Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications.

Background: Flexible wearable medical devices drive healthcare transformation via non-invasive, real-time physiological monitoring and personalized management. Traditional rigid devices lack long-term comfort, while chronic disease care and telemedicine demand reliable, patient-centered solutions. Advances in materials (carbon nanomaterials, liquid metals, hydrogels) enable stretchable, biocompatible substrates adapting to bodily movements.

A qualitative exploration of barriers to narrative nursing practice among early-career nurses.

Objective: To explore the barriers faced by early-career nurses in practicing narrative nursing, covering individual competence, patient cooperation, institutional support, and sociocultural factors, aiming to provide theoretical and practical references for enhancing nurses' humanistic care ability, optimizing nurse-patient relationships, and improving care quality.

Methods: A phenomenological qualitative study was conducted using purposive sampling to select seven early-career nurses from the Second Affiliated Hospital of Xi'an Jiaotong University between March and June 2024. Semi-structured face-to-face interviews were performed, and data were analyzed using Colaizzi's seven-step method to extract themes.

Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1.

Background: Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Our previous investigation provided preliminary evidence that single nucleotide polymorphisms (SNPs) may functionally interact with the LINC00339, potentially contributing to the pathogenesis and progression of osteoporosis through undefined molecular pathways. However, the exact mechanistic basis of LINC00339's involvement in osteoporotic bone remodeling remains incompletely characterized and warrants systematic exploration.

An ovalbumin-based hydrogel loaded with dendrobium polysaccharide for promoting wound healing while reducing inflammations.

The challenges associated with wound healing are multifaceted, encompassing factors such as susceptibility to infection, inadequate blood supply to injured tissues, and the retention of foreign bodies. Development of a wound repair product that can effectively overcome the aforementioned issues at a relatively low cost would better meet the needs of patients. Consequently, this research aimed to develop a low-cost hydrogel with a simple preparation process to accelerate wound healing and reduce the risk of infection.

The Nrf2-HMOX1 pathway as a therapeutic target for reversing cisplatin resistance in non-small cell lung cancer via inhibiting ferroptosis.

Cisplatin resistance is a major cause of poor prognosis in non-small cell lung cancer (NSCLC). Cisplatin-induced lung cancer cell death is associated with ferroptosis, a type of recently identified programmed cell death. Nrf2 is a critical component of the antioxidant system, and its protumorigenic activity in lung cancer has been extensively studied.

Spin-Splitting Magnetoresistance in Altermagnetic RuO Thin Films.

The recently discovered altermagnets, featured by the exotic correlation of magnetic exchange interaction and alternating crystal environments, have offered exciting cutting-edge opportunities for spintronics. Nevertheless, the altermagnetism of RuO, one of the earliest-discovered altermagnets, is currently under intense debate. Here, this controversy is attempted to be resolved by demonstrating a spin-splitting magnetoresistance (SSMR) effect that is driven by a spin current associated with the giant nonrelativistic spin splitting of an altermagnet.

Characterization of m6A-Related Genes in Tumor-Associated Macrophages for Prognosis, Immunotherapy, and Drug Prediction in Lung Adenocarcinomas Based on Machine Learning Algorithms.

Tumor-associated macrophages (TAMs) are a vital immune component within the tumor microenvironment (TME) of lung adenocarcinoma (LUAD), exerting significant influence on tumor growth, metastasis, and drug resistance. N6-methyladenosine (m6A) modifications regulate gene expression and various facets of cancer biology; nonetheless, the mechanisms by which they modulate gene expression in TAMs and their impact on LUAD progression remain inadequately elucidated. Single-cell transcriptome analysis identified the macrophage m6A-related genes (MMRGs) with high expression in TAMs and linked to m6A modifications in LUAD.

OsPPR8, a pentatricopeptide repeat protein, regulates splicing of mitochondrial nad2 intron 3 to affect grain quality and high-temperature tolerance in rice.

Pentatricopeptide repeat (PPR) proteins, a large family of plant proteins, play critical roles in regulating various biological functions. However, their contributions to rice grain quality and high-temperature (HT) tolerance remain poorly understood. In this study, we identified OsPPR8, a canonical P-type PPR protein characterized by eight PPR motifs.

Large Grain 2, an NHL Domain-Containing Protein, Interacts with FUWA and Regulates Plant Architecture and Grain Size Through the Brassinosteroid Signaling Pathway in Rice.

Plant architecture and grain size are critical traits for rice breeding. Brassinosteroid (BR), a class of plant hormones, regulates these traits by modulating cell elongation, division, and differentiation. Therefore, exploring BR-related genes to leverage their pleiotropic effects is crucial for crop improvement.

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation.

Triple-negative breast cancer (TNBC) has no expression on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), resulting in an ineffective treatment using current therapeutic therapies. As a heterogeneous disease, the notable refractory, high recurrence rate and unfavorable prognosis facilitate some researches to further elaborate novel insights into the biology of TNBC and formulate the precision treatment. Ferroptosis is a unique regulated-cell-death modality characterized by the excessive accumulation of the lipid peroxides on cellular membranes in an iron-dependent manner.

Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy.

Tumor is one of the major diseases endangering human health while establishing an efficient in vitro tumor microenvironment (TME) model, which is an effective way to reveal the nature of the tumor and develop therapeutic methods. In recent years, due to the continuous development of lab-on-a-chip technology and tumor biology, various tumor-on-a-chip models applied to oncology research have emerged. Among them, the Immunotherapy-on-a-chip (ITOC) platform stands out with its ability to reflect immunological behavior in the TME.

Giant Non-Saturating Exchange Striction in a Noncollinear Antiferromagnet.

Magnetostriction, discovered by Joule in 1842, refers to the mechanical strain that a material undergoes in the presence of a magnetic field. Conventionally, it originates from the spin-orbit coupling and has been predominantly explored in ferromagnets. In this work, a giant magnetostriction effect is reported in the high-quality single crystal of a noncollinear antiferromagnet MnSn.

Largely Enhanced Oxygen Evolution Performance in a Ferromagnetic Ruddlesden-Popper Phase Cobaltate.

The oxygen evolution reaction (OER), as a key half-reaction in water splitting, plays a critical role in various energy conversion and storage systems. Novel high-performance catalysts have always been desirable. In this work, we have fabricated insulating perovskite LaCoO and its corresponding Ruddlesden-Popper (RP) phase LaCoO films.

A customized postoperative wound management model tailored to the healing dynamics of the upper lip: a retrospective cohort study.

Background: Clinical observations suggest that upper lip injuries often exhibit prolonged healing and reduced healing efficacy. The unique anatomical and physiological characteristics of the lips make them particularly susceptible to infection and delayed recovery, posing significant challenges for postoperative management. The aim of this research, grounded in the anatomical and physiological subtleties of the upper lip, was to contrast the wound management outcomes between patients treated with a conventional wound management approach and those treated with a customized wound management model.

Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways.

Background: Gliomas currently have a poor prognosis and limited therapy options. Betulinic acid (BA) has demonstrated antitumor activity in various cancers. This study is aimed at clarifying the underlying mechanisms by which BA inhibits gliomas.

GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.

Introduction: Nucleic acid-based therapeutics have become a key pillar of the 'third wave' of modern medicine, following the eras of small molecule inhibitors and antibody drugs. Their rapid progress is heavily dependent on delivery technologies, with the development of N-acetylgalactosamine (GalNAc) conjugates marking a breakthrough in targeting liver diseases. This technology has gained significant attention for its role in addressing chronic conditions like chronic hepatitis B (CHB) and nonalcoholic steatohepatitis (NASH), which are challenging to treat with conventional methods.

Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes.

Background And Aims: Immunologically hot tumors, characterized by an inflamed tumor microenvironment (TME), contrast significantly with immunologically cold tumors. The identification of these tumor immune subtypes holds clinical significance, as hot tumors may exhibit improved prognoses and heightened responsiveness to checkpoint blockade therapy. Nevertheless, as yet there is no consensus regarding the clinically relevant definition of hot/cold tumors, and the influence of immune genes on the formation of hot/cold tumors remains poorly understood.

Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy.

The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance.

Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression.

Rheumatoid arthritis (RA) is an autoimmune disorder that leads to severe cartilage deterioration and synovial impairment in the joints. Previous studies have indicated that the aberrant activation of the NLRP3 inflammasome in synovial macrophages plays a significant role in the pathogenesis of RA and has been regarded as a therapeutic target for the disease. In this study, we synthesized a novel canthin-6-one alkaloid, namely methyl canthin-6-one-2-carboxylate (Cant), and assessed its effects on NLRP3 inflammasome activation in macrophages.

Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas.

Background: Recent advancements in contemporary therapeutic approaches have increased the survival rates of lung cancer patients; however, the long-term benefits remain constrained, underscoring the pressing need for novel biomarkers. Surfactant-associated 3 (SFTA3), a long non-coding RNA predominantly expressed in normal lung epithelial cells, plays a crucial role in lung development. Nevertheless, its function in lung adenocarcinoma (LUAD) remains inadequately understood.

Comprehensive Analysis Reveals That ISCA1 Is Correlated with Ferroptosis-Related Genes Across Cancers and Is a Biomarker in Thyroid Carcinoma.

Background: (Iron-Sulfur Cluster Assembly 1) is involved in the assembly of iron-sulfur (Fe-S) clusters, which are vital for electron transport and enzyme activity. Some studies suggest the potential involvement of in tumor progression through interactions with ferroptosis-related genes (FRGs) and the tumor immune microenvironment (TME). However, there has been no systematic analysis of its role in FRGs and the TME or its predictive value for prognosis and immunotherapy response across different cancer types.

Long Non-Coding RNA LINC01116 Promotes the Proliferation of Lung Adenocarcinoma by Targeting miR-9-5p/CCNE1 Axis.

Long non-coding RNA (lncRNA) LINC01116 is crucial in promoting cell proliferation, invasion and migration in solid tumours, including lung adenocarcinoma (LUAD). LINC01116 acts as a competing endogenous RNAs (ceRNA) that binds competitively to microRNAs and plays a critical role in tumour migration and invasion. However, other mechanisms of action besides the ceRNA theory have been rarely reported and remain to be elucidated further.

Myocardial ischemia-reperfusion injury upregulates nucleostemin expression via HIF-1α and c-Jun pathways and alleviates apoptosis by promoting autophagy.

Myocardial ischemia-reperfusion (I/R) injury, often arising from interventional therapy for acute myocardial infarction, leads to irreversible myocardial cell death. While previous studies indicate that nucleostemin (NS) is induced by myocardial I/R injury and mitigates myocardial cell apoptosis, the underlying mechanisms are poorly understood. Here, our study reveals that NS upregulation is critical for preventing cardiomyocyte death following myocardial I/R injury.

Unraveling shared and unique genetic causal relationship between gut microbiota and four types of uterine-related diseases: Bidirectional Mendelian inheritance approaches to dissect the "Gut-Uterus Axis".

Background: The gut microbiota has emerged as a pivotal factor in the etiology of uterine-related diseases. This study aims to elucidate the genetic causal link between gut microbiota composition and these conditions, focusing on the systemic impact and uterine pathology to better understand the "Gut-Uterus Axis."

Methods: We utilized pooled data from two different GWAS databases, including data from 209 gut microbiota traits and data from four uterus-related diseases.