Psychometric evaluation of the Chinese version of the Caregiver-Centered Communication Questionnaire (CCCQ) in caregivers of cancer patients.

Background: Scientific assessment is a crucial first step in establishing effective communication between healthcare teams and caregivers. Given the lack of reliable and effective tools to comprehensively assess the quality of communication between healthcare teams and caregivers of cancer patients in China. This study aimed to translated and culturally adapted the Caregiver-Centered Communication Questionnaire (CCCQ) and assessed its psychometric properties in caregivers of cancer patients in China.

Identification of childhood-onset lupus nephritis through integrative bioinformatics: otoferlin as a novel biomarker.

Background: Childhood-onset systemic lupus erythematosus (cSLE) exhibits a higher incidence of lupus nephritis (LN) compared to adult-onset SLE (aSLE). However, the underlying molecular mechanisms remain elusive.

Methods: Gene expression datasets from childhood-onset (GSE65391) and adult-onset (GSE72798) LN patients were obtained.

Genome-based reclassification of Micromonospora veneta Kaewkla et al. 2022 as a later heterotypic synonym of Micromonospora coerulea Jensen 1932 (Approved lists 1980).

In this study, we aimed to clarify the taxonomic positions of Micromonospora veneta DSM 109713 and Micromonospora coerulea JCM 3175 using whole-genome phylogenetic analysis, pangenomic analysis and chemotaxonomic characteristics. The 16S rRNA gene sequences of veneta DSM 109713 and M. coerulea JCM 3175 were highly similar (99.

Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation.

Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are persistent environmental contaminants linked to adverse health effects, including an increased risk of breast cancer. However, the molecular mechanisms through which PFAS contribute to breast cancer development remain poorly understood. In this study, we employed an integrated approach combining network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation to investigate the effects of PFAS on breast cancer.

Efficacy of Astragalus Membranaceus (Huang Qi) for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

Cancer-related fatigue is the most common complication in patients. Astragalus membranaceus is widely used in many countries to treat cancer, but its efficacy and safety is uncertain. This study aimed to summarize the evidence on Astragalus membranaceus on cancer-related fatigue and quality of life in patients with cancer.

Breaking barriers: novel reference equations for the six-minute walk distance and work in obese Chinese adults.

Background: The six-minute walk test (6MWT) is a key tool for assessing fitness in obese individuals, but existing reference equations for the six-minute walk distance (6MWD) are limited and overlook the six-minute walk work (6MWW), in turn limiting the clinical applicability of the test. This study aims to establish new 6MWD and 6MWW equations to improve our understanding of functional capacity in obese Chinese adults.

Methods: A cross-sectional study was conducted at Wenzhou People's Hospital from July 2021 to June 2023.

Identification of as a Key Biomarker Linking Iron Metabolism and Dendritic Cell Activation in Systemic Lupus Erythematosus Through Bioinformatics and Experimental Validation.

Background: Systemic lupus erythematosus (SLE) is characterized by aberrant immune activation and disrupted iron metabolism, yet the molecular mediators that govern both processes remain unclear. This study aims to identify pivotal genes that modulate immune responses and iron metabolism, and to delineate their contributions to SLE pathogenesis.

Methods: Differentially expressed genes related to iron metabolism (IM-DEGs) were identified using datasets (GSE72326, GSE110169, GSE126307, and GSE50772) from the GEO database and the MSigDB.

Solvent-Free Supramolecular Polymerization for Feather-Like Nanostructured Chiral Fluorescent Polyurethanes with Multimodal Chiroptical Stimuli Responsiveness.

Chiral supramolecular polymers with stimuli-responsive circularly polarized luminescence (CPL) are highly desirable for smart flexible optoelectronic devices, but remain rarely reported. Here, a simple solvent-free supramolecular polymerization for preparing chiral polyurethanes is presented by in situ induced self-assembly strategy, using cellulose nanocrystals (CNCs)-based isocyanate prepolymers and macromolecular polyols as precursors, achieving precise control over polymer chain assembly with spot-like arrangement. More importantly, by further incorporating a π-conjugated luminescent dihydroxynaphthalene molecule, CPL-active flexible polyurethane films with feather-like nanostructures are constructed, which promote the ordered arrangement of CNCs-based isocyanate segments due to the increased spatial resistance.

Hesperidin alleviates endothelial cell inflammation and apoptosis of Kawasaki disease through inhibiting the TLR4/IĸBα/NF-ĸB pathway.

Kawasaki Disease (KD) is an acute and self-limiting vasculitis of unknown etiology that mainly occurs in infancy and can lead to vascular endothelial injury. Hesperidin (HES) is an economical dietary biological flavonoid with anti-oxidant, anti-inflammatory, and anti-apoptotic pharmacological effects. The main objective of this study was to investigate the protective effects of HES on KD, and try to elucidate the underlying mechanism.

Pulmonary Ridge Coverage: A Two-edged Sword in Left Atrial Appendage Closure With LAmbre.

Background: The LAmbre occluder, available in 2 versions, allows for selective coverage of the pulmonary ridge (PR) during left atrial appendage closure (LAAC). In this study we evaluated the effects of PR coverage on imaging and clinical outcomes in patients undergoing LAAC.

Methods: Imaging data and clinical events were retrospectively analyzed for patients with nonvalvular atrial fibrillation who successfully underwent LAAC using the LAmbre device at the First Affiliated Hospital of Wenzhou Medical University between October 2018 and May 2022.

An integrated analysis for spatio-temporal evolution of food water-carbon-energy footprint and its sustainable production in northwest China.

The increasing demand for food production has led to significant resource consumption and environmental stress in ecologically fragile areas. A comprehensive quantification of the environmental impact of crop production can provide essential support for the sustainable development of agriculture in these regions. In this study, we utilized water, carbon, and energy footprint of food production to analyze its water consumption, greenhouse gas emissions and energy use.

Automated and quantitative assessment of aortic root based on cardiac computed tomography angiography using a new deep-learning tool: a comparison study.

Background: Accurate assessment of aortic root is crucial for the preprocedural planning of transcatheter aortic valve replacement (TAVR). A variety software is emerging for the semiautomated or automated measurements during TAVR planning. This study evaluated a new deep-learning (DL) tool based on cardiac computed tomography angiography (CCTA) for fully automatic assessment of aortic root.

Genome-based reclassification of (Rajasabapathy . 2016) Wirth . 2018 as a later heterotypic synonym of (Lai . 2011) Wirth . 2018.

VSW210 was compared with CK-I3-6 to examine the taxonomic relationship between the two type strains. In phylogenetic trees drawn using whole genome sequences and 16S rRNA gene sequences, VSW210 and CK-I3-6 clade together and showed a 99.6 % 16S rRNA sequence similarity.

Synthesis and Modulation of Low-Dimensional Transition Metal Chalcogenide Materials via Atomic Substitution.

In recent years, low-dimensional transition metal chalcogenide (TMC) materials have garnered growing research attention due to their superior electronic, optical, and catalytic properties compared to their bulk counterparts. The controllable synthesis and manipulation of these materials are crucial for tailoring their properties and unlocking their full potential in various applications. In this context, the atomic substitution method has emerged as a favorable approach.

The efficacy of progressive muscle relaxation training on cancer-related fatigue and quality of life in patients with cancer: A systematic review and meta-analysis of randomized controlled studies.

Background: Cancer-related fatigue is one of the most common symptoms in cancer patients, usually accompanied by anxiety, depression and insomnia, which seriously affect patients' quality of life. Progressive muscle relaxation training is widely used for cancer-related fatigue, but the overall effect is unclear.

Objectives: The aim of this study was to summarize the evidence on the effects of progressive muscle relaxation training on cancer-related fatigue and quality of life in cancer patients.

Mechanism of balloon burst during transcatheter aortic valve replacement pre-dilatation: Image observation and validation by finite element analysis.

Background: Balloon burst during transcatheter aortic valve replacement (TAVR) is serious complication. This study pioneers a novel approach by combining image observation and computer simulation validation to unravel the mechanism of balloon burst in a patient with bicuspid aortic valve (BAV) stenosis.

Method: A new computational model for balloon pre-dilatation was developed by incorporating the element failure criteria according to the Law of Laplace.

Angiography and optical coherence tomography derived shear stress: are they equivalent in my opinion?

Advances in image reconstruction using either single or multimodality imaging data provide increasingly accurate three-dimensional (3D) patient's arterial models for shear stress evaluation using computational fluid dynamics (CFD). We aim to evaluate the impacts on endothelial shear stress (ESS) derived from a simple image reconstruction using 3D-quantitative coronary angiography (3D-QCA) versus a multimodality reconstruction method using optical coherence tomography (OCT) in patients' vessels treated with bioresorbable scaffolds. Seven vessels at baseline and five-year follow-up of seven patients from a previous CFD investigation were retrospectively selected for a head-to-head comparison of angiography-derived versus OCT-derived ESS.

Constraints on the maintenance of wild populations based on regression conservation.

To clarify the key factors constraining the maintenance of wild populations and to develop conservation strategies and technical links for current populations, we investigated the renewal status and distribution patterns of wild populations in the main distribution areas of China. We analyzed the effects of stand factors and human disturbance on population renewal and maintenance. The results showed that the overall regeneration of wild populations was poor.

Investigation of Vibration During Wire and Arc Additive Manufacturing.

Wire and arc additive manufacturing (WAAM) is becoming a promising technique due to its high deposition rate and low cost. However, WAAM faces challenges of coarse grains. In this study, a novel vibration method was proposed to suppress these imperfections of WAAM.

Wnt/-catenin signalling pathway in breast cancer cells and its effect on reversing tumour drug resistance by alkaloids extracted from traditional Chinese medicine.

Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs.

An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft.

Endothelial shear stress (ESS) plays a key role in the clinical outcomes in native and stented segments; however, their implications in bypass grafts and especially in a synthetic biorestorative coronary artery bypass graft are yet unclear. This report aims to examine the interplay between ESS and the morphological alterations of a biorestorative coronary bypass graft in an animal model. Computational fluid dynamics (CFD) simulation derived from the fusion of angiography and optical coherence tomography (OCT) imaging was used to reconstruct data on the luminal anatomy of a bioresorbable coronary bypass graft with an endoluminal "flap" identified during OCT acquisition.

Effects of sacubitril/valsartan on cardiac reverse remodeling and cardiac resynchronization in patients with acute myocardial infarction.

Introduction: In 2014, the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) has shown that sacubitril/valsartan can reduce the risk of hospitalization and death from cardiovascular causes more effectively than enalapril (an ACEI) in heart failure patients with reduced ejection fraction (HFrEF). Similarly, the PARADIGM-HF trial (Comparison of Sacubitril-Valsartan vs. Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode) came to similar conclusions and extended the PARADIGM-HF trial results in 2019.