Anion-templated silver thiolated clusters affected by carboxylate ligands.

Under the guidance of anion templates VO and SO, the novelty of cluster assembly can be increased by using different carboxylate ligands. Herein, the synthesis, crystal structure and electrochemical properties of three anion-templated silver thiolated clusters are reported, namely VO@Ag(PrS)(CFCO)(DMF) (1), VO@Ag(PrS)(CFCO)(PhCO)(DMF) (2), and [SO@Ag(PrS)(PTA)(HPTA)] (3, HPTA = phthalic acid). Single-crystal X-ray diffraction analysis showed that 1 and 2 are discrete clusters VO@Ag.

Effect of mild intermittent cold stimulation on thymus immune function in broilers.

This study aims to assess the effect of intermittent and mild cold stimulation (IMCS) on thymus function and the ability of 1-day-old male Ross 308 broilers to withstand cold. Four hundred broilers were reared under normal and mild cold temperatures at 3°C below the normal feeding temperature and were subjected to acute cold stress (ACS) at 10°C on d 50 at 7 am for 6 h, 12 h, and 24 h. We determined the expression levels of toll-like receptors (TLRs), cytokines and avian β-defencins (AvBDs), encoding genes in thymus of broilers at 22, 36, 43, and 50 d of age, and the serum ACTH and cortisol (CORT) levels at 50 d of age.

A Berberine Bridge Enzyme-Like Protein, , Confers Soybean's Coordinated Adaptation to Aluminum Toxicity and Phosphorus Deficiency.

Phosphorus (P) deficiency and aluminum (Al) toxicity often coexist and are two major limiting factors for crop production in acid soils. The purpose of this study was to characterize the function of , a berberine bridge enzyme-like protein-encoding gene, in soybean () adaptation to Al and low P stresses. Present quantitative real-time PCR (qRT-PCR) assays confirmed the phosphate (Pi)-starvation enhanced and Al-stress up-regulated expression pattern of in soybean roots.

Transcriptional regulation by a RecQ helicase.

RecQ helicases participate in a variety of DNA metabolic processes through their multiple biochemical activities. In vitro characterization and cellular studies have suggested that RECQ1 (also known as RECQL or RECQL1) performs its diverse functions through specific interactions with DNA and protein partners. We have taken an unbiased approach to determine the contribution of RECQ1 in genome maintenance and as a putative susceptibility factor in breast cancer.

Long-Term Hearing Stability at Different Frequencies after Lower Intact Bridge Tympanomastoidectomy and Possible Theoretical Basis.

We aimed to review the long-term hearing outcomes of intact bridge tympanomastoidectomy (IBM) to discuss hearing preservation and combine the theory of "modified miniature lung," middle ear ventilation, and gas pressure balance theory to explore the possible reasons for long-term stable hearing. We designed a collection of patients with chronic suppurative otitis media (CSOM) who underwent IBM and divided them into 2 groups to compare long-term and short-term hearing level. From April 2007 to July 2017, 102 patients received IBM for CSOM treatment in Eye & ENT Hospital of Fudan University.

The circRERE/miR-144-3p/TLR2/MMP9 signaling axis in COPD pulmonary monocytes promotes the EMT of pulmonary epithelial cells.

Chronic obstructive pulmonary disease (COPD) is a serious threat to human health, but an effective targeted therapy for COPD is still lacking at present. During the progression of COPD, the epithelial mesenchymal transition (EMT) ensures the remodeling of pulmonary epithelial cells, and it could not be precisely targeted due to its complex and elusive mechanism. In this study, we determined that the TLR2/MMP9 axis is upregulated in the pulmonary monocytes in cigarette smoke (CS)-induced COPD mice.

Developing dynamic speed limit strategies for mixed traffic flow to reduce collision risks at freeway bottlenecks.

Connected and automated vehicles (CAVs) have the great potential to improve traffic flow because of their particular characteristics of connectivity and automation. This study aims to develop CAV control strategies based on car-following speed balance, which are defined as dynamic speed limit (DSL) strategies, and examine their performances on reducing freeway collision risks via microscopic simulations. The core idea of DSL strategy is to command the CAVs to slow down actively before reaching the bottlenecks, and form moving barriers to guide the following human driven vehicles to passively decelerate.

RadBERT: Adapting Transformer-based Language Models to Radiology.

Purpose: To investigate if tailoring a transformer-based language model to radiology is beneficial for radiology natural language processing (NLP) applications.

Materials And Methods: This retrospective study presents a family of bidirectional encoder representations from transformers (BERT)-based language models adapted for radiology, named RadBERT. Transformers were pretrained with either 2.

Cluster-Geometry-Associated Metal-Metal Bonding in Trimetallic Carbide Clusterfullerenes.

Geometry configurations of the metallic clusters play a significant role in the involved bonding nature. Herein, we report the crystallographic characterization of unprecedented erbium-based trimetallic clusterfullerenes, namely, ErC@(7)-C, in which the inner ErC cluster presents a lifted bat ray configuration with the C unit elevated by ∼1.62 Å above the Er plane.

Development of Novel Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Tumor Immunotherapy.

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes-TANK-binding kinase 1-interferon regulating factor 3 (cGAS-STING-TBK1-IRF3) axis is now acknowledged as the major signaling pathway in innate immune responses. However, 2',3'-cGAMP as a STING stimulator is easily recognized and degraded by ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which reduces the effect of tumor immunotherapy and promotes metastatic progression. In this investigation, the structure-based virtual screening strategy was adopted to discover eight candidate compounds containing zinc-binding quinazolin-4(3H)-one scaffold as ENPP1 inhibitors.

(), a Novel Reduced-Height () Gene in Wheat.

In wheat, a series of dwarf and semi-dwarf plant varieties have been developed and utilized worldwide since the 1960s and caused the 'Green Revolution'. To date, 25 reduced-height () genes have been identified, but only several genes for plant height (PH) have been isolated previously. In this study, we identified a candidate gene, (), for PH via QTL mapping and genome-wide association study (GWAS) methods.

[Action mechanism and active components of Fuzheng Huayu Recipe against liver fibrosis via regulating macrophage with network pharmacology and transcriptomics methods].

We have demonstrated that Fuzheng Huayu Recipe(FZHY) plays an anti-liver fibrosis role by regulating the polarization of intrahepatic macrophages, while the key targets in macrophages and the effective components of FZHY remain unclear. In this study, we obtained the potential anti-liver fibrosis target set of FZHY through network pharmacological analysis, and the differentially expressed gene set of FZHY for the prevention and treatment of mouse liver fibrosis through RNA-Seq of the liver tissue. The potential core targets of FZHY against liver fibrosis were obtained by degree value analysis of the common target proteins between the above two sets.

The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery.

Objective: To analyze the relationship between monocyte-to-lymphocyte ratio (MLR) and postoperative delirium (POD).

Methods: This cohort study was conducted in the Medical Information Mart for Intensive Care-III (MIMIC-III) version 1.4 database.

Comprehensive understanding the impacts of dietary exposure to polyethylene microplastics on genetically improved farmed tilapia (Oreochromis niloticus): tracking from growth, microbiota, metabolism to gene expressions.

Microplastics (MPs) pollution has been recognized as a threat to sustainable fisheries due to the risks of MPs contamination in the process of feed production and susceptibility of fish to ingest MPs from the aquatic environment. In this study, we applied comprehensive approaches to investigate the impacts of polyethylene microplastics (PE-MPs) on juvenile genetically improved farmed tilapia (GIFT, Oreochromis niloticus) through 9-week dietary exposure based on growth performance, gut microbiota, liver metabolism, and gene expressions in brain and liver tissues. Dietary exposure to two kinds of PE-MPs with different median size (27 μm and 63 μm, respectively) concentration-dependently decreased weight gain (WG), while increased feed conversion ratio (FCR) and hepatosomatic index (HSI) of the tilapia.

Abnormal Expression of N6-Methyladenosine RNA Methylation Regulator IGF2BP3 in Colon Cancer Predicts a Poor Prognosis.

The value of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an N6-methyladenosine (m6A) RNA methylation regulatory factor, in the prognosis of colon cancer was still unclear. High levels of IGF2BP3 were expressed in colon adenocarcinoma (COAD) samples and in human colon cancer tissues, which was associated with poorer overall survival (OS). We validated IGF2BP3 as an independent prognostic risk biomarker in COAD patients.

Receiving feedback after posting status updates on social networking sites predicts lower loneliness: A mediated moderation model.

People are increasingly relying on social networking sites (SNSs) to satisfy their needs for relatedness. However, the psychological benefits of receiving others' feedback on SNSs remain relatively understudied. To fill this research gap, the present research examined whether and how others' feedback to one's status updates on WeChat Moments (i.

Retraction Notice to: Growth Arrest-Specific Transcript 5 (GAS5) Exerts Important Roles on the Treatment of BM45 Cells of Liver Cirrhosis.

[This retracts the article DOI: 10.1016/j.omtn.

Chronic exposure to high-density polyethylene microplastic through feeding alters the nutrient metabolism of juvenile yellow perch ().

Microplastics are emergent contaminants threatening aquatic organisms including aquacultured fish. This study investigated the effects of high-density polyethylene (HDPE, 100 to 125 μm) on yellow perch () based on integrative evaluation including growth performance, nutritional status, nutrient metabolism, fish health, and gut microbial community. Five test diets (0, 1, 2, 4, or 8 g HDPE/100 g diet) containing 41% protein and 10.

Mechanisms Underlying Soybean Response to Phosphorus Deficiency through Integration of Omics Analysis.

Low phosphorus (P) availability limits soybean growth and yield. A set of potential strategies for plant responses to P deficiency have been elucidated in the past decades, especially in model plants such as and rice (). Recently, substantial efforts focus on the mechanisms underlying P deficiency improvement in legume crops, especially in soybeans ().

[The value of magnetic resonance hydrography in the localization of fistula in patients with cerebrospinal fluid rhinorrhea].

To evaluate the application value of magnetic resonance hydrography in determine the leak location of patients with cerebrospinal fluid rhinorrhea. Clinical data of 58 patients with cerebrospinal fluid rhinorrhea treated in Tianjin Huanhu Hospital from February 2015 to February 2021 were analyzed retrospectively. The leak position was judged by three methods: nasal sinus coronal CT, magnetic resonance hydrography and magnetic resonance hydrography combined with nasal sinus coronal CT.

Role of creatine supplementation on the myofibre characteristics and muscle protein synthesis of grass carp ().

To assess the role of dietary creatine on myofibre characteristics and protein synthesis in muscle, we fed grass carp (, initial body weight: 88·47 ± 1·44 g) creatine-supplemented diets (1·84, 5·91, 8·48 and 15·44 g/kg diet) for 8 weeks. Creatine supplementation did not affect growth performance, but significantly increased creatine contents in muscle and liver. At 8·48 g/kg, creatine decreased the activities of alanine transaminase and aspartate aminotransferase in serum and improved hardness and chewiness of muscle due to shorter myofibre mean diameter, higher myofibre density and the frequencies of the diameters of classes I and III and collagen content, longer sarcomere length and upregulated mRNA levels of slow myosin heavy chains.

Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway.

Objective: Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation.

Methods: In vivo study, 8-week-old MRL/MpJ-Faslpr/J (MRL/lpr) mice were randomly divided into two groups (n=12 each): daily administration of 0.

Rubrene-Directed Structural Transformation of Fullerene (C) Microsheets to Nanorod Arrays with Enhanced Photoelectrochemical Properties.

One-dimensional (1D) nanostructures possess huge potential in electronics and optoelectronics, but the axial alignment of such 1D structures is still a challenging task. Herein, we report a simple method that enables two-dimensional (2D) C microsheets to evolve into highly ordered nanorod arrays using rubrene as a structure-directing agent. The structural transformation is accomplished by adding droplets of rubrene--xylene solution onto C microsheets and allowing the -xylene solvent to evaporate naturally.

Spheres of Graphene and Carbon Nanotubes Embedding Silicon as Mechanically Resilient Anodes for Lithium-Ion Batteries.

Novel anode materials for lithium-ion batteries were synthesized by growth of spheres of graphene and carbon nanotubes (CNTs) around silicon particles. These composites possess high electrical conductivity and mechanical resiliency, which can sustain the high-pressure calendering process in industrial electrode fabrication, as well as the stress induced during charging and discharging of the electrodes. The resultant electrodes exhibit outstanding cycling durability (∼90% capacity retention at 2 A g after 700 cycles or a capacity fading rate of 0.