic pathogen that causes human gastroenteritis and potentially fatal systemic infections. The invasion of intestinal epithelial cells and the survival and replication within host macrophages are essential for the intestinal and systemic infections caused by , respectively. To precisely regulate the expression of virulence-related genes, relies on a series of regulatory proteins.
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