Thyroiditis and human blood metabolites: A mendelian randomization study.

Background: The risk factors for thyroiditis, an inflammatory disease with a complex etiology, remain poorly understood. Blood metabolites are known to change during thyroiditis development, suggesting a close relationship between blood metabolites and thyroiditis progression. However, evidence for a causal link is lacking.

Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disorder characterized by chronic inflammation and pathological lung remodeling driven by excessive extracellular matrix deposition. While the flavonol quercetin exhibits established anti-inflammatory and antioxidant properties, its therapeutic mechanisms against IPF-particularly regarding epithelial-mesenchymal transition (EMT) and inflammation regulation via the follistatin-like 1 (FSTL1)/nuclear factor kappa B (NF-κB) axis-remain incompletely elucidated. This study therefore investigates quercetin's capacity to mitigate pulmonary fibrosis through targeted modulation of the FSTL1/NF-κB pathway.

Monotonic phase coding with dynamic boundary alignment for high-speed 3D profilometry.

This study explores the important balance between efficiency and robustness in temporal phase unwrapping (TPU) for fringe projection profilometry (FPP). Traditional phase-coding techniques require multiple coded patterns to accurately determine fringe orders, which limits their use in high-speed dynamic measurements. We introduce a robust framework that employs three phase-shifting patterns alongside a single coded pattern to achieve accurate absolute phase retrieval.

Correlation between allergic diseases and lung cancer: a systematic review and meta-analysis.

Objectives: This meta-analysis aims to investigate the potential association between allergic diseases and lung cancer.

Methods: A systematic search was conducted in PubMed, Cochrane Library, Embase, and Web of Science databases up to October 8, 2024. Data analysis was performed using Stata 14.

Clinical characteristics of solitary hilar biliary cyst in children and prognosis of single-port laparoscopic cysto-cholecystostomy.

Objective: To summarize the clinical characteristics of children with solitary hilar biliary cysts and evaluate the medium- and long-term prognosis of single port laparoscopic cysto-cholecystostomy for this disease.

Methods: A retrospective analysis were performed on the data of 47 patients with solitary hilar bile duct cysts admitted to our center from January 2010 to January 2025. Among them, 44 cases meeting the surgical indications underwent single-port laparoscopic cysto-cholecystostomy, while 3 asymptomatic cases were followed up in outpatient clinic.

Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B.

Excessive type 2 immunity underlies various disease conditions, including allergies, yet the homeostatic mechanisms that limit type 2 responses are not fully understood. Here, we revealed that intestinal tuft cells, specialized epithelial cells known for triggering type 2 immune activation, also have a molecular circuit that restrains type 2 responses. Ablation of the transcription factor Spi-B in tuft cells was sufficient to elicit spontaneous type 2 inflammation.

Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database.

Introduction: Carboplatin is frequently employed in the treatment of non-small cell lung cancer (NSCLC), yet the real-world safety profile-including underrecognized adverse events (AEs) and subgroup-specific risk variations-remains incompletely understood. This study aims to systematically assess carboplatin-related AEs and explore demographic factors that may influence risk.

Methods: A retrospective analysis was performed using data from the FDA Adverse Event Reporting System (FAERS) spanning the first quarter of 2004 to the third quarter of 2024.

Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma.

This study investigated the prognostic impact of migrasome-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD). We analyzed transcriptomic data from The Cancer Genome Atlas (TCGA) database, comprising 541 tumor samples and 59 normal tissue samples, to pinpoint key migrasome genes and related lncRNAs, using correlation analysis to detect those pertinent to patient outcomes. A risk score model based on 17 migrasome-related lncRNAs, constructed via univariate, LASSO, and multivariate Cox regression, was then validated in an independent dataset to ensure reliability.

Enhanced oxidation of Cr(III) with the mineral transformation of CrFe(OH) in the presence of Mn(II): overlooked process during the reoccurrence of Cr(VI) in reduced chromite ore processing residue.

The reoccurrence of Cr(VI) in reduced chromium ore processing residue (rCOPR) causes secondary pollution after remediation, with Mn(II)-induced catalytic oxidation identified as one of its key contributors. The mineral transformation of Cr-Fe coprecipitate (CrFe(OH) dominant phase in rCOPR) tends to form goethite along with Cr(III) in alkaline environments. However, the effect of this critical process on Cr(VI) reoccurrence remains unknown and requires further investigation.

Anatomical and clinical significance of the Cyrano long-nosed patella in combination with patellofemoral instability: a case report and review of literature.

Background: The combination of a long-nosed patella and patella alta can lead to symptoms such as anterior knee pain and patellofemoral instability.

Purpose: Our objective was to address this uncommon, multifactorial cause of patellar pain and instability by a single-stage combined surgical approach.

Case Presentation: A 14-year-old German female presented to our hospital for recurrent patellar dislocations and exacerbated infrapatellar pain during kneeling.

Fast and Massive Production of Aramid Nanofibers via Molecule Intercalation.

Para-aramid nanofibers, one of the newest high-performance building blocks at the nanoscale, have attracted great attention due to their hard-to-find property sets and ability to form high-porosity solids. However, there are great difficulties in their scalable and sustainable production because the strong intermolecular hydrogen bonds and other interactions of aramid macromolecules lead to lengthy processes with highly corrosive solvents. Taking advantage of uniquely efficient delamination of polymer nanocrystallites, here we show that the preparation time of para-aramid nanofibers can be reduced by 2520 times (from 1 week to four min), while their concentration can be increased by 10 times.

Omega-3 and omega-6 fatty acids: Inverse association with body fat percentage and obesity risk.

To investigate the association between the omega-6 and omega-3 intakes and body fat percentage (BF%), and the risk of obesity, we conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES). We hypothesized that increasing omega-3 or omega-6 intakes could reduce BF% and, consequently, the risk of obesity. Therefore, we utilized data from NHANES collected between 2011 and 2018, focusing on adults aged 20 to 59 years.

Sargassum Nanocellulose-Based Fully Ingestible Supercapacitor.

Small high-performance energy modules have significant practical value in the biomedical field, such as painless diagnosis, alleviation of gastrointestinal discomfort, and electrical stimulation therapy. However, due to performance limitations and safety concerns, it is a formidable challenge to design a small, emerging ingestible power supply. Here, a fully ingestible supercapacitor (FISC) constructed of sargassum cellulose nanofiber is presented.

PAR2 promotes malignancy in lung adenocarcinoma.

Proteinase-activated receptor-2 (PAR2) is closely linked to tumor malignancy, but its biological role in cancer remains underexplored. In this study, we assessed PAR2 expression in lung adenocarcinoma (LUAD) and normal lung tissues, analyzed associations between clinicopathological features and survival rates, and confirmed that PAR2 promotes apoptosis resistance and reduces cisplatin-induced cytotoxicity in lung cancer cells. Using TCGA datasets, western blotting, qPCR, and immunohistochemistry (IHC), we observed a significant increase in PAR2 levels in LUAD samples compared to normal tissues (P<0.

Strong and Fireproof Regenerated Wood a Combined Phosphorylation-Surface Nanofibrillation and Ionic Cross-Linking Strategy.

To reduce the environmental impact of plastics, an increasing number of high-performance sustainable materials have emerged. Among them, wood-based high-performance structural materials have gained growing attention due to their outstanding mechanical and thermal properties. Here, we introduce phosphate groups onto the wood veneers for surface nanofibrillation, effectively altering both the molecular structure and surface morphology of wood, which enhances the interactions between wood veneers and endows the wood with excellent fire resistance properties.

A Robust, Biodegradable, and Fire-Retardant Cellulose Nanofibers-Based Structural Material Fabricated from Natural Sargassum.

With increasing concern about the environmental pollution of petrochemical plastics, people are constantly exploring environmentally friendly and sustainable alternative materials. Compared with petrochemical materials, cellulose has overwhelming superiority in terms of mechanical properties, thermal properties, cost, and biodegradability. However, the flammability of cellulose hinders its practical application to a certain extent, so improving the fire-retardant properties of cellulose nanofiber-based materials has become a research focus.

Sustainable High-Performance Structural Materials from Micro/nanostructured Corn Stover.

Corn stover, as an abundant agricultural residue, has not been well reutilized due to the lack of efficient utilization methods. Based on micro/nanoscale structure design of corn stover, we report an environmentally friendly strategy to prepare micro/nanostructured corn stover-based building blocks. Then, through the directed deformation assembly approach, a high value-added corn stover structural material (CSSM) that with higher strength and more excellent thermal stability than most widely used plastics and wood-plastic composites can be prepared.

Unraveling immobilization mechanisms of Cd in soil by MgO-modified palygorskite/biochar composite: DFT calculation and combined-artificial aging.

In this study, a combination method of freeze-thaw cycle, dry-wet cycle, and chemical agings was used to investigate the aging effect of MgO-modified palygorskite/biochar composite (MPBC) in soil, and its immobilization capacity on Cd under aging. The immobilization mechanisms of MPBC for Cd were explored through several characterizations and DFT calculations. The results showed that MPBC effectively reduced the activate state of Cd by 56.

Cultivating High-Performance Flexible All-in-One Supercapacitors With 3D Network Through Continuous Biosynthesis.

Flexible supercapacitors can potentially power next-generation flexible electronics. However, the mechanical and electrochemical stability of flexible supercapacitors under different flexible conditions is limited by the weak bonding between adjacent layers, posing a significant hindrance to their practical applicability. Herein, based on the uninterrupted 3D network during the growth of bacterial cellulose (BC), a flexible all-in-one supercapacitor is cultivated through a continuous biosynthesis process.

A Bioinspired Gradient Design Strategy for Cellulose-Based Electromagnetic Wave Absorbing Structural Materials.

Cellulose nanofiber (CNF) possesses excellent intrinsic properties, and many CNF-based high-performance structural and functional materials have been developed recently. However, the coordination of the mechanical properties and functionality is still a considerable challenge. Here, a CNF-based structural material is developed by a bioinspired gradient structure design using hollow magnetite nanoparticles and the phosphorylation-modified CNF as building blocks, which simultaneously achieves a superior mechanical performance and electromagnetic wave absorption (EMA) ability.

Nacre-Inspired Bacterial Cellulose/Mica Nanopaper with Excellent Mechanical and Electrical Insulating Properties by Biosynthesis.

The exploration of extreme environments has become necessary for understanding and changing nature. However, the development of functional materials suitable for extreme conditions is still insufficient. Herein, a kind of nacre-inspired bacterial cellulose (BC)/synthetic mica (S-Mica) nanopaper with excellent mechanical and electrical insulating properties that has excellent tolerance to extreme conditions is reported.

An All-Natural Wood-Inspired Aerogel.

The oriented pore structure of wood endows it with a variety of outstanding properties, among which the low thermal conductivity has attracted researchers to develop wood-like aerogels as excellent thermal insulation materials. However, the increasing demands of environmental protection have put forward new and strict requirements for the sustainability of aerogels. Here, we report an all-natural wood-inspired aerogel consisting of all-natural ingredients and develop a method to activate the surface-inert wood particles to construct the aerogel.