Dietary Intakes of Soy and Isoflavones and Risk of Mortality in a Population with High Soy Consumption.

Background: Soy and isoflavones have been linked to various health benefits, but their associations with all-cause and cause-specific mortality remain unclear.

Objectives: We examined the associations of dietary intakes of isoflavones, soy protein, and soy foods with mortality risk in a population-based cohort study.

Methods: We included 39,286 adults aged ≥ 19 y from the Korea National Health and Nutrition Examination Survey (2007-2015).

Dietary soy and isoflavone intake and mortality in Korean adults: a prospective cohort study.

Background: The association between dietary soy and isoflavone intake and mortality remains inconclusive. This study aimed to examine the relationships of dietary intakes of isoflavones, soy protein, and soy foods with all-cause, cancer, and cardiovascular disease (CVD) mortality in Korean adults.

Methods: This prospective cohort study included 118,450 Korean adults aged 40-79 years from the Health Examinees Study (2004-2013).

Menstrual Disorders Are Associated With Depressive Symptoms Among Women of Reproductive Age: Findings From the Korean Women's Health Survey for Sexual and Reproductive Health.

Background: Menstrual disorders and depressive symptoms are common health concerns for women. This study examined the association between menstrual disorders and depressive symptoms in women of reproductive age.

Methods: A total of 3,088 premenopausal women aged 13-55 years were included in the current analysis from a nationwide survey conducted in 2022 to assess the reproductive health of Korean women.

Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation.

Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are persistent environmental contaminants linked to adverse health effects, including an increased risk of breast cancer. However, the molecular mechanisms through which PFAS contribute to breast cancer development remain poorly understood. In this study, we employed an integrated approach combining network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation to investigate the effects of PFAS on breast cancer.

Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.

Background: The link between vitamin D and cancer remains inconclusive. In this study, we aimed to explore the relationship between circulating vitamin D levels and overall and site-specific cancers in Korean adults using data from two large prospective cohort studies.

Methods: Baseline serum 25-hydroxyvitamin D [25(OH)D] levels were measured in a subset of participants from the Cardiovascular Disease Association Study (2005-2012) and the Health Examinees Study (2009-2013).

Dietary intake and plasma isoflavones are inversely associated with inflammatory markers in breast cancer survivors: A cross-sectional study.

The role of isoflavones in breast cancer, particularly their relationship with inflammatory markers, remains underexplored. We hypothesized that higher intakes of soy and isoflavones are inversely associated with inflammatory markers in breast cancer survivors. This cross-sectional study included 432 breast cancer survivors (mean age: 52 years).

Plasma metabolite based clustering of breast cancer survivors and identification of dietary and health related characteristics: an application of unsupervised machine learning.

Background/objectives: This study aimed to use plasma metabolites to identify clusters of breast cancer survivors and to compare their dietary characteristics and health-related factors across the clusters using unsupervised machine learning.

Subjects/methods: A total of 419 breast cancer survivors were included in this cross-sectional study. We considered 30 plasma metabolites, quantified by high-throughput nuclear magnetic resonance metabolomics.

Dietary isoflavone intake among breast cancer survivors and cancer-free women.

Background/objectives: Isoflavones are estrogen-like compounds found in plants and their health effects remain equivocal. We investigated dietary isoflavone intake and its associated factors in Korean breast cancer survivors, with a comparison to cancer-free women.

Subjects/methods: The usual dietary intake of breast cancer survivors (n = 981, mean age 52 yrs) in 9 hospitals between 2012 and 2019 was assessed using 3-day food records or food frequency questionnaires (FFQs).

Serum 25-hydroxyvitamin D levels and risk of all-cause and cause-specific mortality: A 14-year prospective cohort study.

Background & Aims: The circulating vitamin D level that is optimal for health is unknown. This study aimed to examine the association between circulating vitamin D level and risk of all-cause and cause-specific mortality.

Methods: This prospective cohort study included 18,797 Korean adults aged 40 years or older, living in rural areas, with no history of cancer or cardiovascular disease (CVD) at baseline.

Korea Nurses' Health Study and the health of reproductive-aged women: a cohort profile.

The Korea Nurses' Health Study (KNHS) is an ongoing, large-scale, prospective cohort study of women nurses, focusing on the effects of occupational, environmental, and lifestyle factors on the health of women. The first KNHS survey was performed in 2013-2014 (n=20,613). As of December 2023, 11 follow-up surveys have been conducted.

Folate, vitamin B12, and homocysteine status in the Korean population: data from the 2013-2015 Korea National Health and Nutrition Examination Survey.

Objectives: We aimed to assess the serum folate, vitamin B12, and homocysteine status in Korean adolescents and adults using national data.

Methods: Blood samples were collected from participants aged ≥10 years in the Korea National Health and Nutrition Examination Survey 2013-2015. The stored serum samples were used to measure folate, vitamin B12, and homocysteine concentrations.

The effects of dietary self-monitoring intervention on anthropometric and metabolic changes via a mobile application or paper-based diary: a randomized trial.

Background/objectives: Weight loss via a mobile application (App) or a paper-based diary (Paper) may confer favorable metabolic and anthropometric changes.

Subjects/methods: A randomized parallel trial was conducted among 57 adults whose body mass indices (BMIs) were 25 kg/m or greater. Participants randomly assigned to either the App group (n = 30) or the Paper group (n = 27) were advised to record their foods and supplements through App or Paper during the 12-week intervention period.

Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis.

We aimed to examine the association between dietary isoflavone intake and the risk of breast cancer recurrence and summarize evidence on the role of dietary isoflavone intake in breast cancer prognosis. This prospective study included 592 breast cancer survivors who completed a dietary assessment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.

Predicted pro-inflammatory hs-CRP score and non-alcoholic fatty liver disease.

Background: Non-alcoholic fatty liver disease (NAFLD) is a major contributor to liver diseases globally, yet there are limited studies investigating the impact of diet and lifestyle factors on its development. This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score.

Methods: We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in 2021.

Risk of uterine leiomyomata with menstrual and reproductive factors in premenopausal women: Korea nurses' health study.

Background: Uterine leiomyomata (UL) are benign smooth muscle tumors that may cause significant morbidity in women of reproductive age. This study aimed to investigate the relationship of menstrual and reproductive factors with the risk of UL in premenopausal women.

Methods: This prospective study included 7,360 premenopausal women aged 22-48 years who were part of the Korea Nurses' Health Study.

Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.

Background: Evidence on the association of serum folate and homocysteine concentrations with risk of mortality in the general population is unclear.

Objectives: This study aimed to examine the associations of serum folate and homocysteine concentrations with all-cause, CVD, and cancer mortality risk in Korean men and women aged ≥40 y.

Methods: In this population-based prospective cohort study, serum folate and homocysteine concentrations were measured in a subset of participants enrolled between 2005 and 2012.

Validity and reproducibility of a food frequency questionnaire for breast cancer survivors in Korea.

Background/objectives: The aim of this study was to examine the validity and reproducibility of a food frequency questionnaire (FFQ) developed in Korea for breast cancer survivors.

Subjects/methods: Ninety-nine breast cancer survivors who completed an FFQ twice and three 3-day dietary records (DRs) between 2016-2017 were included. Energy and 14 nutrient intakes were calculated from FFQs and DRs.

Factors associated with regularity and length of menstrual cycle: Korea Nurses' Health Study.

Background: Menstrual cycle characteristics are linked to reproductive function and long-term health outcomes. This study aimed to evaluate menstrual cycle patterns, characterized by regularity and length, and associated factors among women in the Korea Nurses' Health Study.

Methods: A total of 9335 premenopausal women aged 22-45 years were included in this cross-sectional study.

Associations of body mass index and weight change with circulating levels of high-sensitivity C-reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors.

Aim: This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea.

Methods: A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis.

Reproducibility of a food frequency questionnaire: Korea Nurses' Health Study.

Background/objectives: This study aimed to examine the reproducibility of food frequency questionnaires (FFQs) designed for young female nurses in the Korea Nurses' Health Study.

Subjects/methods: The reproducibility of web-based, self-administered FFQs was evaluated among 243 Korean female nurses. The first FFQ (FFQ1) was administered from March 2014 to February 2019 and the second FFQ (FFQ2) from November 2019, with a mean interval of 2.

Nutrient intakes from supplement and factors associated with supplement use among breast cancer survivors: A cross-sectional study.

Objective: We investigated the contribution of supplement use to total nutrient intake, the prevalence of inadequate nutrient intake and the factors associated with supplement use among breast cancer survivors.

Methods: A total of 701 Korean breast cancer survivors were included. We calculated the contribution of dietary supplements to total nutrient intake and the proportion of the population below the estimated average requirements (EARs) or exceeding the tolerable upper intake levels (ULs).

The association between predicted inflammatory status and colorectal adenoma.

We developed a diet and lifestyle score based on high sensitivity C-reactive protein (hsCRP), and investigated its association with odds of adenoma. We performed stepwise linear regression to develop the predicted hsCRP score among 23,330 participants in the Health Examinee Study and examined its association with colorectal adenoma among 1,711 participants in a cross-sectional study of colorectal adenoma. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) of colorectal adenoma using logistic regression models.