Experiences and Needs in the Dietary Management of Chronic Kidney Disease: A Qualitative Study of Patient, Caregiver and Healthcare Professionals' Perspectives.

Dietary management is crucial in the disease management of patients with chronic kidney disease (CKD). However, there is still a lack of research on the genuine experiences and needs of patients, caregivers, and healthcare professionals involved in CKD dietary management, especially in the Chinese context. To explore the experiences and needs of Chinese patients with CKD, caregivers, and healthcare professionals regarding dietary management.

Integrating Multi-Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury.

Renal ischemia-reperfusion (I/R) injury is an unavoidable complication associated with renal transplantation, and currently, there are no targeted therapeutic interventions. The objective of this study was to explore the molecular mechanisms that contribute to I/R-induced acute kidney injury (I/R-AKI) and to discover potential targets for effective renal safeguarding. Bioinformatics techniques were employed to analyse critical genes regulating I/R-AKI at the single-cell level and to develop diagnostic models.

Land availability and policy commitments limit global climate mitigation from forestation.

Forestation (afforestation and reforestation) could mitigate climate change by sequestering carbon within biomass and soils. However, global mitigation from forestation remains uncertain owing to varying estimates of carbon sequestration rates (notably in soil) and land availability. In this study, we developed global maps of soil carbon change that reveal carbon gains and losses with forestation, primarily in the topsoil.

The Biological Functions of Yeast and Yeast Derivatives and Their Application in Swine Production: A Review.

Yeast and its derivatives, including yeast extract and yeast cell wall, are well established as safe and environmentally sustainable feed additives that significantly improve animal production performance and health. Their incorporation into swine production serves as an innovative nutritional strategy aimed at improving growth performance, bolstering health status, and enhancing immune function in pigs. As a versatile microorganism, yeast generates a variety of bioactive compounds through fermentation, such as amino acids, vitamins, enzymes, and growth factors, which collectively contribute to improved growth and overall health in pigs.

Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma.

This study investigated the prognostic impact of migrasome-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD). We analyzed transcriptomic data from The Cancer Genome Atlas (TCGA) database, comprising 541 tumor samples and 59 normal tissue samples, to pinpoint key migrasome genes and related lncRNAs, using correlation analysis to detect those pertinent to patient outcomes. A risk score model based on 17 migrasome-related lncRNAs, constructed via univariate, LASSO, and multivariate Cox regression, was then validated in an independent dataset to ensure reliability.

β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation.

Ischemia‑reperfusion injury‑induced acute kidney injury (IRI‑AKI) involves inflammatory cell infiltration and increased apoptosis, although the potential association between these processes remains unclear. The aim of the present study was to assess the impact of β‑elemene treatment on the IRI‑AKI using both and models, reverse transcription‑quantitative PCR, western blot assays, hematoxylin and Eosin (H&E) staining, Immunohistochemical staining and TUNEL staining. β‑elemene significantly decreased morphological and pathological kidney inflammation in mice caused by IRI.

Effectiveness of photobiomodulation therapy in improving health indicators in obese patients: a systematic review and meta-analysis of RCTs.

Objective: This meta-analysis is aimed to verify the effectiveness and safety of Photobiomodulation (PBM) on body measurements, metabolic indicators, and inflammation indicators in obese patients across randomized controlled trials with various comparators.

Methods: From the inception of databases to January 5, 2025, we conducted a comprehensive literature search across PubMed, OVID, Cochrane, Embase, Web of Science, LILACS, Chinese Scientific Journals Database (VIP), Wanfang and China National Knowledge Infrastructure (CNKI). Two reviewers independently performed the search, extracted data, and assessed study quality based on predefined inclusion and exclusion criteria.

Construction of a sensitive index system for nursing quality in the perioperative period of liver transplantation based on the Three-Dimensional Quality Structure theory.

Objective: Based on the "Three-Dimensional Quality Structure" theory, a sensitive index system of nursing quality during the perioperative period of liver transplantation patients was constructed.

Methods: Through a comprehensive literature review and rigorous application of the Delphi method, a panel of 27 experts completed three rounds of effective letter consultation to obtain expert consensus opinions. The contents of indicators were determined based on this process, and the analytic hierarchy process was employed to confirm the weightage assigned to each indicator.

Effects of Different Hemicellulose Components on Fermentation Kinetics and Microbial Composition in Fecal Inoculum from Suckling Piglets .

This study investigated the fermentation characteristics of different hemicellulose components using a fecal inoculum derived from suckling piglets. The results showed that after 60 h of fermentation, the arabinogalactan (Ara-gal), glucomannan (Glu-man), galactomannan (Gal-man), and mannan (Man) groups exhibited similar levels of gas production, which were higher than those of the β-glucan (β-Glu) group. The β-Glu group had the lowest pH value.

Rapid Screening of 60 Types of Natural Toxins in Whole Blood by UPLC-Q/Orbitrap HRMS.

Objectives: To establish a rapid screening method for 60 types of natural toxins in whole blood by ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q/Orbitrap HRMS).

Methods: The chromatographic and mass spectrometric information of 60 standard samples of natural toxins were analyzed and recorded, and a screening database was built. Whole blood was pretreated by protein precipitation method combined with ultrasonic-assisted dispersion, and then a Hypersil GOLD C column was used with 5 mmol/L ammonium formate aqueous solution (containing 0.

Identification of a Novel Synthetic Cathinone CMMP.

Objectives: To establish a method to identify an unknown substance based on the combined use of gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-MS), ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q/Orbitrap HRMS)and nuclear magnetic resonance (NMR) techniques.

Methods: The unknown substance was dissolved in methanol and was detected by GC-QTOF-MS and UPLC-Q/Orbitrap HRMS, and was dissolved in methanol-d4 to be detected by NMR.

Results: The main characteristics ion peaks of components with retention time of 9.

Effect of β-catenin on hypoxia induced epithelial mesenchymal transition in HK-2 cells by regulating Brachyury.

Background: Chronic kidney disease (CKD) has become a worldwide health problem and the incidence rate and mortality of CKD have been rising. Renal fibrosis (RF) is the final common pathological feature of almost all kinds of CKD and Epithelial-mesenchymal transition (EMT) is the predominant stage of RF. β-catenin is a key component of the Wnt signaling pathway, which has been fully proven to promote EMT.

Differential diversity and structure of autotrophs in agricultural soils of Qinghai Province.

Unlabelled: The biodiversity of CO-assimilating bacterial communities is pivotal for carbon sequestration in agricultural systems. Changes in the diversity, structure, and activity of the soil chemolithoautotrophic bacteria were examined in four agricultural areas, Dulan (DL), Gonghe (GH), Huzhu (HZ), and Datong (DT) counties in Qinghai Province, where wheat, oilseed rape, and barley were planted. This process was performed using Illumina amplicon sequencing of the ribulose-1,5-bisphosphatecarboxylase/oxygenase (RubisCO) gene ( Form I) and activity data.

Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets.

Indole-3-propionic acid (IPA) has anti-inflammatory properties, which can be beneficial for weaned piglets with underdeveloped immune systems. The study explores the impact of IPA supplementation on growth performance, oxidative stress, and inflammation response in weaned piglets. In Exp.

AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignant neoplasm, and up to now, the role of long non-coding RNA (lncRNA) AP001885.4 in cancer, including ESCC, is absolutely unclear. The GEPIA database was applied to identify differentially expressed and prognosis-associated genes in esophageal cancer (ESCA).

The therapeutic effect of dressing of exposed reconstructed auricle on patients after reconstruction of auricle.

The dressing of the reconstructed auricle after total auricle reconstruction surgery is an important measure of postoperative nursing. However, a uniform dressing of the reconstructed auricle after total auricle reconstruction surgery has not been formed. We carried out this clinical study to provide a new idea and method for the postoperative dressing of reconstructed auricle by comparing the therapeutic effect of the completely covered dressing method and the dressing method of exposed reconstructed auricle.

Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review.

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds of millions of years. Over the past decade, a growing body of knowledge has underscored the intricate connections among diet, gut microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, and fungi have diverse biological functions including antioxidant, immunoregulatory, and metabolic activities.

[Corrigendum] The role of IGFBP‑5 in mediating the anti‑proliferation effect of tetrandrine in human colon cancer cells.

Following the publication of the above article, a concerned reader drew to the authors' attention that, among Figs. 1D, 2A and 4B, certain of the control western blots had been re‑used in different blots. The authors have retrieved and re‑examined their original data, and were able to identify the correct control western blots where the data had been inadvertently duplicated in the affected original figures.

Fermented Purslane ( L.) Supplementation Enhances Growth and Immune Function Parallel to the Regulation of Gut Microbial Butyrate Production in Weaned Piglets.

Weaning is a challenging period for piglets, characterized by stress-related growth checks, compromised immunity, and gut dysbiosis. Purslane ( L.), known for its rich content of antioxidants, has potential as a functional feed ingredient.

The sensitivity outcome index system for home care of elderly liver transplant patients was developed based on the Omaha problem classification system.

Objective: Based on the Omaha problem classification system, a sensitivity outcome index system for home nursing of elderly liver transplant patients was established.

Methods: Through a comprehensive literature review and rigorous application of the Delphi method, a panel of 20 experts completed two rounds of effective letter consultation to obtain expert consensus opinions. The contents of indicators were determined based on this process, and the analytic hierarchy process was employed to confirm the weightage assigned to each indicator.

Increased straw return promoted soil organic carbon accumulation in China's croplands over the past 40 years.

Quantifying changes in soil organic carbon (SOC) stocks within croplands across a broad spatiotemporal scale in response to anthropogenic and environmental factors offers valuable insights for sustainable agriculture aimed to improve soil health. Using a validated and widely used soil carbon model RothC, we simulated the SOC dynamics across intensive croplands in China that support ∼22 % of the global population using only 7 % of the global cropland area. The modelling results demonstrate that the optimized RothC effectively captures SOC dynamics measured across 29 long-term field trials during 40 years.

Development and validation of a prenatal predictive nomogram for the risk of NICU admission in infants born to Chinese mothers over 35 years of age: a retrospective cohort study.

Background: The rising number of women giving birth at advanced maternal age has posed significant challenges in obstetric care in recent years, resulting in increased incidence of neonatal transfer to the Neonatal Intensive Care Unit (NICU). Therefore, identifying fetuses requiring NICU transfer before delivery is essential for guiding targeted preventive measures.

Objective: This study aims to construct and validate a nomogram for predicting the prenatal risk of NICU admission in neonates born to mothers over 35 years of age.